Pathology L5: Cell Adaptation and Homeostasis
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Questions and Answers

What is the primary consequence if a cell fails to adapt to stress?

  • The cell will experience cellular injury. (correct)
  • The cell will undergo hyperplasia.
  • The cell will maintain its normal function.
  • The cell will stabilize through homeostasis.

Which of the following types of adaptation is characterized by an increase in cell size?

  • Metaplasia
  • Hypertrophy (correct)
  • Dysplasia
  • Atrophy

Which type of cellular adaptation involves an increase in the number of cells?

  • Atrophy
  • Dysplasia
  • Hyperplasia (correct)
  • Metaplasia

What defines homeostasis in relation to cellular function?

<p>The tendency for an organism to maintain stability in normal body states. (A)</p> Signup and view all the answers

Which of the following adaptations is not considered a minor type?

<p>Dysfunction (C)</p> Signup and view all the answers

Which of the following statements regarding cell adaption is false?

<p>It has an irreversible change (C)</p> Signup and view all the answers

What are the five minor types of adaption?

<p>Atrophy, hypertrophy, hyperplasia, dysplasia and metaplasia</p> Signup and view all the answers

Which factor does NOT contribute to cellular atrophy?

<p>Increased protein synthesis (A)</p> Signup and view all the answers

What is an example of physiological atrophy?

<p>Non-lactating mammary gland post pregnancy (B)</p> Signup and view all the answers

Which of the following correctly explains the role of denervation in cellular atrophy?

<p>It leads to a decrease in cell function due to loss of nerve supply (A)</p> Signup and view all the answers

List some common causes of atrophy (hint 6 in class)

<p>Decrease workload, denervation, decrease in blood supply or oxygen, inadequate nutrition, loss of endocrine function, aging (senescence)</p> Signup and view all the answers

What is the primary distinction between hypoplasia and atrophy?

<p>Hypoplasia is congenital, while atrophy occurs after full development. (A)</p> Signup and view all the answers

Which of the following terms refers to incomplete or underdevelopment of an organ?

<p>Hypoplasia (C)</p> Signup and view all the answers

A condition characterized by the complete lack of development of an organ is known as:

<p>Aplasia (B)</p> Signup and view all the answers

What does the term "hypotrophy" or "abiotrophy" describe?

<p>Progressive loss of tissue vitality and function (C)</p> Signup and view all the answers

What does hypertrophy refer to?

<p>An increase in the size of cells. (B)</p> Signup and view all the answers

Which of the following is NOT commonly associated with hypertrophy?

<p>Labile cells such as intestinal epithelium. (B)</p> Signup and view all the answers

Which of the following mechanisms contributes to hypertrophy?

<p>Mechanical stretch from increased workload (B)</p> Signup and view all the answers

Which of the following is a growth factor that plays a role in hypertrophy?

<p>IGF1 (C)</p> Signup and view all the answers

What happens when cardiac hypertrophy reaches its limit and the muscle mass can no longer cope with the increased burden?

<p>Regressive changes occur in the myocardial fibers. (B)</p> Signup and view all the answers

In extreme cases of cardiac hypertrophy, what may ultimately occur?

<p>Myocyte death. (C)</p> Signup and view all the answers

What is hyperplasia?

<p>An increase in the number of cells in an organ, often leading to increased tissue/organ size. (D)</p> Signup and view all the answers

Which of the following cell types are most likely to undergo hyperplasia?

<p>Labile cells such as epidermis and intestinal epithelium. (A)</p> Signup and view all the answers

What is an example of physiologic hyperplasia?

<p>Mammary gland enlargement during pregnancy. (B)</p> Signup and view all the answers

Which statement about permanent cells is correct?

<p>They have very little capacity to regenerate or become hyperplastic. (B)</p> Signup and view all the answers

What is a common cause of pathological hyperplasia?

<p>Excessive hormonal or growth factor stimulation. (B)</p> Signup and view all the answers

What is the most common cause of pathological hyperplasia?

<p>Excessive hormonal or growth factor stimulation (D)</p> Signup and view all the answers

Which of the following is not an example of pathological hyperplasia?

