Chapter 7 practice patho
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Questions and Answers

Which characteristic of neoplasms alters the metabolism and degrades neighboring unaffected cells?

  • Hormone secretion
  • Protein synthesis
  • Substance secretion (correct)
  • Tissue growth
  • What are the three tumor suppressor genes that, when mutated, allow neoplasias to form?

  • NF1/NF2/APC
  • PTEN/SHH/NOTCH1
  • BRCA1/BRCA2/EGFR
  • TP53/Rb/BCL-2 (correct)
  • What type of tumors stem from chondrocytes?

  • Chondromas (correct)
  • Gliomas
  • Rhabdomyosarcomas
  • Angiosarcomas
  • Which cancer is caused by environmental toxins damaging DNA and inducing mutations in the ras family of oncogenes?

    <p>Lung cancer</p> Signup and view all the answers

    What is the classification of distant metastasis where cancer has not spread to other body parts?

    <p>M0</p> Signup and view all the answers

    What is the most common tumor type in the brain?

    <p>Astrocytomas</p> Signup and view all the answers

    What do we call it when a chromosome breaks, relocates, and unites with another chromosome, leading to excessive gene activity and abnormal cell growth?

    <p>Chromosomal translocation</p> Signup and view all the answers

    In the initiation-promotion-progression theory of cancer, which phase involves the growth and reproduction of mutated cells?

    <p>Promotion</p> Signup and view all the answers

    Which type of tumors arise from bone cells?

    <p>Osteomas</p> Signup and view all the answers

    What is the term for genes that control cell division and cell death rates?

    <p>Tumor suppressor genes</p> Signup and view all the answers

    Which stage of lung cancer involves cancer being present in the lungs and nearby lymph nodes?

    <p>Stage II</p> Signup and view all the answers

    What kind of mutation involves damage to a single nucleotide base pair in DNA, leading to the development of altered proteins in somatic cells?

    <p>Point mutation</p> Signup and view all the answers

    What is the primary source of the carcinogenic ultraviolet radiation that can induce cancer?

    <p>Sun exposure</p> Signup and view all the answers

    Which phase in the initiation-promotion-progress theory of cancer is characterized by the cancerous growth becoming independent of continued exposure to promoters?

    <p>Progression</p> Signup and view all the answers

    Which gene, when mutated and activated, inhibits apoptosis, making the cell immortal by ignoring normal triggers to die?

    <p>BCL-2</p> Signup and view all the answers

    Which component in the body is primarily responsible for metabolizing and deactivating potentially carcinogenic chemicals?

    <p>Enzymes</p> Signup and view all the answers

    What is the term used for malignant neoplasms originating from the blood and blood forming organs?

    <p>Leukemia</p> Signup and view all the answers

    Which gene mutation, caused by environmental exposures after fertilization, is associated with acquired changes in DNA?

    <p>TP53</p> Signup and view all the answers

    What is the classification for distant metastasis where cancer has spread to other body parts?

    <p>M1</p> Signup and view all the answers

    Which gene variants are inherited differences that are not mutations but can still impact cell growth?

    <p>Polymorphisms</p> Signup and view all the answers

    What is the hormone that can directly kill tumor cells and inhibit mitosis?

    <p>Adrenal corticosteroid</p> Signup and view all the answers

    Which classification is used to describe the size or extent of the primary tumor?

    <p>T1</p> Signup and view all the answers

    What is the main characteristic of neoplasms that provides extensive blood flow to tumor cells?

    <p>Rapid angiogenesis</p> Signup and view all the answers

    Which of the following goals of cancer treatment involves reducing symptoms without curing cancer?

    <p>Reducing symptoms w/o curing cancer</p> Signup and view all the answers

    What type of tumor is characteristic of glandular epithelial origin?

    <p>Adenocarcinoma</p> Signup and view all the answers

    Which drug inhibits tumor growth in estrogen-sensitive breast tissues by blocking the action of estrogen?

