Cell Biology: Cell-Cell Interactions
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Questions and Answers

What is the primary role of the extracellular matrix (ECM) in both plants and animals?

  • Nutrient absorption
  • Photosynthesis
  • Structural support and shape (correct)
  • Energy storage
  • The primary cell wall is formed after the secondary cell wall in plants.

    False (B)

    What are the two primary components of the plant cell wall?

    Cellulose and pectin

    The two types of plant cell walls are the primary wall and the ______.

    <p>secondary wall</p> Signup and view all the answers

    Match the following components of the plant cell wall with their functions:

    <p>Cellulose = Provides structural integrity Pectin = Binds water and aids in cell adhesion Hemicellulose = Forms a network with cellulose Extensin = Acts as a barrier against microorganisms</p> Signup and view all the answers

    Which of the following is NOT a component of the extracellular matrix in animals?

    <p>Cellulose (C)</p> Signup and view all the answers

    The extracellular matrix in animals is inert and does not play a role in cellular activities.

    <p>False (B)</p> Signup and view all the answers

    Name one protein found in the extracellular matrix in animals.

    <p>Collagen</p> Signup and view all the answers

    What is the primary role of anchoring junctions?

    <p>Connect cells to the extracellular matrix (B)</p> Signup and view all the answers

    Tight junctions are present in both vertebrates and invertebrates.

    <p>False (B)</p> Signup and view all the answers

    What are the transmembrane proteins that form the basis of tight junctions?

    <p>claudin and ocludin</p> Signup and view all the answers

    Gap junctions consist of transmembrane proteins called ________, which allow communication between adjacent cells.

    <p>connexons</p> Signup and view all the answers

    Match the following junctions with their primary function:

    <p>Tight Junctions = Barrier for selective permeability Desmosomes = Mechanical strength Gap Junctions = Signal transmission Plasmodesmata = Connect cytoplasm of plant cells</p> Signup and view all the answers

    Which type of junction is primarily involved in signal relaying between adjacent cells?

    <p>Signal relaying junctions (B)</p> Signup and view all the answers

    Integrins are solely involved in cell adhesion to other cells.

    <p>False (B)</p> Signup and view all the answers

    What is the main function of desmosomes in a multicellular organism?

    <p>Providing mechanical strength to cells</p> Signup and view all the answers

    ______ junctions are characterized by tightly packed cells preventing the diffusion of substances, found mainly in vertebrates.

    <p>Tight</p> Signup and view all the answers

    Which junction is exclusive to plant cells?

    <p>Plasmodesmata (D)</p> Signup and view all the answers

    Flashcards

    Basement Membrane (in Kidney)

    A specialized layer found in the kidneys, acting as a barrier between capillaries and the tubule walls, preventing the passage of proteins.

    Extracellular Matrix (ECM)

    A complex network of molecules outside the cell membrane, providing structural support, regulating cell behavior, and acting as a communication hub.

    Plant Cell Wall

    A rigid, protective structure surrounding plant cells, composed of cellulose, hemicellulose, pectin, and proteins. It provides structural support, regulates cell growth, and acts as a barrier.

    Cellulose

    The main structural component of plant cell walls, a long chain of glucose molecules forming strong fibers.

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    Hemicellulose

    Branched polysaccharides found in plant cell walls, acting as a filler and providing flexibility to the structure.

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    Pectin

    Negatively charged polysaccharides in plant cell walls, attracting water and providing gel-like properties.

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    Extensins (Plant Cell Wall)

    Fibrous proteins in plant cell walls, providing strength and resistance against pathogens.

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    Animal Extracellular Matrix

    A type of ECM found in animals, composed of collagen, proteoglycans, and other proteins. It provides structural support and plays a role in tissue development and repair.

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    What are cell junctions?

    Cell junctions are specialized structures that connect cells and contribute to tissue organization, communication, and function. They facilitate interactions between cells and the extracellular matrix, maintaining tissue integrity and enabling coordinated responses.

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    What are anchoring junctions?

    Anchoring junctions, tightly connecting cells to their neighbors or the ECM, use cytoskeletal filaments for structural support. These junctions are essential for maintaining tissue integrity and resisting mechanical stress.

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    What are adherens junctions?

    Adherens junctions, a type of anchoring junction, link the cytoskeleton of neighboring cells through transmembrane proteins and cadherins. They play a crucial role in maintaining cell shape and tissue integrity during development and growth.

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    What are desmosomes?

    Desmosomes, another type of anchoring junction, connect cells through intermediate filaments. They contribute to the mechanical strength and resilience of tissues, providing resistance to tearing and shearing forces.

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    What is integrin?

    Integrin, a transmembrane adhesion protein, mediates cell-ECM interactions. It plays a role in cell signaling, adhesion, and migration, linking the cytoskeleton to the extracellular matrix.

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    What are tight junctions?

