Cancer Treatment and Biologic Response Modifiers
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Questions and Answers

What are the two main classes of Biologic Response Modifiers?

  • Antiviral and Antibacterial
  • Hormonal and Anti-inflammatory
  • Hematopoietic and Immunomodulating (correct)
  • Antineoplastic and Immunosuppressant
  • Which of the following is NOT a typical adverse effect associated with Immunomodulating Monoclonal Antibodies?

  • Immunosuppression
  • Inflammatory reaction
  • Hepatitis (correct)
  • Hypokalemia
  • Which of these drugs is classified as a Purine Analog?

  • Methotrexate
  • Vincristine
  • Hydroxurea
  • Fludarabine (correct)
  • What is a potential life-threatening complication associated with Rituximab?

    <p>Severe Bronchospasms (C)</p> Signup and view all the answers

    Which of the following drugs is classified as an Epiodophyllotoxin?

    <p>Etoposide (B)</p> Signup and view all the answers

    Which of the following is an example of a drug that inhibits the development of new blood vessels in a tumor?

    <p>Bevacizumab (C)</p> Signup and view all the answers

    What is the primary action of Interferons in the treatment of cancer?

    <p>Inhibiting cancer cell division (B)</p> Signup and view all the answers

    A patient receiving Aldesleukin (Proleukin) should be carefully monitored for:

    <p>Hypotension (A)</p> Signup and view all the answers

    Which of the following cancers primarily metastasizes to the brain?

    <p>Breast Cancer (B), Lung Cancer (C)</p> Signup and view all the answers

    What is a characteristic feature of malignant cells compared to normal cells?

    <p>High mitotic index (C)</p> Signup and view all the answers

    Which method of radiation therapy is used to deliver a high dose of radiation to a localized area?

    <p>Brachytherapy (D)</p> Signup and view all the answers

    What cognitive effects are associated with 'chemo brain'?

    <p>Decreased concentration and cognitive changes (C)</p> Signup and view all the answers

    Which cancer is most commonly associated with metastasis to the liver?

    <p>Colorectal Cancer (B), Breast Cancer (D)</p> Signup and view all the answers

    In terms of cell division rate, how do benign tumor cells compare to malignant cells?

    <p>They divide at a slower rate (A)</p> Signup and view all the answers

    Which statement is true about systemic chemotherapy?

    <p>It affects the entire body (C)</p> Signup and view all the answers

    What is the common target area for metastasis in prostate cancer?

    <p>Bone (C)</p> Signup and view all the answers

    What is necessary for an infant to develop trust?

    <p>Interactions that provide reliability, care, and affection (D)</p> Signup and view all the answers

    Which outcome is a result of successful exploration of abilities in early childhood?

    <p>Feelings of autonomy (A)</p> Signup and view all the answers

    What do parents need to provide to foster autonomy in their children during early childhood?

    <p>Opportunities for free play and exploration (B)</p> Signup and view all the answers

    What leads to feelings of shame and doubt in children during the autonomy vs shame stage?

    <p>Experiencing failure without support (A)</p> Signup and view all the answers

    Which concept best encapsulates the developmental challenge faced by infants in the first stage of trust versus mistrust?

    <p>Developing a sense of trust through care and reliability (C)</p> Signup and view all the answers

    What is the primary focus of Erikson's stage of Autonomy vs Shame?

    <p>Sense of personal control over physical skills (C)</p> Signup and view all the answers

    Which parenting style is NOT beneficial for a child's development of autonomy?

    <p>Allowing unlimited access to all activities (C)</p> Signup and view all the answers

    What is an implication of mistrust developing in early childhood?

    <p>Lower likelihood of developing autonomy (C)</p> Signup and view all the answers

    Which of the following risk factors is associated with breast cancer? (Select all that apply)

    <p>Alcohol (A), Late first pregnancy (D)</p> Signup and view all the answers

    According to the table, which grading is most descriptive of cancer that is poorly differentiated?

    <p>G3- (D)</p> Signup and view all the answers

    Which of the following cancers is associated with aflatoxin exposure?

    <p>Liver (D)</p> Signup and view all the answers

    Which of these is NOT a risk factor for cancer?

    <p>Sleep (A)</p> Signup and view all the answers

    According to the table, which type of radiation is associated with skin cancer?

    <p>Ultraviolet radiation (B)</p> Signup and view all the answers

    Which of these is NOT a risk factor associated with an increased risk of developing lung cancer?

    <p>Estrogens (A)</p> Signup and view all the answers

    Which of the following lifestyle factors is linked to an increased risk of developing esophageal cancer?

    <p>Alcohol (B)</p> Signup and view all the answers

    According to the table, which of the following cancers is associated with late first pregnancy?

    <p>Breast (B)</p> Signup and view all the answers

    What is the normal magnesium level range in adults?

    <p>1.7-2.1 mg/dL (C)</p> Signup and view all the answers

    Which condition is associated with reduced renal function?

    <p>Addison's disease (A)</p> Signup and view all the answers

    What can falsely elevate magnesium levels in the body?

    <p>Hemolysis (A)</p> Signup and view all the answers

    Which of the following symptoms may indicate excessive loss of body fluids?

    <p>Diarrhea (C)</p> Signup and view all the answers

    Which of the following can contribute to magnesium deficiency?

