Cancer Cells and Cancer Stem Cells
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Questions and Answers

What is the primary function of the immune inflammatory cells present in tumors?

  • To only promote tumor growth
  • To have no effect on tumor growth
  • To play a dual role, both promoting and killing tumors (correct)
  • To only kill tumors
  • What characterizes the stromal cell types during tumor progression?

  • They remain constant and unchanged
  • They evolve and change during progression (correct)
  • They are absent in primary tumors
  • They decrease in abundance
  • What is the role of the extracellular matrix in tumor microenvironments?

  • It evolves during progression, enabling primary, invasive, and metastatic growth (correct)
  • It hinders tumor growth
  • It is a passive component of the tumor microenvironment
  • It is only present in primary tumors
  • What is the result of the succession of tumor microenvironments during tumor progression?

    <p>Tumor growth and progression are enabled</p> Signup and view all the answers

    What is the relationship between the stromal cell types and tumor growth?

    <p>They collectively enable tumor growth and progression</p> Signup and view all the answers

    What is the role of the surrounding normal cells in the primary and metastatic sites?

    <p>They likely affect the character of the various neoplastic microenvironments</p> Signup and view all the answers

    What is the primary function of the reciprocal heterotypic signaling interactions in the tumor microenvironment?

    <p>To maintain the collective contributions of assorted cell types</p> Signup and view all the answers

    What is the consequence of the changes in intracellular signaling during tumor progression?

    <p>Development of a more aggressive phenotype</p> Signup and view all the answers

    What influences the predisposition to spawn metastatic lesions in cancer cells?

    <p>The differentiation program of the normal cell-of-origin</p> Signup and view all the answers

    What is the term used to describe certain organ sites that are permissive for metastatic seeding and colonization?

    <p>Fertile soil or metastatic niches</p> Signup and view all the answers

    What is the role of cancer stem cells in tumorigenesis and metastasis?

    <p>They are involved in some or all stages of primary tumorigenesis and metastasis</p> Signup and view all the answers

    What is the result of the systemic actions of primary tumors on distant organ sites?

    <p>Induction of local properties that are permissive for metastatic seeding and colonization</p> Signup and view all the answers

    What is the prevailing understanding of tumors in recent years?

    <p>Organs with complexity similar to healthy tissues</p> Signup and view all the answers

    What is the primary focus of studying the tumor microenvironment?

    <p>Understanding the collective functions of specialized cell types</p> Signup and view all the answers

    What is a key feature of carcinomas?

    <p>The neoplastic cells form a distinct compartment from the tumor-associated stroma</p> Signup and view all the answers

    What is the significance of studying individual cell types within the tumor microenvironment?

    <p>To understand the collective functions of these cells</p> Signup and view all the answers

    What has led to a shift in perspective on tumor biology?

    <p>The recognition of tumors as complex organs</p> Signup and view all the answers

    What is implied by the concept of 'tumor microenvironment'?

    <p>The tumor is a complex entity comprising diverse cell types</p> Signup and view all the answers

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