THC and CBD: Pharmacokinetic Properties
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Questions and Answers

What is the primary enzyme responsible for metabolizing THC?

  • CYP3A4
  • CYP2C19
  • CYP2C9 (correct)
  • CYP1A2

    • What is the potential effect of CBD on the metabolism of warfarin?

  • Decrease the metabolism of warfarin (correct)
  • Have no effect on the metabolism of warfarin
  • Increase the sedative effects of warfarin
  • Increase the metabolism of warfarin

    • What is the substrate of CYP2C9 and CYP3A4?

  • Dronabinol
  • CBD
  • THC (correct)
  • Cannabidiol

    • What is the potential effect of THC on the sedative effects of CNS depressant drugs?

    <p>Increase the sedative effects</p> Signup and view all the answers

    What is the effect of rifampin on the metabolism of Epidiolex®?

    <p>Increase the metabolism of Epidiolex®</p> Signup and view all the answers

    What is the potential effect of CBD on the activity of P-gp?

    <p>Decrease the activity of P-gp</p> Signup and view all the answers

    What is the primary enzyme responsible for metabolizing CBD?

    <p>CYP2C19</p> Signup and view all the answers

    What is the potential effect of THC on the risk of pancreatitis?

    <p>Increase the risk of pancreatitis</p> Signup and view all the answers

    What is the potential effect of CBD on the metabolism of opioids?

    <p>Decrease the metabolism of opioids</p> Signup and view all the answers

    What is the potential effect of THC on the risk of anxiety?

    <p>Increase the risk of anxiety</p> Signup and view all the answers

    What is the primary concern when using TCA in patients with underlying chronic liver disease?

    <p>Potential liver damage</p> Signup and view all the answers

    What is the recommended dose of duloxetine for neuropathic pain?

    <p>20 mg daily, titrate up after 1 week</p> Signup and view all the answers

    What is the primary mechanism by which CBD exhibits therapeutic effects?

    <p>Inhibiting the degradation of anandamide</p> Signup and view all the answers

    What is the primary difference between hashish and hashish oil?

    <p>One is more concentrated than the other</p> Signup and view all the answers

    What is the primary effect of dopamine release mediated by CB1 receptors?

    <p>Feeling of reward or pleasure</p> Signup and view all the answers

    What is the primary reason why CBD does not cause a 'high'?

    <p>It binds weakly to CB1 receptors</p> Signup and view all the answers

    What is the primary concern when using CBD with Coumadin?

    <p>CBD can enhance the effects of Coumadin, increasing the potential for bleeding</p> Signup and view all the answers

    What is the recommended maximum daily dose of acetaminophen for adults with liver impairment?

    <p>2 g/day</p> Signup and view all the answers

    What is the primary indication for using IV acetaminophen (Ofirmev)?

    <p>Acute pain management</p> Signup and view all the answers

    What is the recommended maximum single dose of IV acetaminophen in adults weighing ≥ 50 kg?

    <p>1 g/dose</p> Signup and view all the answers

    What is a major concern when using acetaminophen with other medications?

    <p>Risk of hepatic toxicity</p> Signup and view all the answers

    What is the recommended dosing range for infants and pediatrics using oral acetaminophen?

    <p>10-15 mg/kg/dose every 4-6 hours prn</p> Signup and view all the answers

    What is a rare but serious skin reaction associated with acetaminophen use?

    <p>All of the above</p> Signup and view all the answers

    What is the recommended maximum daily dose of acetaminophen for adults with severe renal impairment?

    <p>Reduce dose/extend interval</p> Signup and view all the answers

    What is the primary reason for avoiding alcohol use with acetaminophen?

    <p>Risk of hepatotoxicity</p> Signup and view all the answers

    What is the recommended counseling point for patients using acetaminophen?

    <p>All of the above</p> Signup and view all the answers

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