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Questions and Answers
What was the shift in the identification of cancer genes in 2003?
What was the shift in the identification of cancer genes in 2003?
- From the identification of tyrosine-kinase domains to the identification of protein tyrosine phosphatase
- From a candidate gene approach to the mutational analyses of gene families (correct)
- From the mutational analyses of gene families to a candidate gene approach
- From the identification of kinases to the identification of phosphatases
Which gene families were the first to be completely sequenced?
Which gene families were the first to be completely sequenced?
- Protein kinase gene families
- Tyrosine-kinase gene families
- Protein and lipid phosphorylation gene families (correct)
- Protein tyrosine phosphatase gene families
What was the rationale for initially focusing on the protein and lipid phosphorylation gene families?
What was the rationale for initially focusing on the protein and lipid phosphorylation gene families?
- The corresponding proteins were already known to play a pivotal role in the signaling and proliferation of normal and cancerous cells
- Multiple members of the protein kinases family had already been linked to tumorigenesis
- Kinases are clearly amenable to pharmacologic inhibition, making them attractive drug targets
- All of the above (correct)
What did the mutational analysis of all the tyrosine-kinase domains in colorectal cancers reveal?
What did the mutational analysis of all the tyrosine-kinase domains in colorectal cancers reveal?
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What was the additional mutational analysis performed on 518 protein kinase genes in 210 diverse human cancers?
What was the additional mutational analysis performed on 518 protein kinase genes in 210 diverse human cancers?
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What was the rational next step in these studies, given that kinase activity is attenuated by enzymes that remove phosphate groups called phosphatase?
What was the rational next step in these studies, given that kinase activity is attenuated by enzymes that remove phosphate groups called phosphatase?
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