Cell Cycle Phases and Regulation

Play an AI-generated podcast conversation about this lesson

What occurs during the S phase of the cell cycle?

Apoptosis

Cell division

Protein synthesis

DNA replication (correct)

What is the role of CDK dependent kinases in the cell cycle?

To inhibit cell division

To activate cyclin

To phosphorylate targets (correct)

To degrade proteins

What is the function of Ubiquitination in the cell cycle?

To phosphorylate targets

To inhibit cell division

To degrade proteins (correct)

To activate protein synthesis

During which phase of the cell cycle does protein activation occur?

G1 phase Signup and view all the answers

What is the role of Cyclin in the cell cycle?

To activate CDK dependent kinases Signup and view all the answers

What is the outcome of E-CDK2 inhibition?

Cell division is inhibited Signup and view all the answers

During which phase of the cell cycle does transcription activation occur?

G1 phase Signup and view all the answers

What is the outcome of API transcription and degradation?

Protein levels decrease Signup and view all the answers

What is the primary function of Polyubiquitination in the cell cycle?

To mark Cyclin for degradation Signup and view all the answers

What is the result of APC/C-mediated degradation of Securin?

Release of cohesin complex Signup and view all the answers

During which phase of the cell cycle is Cyclin-CDK 62 first transcribed?

S phase Signup and view all the answers

What is the role of SCF in the cell cycle?

To target inhibitors of START for degradation Signup and view all the answers

What is the consequence of CDK phosphorylation during the cell cycle?

Triggering of the Metaphase-Anaphase transition Signup and view all the answers

What is the function of APC/C during the cell cycle?

To target Cyclin for degradation Signup and view all the answers

What is the result of CDK inhibition during the cell cycle?

Inhibition of the G2-M transition Signup and view all the answers

What is the role of the cohesin complex during the cell cycle?

To hold sister chromatids together Signup and view all the answers

What is the primary function of the Nuclear Lamina in the cell?

To provide a structural support and sustain the nuclear membrane Signup and view all the answers

Why does CDK phosphorylate Lamin A only during mitotic prophase?

Because the substrate specificity of CDK changes during mitotic prophase Signup and view all the answers

What is the role of Cyclin in the regulation of CDK activity?

To activate CDK activity by providing a binding site Signup and view all the answers

What is the mechanism by which CDK activity is regulated?

Through the orylation/de-phosphorylation of CDK Signup and view all the answers

What is the result of CDK phosphorylating Lamin A during mitotic prophase?

The inactivation of Lamin A Signup and view all the answers

What is the characteristic of CDK substrate recognition?

CDK recognizes different substrates through different Cyclin types Signup and view all the answers

What is the fate of Cyclin during certain periods of the cell cycle?

It is rapidly degraded Signup and view all the answers

What is the role of CAK in the regulation of CDK activity?

It phosphorylates CDK to activate it Signup and view all the answers