<p>Mammary gland enlargement during pregnancy. (B)</p> Signup and view all the answers

What is metaplasia?

<p>A reversible change in the phenotype of a differentiated cell in response to chronic irritation. (B)</p> Signup and view all the answers

Which of the following is not an example of metaplasia?

<p>Mammary gland changes during pregnancy. (C)</p> Signup and view all the answers

What is a possible outcome of metaplasia if the cause is not removed?

<p>Malignant transformation (neoplasia). (B)</p> Signup and view all the answers

What does dysplasia refer to?

<p>Abnormal development affecting the shape, size, and organization of cells, often associated with neoplastic transformation. (B)</p> Signup and view all the answers

Which type of cells are most often affected by metaplasia?

<p>Epithelial cells (C)</p> Signup and view all the answers

Dysplasia can also be described as the alteration in its ___, ___, and ____, usually affecting the epithelium, occasionally associated with neoplastic transformation.

<p>Shape, size and organization</p> Signup and view all the answers

Flashcards

Cell Adaptation

Cells adjust to stressors to maintain viability and function. This is a reversible change, necessary for survival.

Atrophy

Decrease in cell size due to reduced workload, decreased nutrients, or hormonal stimulation. Think of a muscle shrinking from lack of use.

Hypertrophy

Increase in cell SIZE due to increased workload, stimulation, or hormonal factors. Think of a muscle growing from exercise.

Hyperplasia

Increase in the NUMBER of cells due to increased workload, stimulation, or hormonal factors.

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Dysplasia

Abnormal change in cells' size, shape, and organization. It is a potentially pre-cancerous change.

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What is Atrophy?

A decrease in the size and/or number of cells, leading to reduced metabolic activity. Cells are not dead, just smaller and less active.

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What are the common causes of Atrophy?

Reduced workload, lack of nerve stimulation, insufficient blood supply, inadequate nutrition, decreased hormonal stimulation, and aging can all cause atrophy.

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What is Sedentary Atrophy?

When a muscle isn't used, it can shrink due to lack of stimulation and workload.

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How can steroid therapy affect the adrenal cortex?

The adrenal cortex can shrink when there's reduced ACTH stimulation, which can occur due to steroid therapy.

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What is a potential consequence of tumor growth on surrounding tissues?

Tissues adjacent to a tumor can atrophy due to pressure and compromised blood supply.

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Study Notes

Cell Adaptation

  • Cell adaptation occurs when cellular homeostasis is disrupted by stress or disease.
  • Cells adapt to stress; failure to adapt leads to cellular injury.
  • Adaptation preserves cellular viability and function.
  • Adaptation is not an irreversible change.
  • Adaptation can be physiological or pathological.

Types of Cellular Adaptation

  • Atrophy: Decreased cell size and/or number, along with decreased metabolic activity after normal growth has been reached. Cells are not dead. This is characterized by a decrease in protein synthesis and an increase in protein degradation.
    • Causes: Decreased workload, denervation, reduced blood supply or oxygen, inadequate nutrition, loss of endocrine stimulation, and aging (senescence).
    • Examples: Muscle disuse (e.g., limb in a cast), sedentary lifestyle, atrophy of the adrenal cortex due to reduced ACTH stimulation (steroid therapy), atrophy in tissues adjacent to tumors due to pressure and compromised blood supply, and physiological atrophy (e.g., non-lactating mammary gland, postpartum uterus).
  • Hypertrophy: Increased cell size.
  • Hyperplasia: Increased cell number.
  • Dysplasia: Disordered cell growth and maturation.
  • Metaplasia: Replacement of one cell type by another.

Homeostasis

  • Homeostasis is the tendency toward stability in the normal state of an organism.

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Description

Explore the concepts of cellular adaptation and homeostasis. This quiz covers the types of cell adaptation, including atrophy, hypertrophy, hyperplasia, dysplasia, and metaplasia, as well as the importance of maintaining cellular viability and function. Test your understanding of how cells respond to stress and disease.

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