26 Questions
What is the primary enzyme responsible for metabolizing THC?
CYP2C9
What is the potential effect of CBD on the metabolism of warfarin?
Decrease the metabolism of warfarin
What is the substrate of CYP2C9 and CYP3A4?
THC
What is the potential effect of THC on the sedative effects of CNS depressant drugs?
Increase the sedative effects
What is the effect of rifampin on the metabolism of Epidiolex®?
Increase the metabolism of Epidiolex®
What is the potential effect of CBD on the activity of P-gp?
Decrease the activity of P-gp
What is the primary enzyme responsible for metabolizing CBD?
CYP2C19
What is the potential effect of THC on the risk of pancreatitis?
Increase the risk of pancreatitis
What is the potential effect of CBD on the metabolism of opioids?
Decrease the metabolism of opioids
What is the potential effect of THC on the risk of anxiety?
Increase the risk of anxiety
What is the primary concern when using TCA in patients with underlying chronic liver disease?
Potential liver damage
What is the recommended dose of duloxetine for neuropathic pain?
20 mg daily, titrate up after 1 week
What is the primary mechanism by which CBD exhibits therapeutic effects?
Inhibiting the degradation of anandamide
What is the primary difference between hashish and hashish oil?
One is more concentrated than the other
What is the primary effect of dopamine release mediated by CB1 receptors?
Feeling of reward or pleasure
What is the primary reason why CBD does not cause a 'high'?
It binds weakly to CB1 receptors
What is the primary concern when using CBD with Coumadin?
CBD can enhance the effects of Coumadin, increasing the potential for bleeding
What is the recommended maximum daily dose of acetaminophen for adults with liver impairment?
2 g/day
What is the primary indication for using IV acetaminophen (Ofirmev)?
Acute pain management
What is the recommended maximum single dose of IV acetaminophen in adults weighing ≥ 50 kg?
1 g/dose
What is a major concern when using acetaminophen with other medications?
Risk of hepatic toxicity
What is the recommended dosing range for infants and pediatrics using oral acetaminophen?
10-15 mg/kg/dose every 4-6 hours prn
What is a rare but serious skin reaction associated with acetaminophen use?
All of the above
What is the recommended maximum daily dose of acetaminophen for adults with severe renal impairment?
Reduce dose/extend interval
What is the primary reason for avoiding alcohol use with acetaminophen?
Risk of hepatotoxicity
What is the recommended counseling point for patients using acetaminophen?
All of the above
This quiz covers the key pharmacokinetic properties of THC and CBD, including their absorption, bioavailability, and distribution. Test your knowledge of medical cannabis and its components!
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