Questions and Answers
What was the shift in the identification of cancer genes in 2003?
From a candidate gene approach to the mutational analyses of gene families
Which gene families were the first to be completely sequenced?
Protein and lipid phosphorylation gene families
What was the rationale for initially focusing on the protein and lipid phosphorylation gene families?
All of the above
What did the mutational analysis of all the tyrosine-kinase domains in colorectal cancers reveal?
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What was the additional mutational analysis performed on 518 protein kinase genes in 210 diverse human cancers?
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What was the rational next step in these studies, given that kinase activity is attenuated by enzymes that remove phosphate groups called phosphatase?
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