17 Questions
What is the key process involved in the formation of polykaryocytes?
Cell aggregation
Which technique is used to produce fully human monoclonal antibodies?
Large-scale plasma fractionation
In which field are bevacizumab, trastuzumab, and rituximab commonly used?
Cardiology
What was demonstrated in the late 1930s regarding measles prevention?
Vaccination is ineffective against measles
Which process facilitated the use of immunoglobulin preparations for preventing or treating diseases?
Protein crystallization
What is the most effective application of monoclonal antibodies mentioned in the text?
Treating autoimmune diseases
What is the first step in the generation of hybridoma cells for monoclonal antibody production?
Immunization of mice and selection of mouse donors
What is a hybridoma?
A cell line capable of producing one type of antibody protein
Which type of cell is a myeloma?
A cancer cell
What is the function of healthy plasma cells in the body?
Produce antibodies to fight infections
Which type of in vitro system allows for high-density cell culture in monoclonal antibody production?
Double-compartment systems
What is the final step in the generation of hybridoma cells for monoclonal antibody production?
Cloning of hybridoma cell lines
What is the main purpose of therapies using monoclonal antibodies?
To activate antibody-dependent cytotoxic pathways
How are fully human monoclonal antibodies typically produced?
Using transgenic mice
What differentiates polyclonal serum from monoclonal antibodies?
Polyclonal serum consists of antibodies directed to multiple epitopes
What is the primary source material for generating recombinant antibodies?
Plasma cells from immunized animals
Which pathway is NOT typically activated by therapies using monoclonal antibodies?
Intramuscular injections
Test your knowledge on cell surfaces, polykaryocytes formation, synkaryon formation, and the production of fully human monoclonal antibodies using the Hybridomas approach in a transgenic mouse.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
