THC and CBD: Pharmacokinetic Properties

Play an AI-generated podcast conversation about this lesson

What is the primary enzyme responsible for metabolizing THC?

CYP3A4
CYP2C19
CYP2C9 (correct)
CYP1A2

What is the potential effect of CBD on the metabolism of warfarin?

Decrease the metabolism of warfarin (correct)
Have no effect on the metabolism of warfarin
Increase the sedative effects of warfarin
Increase the metabolism of warfarin

What is the substrate of CYP2C9 and CYP3A4?

Dronabinol
CBD
THC (correct)
Cannabidiol

What is the potential effect of THC on the sedative effects of CNS depressant drugs?

Increase the sedative effects (B) Signup and view all the answers

What is the effect of rifampin on the metabolism of Epidiolex®?

Increase the metabolism of Epidiolex® (A) Signup and view all the answers

What is the potential effect of CBD on the activity of P-gp?

Decrease the activity of P-gp (D) Signup and view all the answers

What is the primary enzyme responsible for metabolizing CBD?

CYP2C19 (C) Signup and view all the answers

What is the potential effect of THC on the risk of pancreatitis?

Increase the risk of pancreatitis (B) Signup and view all the answers

What is the potential effect of CBD on the metabolism of opioids?

Decrease the metabolism of opioids (A) Signup and view all the answers

What is the potential effect of THC on the risk of anxiety?

Increase the risk of anxiety (D) Signup and view all the answers

What is the primary concern when using TCA in patients with underlying chronic liver disease?

Potential liver damage (D) Signup and view all the answers

What is the recommended dose of duloxetine for neuropathic pain?

20 mg daily, titrate up after 1 week (D) Signup and view all the answers

What is the primary mechanism by which CBD exhibits therapeutic effects?

Inhibiting the degradation of anandamide (B) Signup and view all the answers

What is the primary difference between hashish and hashish oil?

One is more concentrated than the other (C) Signup and view all the answers

What is the primary effect of dopamine release mediated by CB1 receptors?

Feeling of reward or pleasure (A) Signup and view all the answers

What is the primary reason why CBD does not cause a 'high'?

It binds weakly to CB1 receptors (D) Signup and view all the answers

What is the primary concern when using CBD with Coumadin?

CBD can enhance the effects of Coumadin, increasing the potential for bleeding (A) Signup and view all the answers

What is the recommended maximum daily dose of acetaminophen for adults with liver impairment?

2 g/day (C) Signup and view all the answers

What is the primary indication for using IV acetaminophen (Ofirmev)?

Acute pain management (C) Signup and view all the answers

What is the recommended maximum single dose of IV acetaminophen in adults weighing ≥ 50 kg?

1 g/dose (A) Signup and view all the answers

What is a major concern when using acetaminophen with other medications?

Risk of hepatic toxicity (A) Signup and view all the answers

What is the recommended dosing range for infants and pediatrics using oral acetaminophen?

10-15 mg/kg/dose every 4-6 hours prn (A) Signup and view all the answers

What is a rare but serious skin reaction associated with acetaminophen use?

All of the above (D) Signup and view all the answers