    <p>Long-term hyperalimentation (A)</p> Signup and view all the answers

    What condition might cause the body to retain excessive magnesium?

    <p>Hypoparathyroidism (C)</p> Signup and view all the answers

    Which electrolyte imbalance can be caused by malabsorption syndromes?

    <p>Hypomagnesemia (C)</p> Signup and view all the answers

    What is a common risk associated with prolonged use of magnesium-containing antacids?

    <p>Hypermagnesemia (A)</p> Signup and view all the answers

    What condition may result from excessive sweating leading to low magnesium levels?

    <p>Chronic dehydration (C)</p> Signup and view all the answers

    Which of the following can cause false results in magnesium level testing?

    <p>Hemolysis (A)</p> Signup and view all the answers

    What is the normal potassium level range for infants?

    <p>4.1-5.3 mEq/L (A)</p> Signup and view all the answers

    Which condition is most likely to cause hyperkalemia?

    <p>Severe burns (A)</p> Signup and view all the answers

    Which of the following factors can contribute to increased sodium levels?

    <p>Cushing's disease (D)</p> Signup and view all the answers

    How can primary hyperaldosteronism affect potassium levels?

    <p>It decreases potassium levels (A)</p> Signup and view all the answers

    Which electrolyte imbalance is associated with excessive licorice intake?

    <p>Hyponatremia (A)</p> Signup and view all the answers

    What is the effect of severe dehydration on sodium levels?

    <p>Increases sodium levels (C)</p> Signup and view all the answers

    How does alcohol affect potassium levels?

    <p>Causes hypokalemia (B)</p> Signup and view all the answers

    In which situation is osmotic diuresis most likely to cause elevated potassium levels?

    <p>Uncontrolled diabetes mellitus (D)</p> Signup and view all the answers

    What is the potential effect of a kidney transplant on electrolyte levels?

    <p>Decrease in potassium (B)</p> Signup and view all the answers

    Which of the following is a common cause of hypokalemia?

    <p>Laxative abuse (D)</p> Signup and view all the answers

    What does aldosteronism cause in terms of sodium and potassium balance?

    <p>Increased sodium, decreased potassium (D)</p> Signup and view all the answers

    How does hypoparathyroidism affect calcium levels?

    <p>Decreases calcium levels (B)</p> Signup and view all the answers

    What impact does severe diarrhea have on electrolytes?

    <p>Decreases both sodium and potassium (C)</p> Signup and view all the answers

    What is the main symptom that Van Nortwick's mother experienced that alerted her to the spinal cord compression?

    <p>Change in her gait (D)</p> Signup and view all the answers

    What is the primary function of palliative care, as illustrated by Van Nortwick's mother's experience?

    <p>To improve the quality of life by reducing pain and discomfort (B)</p> Signup and view all the answers

    Which of the following colostomy types produces the most formed stool?

    <p>Sigmoid Colostomy (C)</p> Signup and view all the answers

    Which of the following colostomy types is most likely to require emptying the pouch 4-6 times a day?

    <p>Transverse Colostomy (C), Ascending Colostomy (D)</p> Signup and view all the answers

    Which of the following is NOT a common concern associated with colostomy care?

    <p>Maintaining a strict diet free of all gas-producing foods (C)</p> Signup and view all the answers

    Which of the following best reflects the impact of achieving success in the stages of development mentioned in the first table?

    <p>Feeling a sense of wisdom and fulfillment (A)</p> Signup and view all the answers

    What is the primary concern regarding foods to avoid with a colostomy?

    <p>Foods that can contribute to gas production (B)</p> Signup and view all the answers

    What is the primary reason for the use of a temporary colostomy bag in Van Nortwick's mother's case?

    <p>To manage bowel incontinence caused by spinal cord compression (D)</p> Signup and view all the answers

    What is the key element that contributes to the development of trust in infants?

    <p>Providing consistent and predictable care (B)</p> Signup and view all the answers

    According to Erikson, what is the primary focus of the Autonomy vs Shame stage of development?

    <p>Developing a sense of self-control and independence (A)</p> Signup and view all the answers

    What is the main consequence of a child's failure to develop a sense of autonomy during the Autonomy vs Shame stage?

    <p>They may become overly dependent on others (D)</p> Signup and view all the answers

    Which of the following parenting styles is MOST likely to hinder a child's development of autonomy?

    <p>Authoritarian parenting (B)</p> Signup and view all the answers

    What is the PRIMARY role of parents in fostering autonomy in their children during the Autonomy vs Shame stage?

    <p>Encouraging them to participate in decision-making (D)</p> Signup and view all the answers

    What is the MOST LIKELY implication of an infant developing mistrust in their early childhood?

    <p>They may struggle to trust others in future relationships (D)</p> Signup and view all the answers

    According to the provided information, what is the core concept behind Erikson's theory of trust versus mistrust?

    <p>The capacity to trust and rely on others (A)</p> Signup and view all the answers

    Which of these scenarios illustrates the development of mistrust in an infant?

    <p>An infant's needs are met inconsistently, leading to feelings of uncertainty (D)</p> Signup and view all the answers

    What is a potential cause for a decreased BUN level?

    <p>Anabolic steroid use (D)</p> Signup and view all the answers

    Which of these conditions is NOT associated with an increased BUN level?

    <p>Severe diarrhea (C)</p> Signup and view all the answers

    Which is a common factor that can interfere with BUN levels?

