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Cell-Cell Junctions in Medical Biology

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Questions and Answers

What is the contribution of E-cadherin loss to cancer development?

Increased expression of actin microfilaments

Enhanced cell-cell communication

Increased intermediate filament formation

Formation of metastasis in epithelial tissue cancers (correct)

What type of cell-cell junction is characterized by a belt-like structure?

Tight junction

Desmosome

Zonula adherens (correct)

Gap junction

Which type of junction permits the direct transfer of ions and small molecules?

Gap junction (correct)

Zonula occludens

Tight junction

Desmosome

What is the structure of anchoring junctions?

Transmembrane cadherin proteins - intracellular catenin proteins - linked to intermediate filaments Signup and view all the answers

What is the autoimmune disease characterized by blister formation due to autoantibodies against cadherin proteins?

Pemphigus Signup and view all the answers

Which type of cell-cell junction is characterized by a spot-like structure?

Macula adherens Signup and view all the answers

What type of filaments is zonula adherens associated with?

Actin microfilaments Signup and view all the answers

What is the function of gap junctions in the inner ear?

Permits the direct transfer of ions and small molecules Signup and view all the answers

What type of cell-cell junction is formed between heart muscle cells?

Anchoring junction Signup and view all the answers

What is the role of catenin proteins in cell-cell junctions?

Links transmembrane cadherin proteins to the cytoskeleton Signup and view all the answers