Cancer Treatment Factors
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Questions and Answers

What type of mutation can affect the choice of cancer treatment?

  • KRAS mutation
  • BRCA1 or BRCA2 (correct)
  • TP53 mutation
  • BRAF mutation

    • What is a potential limitation of combination therapy approach in cancer treatment?

  • Increased risk of disease recurrence
  • Reduced quality of life
  • Resistance to these treatments (correct)
  • Higher cost of treatment

    • What is a potential side effect of chemotherapy?

  • Cardiovascular toxicity
  • Hepatotoxicity
  • Peripheral neuropathy (correct)
  • Bone marrow suppression

    • What is a type of estrogen receptor modulator used in cancer treatment?

    <p>Selective Estrogen Receptor Modulators (SERMs)</p> Signup and view all the answers

    What is a consequence of chemotherapy-resistance in cancer cells?

    <p>Survival of treatment-resistant cells</p> Signup and view all the answers

    What is a factor that affects the economic burden of metastatic breast cancer?

    <p>Cost of chemotherapy</p> Signup and view all the answers

    What is the primary mechanism by which Betulinic Acid inhibits Topoisomerase I?

    <p>By inhibiting the formation of reactive oxygen species-mediated apoptotic Topoisomerase I-DNA cleavable complex</p> Signup and view all the answers

    Which of the following is a characteristic of Multidrug Resistant Tumors?

    <p>Increased expression of P-glycoprotein</p> Signup and view all the answers

    What is the primary mechanism by which Taxol/Paclitaxel kills cancer cells?

    <p>By inhibiting the formation of microtubules</p> Signup and view all the answers

    What is the primary function of P-glycoprotein in Multidrug Resistant Tumors?

    <p>To efflux anticancer drugs from the tumor cells</p> Signup and view all the answers

    What is the primary mechanism by which Antitubulin plant-derived drugs inhibit the growth of cancer cells?

    <p>By inhibiting the formation of microtubules</p> Signup and view all the answers

    What is the primary function of Topoisomerase I in cancer cells?

    <p>To relax DNA supercoils during DNA replication</p> Signup and view all the answers

    The BRCA1 or BRCA2 mutation is a genetic factor that affects the choice of cancer treatment.

    <p>True</p> Signup and view all the answers

    The Foster et al. (2011) study focuses on the economic burden of metastatic breast cancer in developing countries.

    <p>False</p> Signup and view all the answers

    Kolch and Pitt (2010) discuss the role of tyrosine kinase signalling pathways in cancer treatment.

    <p>True</p> Signup and view all the answers

    The Starobova and Vetter (2017) study investigates the pathophysiology of chemotherapy-induced peripheral neuropathy.

    <p>True</p> Signup and view all the answers

    The combination therapy approach is not associated with drug interactions.

    <p>False</p> Signup and view all the answers

    Patel and Bihani (2018) discuss the role of selective estrogen receptor modulators (SERMs) in cancer treatment.

    <p>True</p> Signup and view all the answers

    The molecular mechanism of antitubulin plant-derived drugs involves the inhibition of Topoisomerase I.

    <p>False</p> Signup and view all the answers

    P-glycoprotein is a protein involved in the development of multidrug resistance in cancer cells.

    <p>True</p> Signup and view all the answers

    Betulinic acid is a catalytic inhibitor of Topoisomerase I that enhances reactive oxygen species-mediated apoptotic Topoisomerase I-DNA cleavable complex formation in prostate cancer cells.

    <p>False</p> Signup and view all the answers

    Taxol/Paclitaxel kills cancer cells by inhibiting Topoisomerase I.

    <p>False</p> Signup and view all the answers

    Combination therapy approach is a strategy to overcome chemotherapy resistance in cancer treatment.

    <p>True</p> Signup and view all the answers

    DNA Topoisomerase I is an enzyme that relieves torsional stress in DNA by creating double-strand breaks.

    <p>True</p> Signup and view all the answers

    Study Notes

    Cancer Treatment and Resistance

    • Antitubulin plant-derived drugs, such as Taxol/paclitaxel, kill cancer cells by inhibiting microtubule dynamics.
    • Combination therapy approaches, including modulation of P-glycoprotein through dietary nutraceuticals, can enhance the activity of anticancer drugs in multidrug-resistant tumors.
    • Cancer drug resistance is an evolving paradigm, with treatment-resistant cells surviving due to various mechanisms, including genetic mutations and reactive oxygen species-mediated apoptosis.

    Factors Affecting Treatment Choice

    • Genetic factors, such as BRCA1 or BRCA2 mutations, can influence treatment decisions.
    • Combination therapy approaches and drug interactions must be considered when selecting a treatment regimen.
    • Patients' tolerance of side effects and the economic burden of treatment are also important factors to consider.

    Side Effects and Resistance

    • Chemotherapy-induced peripheral neuropathy is a common side effect of cancer treatment.
    • Resistance to cancer treatments can occur due to various mechanisms, including topoisomerase I inhibition and reactive oxygen species-mediated apoptosis.
    • Survival of treatment-resistant cells is a significant challenge in cancer treatment.

    Molecular Mechanisms

    • Betulinic acid, a catalytic inhibitor of topoisomerase I, inhibits reactive oxygen species-mediated apoptotic topoisomerase I-DNA cleavable complex formation in prostate cancer cells.
    • DNA topoisomerase I inhibitors, such as camptothecin, work by inhibiting the religation step of the topoisomerase I reaction, leading to DNA damage and apoptosis.
    • Antitubulin plant-derived drugs, such as Taxol/paclitaxel, bind to β-tubulin, inhibiting microtubule dynamics and leading to cell death.

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    Related Documents

    BMS2047_06 Other Considerations Lecture Notes PDF

    Description

    Learn about the factors that influence cancer treatment, including genetics, combination therapy, and patient considerations. This quiz covers the effects of drug interactions, resistance, and side effects on cancer treatment outcomes.

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