Cancer and Radiation Pharm
30 Questions
0 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the stage of cancer where it has spread to other parts of the body?

  • Stage 1
  • Stage 2
  • Stage 3
  • Stage 4 (correct)

What is the type of agent that targets specific phases of cell division?

  • Acetylating agents (correct)
  • Antimetabolites (correct)
  • Quinolones
  • Alkylating agents

What is the effect of chemotherapy on cells?

  • It stimulates cell growth
  • It repairs damaged DNA
  • It slows down cell division
  • It kills cells at a constant single rate (correct)

What type of agent inhibits the synthesis of folic acid?

<p>Antimetabolites (C)</p> Signup and view all the answers

What is the site where cancer cells can break away and spread to other parts of the body?

<p>Lymph fluid (C)</p> Signup and view all the answers

What is the first line of defense against cancer?

<p>Cytotoxic agents (C)</p> Signup and view all the answers

What phase of the cell cycle is associated with synthesis of cellular components needed for DNA synthesis

<p>G1 (B)</p> Signup and view all the answers

What phase of the cell cycle is associated with replication of the genome (DNA synthesis)

<p>S (A)</p> Signup and view all the answers

What phase of the cell cycle is associated with synthesis of cellular components for mitosis

<p>G2 (C)</p> Signup and view all the answers

Which cytotoxic drug is a antimetabolite that is a folate analogue

<p>methotrexate (A)</p> Signup and view all the answers

Which cytotoxic drugs target the S phase of the cell cycle

<p>Antimetabolites &amp; Topoisomerase-1 inhibitors (A)</p> Signup and view all the answers

Which cytotoxic drugs target the G2 phase of the cell cycle

<p>Epipodophyllotoxin derivatives &amp; Taxanes (C)</p> Signup and view all the answers

Which cytotoxic drugs target the M phase of the cell cycle

<p>Taxanes &amp; Vinca Alkaloids (A)</p> Signup and view all the answers

Which cytotoxic drugs target the G1 phse of the cell cycle

<p>Hormonal drugs &amp; Antineoplastic enzymes (B)</p> Signup and view all the answers

Which drugs are effective for high-growth fraction malignancies such as hematologic cancers

<p>Cell cycle specific drugs (A)</p> Signup and view all the answers

Which drugs are effective for both low-growth fraction malignancies, such as solid tumors, as well as high growth fraction malignancies like hematologic cencers

<p>Cell cycle NON-specific drugs (B)</p> Signup and view all the answers

Folate inhibitors, pyrimidine inhibitors and purine analogs are examples of which cytotoxic drugs

<p>Antimetabolites (A)</p> Signup and view all the answers

Cyclophosphamide, ifosfamide, cisplatin, carboplatin and oxaliplatin are examples of which kind of cytotoxic drugs

<p>Alkylating agents (A)</p> Signup and view all the answers

Vinca alkaloids (vincristine, vinblastin, vinorelbine) and Taxanes (paclitaxol, docetaxol) are examples of which type of cytotoxic drugs

<p>Microtubule targeting agents (A)</p> Signup and view all the answers

Which cytotoxic drugs prevent the relaxation of supercoiled DNA

<p>Topotecan and irinotecan (A)</p> Signup and view all the answers

Which cytotoxic drugs prevent the recoiling of DNA after transcription?

<p>Epotoside &amp; Teniposide (B)</p> Signup and view all the answers

Which cancer drugs have various MOA includig intervalate DNA, inhibit topoisomerase-2, generate ROS and perhaps alkylation

<p>Anthracyclines (D)</p> Signup and view all the answers

Which drug is a glycopeptide antibiotic with a unique mechanism of antitumor activity and works by breaking single strands of DNA

<p>Bleomycin (B)</p> Signup and view all the answers

Which hormonal is an anti-estrogen; blocks the estrogen stimulation of breast cancer

<p>Tamoxifen (A)</p> Signup and view all the answers

Which hormonal drugs are aromatase inhibitors; block the synthesis of estrogen

<p>Anastrozole, letrozole (A)</p> Signup and view all the answers

Oral mucositis, salivary gland dysfunction, neurotoxicity, trigeminal neuropathies, dental hypersensitivity, taste dysfunction, myofascial pain, TMD, abnormalities in dentition are

<p>Direct toxicities (A)</p> Signup and view all the answers

Myelosuppression, neutropenia, anemia, thrombocytopenia, infection, nausea vomiting, acididc damage to oral tissues and gag reflexes are examples of

<p>indirect toxicities (B)</p> Signup and view all the answers

Select all that apply to monoclonal antibody cancer drugs

<p>Target specific; only target 1 antibody (A), used as a secondary line of tx for cancer pts (B)</p> Signup and view all the answers

Which cancer drugs are monoclonal antibodies? select all that apply

<p>Cetuximab (A), Bevacuzimab (D)</p> Signup and view all the answers

Select all that apply to tyrosine kinase inhibitors

<p>spontaneously dimerize/phosphorylate and activate themselves in cancer (A), they have the suffic &quot;-NIB&quot; (C)</p> Signup and view all the answers

Study Notes

Radiation and Cancer

  • Radiation kills cells at a constant single rate, making it a cytotoxic agent and the first line of defense against cancer.
  • Cancer can spread fast and become malignant, and it can metastasize.

Stages of Cancer

  • There are different stages of cancer, including Stage 3.

Cytotoxic Drugs

  • Cytotoxic drugs target specific phases of cell division.
  • They can inhibit cell synthesis and division.
  • Examples of cytotoxic drugs include:
    • Alkylating agents
    • Platinum agents (e.g. cisplatin)
    • Folic acid inhibitors (e.g. SFU)
    • Hormone-releasing hormone agonists (e.g. Levfiniang)

Effects of Cytotoxic Drugs

  • Cytotoxic drugs can bind to DNA, causing single-strand breaks.
  • They can also suppress the immune system.
  • Side effects of chemotherapy include:
    • Hair loss
    • Nausea and vomiting
    • Fatigue
    • Suppressed immune system
    • Neuropathy
    • Adjuvant therapy is used to overcome these side effects.

Chemotherapy

  • Chemotherapy is a type of cancer treatment that uses cytotoxic drugs.
  • It can be used as an adjuvant therapy to overcome the side effects of cancer treatment.
  • Chemotherapy can be used to treat various types of cancer, including lung cancer.

Angiogenesis and VEGF

  • Angiogenesis is the process of growth and metastasis
  • VEGF (Vascular Endothelial Growth Factor) is a key factor in angiogenesis

Target-Specific Therapy

  • Two lines of treatment: Surfix MAB (monoclonal antibody) and SUFFIX NIB (Tyrosine Kinase Inhibitor)
  • Surfix MAB is an antibody that binds strongly to its target
  • SUFFIX NIB inhibits tyrosine kinase activity
  • Both treatments target specific molecules involved in angiogenesis and cancer growth

Mechanisms of Action

  • Surfix MAB has a long half-life, allowing it to block targets necessary for homeostasis
  • SUFFIX NIB blocks the activation of Mer/Tyk2, a tyrosine kinase that is spontaneously activated in cancer cells

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Description

FA- D1 fall

More Like This

Radiation Therapy and Cancer Treatment
30 questions
Radiation Therapy and Oncology Basics
33 questions
Stoma Care and Cancer Treatment Quiz
37 questions
Radiation Therapy: Treatment & Spread Routes
18 questions
Use Quizgecko on...
Browser
Browser