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Questions and Answers
What is the primary function of the cell membrane?
What is the primary function of the cell membrane?
Which of the following is NOT a type of cell adaptation?
Which of the following is NOT a type of cell adaptation?
What is the primary function of the nucleus?
What is the primary function of the nucleus?
Which of the following is a common cause of cell injury?
Which of the following is a common cause of cell injury?
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What is the difference between apoptosis and necrosis?
What is the difference between apoptosis and necrosis?
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Which of the following is NOT a cause of hypoxic injury?
Which of the following is NOT a cause of hypoxic injury?
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What is the primary consequence of decreased oxygen delivery to cells?
What is the primary consequence of decreased oxygen delivery to cells?
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Which of the following is a characteristic of anaerobic metabolism in hypoxic cells?
Which of the following is a characteristic of anaerobic metabolism in hypoxic cells?
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What is the term for an increase in the size of a cell, often associated with an increase in the amount of actin and myosin?
What is the term for an increase in the size of a cell, often associated with an increase in the amount of actin and myosin?
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What is the term for the transformation of one cell type into another, which can occur as a response to chronic irritation or injury?
What is the term for the transformation of one cell type into another, which can occur as a response to chronic irritation or injury?
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Which of the following cellular adaptations is characterized by a reversible replacement of one mature cell type by another?
Which of the following cellular adaptations is characterized by a reversible replacement of one mature cell type by another?
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Which of the following cellular adaptations is often associated with an increase in the size of cells due to increased workload?
Which of the following cellular adaptations is often associated with an increase in the size of cells due to increased workload?
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Which cellular adaptation is characterized by an abnormal change in the size, shape, and organization of mature cells, often associated with an increased risk of cancer development?
Which cellular adaptation is characterized by an abnormal change in the size, shape, and organization of mature cells, often associated with an increased risk of cancer development?
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Which of the following cellular adaptations involves a decrease in the size of cells, often due to reduced workload or inadequate nutrition?
Which of the following cellular adaptations involves a decrease in the size of cells, often due to reduced workload or inadequate nutrition?
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What is the underlying mechanism behind hormonal hyperplasia?
What is the underlying mechanism behind hormonal hyperplasia?
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Which type of cellular adaptation is considered a protective mechanism, replacing fragile epithelium with more resilient cell types?
Which type of cellular adaptation is considered a protective mechanism, replacing fragile epithelium with more resilient cell types?
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Which of the following is NOT a possible cause of atrophy?
Which of the following is NOT a possible cause of atrophy?
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What is the characteristic feature of dysplasia that distinguishes it from other adaptive changes?
What is the characteristic feature of dysplasia that distinguishes it from other adaptive changes?
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Which of the following scenarios would be most likely to lead to hypertrophy of skeletal muscle?
Which of the following scenarios would be most likely to lead to hypertrophy of skeletal muscle?
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Which cellular adaptation could be described as a compensatory response to tissue damage, helping to replace lost cells and regenerate tissues?
Which cellular adaptation could be described as a compensatory response to tissue damage, helping to replace lost cells and regenerate tissues?
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What is a characteristic of free radicals that makes them reactive?
What is a characteristic of free radicals that makes them reactive?
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How can free radicals damage DNA?
How can free radicals damage DNA?
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Which of the following is NOT a consequence of free radical damage to lipids and proteins?
Which of the following is NOT a consequence of free radical damage to lipids and proteins?
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Which of the following is NOT an example of a disease linked to free radical damage?
Which of the following is NOT an example of a disease linked to free radical damage?
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Why are antioxidants important for preventing free radical damage?
Why are antioxidants important for preventing free radical damage?
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Which of the following is NOT a good source of antioxidants?
Which of the following is NOT a good source of antioxidants?
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Based on the information provided, how might free radicals contribute to the development of cardiovascular disease?
Based on the information provided, how might free radicals contribute to the development of cardiovascular disease?
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What is the primary way that free radicals cause cell injury?
What is the primary way that free radicals cause cell injury?
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Which of the following clinical examples is NOT directly related to apoptosis?
Which of the following clinical examples is NOT directly related to apoptosis?
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What is a major difference between apoptosis and necrosis?
What is a major difference between apoptosis and necrosis?