    <p>Dietary factors (C)</p> Signup and view all the answers

    What is a plausible reason for a decreased BUN level in a child compared to an adult?

    <p>Children have a lower muscle mass. (C)</p> Signup and view all the answers

    Which condition is MOST likely to cause a decreased WBC count?

    <p>Viral infection (C)</p> Signup and view all the answers

    What is a potential reason for an increased WBC count in a person NOT experiencing an infection?

    <p>Use of certain medications (B)</p> Signup and view all the answers

    Which of these factors can influence the WBC count fluctuations throughout the day?

    <p>Hormonal changes (C)</p> Signup and view all the answers

    What is the most likely reason for an increased WBC count in a patient with a bacterial infection?

    <p>Increased production of white blood cells to fight the infection. (C)</p> Signup and view all the answers

    Which is NOT a potential reason for an increased WBC count?

    <p>Chronic kidney disease (A)</p> Signup and view all the answers

    Which of these factors is LEAST likely to cause a decrease in WBC count?

    <p>Regular exercise (C)</p> Signup and view all the answers

    What is the probable outcome of a low WBC count in an individual with a serious infection?

    <p>Increased susceptibility to infection. (D)</p> Signup and view all the answers

    Which of these factors is most likely to cause a decrease in red blood cell count?

    <p>Chronic blood loss (B)</p> Signup and view all the answers

    What is a potential outcome of a decreased red blood cell count?

    <p>Increased risk of anemia (B)</p> Signup and view all the answers

    Which of these factors is MOST likely to cause an increase in hemoglobin levels?

    <p>High altitude exposure (A)</p> Signup and view all the answers

    Why is it important to monitor hemoglobin levels in patients with chronic kidney disease?

    <p>Chronic kidney disease can impair red blood cell production. (B)</p> Signup and view all the answers

    Which of the following conditions is most likely to cause an increase in the blood pH level?

    <p>Hyperventilation (A)</p> Signup and view all the answers

    Which of the following factors can cause a falsely elevated creatinine level?

    <p>Both A and C (B)</p> Signup and view all the answers

    Which of the following conditions may cause a decrease in Hemoglobin (Hb) levels?

    <p>Pregnancy (C)</p> Signup and view all the answers

    What condition can cause a falsely elevated Hct (hematocrit) level?

    <p>Severe dehydration (A)</p> Signup and view all the answers

    Which of the following conditions can cause a decrease in serum chloride (Cl-) levels?

    <p>Metabolic acidosis with prolonged diarrhea (D)</p> Signup and view all the answers

    Which of the following conditions is most likely to cause hyperkalemia (increased potassium levels)?

    <p>Renal failure (B)</p> Signup and view all the answers

    Which of the following factors can contribute to an increase in sodium levels?

    <p>All of the above (D)</p> Signup and view all the answers

    What condition can cause a decrease in blood glucose levels?

    <p>Starvation (A)</p> Signup and view all the answers

    Which of the following conditions can cause an increase in blood glucose levels?

    <p>Pancreatitis (C)</p> Signup and view all the answers

    Which of the following factors can cause a decrease in RBC (red blood cell) count?

    <p>Anemia (B)</p> Signup and view all the answers

    Which of the following conditions is most likely to cause an increase in RBC (red blood cell) count?

    <p>Polycythemia (B)</p> Signup and view all the answers

    Which of the following factors can contribute to an increase in Paco₂ (partial pressure of carbon dioxide) levels?

    <p>Both B and C (D)</p> Signup and view all the answers

    Which of the following conditions is associated with a decrease in Pao₂ (partial pressure of oxygen) levels?

    <p>Both B and C (C)</p> Signup and view all the answers

    Which of the following factors can cause a decrease in HCO₃- (bicarbonate) levels?

    <p>Both A and C (C)</p> Signup and view all the answers

    What is the primary focus of nursing care for a patient with a malignant skin lesion?

    <p>Controlling bleeding and reducing odor (B)</p> Signup and view all the answers

    Which of the following is a potential complication associated with chemotherapy?

    <p>Tissue necrosis (D)</p> Signup and view all the answers

    What is the recommended action for a patient with a platelet count of 25,000 who experiences a bump?

    <p>Apply ice for 1 hour (A)</p> Signup and view all the answers

    What is the most significant risk factor for developing infection in a patient with cancer?

    <p>Decreased ANC (A)</p> Signup and view all the answers

    Which of the following is a key nursing intervention when caring for a patient with neutropenia?

    <p>Restricting the use of fresh flowers (A)</p> Signup and view all the answers

    What is the most crucial aspect of managing sepsis in a patient with cancer?

    <p>Administering antibiotics promptly (D)</p> Signup and view all the answers

    Which of the following is a characteristic feature of Disseminated Intravascular Coagulation (DIC)?

    <p>Impaired blood clotting (A)</p> Signup and view all the answers

    Why is it crucial for patients receiving radiation therapy to avoid sun exposure for one year?

    <p>To minimize the risk of developing cancer (B)</p> Signup and view all the answers

    Which of Erikson's stages of psychosocial development focuses on a sense of self and exploration of personal identity?

    <p>Ego Identity vs. Role Confusion (C)</p> Signup and view all the answers

    According to Erikson, what is the main conflict experienced by individuals during the stage of Intimacy vs. Isolation?

