Chapter 7 practice patho

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Questions and Answers

Which characteristic of neoplasms alters the metabolism and degrades neighboring unaffected cells?

  • Hormone secretion
  • Protein synthesis
  • Substance secretion (correct)
  • Tissue growth

What are the three tumor suppressor genes that, when mutated, allow neoplasias to form?

  • NF1/NF2/APC
  • PTEN/SHH/NOTCH1
  • BRCA1/BRCA2/EGFR
  • TP53/Rb/BCL-2 (correct)

What type of tumors stem from chondrocytes?

  • Chondromas (correct)
  • Gliomas
  • Rhabdomyosarcomas
  • Angiosarcomas

Which cancer is caused by environmental toxins damaging DNA and inducing mutations in the ras family of oncogenes?

<p>Lung cancer (B)</p> Signup and view all the answers

What is the classification of distant metastasis where cancer has not spread to other body parts?

<p>M0 (A)</p> Signup and view all the answers

What is the most common tumor type in the brain?

<p>Astrocytomas (C)</p> Signup and view all the answers

What do we call it when a chromosome breaks, relocates, and unites with another chromosome, leading to excessive gene activity and abnormal cell growth?

<p>Chromosomal translocation (A)</p> Signup and view all the answers

In the initiation-promotion-progression theory of cancer, which phase involves the growth and reproduction of mutated cells?

<p>Promotion (D)</p> Signup and view all the answers

Which type of tumors arise from bone cells?

<p>Osteomas (C)</p> Signup and view all the answers

What is the term for genes that control cell division and cell death rates?

<p>Tumor suppressor genes (A)</p> Signup and view all the answers

Which stage of lung cancer involves cancer being present in the lungs and nearby lymph nodes?

<p>Stage II (C)</p> Signup and view all the answers

What kind of mutation involves damage to a single nucleotide base pair in DNA, leading to the development of altered proteins in somatic cells?

<p>Point mutation (B)</p> Signup and view all the answers

What is the primary source of the carcinogenic ultraviolet radiation that can induce cancer?

<p>Sun exposure (B)</p> Signup and view all the answers

Which phase in the initiation-promotion-progress theory of cancer is characterized by the cancerous growth becoming independent of continued exposure to promoters?

<p>Progression (C)</p> Signup and view all the answers

Which gene, when mutated and activated, inhibits apoptosis, making the cell immortal by ignoring normal triggers to die?

<p>BCL-2 (B)</p> Signup and view all the answers

Which component in the body is primarily responsible for metabolizing and deactivating potentially carcinogenic chemicals?

<p>Enzymes (A)</p> Signup and view all the answers

What is the term used for malignant neoplasms originating from the blood and blood forming organs?

<p>Leukemia (A)</p> Signup and view all the answers

Which gene mutation, caused by environmental exposures after fertilization, is associated with acquired changes in DNA?

<p>TP53 (B)</p> Signup and view all the answers

What is the classification for distant metastasis where cancer has spread to other body parts?

<p>M1 (B)</p> Signup and view all the answers

Which gene variants are inherited differences that are not mutations but can still impact cell growth?

<p>Polymorphisms (C)</p> Signup and view all the answers

What is the hormone that can directly kill tumor cells and inhibit mitosis?

<p>Adrenal corticosteroid (B)</p> Signup and view all the answers

Which classification is used to describe the size or extent of the primary tumor?

<p>T1 (B)</p> Signup and view all the answers

What is the main characteristic of neoplasms that provides extensive blood flow to tumor cells?

<p>Rapid angiogenesis (D)</p> Signup and view all the answers

Which of the following goals of cancer treatment involves reducing symptoms without curing cancer?

<p>Reducing symptoms w/o curing cancer (C)</p> Signup and view all the answers

What type of tumor is characteristic of glandular epithelial origin?

<p>Adenocarcinoma (A)</p> Signup and view all the answers

Which drug inhibits tumor growth in estrogen-sensitive breast tissues by blocking the action of estrogen?

