Questions and Answers
What is the stage of cancer where it has spread to other parts of the body?
What is the type of agent that targets specific phases of cell division?
What is the effect of chemotherapy on cells?
What type of agent inhibits the synthesis of folic acid?
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What is the site where cancer cells can break away and spread to other parts of the body?
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What is the first line of defense against cancer?
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What phase of the cell cycle is associated with synthesis of cellular components needed for DNA synthesis
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What phase of the cell cycle is associated with replication of the genome (DNA synthesis)
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What phase of the cell cycle is associated with synthesis of cellular components for mitosis
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Which cytotoxic drug is a antimetabolite that is a folate analogue
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Which cytotoxic drugs target the S phase of the cell cycle
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Which cytotoxic drugs target the G2 phase of the cell cycle
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Which cytotoxic drugs target the M phase of the cell cycle
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Which cytotoxic drugs target the G1 phse of the cell cycle
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Which drugs are effective for high-growth fraction malignancies such as hematologic cancers
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Which drugs are effective for both low-growth fraction malignancies, such as solid tumors, as well as high growth fraction malignancies like hematologic cencers
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Folate inhibitors, pyrimidine inhibitors and purine analogs are examples of which cytotoxic drugs
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Cyclophosphamide, ifosfamide, cisplatin, carboplatin and oxaliplatin are examples of which kind of cytotoxic drugs
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Vinca alkaloids (vincristine, vinblastin, vinorelbine) and Taxanes (paclitaxol, docetaxol) are examples of which type of cytotoxic drugs
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Which cytotoxic drugs prevent the relaxation of supercoiled DNA
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Which cytotoxic drugs prevent the recoiling of DNA after transcription?
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Which cancer drugs have various MOA includig intervalate DNA, inhibit topoisomerase-2, generate ROS and perhaps alkylation
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Which drug is a glycopeptide antibiotic with a unique mechanism of antitumor activity and works by breaking single strands of DNA
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Which hormonal is an anti-estrogen; blocks the estrogen stimulation of breast cancer
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Which hormonal drugs are aromatase inhibitors; block the synthesis of estrogen
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Oral mucositis, salivary gland dysfunction, neurotoxicity, trigeminal neuropathies, dental hypersensitivity, taste dysfunction, myofascial pain, TMD, abnormalities in dentition are
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Myelosuppression, neutropenia, anemia, thrombocytopenia, infection, nausea vomiting, acididc damage to oral tissues and gag reflexes are examples of
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Select all that apply to monoclonal antibody cancer drugs
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Which cancer drugs are monoclonal antibodies? select all that apply
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Select all that apply to tyrosine kinase inhibitors
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Study Notes
Radiation and Cancer
- Radiation kills cells at a constant single rate, making it a cytotoxic agent and the first line of defense against cancer.
- Cancer can spread fast and become malignant, and it can metastasize.
Stages of Cancer
- There are different stages of cancer, including Stage 3.
Cytotoxic Drugs
- Cytotoxic drugs target specific phases of cell division.
- They can inhibit cell synthesis and division.
- Examples of cytotoxic drugs include:
- Alkylating agents
- Platinum agents (e.g. cisplatin)
- Folic acid inhibitors (e.g. SFU)
- Hormone-releasing hormone agonists (e.g. Levfiniang)
Effects of Cytotoxic Drugs
- Cytotoxic drugs can bind to DNA, causing single-strand breaks.
- They can also suppress the immune system.
- Side effects of chemotherapy include:
- Hair loss
- Nausea and vomiting
- Fatigue
- Suppressed immune system
- Neuropathy
- Adjuvant therapy is used to overcome these side effects.
Chemotherapy
- Chemotherapy is a type of cancer treatment that uses cytotoxic drugs.
- It can be used as an adjuvant therapy to overcome the side effects of cancer treatment.
- Chemotherapy can be used to treat various types of cancer, including lung cancer.
Angiogenesis and VEGF
- Angiogenesis is the process of growth and metastasis
- VEGF (Vascular Endothelial Growth Factor) is a key factor in angiogenesis
Target-Specific Therapy
- Two lines of treatment: Surfix MAB (monoclonal antibody) and SUFFIX NIB (Tyrosine Kinase Inhibitor)
- Surfix MAB is an antibody that binds strongly to its target
- SUFFIX NIB inhibits tyrosine kinase activity
- Both treatments target specific molecules involved in angiogenesis and cancer growth
Mechanisms of Action
- Surfix MAB has a long half-life, allowing it to block targets necessary for homeostasis
- SUFFIX NIB blocks the activation of Mer/Tyk2, a tyrosine kinase that is spontaneously activated in cancer cells
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FA- D1 fall
