10 Questions
What type of receptor does epinephrine act on to produce tachycardia?
Metabotropic receptor
Which of the following is NOT a criterion for physiological receptors?
Irreversible ligand binding
What type of interactions are involved in weak and reversible binding of physiological ligands and drugs to receptors?
Hydrogen bonds
What effect does increasing the number of productive interactions have on ligand-receptor binding affinity?
Increases the affinity
What is the function of spare receptors in some systems?
To amplify the response via signal transduction cascades
In myasthenia gravis, what happens to over 80% of receptors in symptomatic patients?
They are lost, leading to muscle contraction failure
What does activation of only 1% of Acetylcholine Receptors (AChR) at the neuromuscular junction produce?
$EPP_{ ext{suprathreshold}}$
'Structural specificity (hand in glove)' refers to receptors being able to distinguish between what?
$eta$-Adrenergic agonists and similar ligand structures
'Response is a Function of Receptor Occupancy' states that a maximum response can be achieved with less than 100% receptor occupancy due to what?
'Spare' receptors amplifying the response via signal transduction cascades
'Stereo-Selective and Saturable Binding' means that receptors can distinguish between what type of ligands?
$eta$-Adrenergic agonists and stereoisomeric ligands
Learn about the metabolism of catecholamines like epinephrine and norepinephrine, and the effects of b-adrenergic agents on muscle physiology. Understand how beta blockers like Metoprolol affect cAMP levels, vascular smooth muscle, heart rate, and calcium cycling in muscle cells.
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