    <p>Forming meaningful and lasting relationships with others (C)</p> Signup and view all the answers

    What is the primary outcome of successfully navigating the Ego Identity vs. Role Confusion stage?

    <p>A well-defined sense of self and a direction in life. (D)</p> Signup and view all the answers

    How does Erikson describe the outcome of successfully navigating the stage of Intimacy vs. Isolation?

    <p>Individuals develop a sense of belonging and connection to others. (C)</p> Signup and view all the answers

    Which of the following statements accurately reflects the core idea behind Erikson's stages of psychosocial development?

    <p>Each stage presents a unique challenge that shapes our social and emotional development. (A)</p> Signup and view all the answers

    Which of Erikson's stages is primarily focused on developing a sense of competence and accomplishment?

    <p>Industry vs. Inferiority (A)</p> Signup and view all the answers

    Which Erikson stage focuses on developing a sense of belonging and intimacy with others?

    <p>Intimacy vs. Isolation (D)</p> Signup and view all the answers

    According to Erikson, what is the primary concern for individuals in the Identity vs. Role Confusion stage?

    <p>Establishing a sense of self and identity (B)</p> Signup and view all the answers

    During the stage of Initiative vs Guilt, what is the primary developmental challenge faced by a child?

    <p>Asserting control over their environment and developing a sense of purpose. (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the Industry vs Inferiority stage?

    <p>The primary focus is on developing a sense of autonomy and independence. (B)</p> Signup and view all the answers

    What is a potential consequence of a child experiencing excessive criticism or control during the Initiative vs Guilt stage?

    <p>They may develop a sense of guilt and inadequacy about their actions. (C)</p> Signup and view all the answers

    How does the peer group's role in a child's self-esteem change during the Industry vs Inferiority stage?

    <p>The peer group gains greater significance, becoming a major source of self-esteem. (A)</p> Signup and view all the answers

    What is the primary focus of the Initiative vs Guilt stage?

    <p>Exploring their own abilities and developing a sense of purpose. (A)</p> Signup and view all the answers

    What is the developmental task that children are primarily working on during the Industry vs Inferiority stage?

    <p>Mastering basic skills and achieving competence in their learning and social interactions. (A)</p> Signup and view all the answers

    Which of the following is NOT a potential outcome of successful development during the Initiative vs Guilt stage?

    <p>The child develops a strong sense of trust in their caregivers. (D)</p> Signup and view all the answers

    Which of the following statements best describes the impact of discouraging a child's initiative during the Initiative vs Guilt stage?

    <p>It can contribute to a sense of guilt and inadequacy about their actions. (A)</p> Signup and view all the answers

    Which of the following conditions can lead to a false increase in magnesium levels?

    <p>Lithium Therapy (C)</p> Signup and view all the answers

    What is the normal range of magnesium levels in adults?

    <p>1.7-2.1 mg/dL (D)</p> Signup and view all the answers

    Which of the following conditions might cause the body to retain excessive magnesium?

    <p>Addison's Disease (C)</p> Signup and view all the answers

    Which of the following can contribute to a false decrease in magnesium levels?

    <p>Hemolysis (B)</p> Signup and view all the answers

    Which of the following factors can lead to excessive loss of body fluids, potentially resulting in low magnesium levels?

    <p>Diuretic Abuse (B)</p> Signup and view all the answers

    Which of the following conditions is associated with reduced renal function, potentially leading to altered magnesium levels?

    <p>Prolonged Salicylate Therapy (B)</p> Signup and view all the answers

    What is the normal range of magnesium levels in newborns?

    <p>0.62-0.91 mmol/L (A)</p> Signup and view all the answers

    Which of these conditions can cause a false increase in magnesium levels?

    <p>Chronic Alcoholism (A)</p> Signup and view all the answers

    What is a potential complication associated with prolonged use of magnesium-containing antacids?

    <p>Hypocalcemia (C)</p> Signup and view all the answers

    Which of the following conditions can lead to magnesium deficiency?

    <p>Chronic Pancreatitis (D)</p> Signup and view all the answers

    What characterizes neoplasia in cellular biology?

    <p>Abnormal and progressive multiplication of cells (D)</p> Signup and view all the answers

    Which of the following describes the primary role of T-cells in the immune system?

    <p>Destroy foreign invaders (D)</p> Signup and view all the answers

    What is a significant consequence of cachexia in patients?

    <p>Extreme body wasting and malnutrition (B)</p> Signup and view all the answers

    What does the process of differentiation in cellular biology involve?

    <p>The acquisition of a specific cell function (D)</p> Signup and view all the answers

    How does capillary leak syndrome impact the body?

    <p>Leads to fluid retention and tissue swelling (A)</p> Signup and view all the answers

    What is the primary common site of metastasis for melanoma?

    <p>GI tract (D)</p> Signup and view all the answers

    Which of the following correctly describes the growth behavior of malignant cells?

    <p>Invasion (D)</p> Signup and view all the answers

    Which type of radiation therapy delivers a high dose to a localized area for cases such as prostate cancer?

    <p>Brachytherapy (C)</p> Signup and view all the answers

    Which cancer commonly metastasizes to the brain?

    <p>Melanoma (A)</p> Signup and view all the answers

    What effect does chemotherapy have on cognitive functions?

    <p>Leads to cognitive changes (D)</p> Signup and view all the answers

    What characteristic do malignant cells exhibit in terms of nuclear size compared to normal cells?