    <p>Letrozole</p> Signup and view all the answers

    Which phase in the initiation-promotion-progression theory causes a mutation in a cell?

    <p>Initiation</p> Signup and view all the answers

    What is the process referred to as when tumor cells move into adjacent tissues and organs?

    <p>Metastasis</p> Signup and view all the answers

    Which classification system relates to the number and location of regional lymph nodes with cancer?

    <p>NX, N0, N1, N2, N3</p> Signup and view all the answers

    What is the term for the loss of cell differentiation and cell function?

    <p>Anaplasia</p> Signup and view all the answers

    Which gene mutation has the potential to cause cancer by promoting unregulated cell growth and development?

    <p>Oncogenes</p> Signup and view all the answers

    What is the most common type of tumor found in the brain?

    <p>Astrocytomas</p> Signup and view all the answers

    Which classification of distant metastasis indicates cancer has spread to other body parts?

    <p>M1</p> Signup and view all the answers

    What is the process called by which tumor cells move into adjacent tissues and organs?

    <p>Metastasis</p> Signup and view all the answers

    What is the phase in the initiation-promotion-progression theory where mutated cells' growth and reproduction are expanded?

    <p>Promotion</p> Signup and view all the answers

    Which gene mutation type occurs in the oocyte or sperm and may not result in cancer for everyone with the mutation?

    <p>Inherited mutation</p> Signup and view all the answers

    Which tumor suppressor genes regulate the rate at which cells divide and die?

    <p>TP53 and RB1</p> Signup and view all the answers

    In which stage of lung cancer is the cancer detected in the lung and nearby lymph nodes?

    <p>Stage II</p> Signup and view all the answers

    What type of tumors arise from bone cells?

    <p>Osteosarcomas</p> Signup and view all the answers

    Which characteristic of neoplasms can trigger the immune response by being present on the cancer cell surface?

    <p>Foreign antigens</p> Signup and view all the answers

    What is the goal of controlling growth and speed a part of in cancer treatment?

    <p>Radiation therapy</p> Signup and view all the answers

    Which gene mutation can result in a rare childhood cancer of the retina of the eye and has a major role in suppressing tumor proliferation?

    <p>Rb</p> Signup and view all the answers

    What do we call a primary tumor that cannot be located?

    <p>T0</p> Signup and view all the answers

    In which stage of lung cancer has the cancer spread to both lungs or to another organ like the liver?

    <p>Stage IV</p> Signup and view all the answers

    Which enzyme in the body is responsible for metabolizing and inactivating potentially carcinogenic chemicals?

    <p>Enzymes</p> Signup and view all the answers

    What gene mutation, when permanently activated, allows a cell to ignore normal triggers to die and become immortal?

    <p>BCL-2</p> Signup and view all the answers

    What is the main characteristic of neoplasms that provide extensive blood flow to tumor cells?

    <p>Angiogenesis</p> Signup and view all the answers

    Which classification system relates to the number and location of regional lymph nodes with cancer?

    <p>TNM staging</p> Signup and view all the answers

    What type of tumors arise from bone cells?

    <p>Sarcomas</p> Signup and view all the answers

    What is the term used to describe the process of tumor cells moving into adjacent tissues and organs?

    <p>Metastasis</p> Signup and view all the answers

    Which gene mutation, when activated, inhibits apoptosis, making the cell immortal by ignoring normal triggers to die?

    <p>TP53</p> Signup and view all the answers

    What is the characteristic loss that allows further unrestricted growth of tumor cells and is a direct feature of neoplasms?

    <p>Cell-to-cell communication</p> Signup and view all the answers

    Which classification system pertains to the number and location of regional lymph nodes affected by cancer?

    <p>N1, N2, N3</p> Signup and view all the answers

    What is the term for the phase in the initiation-promotion-progression theory that causes a mutation in a cell?

    <p>Initiation</p> Signup and view all the answers

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