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Questions and Answers
Which compounds are examples of phytocannabinoids?
What is the typical cannabinoid profile of street cannabis?
What is the primary function of endocannabinoids?
Which therapeutic use of cannabis has the highest percentage among the listed options?
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What is the typical cannabinoid profile of strains like cannatonic?
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Which part of the brain has low expression of CB receptors, thus not affecting the cardiovascular or respiratory system?
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What is the function of endocannabinoids traveling from post-synaptic to pre-synaptic neurons?
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Which enzyme is inhibited by THC and CBD, but not hFAAH?
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Which of the following is a potential effect of CB1 activation on pain pathways?
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What is the impact of paracetamol and other NSAIDs on endocannabinoid levels?
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What is the consequence of a patient with FAAH mutation (causing loss of function) having increased blood anandamide concentrations?
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What is the impact of increased AEA concentration detected after exercise and singing?
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In PTSD, what is the association of 2-AG and AEA with response?
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Which of the following is a future drug for social anxiety in phase II trials?
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What is the most effective combination for increasing seizure threshold?
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What evidence suggests possible synergy in anticonvulsant effects?
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What is the relevance of minor cannabinoids in anticonvulsant effects?
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Study Notes
Phytocannabinoids
- Examples include THC (tetrahydrocannabinol) and CBD (cannabidiol).
- Phytocannabinoids are compounds derived from cannabis plants that interact with the body's endocannabinoid system.
Cannabinoid Profiles
- Street cannabis typically has high levels of THC and lower levels of CBD.
- Strains like Cannatonic generally have a balanced cannabinoid profile with a higher CBD content for therapeutic effects.
Endocannabinoids
- Primary function is to regulate homeostasis and modulate neurotransmitter release.
- Endocannabinoids travel from post-synaptic to pre-synaptic neurons, enhancing signaling in the neural circuit.
CB Receptor Expression
- The brain region with low expression of CB receptors is the medulla oblongata, minimizing effects on cardiovascular and respiratory functions.
Cannabis Therapeutic Uses
- Pain management shows the highest percentage among therapeutic uses of cannabis, indicating its effectiveness in treating chronic pain.
Enzymatic Inhibition
- THC and CBD inhibit the enzyme DAGL (diacylglycerol lipase), influencing the production of endocannabinoids but do not affect hFAAH (fatty acid amide hydrolase).
Effects of CB1 Activation
- Activation of CB1 receptors can decrease pain sensation by modulating pain pathways in the central nervous system.
Impact of NSAIDs on Endocannabinoids
- Paracetamol and other NSAIDs can increase endocannabinoid levels, potentially enhancing their analgesic effects.
FAAH Mutation Consequences
- Patients with FAAH mutation and increased blood anandamide levels may experience heightened sensitivity to pain and mood disorders due to disrupted endocannabinoid signaling.
Effects of Exercise and Singing
- Increased AEA (anandamide) concentration after exercise and singing may contribute to "runner's high" or enhanced mood states.
PTSD and Cannabinoids
- In PTSD, 2-AG (2-arachidonoylglycerol) and AEA levels are associated with varying responses to treatment, influencing symptom severity and emotional regulation.
Future Drug Trials
- A compound in phase II trials for social anxiety disorder is known to modulate the endocannabinoid system, showing promise for therapeutic use.
Anticonvulsant Effects
- The combination of CBD and THC has demonstrated effectiveness in increasing seizure threshold, suggesting potential for epilepsy treatment.
Evidence for Synergy
- Suggestions of synergy in anticonvulsant effects exist when combining minor cannabinoids like CBG (cannabigerol) with CBD.
Minor Cannabinoids Relevance
- Minor cannabinoids are relevant in anticonvulsant effects due to their unique mechanisms that complement the actions of major cannabinoids like THC and CBD.
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Description
Test your knowledge of cannabinoids and their various forms in this quiz! Explore the world of phytocannabinoids, synthetic cannabinoids, endocannabinoids, and the therapeutic compounds found in the cannabis plant.