    <p>Larger nuclear to cytoplasmic ratio (D)</p> Signup and view all the answers

    Which type of cancer is primarily associated with metastases to the liver?

    <p>Colorectal Cancer (B)</p> Signup and view all the answers

    What is a common characteristic of benign tumor cells in comparison to malignant cells?

    <p>Tight adherence (D)</p> Signup and view all the answers

    What is a characteristic sign of cancer that involves a sore?

    <p>A sore that does not heal (C)</p> Signup and view all the answers

    Which type of tumor arises from glandular tissues?

    <p>Carcinomas (D)</p> Signup and view all the answers

    What distinguishes a secondary tumor from a primary tumor?

    <p>It metastasizes from the original primary cancer (B)</p> Signup and view all the answers

    Which type of cancer is characterized by a growth from embryonal tissues?

    <p>Blastoma (B)</p> Signup and view all the answers

    Which of the following is true about leukemias?

    <p>They are cancers of the blood (A)</p> Signup and view all the answers

    What does the T in the tumor classification system mainly refer to?

    <p>Size and invasiveness of the primary tumor (D)</p> Signup and view all the answers

    What type of cancer is better defined by the term lymphomas?

    <p>Cancers originating in lymphocytes (C)</p> Signup and view all the answers

    Which of the following does NOT qualify as an early warning sign of cancer?

    <p>Frequent headaches without other symptoms (D)</p> Signup and view all the answers

    What is the normal range of BUN levels for adults?

    <p>6-20 mg/dL (A)</p> Signup and view all the answers

    What condition is associated with decreased BUN levels?

    <p>Malnutrition (A)</p> Signup and view all the answers

    Which of the following factors can lead to an increase in BUN levels?

    <p>Impaired kidney function (C)</p> Signup and view all the answers

    In which scenario would you expect BUN levels to decrease?

    <p>Intravenous feeding only (A)</p> Signup and view all the answers

    What is a possible cause for increased BUN levels aside from renal impairment?

    <p>Starvation (B)</p> Signup and view all the answers

    What does a neutrophilic leukocytosis typically indicate?

    <p>Bacterial infection (C)</p> Signup and view all the answers

    Which demographic is expected to show higher BUN levels due to lower muscle mass?

    <p>Women (C)</p> Signup and view all the answers

    Which condition is primarily indicated by leukocytosis in the WBC differential?

    <p>Acute infection (A)</p> Signup and view all the answers

    Chronic renal disease can lead to which of the following hematologic findings?

    <p>Decreased hemoglobin levels (C)</p> Signup and view all the answers

    The presence of lymphocytosis in a WBC count typically indicates which type of infection?

    <p>Viral infection (A)</p> Signup and view all the answers

    What effect does dehydration have on blood urea nitrogen (BUN) levels?

    <p>Increases BUN levels (D)</p> Signup and view all the answers

    A patient with diabetes and ketoacidosis may present with what type of BUN change?

    <p>Increased BUN (C)</p> Signup and view all the answers

    What is typically observed in a patient experiencing excessive protein intake?

    <p>Increased BUN levels (A)</p> Signup and view all the answers

    How does chronic use of diuretics affect BUN levels?

    <p>Increases BUN levels (B)</p> Signup and view all the answers

    What effect does pregnancy have on BUN levels?

    <p>Decreases BUN levels (A)</p> Signup and view all the answers

    Flashcards

    G1 Phase Drugs

    Drugs that act on the G1 phase of the cell cycle, including hormonal drugs and antineoplastic enzymes like asparaginase.

    S Phase Drugs

    Drugs that target the S phase during DNA synthesis, including antimetabolites like methotrexate and purine/pyrimidine analogs.

    G2 Phase Drugs

    Drugs acting in the G2 phase, like Etoposide and Bleomycin, which prepare cells for mitosis.

    M Phase Drugs

    Drugs that act during mitosis, including taxanes and vinca alkaloids which disrupt cell division.

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    Immunomodulating Drugs

    Drugs that enhance the immune response against tumors, classified into hematopoietic and immunomodulating agents.

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    Monoclonal Antibodies

    Targeted cancer therapies that bind to specific antigens on tumor cells, such as Bevacizumab.

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    Rituximab Adverse Effects

    Potentially fatal reactions including severe bronchospasms and tumor lysis syndrome associated with Rituximab use.

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    Interferon

    Immunomodulating drug that prevents cancer cell division and enhances macrophage activity.

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    Risk Factors for Cancer

    Factors that increase the likelihood of developing cancer, such as lifestyle and environmental influences.

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    Socioeconomic Status

    A risk factor that reflects income, education, and occupation, impacting cancer risk.

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    Ionizing Radiation

    A type of radiation linked to cancers like leukemia and breast cancer.

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    Aflatoxin

    A carcinogenic compound found in improperly stored grains and nuts linked to liver cancer.

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    Tobacco Use

    A major lifestyle risk factor for multiple cancers, including lung and bladder cancer.

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    DES (Diethylstilbestrol)

    A medical drug exposure associated with reproductive cancers in offspring.

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    Alkylating Drugs

    Chemotherapy agents that increase the risk of leukemia and bladder cancer.

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    Reproductive History

    Factors such as age at first pregnancy and number of children affecting cancer risk, particularly breast and ovarian cancer.

