18 Questions
What is the primary function of the immune inflammatory cells present in tumors?
To play a dual role, both promoting and killing tumors
What characterizes the stromal cell types during tumor progression?
They evolve and change during progression
What is the role of the extracellular matrix in tumor microenvironments?
It evolves during progression, enabling primary, invasive, and metastatic growth
What is the result of the succession of tumor microenvironments during tumor progression?
Tumor growth and progression are enabled
What is the relationship between the stromal cell types and tumor growth?
They collectively enable tumor growth and progression
What is the role of the surrounding normal cells in the primary and metastatic sites?
They likely affect the character of the various neoplastic microenvironments
What is the primary function of the reciprocal heterotypic signaling interactions in the tumor microenvironment?
To maintain the collective contributions of assorted cell types
What is the consequence of the changes in intracellular signaling during tumor progression?
Development of a more aggressive phenotype
What influences the predisposition to spawn metastatic lesions in cancer cells?
The differentiation program of the normal cell-of-origin
What is the term used to describe certain organ sites that are permissive for metastatic seeding and colonization?
Fertile soil or metastatic niches
What is the role of cancer stem cells in tumorigenesis and metastasis?
They are involved in some or all stages of primary tumorigenesis and metastasis
What is the result of the systemic actions of primary tumors on distant organ sites?
Induction of local properties that are permissive for metastatic seeding and colonization
What is the prevailing understanding of tumors in recent years?
Organs with complexity similar to healthy tissues
What is the primary focus of studying the tumor microenvironment?
Understanding the collective functions of specialized cell types
What is a key feature of carcinomas?
The neoplastic cells form a distinct compartment from the tumor-associated stroma
What is the significance of studying individual cell types within the tumor microenvironment?
To understand the collective functions of these cells
What has led to a shift in perspective on tumor biology?
The recognition of tumors as complex organs
What is implied by the concept of 'tumor microenvironment'?
The tumor is a complex entity comprising diverse cell types
Learn about the role of cancer cells and cancer stem cells in tumor progression, including their genetic mutations and interactions with the tumor microenvironment.
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