Cell Aggregation and Fully Human mAbs Quiz
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Questions and Answers

What is the key process involved in the formation of polykaryocytes?

  • Cell aggregation (correct)
  • Molecular cloning
  • Hybridomas approach
  • Synkaryon formation

Which technique is used to produce fully human monoclonal antibodies?

  • Immunoprecipitation technique
  • Molecular cloning in a bacterial system
  • Hybridomas approach in a transgenic mouse
  • Large-scale plasma fractionation (correct)

In which field are bevacizumab, trastuzumab, and rituximab commonly used?

  • Cardiology (correct)
  • Dermatology
  • Neurology
  • Oncology

What was demonstrated in the late 1930s regarding measles prevention?

<p>Vaccination is ineffective against measles (C)</p> Signup and view all the answers

Which process facilitated the use of immunoglobulin preparations for preventing or treating diseases?

<p>Protein crystallization (D)</p> Signup and view all the answers

What is the most effective application of monoclonal antibodies mentioned in the text?

<p>Treating autoimmune diseases (A)</p> Signup and view all the answers

What is the first step in the generation of hybridoma cells for monoclonal antibody production?

<p>Immunization of mice and selection of mouse donors (A)</p> Signup and view all the answers

What is a hybridoma?

<p>A cell line capable of producing one type of antibody protein (D)</p> Signup and view all the answers

Which type of cell is a myeloma?

<p>A cancer cell (D)</p> Signup and view all the answers

What is the function of healthy plasma cells in the body?

<p>Produce antibodies to fight infections (B)</p> Signup and view all the answers

Which type of in vitro system allows for high-density cell culture in monoclonal antibody production?

<p>Double-compartment systems (D)</p> Signup and view all the answers

What is the final step in the generation of hybridoma cells for monoclonal antibody production?

<p>Cloning of hybridoma cell lines (B)</p> Signup and view all the answers

What is the main purpose of therapies using monoclonal antibodies?

<p>To activate antibody-dependent cytotoxic pathways (B)</p> Signup and view all the answers

How are fully human monoclonal antibodies typically produced?

<p>Using transgenic mice (C)</p> Signup and view all the answers

What differentiates polyclonal serum from monoclonal antibodies?

<p>Polyclonal serum consists of antibodies directed to multiple epitopes (C)</p> Signup and view all the answers

What is the primary source material for generating recombinant antibodies?

<p>Plasma cells from immunized animals (B)</p> Signup and view all the answers

Which pathway is NOT typically activated by therapies using monoclonal antibodies?

<p>Intramuscular injections (B)</p> Signup and view all the answers

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