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    Common sites of breast cancer metastases

    Breast cancer commonly spreads to bone, lung, liver, and brain.

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    Common sites of lung cancer metastases

    Lung cancer typically metastasizes to brain, bone, liver, lymph nodes, and pancreas.

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    Common sites of colorectal cancer metastases

    Colorectal cancer usually spreads to the liver, lymph nodes, and adjacent structures.

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    Common sites of prostate cancer metastases

    Prostate cancer primarily spreads to bones, especially spine and legs, and pelvic nodes.

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    Chemotherapy vs. Radiation

    Chemotherapy is systemic; radiation is local targeting specific tumors.

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    Chemo brain

    A condition with decreased concentration, memory loss, and cognitive changes due to chemotherapy.

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    Teletherapy

    External beam radiation therapy used most commonly for treating cancer.

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    Brachytherapy

    Internal radiation delivering high doses to localized cancer areas, used for prostate cancer.

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    Mistrust

    A lack of trust due to unreliable interactions.

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    Trust Development

    Formed when interactions are reliable and caring.

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    Autonomy vs Shame

    Erikson's stage where a child seeks independence.

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    Early Childhood Stage

    Lasts from 1.5 to 3 years, focused on personal control.

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    Parental Role

    Parents should encourage exploration within limits.

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    Effect of Success

    Leads to feelings of autonomy and independence.

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    Effect of Failure

    Results in feelings of shame and self-doubt.

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    Encouraging Environment

    An atmosphere that tolerates failure while supporting growth.

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    Hypercalcemia

    Elevated levels of calcium in the blood, often above 8.2 mg/dL.

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    Renal Failure

    A medical condition where kidneys fail to function properly.

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    Diabetic Acidosis

    A condition where acid accumulates in the body due to uncontrolled diabetes.

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    Chronic Renal Disease

    Long-term loss of kidney function, affects waste filtration.

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    Lithium Impact

    Lithium therapy can cause elevated magnesium levels in the body.

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    Adrenalectomy

    Surgical removal of one or both adrenal glands.

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    SIADH

    Syndrome of Inappropriate Antidiuretic Hormone secretion leads to excess fluid retention.

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    Hypoparathyroidism

    Low production of parathyroid hormone leading to low calcium levels.

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    Oliguria

    A condition of producing abnormally small amounts of urine.

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    Malabsorption Syndromes

    Conditions where the intestines cannot absorb nutrients properly.

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    Causes of Hyperkalemia

    Conditions such as renal failure, acidosis, or trauma that result in increased potassium levels.

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    Aldosteronism

    A condition caused by excess production of aldosterone, leading to sodium retention and potassium loss.

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    Metabolic Acidosis

    A condition characterized by decreased blood pH due to increased acid or decreased bicarbonate.

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    Osmotic Hyperglycemia

    A condition that can lead to elevated potassium levels due to hyperglycemia's effect on kidney function.

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    Cystic Fibrosis and K+

    Cystic fibrosis can lead to low potassium levels due to excessive loss via sweat.

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    Effects of Diuretics

    Diuretics can cause potassium loss from the body leading to low potassium or hypokalemia.

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    Sickle Cell Disease and K+

    Sickle cell disease can be linked to moderate increases in potassium levels due to cell breakdown.

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    Diabetic Ketoacidosis

    A condition in diabetes that can lead to elevated potassium levels due to acidosis.

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    Renal Tubular Acidosis

    A condition in which the kidneys fail to properly excrete acids into the urine, leading to acidic blood.

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    Alcoholism and K+

    Chronic alcoholism can lead to electrolyte imbalances, including elevated potassium levels.

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    Low Sodium Regulation

    Decreased sodium levels can also affect potassium levels within the body due to hormonal responses.

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    Primary Hyperaldosteronism

    A condition caused by adrenal tumor leading to excessive aldosterone production and subsequent sodium and potassium changes.

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    Chronic Heart Failure (CHF)

    A condition that often causes sodium retention and potentially increases potassium levels.

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    Ego Identity

    The sense of self that develops during adolescence, involving exploration of roles and identities.

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    Role Confusion

    Uncertainty about oneself and one's place in society, common in adolescence.

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    Stage 5: Adolescence

    Erikson's stage focusing on identity formation and role exploration from ages 12-18.

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    Fidelity

    The ability to form meaningful relationships and commitment during adolescence.

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    Intimacy vs Isolation

    Erikson's stage for young adults (ages 18-40) where the focus is on forming intimate relationships.

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    Stage 6: Young Adulthood

    The stage of life where love and relationships take center stage, from ages 18-40.

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    Identity Exploration

    The process during adolescence where individuals experiment with different roles and identities.

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    Sense of Direction

    The established understanding of one’s goals and life path, developed during adolescence.

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    Malignant skin lesions

    Abnormal growths that can extend locally or metastasize. Symptoms include discoloration and tissue necrosis.

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    Patient Care for Skin Lesions

    Involves cleaning skin, controlling bleeding, and preventing infection. Avoid sun on radiated skin for 1 year.

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    Thrombocytopenia

    A condition with low platelet count (<100,000), increasing bleeding risk among cancer patients.

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    Neutropenic Precautions

    Measures to prevent infection in patients with low neutrophil counts, including limiting visitors and monitoring for fever.