<p>Letrozole (A)</p> Signup and view all the answers

Which phase in the initiation-promotion-progression theory causes a mutation in a cell?

<p>Initiation (A)</p> Signup and view all the answers

What is the process referred to as when tumor cells move into adjacent tissues and organs?

<p>Metastasis (C)</p> Signup and view all the answers

Which classification system relates to the number and location of regional lymph nodes with cancer?

<p>NX, N0, N1, N2, N3 (D)</p> Signup and view all the answers

What is the term for the loss of cell differentiation and cell function?

<p>Anaplasia (D)</p> Signup and view all the answers

Which gene mutation has the potential to cause cancer by promoting unregulated cell growth and development?

<p>Oncogenes (D)</p> Signup and view all the answers

What is the most common type of tumor found in the brain?

<p>Astrocytomas (D)</p> Signup and view all the answers

Which classification of distant metastasis indicates cancer has spread to other body parts?

<p>M1 (A)</p> Signup and view all the answers

What is the process called by which tumor cells move into adjacent tissues and organs?

<p>Metastasis (A)</p> Signup and view all the answers

What is the phase in the initiation-promotion-progression theory where mutated cells' growth and reproduction are expanded?

<p>Promotion (B)</p> Signup and view all the answers

Which gene mutation type occurs in the oocyte or sperm and may not result in cancer for everyone with the mutation?

<p>Inherited mutation (D)</p> Signup and view all the answers

Which tumor suppressor genes regulate the rate at which cells divide and die?

<p>TP53 and RB1 (A)</p> Signup and view all the answers

In which stage of lung cancer is the cancer detected in the lung and nearby lymph nodes?

<p>Stage II (A)</p> Signup and view all the answers

What type of tumors arise from bone cells?

<p>Osteosarcomas (A)</p> Signup and view all the answers

Which characteristic of neoplasms can trigger the immune response by being present on the cancer cell surface?

<p>Foreign antigens (C)</p> Signup and view all the answers

What is the goal of controlling growth and speed a part of in cancer treatment?

<p>Radiation therapy (D)</p> Signup and view all the answers

Which gene mutation can result in a rare childhood cancer of the retina of the eye and has a major role in suppressing tumor proliferation?

<p>Rb (C)</p> Signup and view all the answers

What do we call a primary tumor that cannot be located?

<p>T0 (D)</p> Signup and view all the answers

In which stage of lung cancer has the cancer spread to both lungs or to another organ like the liver?

<p>Stage IV (C)</p> Signup and view all the answers

Which enzyme in the body is responsible for metabolizing and inactivating potentially carcinogenic chemicals?

<p>Enzymes (A)</p> Signup and view all the answers

What gene mutation, when permanently activated, allows a cell to ignore normal triggers to die and become immortal?

<p>BCL-2 (B)</p> Signup and view all the answers

What is the main characteristic of neoplasms that provide extensive blood flow to tumor cells?

<p>Angiogenesis (D)</p> Signup and view all the answers

Which classification system relates to the number and location of regional lymph nodes with cancer?

<p>TNM staging (D)</p> Signup and view all the answers

What type of tumors arise from bone cells?

<p>Sarcomas (D)</p> Signup and view all the answers

What is the term used to describe the process of tumor cells moving into adjacent tissues and organs?

<p>Metastasis (D)</p> Signup and view all the answers

Which gene mutation, when activated, inhibits apoptosis, making the cell immortal by ignoring normal triggers to die?

<p>TP53 (B)</p> Signup and view all the answers

What is the characteristic loss that allows further unrestricted growth of tumor cells and is a direct feature of neoplasms?

<p>Cell-to-cell communication (D)</p> Signup and view all the answers

Which classification system pertains to the number and location of regional lymph nodes affected by cancer?

<p>N1, N2, N3 (B)</p> Signup and view all the answers

What is the term for the phase in the initiation-promotion-progression theory that causes a mutation in a cell?

<p>Initiation (B)</p> Signup and view all the answers

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