Catecholamine and b-Adrenergic Agents in Muscle Physiology
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Questions and Answers

What type of receptor does epinephrine act on to produce tachycardia?

  • Sensory receptor
  • Ionotropic receptor
  • Metabotropic receptor (correct)
  • Olfactory receptor

    • Which of the following is NOT a criterion for physiological receptors?

  • Reversible ligand binding
  • Saturable ligand binding
  • Irreversible ligand binding (correct)
  • Tissue selectivity

    • What type of interactions are involved in weak and reversible binding of physiological ligands and drugs to receptors?

  • Metallic bonds
  • Ionic bonds
  • Covalent bonds
  • Hydrogen bonds (correct)

    • What effect does increasing the number of productive interactions have on ligand-receptor binding affinity?

    <p>Increases the affinity</p> Signup and view all the answers

    What is the function of spare receptors in some systems?

    <p>To amplify the response via signal transduction cascades</p> Signup and view all the answers

    In myasthenia gravis, what happens to over 80% of receptors in symptomatic patients?

    <p>They are lost, leading to muscle contraction failure</p> Signup and view all the answers

    What does activation of only 1% of Acetylcholine Receptors (AChR) at the neuromuscular junction produce?

    <p>$EPP_{ ext{suprathreshold}}$</p> Signup and view all the answers

    'Structural specificity (hand in glove)' refers to receptors being able to distinguish between what?

    <p>$eta$-Adrenergic agonists and similar ligand structures</p> Signup and view all the answers

    'Response is a Function of Receptor Occupancy' states that a maximum response can be achieved with less than 100% receptor occupancy due to what?

    <p>'Spare' receptors amplifying the response via signal transduction cascades</p> Signup and view all the answers

    'Stereo-Selective and Saturable Binding' means that receptors can distinguish between what type of ligands?

    <p>$eta$-Adrenergic agonists and stereoisomeric ligands</p> Signup and view all the answers

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