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    Monitoring WBC Counts

    Regular lab tests to detect changes in white blood cell counts, assessing risk of infection.

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    Sepsis

    A life-threatening response to infection that spreads bacteria or toxins throughout the body.

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    Spinal Cord Compression

    A condition where cancer spreads to the spine, causing nerve pressure and symptoms like gait changes.

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    Palliative Care

    Medical care aimed at improving quality of life and reducing pain, rather than curing the disease.

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    Chronic Pain Management

    Addressing ongoing pain through physical, psychosocial, and spiritual support, often complicated by treatment effects.

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    Ascending Colostomy

    A colostomy located in the ascending colon, producing liquid to semi-liquid stool.

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    Monitoring for Infection Risks

    Regular assessments for signs of infection, especially in common areas like the skin and respiratory tract.

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    Transverse Colostomy

    A colostomy in the transverse colon, producing paste-like stool as water is absorbed.

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    Descending Colostomy

    A colostomy placed in the descending colon, producing semi-formed to formed stool.

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    Sigmoid Colostomy

    A colostomy in the sigmoid colon, usually producing formed stool as most water is absorbed.

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    Stoma Care

    Care required for the surgically created opening (stoma) where waste exits the body.

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    Numbness in Lower Extremities

    Loss of feeling in legs or feet, often due to nerve damage or compression.

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    RBC Count Men

    Normal range for red blood cells in men is 4.2-5.4 x 10⁶/mm³.

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    RBC Count Women

    Normal range for red blood cells in women is 3.6-5.0 x 10⁶/mm³.

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    RBC Count Neonates

    Normal range for red blood cells in neonates is 4.0-6.1 x 10⁶/mm³.

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    ABG Normal pH Range Adult

    Normal arterial blood gas pH range in adults is 7.35-7.45.

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    Creatinine Men

    Normal creatinine range for men is 0.9-1.3 mg/dL.

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    Creatinine Women

    Normal creatinine range for women is 0.6-1.1 mg/dL.

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    Glucose Fasting Adults

    Fasting plasma glucose normal range for adults is ≤100 mg/dL.

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    Glucose Fasting Peds

    Fasting plasma glucose normal range for peds is 60-100 mg/dL.

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    Polycythemia

    An increase in red blood cells which can be due to disease or dehydration.

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    Anemia

    A condition marked by a deficiency of red blood cells.

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    Hyperventilation Effect

    Increased breathing leading to changes in blood pH.

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    Liver Disease Impact on Hb

    Liver disease can lead to decreased hemoglobin levels.

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    Dehydration Effects

    Causes an increase in hemoglobin and hematocrit levels.

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    Diabetes and Glucose

    Diabetes results in higher fasting glucose levels.

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    BUN (Blood Urea Nitrogen) Levels

    Normal range for adults is 6-20 mg/dL. Indicates kidney function.

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    Increased BUN Causes

    Impaired renal function, dehydration, high protein intake.

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    Decreased BUN Causes

    Malnutrition, chronic liver disease, low protein diets.

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    BUN in Pediatrics

    Normal levels for children range from 5-18 mg/dL.

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    Effect of Liver Failure on BUN

    Liver failure can result in decreased BUN levels.

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    CHF and BUN Levels

    Congestive heart failure can increase BUN due to poor kidney perfusion.

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    Urinary Tract Obstruction

    Obstruction can lead to elevated BUN due to backpressure.

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    Malnutrition Effect on BUN

    Low protein diets lead to decreased BUN levels.

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    Drugs Affecting BUN Levels

    Certain drugs can cause either increased or decreased BUN levels.

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    WBC Normal Range

    White blood cell count for adults is 3.2-10.0 x 10³ cells/mm³.

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    Neutrophilia and BUN

    High neutrophils can indicate infection, affecting BUN.

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    Normal RBC Range

    Red blood cells values relate to overall hematocrit and hemoglobin levels.

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    Chronic Conditions Affecting WBC

    Chronic infections or diseases influence white blood cell counts.

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    Hypersplenism Effect

    An enlarged spleen can lead to a lower WBC count due to cell trapping.

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    Hourly Rhythm of WBC

    WBC levels vary throughout the day, typically higher in the morning.

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    Breast Cancer Metastasis

    Breast cancer spreads commonly to bone, lung, liver, and brain.

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    Lung Cancer Metastasis

    Lung cancer frequently metastasizes to the brain, bone, liver, lymph nodes, and pancreas.

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    Colorectal Cancer Metastasis

    Colorectal cancer primarily spreads to the liver, lymph nodes, and adjacent structures.

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    Prostate Cancer Metastasis

    Prostate cancer mainly spreads to the bones, especially the spine and legs, and pelvic nodes.

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    Apoptosis

    The programmed death of a cell, essential for growth and development.

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    Differentiation

    The process by which a less specialized cell becomes a more specialized cell type.

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    Proliferation

    The reproduction of new cells through cell growth and division.

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    Neoplasia

    Abnormal and progressive multiplication of cells, leading to the formation of a neoplasm.

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    Antigen

    Any substance that the immune system recognizes as foreign.

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    Warning Signs of Cancer

    Changes in bowel habits, sores, unusual bleeding, lumps, digestion issues, wart changes, or nagging cough.

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    Carcinomas

    Cancers originating in skin, lungs, breast, pancreas, glands; includes breast, prostate cancers.