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How does wet gangrene differ from dry gangrene?
How does wet gangrene differ from dry gangrene?
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Which of the following is NOT a characteristic of apoptosis?
Which of the following is NOT a characteristic of apoptosis?
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Which of the following scenarios is MOST likely to result in wet gangrene?
Which of the following scenarios is MOST likely to result in wet gangrene?
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What is the direct consequence of decreased ATP production in a cell?
What is the direct consequence of decreased ATP production in a cell?
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What is the key factor responsible for cellular and organelle swelling during decreased ATP production?
What is the key factor responsible for cellular and organelle swelling during decreased ATP production?
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Which of the following consequences directly results from the failure of the Ca++ pump in a cell?
Which of the following consequences directly results from the failure of the Ca++ pump in a cell?
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Which of these events is a direct consequence of the accumulation of lactic acid during anaerobic metabolism?
Which of these events is a direct consequence of the accumulation of lactic acid during anaerobic metabolism?
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What is the main consequence of the release of lysosomal hydrolytic enzymes within a cell?
What is the main consequence of the release of lysosomal hydrolytic enzymes within a cell?
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What is the primary mechanism by which reperfusion injury occurs?
What is the primary mechanism by which reperfusion injury occurs?
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What is the source of the xanthine oxidase enzyme involved in free radical formation during reperfusion?
What is the source of the xanthine oxidase enzyme involved in free radical formation during reperfusion?
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What is the direct consequence of free radical formation during reperfusion?
What is the direct consequence of free radical formation during reperfusion?
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Flashcards
Cell Adaptations
Cell Adaptations
Changes in cell structure or function in response to stress.
Cell Injury
Cell Injury
Damage to a cell that impairs its function but may be reversible.
Cell Death
Cell Death
Permanent loss of cell function and integrity, can be due to injury or stress.
Concept Overview
Concept Overview
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Schematic Diagram of a Cell
Schematic Diagram of a Cell
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Hyperplasia
Hyperplasia
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Muscle Hypertrophy
Muscle Hypertrophy
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Hypoxic Injury
Hypoxic Injury
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Anaerobic Metabolism
Anaerobic Metabolism
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ATP Production
ATP Production
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Lysosomes
Lysosomes
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Mitochondria
Mitochondria
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Ribosomes
Ribosomes
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Atrophy
Atrophy
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Hypertrophy
Hypertrophy
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Metaplasia
Metaplasia
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Dysplasia
Dysplasia
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Compensatory Hyperplasia
Compensatory Hyperplasia
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Hormonal Hyperplasia
Hormonal Hyperplasia
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Decreased ATP Production
Decreased ATP Production
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Na+/K+ Pump Failure
Na+/K+ Pump Failure
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Na+ Accumulation in Cell
Na+ Accumulation in Cell
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Cell Swelling
Cell Swelling
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Ca++ Pump Failure
Ca++ Pump Failure
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Lactic Acid Formation
Lactic Acid Formation
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Hydrolytic Enzymes Release
Hydrolytic Enzymes Release
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Reperfusion Injury
Reperfusion Injury
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Gangrene
Gangrene
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Wet Gangrene
Wet Gangrene
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Dry Gangrene
Dry Gangrene
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Apoptosis
Apoptosis
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Apoptosis Examples
Apoptosis Examples
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Free Radicals
Free Radicals
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DNA Damage from Free Radicals
DNA Damage from Free Radicals
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Lipid and Protein Damage
Lipid and Protein Damage
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Antioxidants
Antioxidants
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Sources of Antioxidants
Sources of Antioxidants
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Necrosis
Necrosis
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Study Notes
Alterations of Cell Function
- NUR3110 course
- Topics: Cell injury, cell death, and alterations in cellular function.
Concept Overview
- This section provides a general introduction to the topic.
Review of Cell Structure
- A diagram showing a schematic of a cell with labeled components such as mitochondria, plasma membrane, lysosomes, nucleus, ribosomes on the rough endoplasmic reticulum, sodium-potassium pump and calcium pump.
Review - ATP Production
- A diagram relating to ATP production in the cell is presented. Oxygen (O2), and glucose (G) are shown as inputs to a process in the cell, and ATP as an output
Review - ATP Utilization
- Multiple diagrams showing the utilization of ATP in various cellular processes, including sodium-potassium pump function, calcium pump function, cell structure and function, lipid transport, and secretion.
