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Questions and Answers
What is the primary function of p53 in DNA damaged cells?
What is the primary function of p53 in DNA damaged cells?
- Enhancing genomic instability
- Inducing apoptosis via mitochondrial pathway (correct)
- Inhibiting DNA repair genes
- Inducing cell proliferation
Which of the following genes is associated with familial predisposition to the development of carcinomas of the colon?
Which of the following genes is associated with familial predisposition to the development of carcinomas of the colon?
- BRCA-2
- Mismatch repair genes (correct)
- BRCA-1
- TP53
What is the result of a loss of function mutation in TP53?
What is the result of a loss of function mutation in TP53?
- Increased genomic instability
- Induction of apoptosis
- Enhanced DNA repair
- Failure to respond to chemotherapy and radiotherapy (correct)
Which of the following proteins is an example of an anti-apoptotic protein?
Which of the following proteins is an example of an anti-apoptotic protein?
What is the primary function of DNA repair genes?
What is the primary function of DNA repair genes?
Which of the following is an example of a tumor suppressor gene?
Which of the following is an example of a tumor suppressor gene?
What is the function of the RAS oncogene?
What is the function of the RAS oncogene?
Which type of RAS gene is commonly associated with melanoma and hematopoietic tumors?
Which type of RAS gene is commonly associated with melanoma and hematopoietic tumors?
What is the primary function of the MYC proto-oncogene?
What is the primary function of the MYC proto-oncogene?
What is required to produce tumors in the case of Retinoblastoma gene?
What is required to produce tumors in the case of Retinoblastoma gene?
What is the role of the p53 protein in stressed cells?
What is the role of the p53 protein in stressed cells?
What type of genes are TP53 and RB?
What type of genes are TP53 and RB?
What is the main difference between a proto-oncogene and an oncogene?
What is the main difference between a proto-oncogene and an oncogene?
Which of the following is NOT a hallmark of cancer?
Which of the following is NOT a hallmark of cancer?
What is the function of HER2/NEU gene in breast and ovarian cancers?
What is the function of HER2/NEU gene in breast and ovarian cancers?
Which of the following genes are involved in regulating apoptosis?
Which of the following genes are involved in regulating apoptosis?
What is the function of signal transduction proteins in a cell?
What is the function of signal transduction proteins in a cell?
What is the function of cyclin-dependent kinases in the cell cycle?
What is the function of cyclin-dependent kinases in the cell cycle?
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