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    Sarcomas

    Cancers arising from connective tissues such as bone, muscle, fat; examples include Osteosarcoma and Fibrosarcoma.

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    Lymphomas

    Cancers of lymphocytes; includes Hodgkin's and Non-Hodgkin's lymphoma.

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    Leukemia

    Cancer of the blood; types include Chronic Lymphocytic and Acute Myeloid Leukemia.

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    Primary Tumor

    Tumor identified by its original tissue type; the first location of cancer.

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    Secondary Tumor

    Metastatic tumor formed by cancer cells spreading from the primary site.

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    Tumor Staging (T)

    Staging system indicating the size and invasiveness of the primary tumor from T0 (none) to T4 (extensive invasion).

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    Initiative vs Guilt

    A stage (3-5 years) where children assert control and power through activities.

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    Sense of Purpose

    Successful completion of tasks during 'Initiative vs Guilt' leads to a sense of purpose.

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    Negative Effects of Criticism

    Criticism during 'Initiative vs Guilt' can develop guilt in children.

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    Industry vs Inferiority

    A stage (5-12 years) where peers become crucial for self-esteem and learning.

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    Peer Group Significance

    During 'Industry vs Inferiority', friends become major influencers on self-esteem.

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    Coping with Social Demands

    Children learn to interact and handle new challenges during 'Industry vs Inferiority'.

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    Erikson's Stages of Development

    Stages describe psychological growth from childhood to adulthood according to Erikson.

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    Fidelity in Adolescence

    The ability to form meaningful relationships during the 'Intimacy vs Isolation' stage.

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    BUN Normal Range

    Normal Blood Urea Nitrogen levels for adults are 6-20 mg/dL.

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    Geriatrics BUN Level

    Normal BUN levels for older adults range from 8-23 mg/dL.

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    Signs of Impaired Kidney Function

    Symptoms may include increased BUN and creatinine levels in blood tests.

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    Effects of High Protein Diet

    A high protein intake can significantly raise BUN levels in the bloodstream.

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    Malnutrition and BUN

    Malnutrition can cause low BUN levels due to reduced protein intake.

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    Alcohol and BUN Levels

    Chronic alcoholism may contribute to variations in BUN levels due to liver health.

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    BUN as Kidney Function Test

    BUN is a common blood test to evaluate kidney function and waste removal.

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    Urine Output Measurement

    Normal urine output ranges from 800-2000 mL per day depending on hydration.

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    Acute Kidney Injury and BUN

    In cases of acute kidney injury, BUN levels may rise significantly.

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    Study Notes

    Cellular Regulation

    • Refers to all internal cell functions maintaining homeostasis
    • Most cell components are proteins
    • Homeostasis is a self-regulating process that maintains stability for optimal survival
    • Apoptosis is cell death
    • Differentiation is the development of a specific cell function from a less specialized cell
    • Proliferation is the process of cell reproduction through growth and division
    • Neoplasia is the abnormal multiplication of cells, leading to the formation of a neoplasm (new tissue growth)
    • Benign neoplasms are non-cancerous
    • Malignant neoplasms are cancerous
    • Replication is the process of duplicating cells with identical genetic material (DNA)
    • 23 pairs of chromosomes are present in each cell
    • Cells replicate faster than they die in normal growth
    • Dysplasia means abnormal cells
    • Cachexia is extreme body wasting and malnutrition
    • Adjuvant therapy involves using chemotherapy alongside radiation or surgery
    • Desquamation is skin peeling (shedding of the outer skin layer)
    • Antigens are substances that trigger an immune response
    • B-cells include memory cells and plasma cells that produce immunoglobulins
    • T-cells destroy foreign invaders, but over-active suppression leads to tumor growth.
    • Macrophages are immune system cells that kill cancer cells.
    • Myeloid blasts are immature tumor cells found in acute myeloid leukemia.
    • Cytokines are immune proteins coordinating humoral and cell-mediated immunity. They boost immunity.
    • Capillary leak syndrome occurs when capillaries lose proteins like albumin, leading to fluid buildup

    Cell Cycle

    • Most cells spend time in the GO phase where they are functioning but not dividing
    • G1 phase (Interphase): Normal cell functions and growth
    • S phase (Interphase): DNA replicates (creating two copies of each chromosome)
    • G2 phase (Interphase): Cell prepares for mitosis and division
    • Prophase: Condensing chromosomes, forming spindle fibers, separating centrioles
    • Metaphase: Double-stranded chromosomes line up, spindle fibers connect to each sister chromatid
    • Anaphase: Sister chromatids separate and move to opposite poles
    • Telophase: Chromosomes reach cell ends, new cell membrane begins to form, spindle disappears
    • Cytokinesis: Cytoplasm and organelles divide to create two genetically identical cells

    Drugs affecting cell cycle phases

    • G1 phase drugs: Hormonal drugs, antineoplastic enzymes (asparaginase);
    • S phase drugs: Antimetabolites (Folate Analogs like Methotrexate, Purine Analogs, and Prymidine Analogs); Miscellaneous (Hydroxurea);
    • G2 phase drugs: Topoisomerase-1 inhibitors; Miscellaneous Bleomycin; Taxanes (Docetaxel, Paclitaxel)
    • M phase drugs: Vinca alkaloids (Vinblastine, Vincristine, Vinorelbine)
    • Taxanes (Docetaxel, Paclitaxel)

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