Review of Normal ATP Production
- A detailed diagram illustrating the Citric acid cycle (Krebs cycle).
- The Krebs cycle is a crucial part of cellular respiration for ATP generation.
- Key components and reactions involved in the Citric acid cycle are referenced, as well as related molecules.
Review of Normal ATP Production (cont.)
- Detailed depictions of processes relating to the electron transport chain for the continued creation of ATP. This is a key part of cellular respiration.
Cellular Adaptation
- Describes cell adaptations like atrophy, hypertrophy, hyperplasia, metaplasia, and dysplasia. Each is described individually below.
Atrophy
- A decrease or shrinkage in the size of cells.
- Examples, such as disuse atrophy and adrenal gland atrophy, are shown.
Hypertrophy
- An increase in the size of cells.
- Examples, such as skeletal muscle hypertrophy and cardiac muscle hypertrophy, are depicted.
Hyperplasia
- An increase in the number of cells.
- Examples of types of hyperplasia include compensatory and hormonal hyperplasia.
- Compensatory hyperplasia is illustrated with liver regeneration following a transplant operation.
- Hormonal changes are illustrated with puberty-linked changes in breast growth.
- Pathologic hyperplasia is illustrated, with benign prostatic hyperplasia. A diagram showing normal prostate compared with an enlarged prostate is included.
Metaplasia
- The reversible replacement of one mature cell type by another.
- Diagrams demonstrate normal vs metaplasia and bronchial metaplasia.
Dysplasia
- Abnormal changes in the size, shape, and organization of mature cells
- Different stages of dysplasia are shown diagramatically - mild, moderate and severe or carcinoma in situ.
Test Your Understanding (iClicker Questions)
- Multiple-choice questions regarding cellular adaptation concepts and examples are presented.
Hypoxic Injury
- Description of mechanisms by which the delivery of oxygen to tissues may be prevented.
- Causes of hypoxic injury such as hypoxemia (low oxygen in blood) and ischemia (reduced blood flow).
- Consequences of hypoxic injury, including decreased ATP production, failure of Na+/K+ pump, and the accumulation of Na+ and Ca²⁺ in the cell.
- A variety of diagrams illustrates consequences of cellular injury including anaerobic metabolism, decreased protein synthesis, increased lactic acid, lysosomal degradation and decreased functional protein availability.
Reperfusion Injury
- The implications of introducing oxygen to hypoxic tissue, and the possibility of further damage to the cell following oxygen restoration. A brief description of how oxygen is then used by cells.
Free Radical Injury
- Overview of free radicals, and impacts on cells including DNA damage, and damage to plasma membranes, enzymes and structural proteins.
- Free radicals are described as having unpaired electrons.
- The clinical relevance is highlighted by illustrations of cancer and cardiovascular disease.
- This section describes how free radicals react with other components in the cell.
Inactivation of Free Radicals
- Mechanisms used to reduce the potential for harm including antioxidants with illustrations, and examples of antioxidant-rich foods.
Cell Death - Overview
- Two types of cell death: necrosis and apoptosis.
- Necrosis is classified as cell death due to injury, while apoptosis is "programmed" cell death.
Necrosis
- Loss of plasma membrane structure leads to swelling of organelles.
- Mitochondria dysfunction leads to cell death.
- Necrosis looks different depending on the tissue.
Gangrene (Gangrenous Necrosis)
- Extensive cell death from severe hypoxic injury
- Types of gangrene include wet/moist (bacterial infection) and dry gangrene.
Apoptosis
- A process of controlled cell death initiated by internal mechanisms.
- Unlike necrosis, an inflammatory response is not triggered.
Apoptosis Clinical Examples
- Illustrates how apoptosis functions in embryonic development and cancer scenarios.
Quizzes and Study Guides
- Information about scheduled quizzes and a study guide in the Canvas online learning platform.
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Description
Test your knowledge on cell biology concepts, particularly focusing on cell membranes, adaptations, and types of cell injury. This quiz will cover essential functions of cell components and the mechanisms behind cellular changes. Perfect for students studying biology or advancing their understanding of cellular processes.