Cancer Gene Identification Shift in 2003

From the identification of tyrosine-kinase domains to the identification of protein tyrosine phosphatase

From a candidate gene approach to the mutational analyses of gene families (correct)

From the mutational analyses of gene families to a candidate gene approach

From the identification of kinases to the identification of phosphatases

Protein kinase gene families

Tyrosine-kinase gene families

Protein and lipid phosphorylation gene families (correct)

Protein tyrosine phosphatase gene families

The corresponding proteins were already known to play a pivotal role in the signaling and proliferation of normal and cancerous cells

Multiple members of the protein kinases family had already been linked to tumorigenesis

Kinases are clearly amenable to pharmacologic inhibition, making them attractive drug targets

All of the above (correct)

<p>Both a and b</p> Signup and view all the answers

<p>It identified approximately 120 mutated genes that probably contribute to oncogenesis</p> Signup and view all the answers

<p>To perform a mutation analysis of the protein tyrosine phosphatase</p> Signup and view all the answers