Cell Aggregation and Fully Human mAbs Quiz
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Questions and Answers

What is the key process involved in the formation of polykaryocytes?

  • Cell aggregation (correct)
  • Molecular cloning
  • Hybridomas approach
  • Synkaryon formation

    • Which technique is used to produce fully human monoclonal antibodies?

  • Immunoprecipitation technique
  • Molecular cloning in a bacterial system
  • Hybridomas approach in a transgenic mouse
  • Large-scale plasma fractionation (correct)

    • In which field are bevacizumab, trastuzumab, and rituximab commonly used?

  • Cardiology (correct)
  • Dermatology
  • Neurology
  • Oncology

    • What was demonstrated in the late 1930s regarding measles prevention?

    <p>Vaccination is ineffective against measles</p> Signup and view all the answers

    Which process facilitated the use of immunoglobulin preparations for preventing or treating diseases?

    <p>Protein crystallization</p> Signup and view all the answers

    What is the most effective application of monoclonal antibodies mentioned in the text?

    <p>Treating autoimmune diseases</p> Signup and view all the answers

    What is the first step in the generation of hybridoma cells for monoclonal antibody production?

    <p>Immunization of mice and selection of mouse donors</p> Signup and view all the answers

    What is a hybridoma?

    <p>A cell line capable of producing one type of antibody protein</p> Signup and view all the answers

    Which type of cell is a myeloma?

    <p>A cancer cell</p> Signup and view all the answers

    What is the function of healthy plasma cells in the body?

    <p>Produce antibodies to fight infections</p> Signup and view all the answers

    Which type of in vitro system allows for high-density cell culture in monoclonal antibody production?

    <p>Double-compartment systems</p> Signup and view all the answers

    What is the final step in the generation of hybridoma cells for monoclonal antibody production?

    <p>Cloning of hybridoma cell lines</p> Signup and view all the answers

    What is the main purpose of therapies using monoclonal antibodies?

    <p>To activate antibody-dependent cytotoxic pathways</p> Signup and view all the answers

    How are fully human monoclonal antibodies typically produced?

    <p>Using transgenic mice</p> Signup and view all the answers

    What differentiates polyclonal serum from monoclonal antibodies?

    <p>Polyclonal serum consists of antibodies directed to multiple epitopes</p> Signup and view all the answers

    What is the primary source material for generating recombinant antibodies?

    <p>Plasma cells from immunized animals</p> Signup and view all the answers

    Which pathway is NOT typically activated by therapies using monoclonal antibodies?

    <p>Intramuscular injections</p> Signup and view all the answers

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