    Tight junctions, specialized junctions that encircle cells, block diffusion of molecules between neighboring cells, forming a barrier that maintains the distinct composition of fluids within tissues. They are found in epithelial tissues.

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    What are gap junctions?

    Gap junctions, channel-forming junctions, allow direct communication between cells through the passage of ions and small molecules. They facilitate rapid and coordinated responses in tissues.

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    What are plasmodesmata?

    Plasmodesmata, similar to gap junctions in plants, connect the cytoplasm of neighboring cells, allowing the passage of molecules and signals. They are crucial for coordinated development and communication between cells.

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    What is the extracellular matrix (ECM)?

    The extracellular matrix (ECM) is a complex network of macromolecules secreted by cells that provides structural support, regulates cell behavior, and facilitates tissue organization. It is important for cell adhesion, migration, and differentiation.

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    What is the basal lamina?

    The basal lamina is a specialized type of ECM that provides structural support for epithelial and other tissues. It acts as a barrier, regulates cell behavior, and facilitates tissue organization and function.

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    Study Notes

    Cell-Cell Interactions

    • Cells in multicellular organisms interact via cytoskeletal filaments
    • Mechanical stresses are transmitted through cytoskeletal filaments, attached to cell-matrix and cell-cell adhesion sites
    • Extracellular matrix directly experiences mechanical stresses, like tension and compression.

    Cell Junction Classification

    • Anchoring junctions: connect cells via actin filaments (adherens junctions, focal contacts). They also connect cells to the extracellular matrix via intermediate filaments (desmosomes, hemidesmosomes).
    • Occluding junctions: tight junctions are found only in vertebrates, septate junctions in invertebrates.
    • Channel-forming junctions: gap junctions facilitate communication and transport of small molecules between cells. Plasmodesmata exist in plant cells.
    • Signal relaying junctions: these facilitate cell signaling, including synapses in the nervous system, interactions in the immune system, and cell-cell interactions involving delta-Notch.

    Cellular Adhesion

    • Adhesion is crucial for proper structure and function of multicellular organisms, involving a variety of cellular adhesions.
    • Mechanisms include:
      • Tight junctions seal gaps between epithelial cells, enabling selective permeability differences.
      • Adherens junctions and desmosomes connect actin and intermediate filaments to create a robust cell-cell anchoring system.
      • Gap junctions allow small molecules to pass between cells, enabling electrical and chemical signaling.
      • Hemidesmosomes anchor intermediate filaments for cell attachment to the extracellular matrix.

    Cell Junctions: Proteins

    • Anchoring junctions involve transmembrane adhesion proteins, extracellular ligands, and intracellular cytoskeletal attachments.
    • Specific anchoring junction types, such as adherens junctions, desmosomes, and hemidesmosomes, use designated proteins (e.g., cadherins, desmoglein, desmocollin, and integrins).
    • Other types of junctions also have specialized protein components, like those involved in tight junctions, gap junctions, and signal relaying junctions.

    Additional Cell Junctions

    • Integrins: Proteins involved in cell adhesion, particularly cell-matrix adhesion. They play roles in cell signaling and are involved in interactions between cells and their surrounding extracellular matrix.
    • Selectins: Cell adhesion molecules primarily involved in cell interaction, primarily within blood vessel pathways. They are important in cell-cell interactions within circulatory systems.
    • Integrins, selectins and other proteins are crucial for cell-cell interactions and communication within tissues. These molecules are involved in establishing and maintaining cell polarity, tissue structure, and communication.

    Basal Membranes

    • Surrounds muscle and fat cells
    • Located beneath epithelial cells and is a critical site for cell attachment
    • Plays a role in cellular migration
    • Functionally acts as a barrier in places such as kidney glomeruli blocking large proteins moving into and out of the glomerular capillaries.

    Extracellular Matrix

    • Cells release protein components into the extracellular matrix that create a strong structural mesh between cells.
    • The matrix creates structure between cells and provides a supportive framework for tissues.
    • ECM components play important functional roles both structure and cell signaling.

    Cell Wall Structure

    • Plant cell walls are composed of primarily cellulose, which creates structural support.
    • These polymers are strengthened and interconnected by hemicellulose and pectin polymers for additional reinforcement.
    • Proteins, especially extensins, contribute to cell wall physical properties and provide a barrier against pathogens.

    ECM Diseases

    • Mutations in collagen components can lead to conditions like osteogenesis imperfecta, characterized by brittle bones and fragile tissues.
    • Conditions that affect collagen production and/or function commonly exhibit connective tissue abnormalities.
    • Genetic disorders and environmental factors can affect ECM structure and lead to abnormalities in tissues which impact their functionality.

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    Description

    Explore the intricate world of cell-cell interactions and junctions in multicellular organisms. This quiz covers various types of cell junctions, including anchoring, occluding, channel-forming, and signal relaying junctions, as well as their roles in mechanical stress transmission and communication. Test your knowledge and understanding of these essential biological concepts.

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