Cancer 1 and 2: Characteristics and Progression
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Questions and Answers

What is the primary characteristic of cancer cells that distinguishes them from normal cells?

  • Their ability to invade adjacent tissues
  • Their competition with normal tissues for oxygen and nutrients
  • Their ability to metastasize to other sites within the body
  • Their unregulated cell division and growth (correct)
  • What is the term for the spread of cancer cells from their site of origin to other sites within the body?

  • Cell growth
  • Metastasis (correct)
  • Tumour formation
  • Invasion
  • What is the term for a mass of cancer cells that are derived from a single original cancer cell?

  • Cancer
  • Tumour (correct)
  • Metastasis
  • Leukaemia
  • What is the primary way in which cancer cells interfere with normal body processes?

    <p>By competing with normal tissues for oxygen and nutrients</p> Signup and view all the answers

    Why are cancers considered genetic diseases?

    <p>Because they are caused by genetic mutations</p> Signup and view all the answers

    What is the exception to the rule that tumours are a mass of cancer cells?

    <p>Leukaemia</p> Signup and view all the answers

    What is the consequence of a mutation occurring in the promoter region of a gene?

    <p>An alteration in the expression of the gene</p> Signup and view all the answers

    What is the estimated percentage of cancers that may originate from chromothripsis events?

    <p>2-3% of all cancers</p> Signup and view all the answers

    What is the consequence of an insertion or deletion mutation in the coding region of a gene?

    <p>A frameshift mutation leading to a truncated protein</p> Signup and view all the answers

    What is the role of error-prone DNA polymerase in gene mutation?

    <p>Exacerbating the formation of adducts and base oxidation</p> Signup and view all the answers

    What is the term for the process by which a large number of genomic rearrangements occur in a single event?

    <p>Chromothripsis</p> Signup and view all the answers

    What is the percentage of the genome that consists of genes?

    <p>1.5% of the genome</p> Signup and view all the answers

    What is the primary mechanism that controls cell numbers in the body?

    <p>Programmed cell death and cell division</p> Signup and view all the answers

    What is the primary difference between benign and malignant tumours?

    <p>Malignant tumours can migrate and invade.</p> Signup and view all the answers

    What is the role of angiogenesis in cancer development?

    <p>To supply tumours with oxygen and nutrients.</p> Signup and view all the answers

    What is the function of oncogenes in normal cells?

    <p>To promote normal cell growth and differentiation</p> Signup and view all the answers

    What is the function of cyclin-dependent kinases (cdks) in the cell cycle?

    <p>To regulate transition between cell cycle phases</p> Signup and view all the answers

    What is the result of unlimited replicative potential in cancer cells?

    <p>Cancer cells maintain telomere length.</p> Signup and view all the answers

    What is the effect of a mutation in a tumor suppressor gene?

    <p>Increased cell growth</p> Signup and view all the answers

    What is reprogramming of energy metabolism in cancer cells?

    <p>A change in energy production to supply increased demand for fuel and biomolecules.</p> Signup and view all the answers

    What is the primary cause of death in cancer patients?

    <p>Invasion and metastasis.</p> Signup and view all the answers

    What is the purpose of the G0 phase in the cell cycle?

    <p>Dormant or quiescent state</p> Signup and view all the answers

    What is the function of the cyclin D/cdk4/6 complex in the cell cycle?

    <p>To arrest the cell cycle at the G1 checkpoint</p> Signup and view all the answers

    What is the percentage of cancer cases that are inherited?

    <p>1-2%.</p> Signup and view all the answers

    What is the primary difference between normal and cancer cells in cell culture?

    <p>Normal cells exhibit contact inhibition.</p> Signup and view all the answers

    What is the effect of disruption of checkpoints in the cell cycle?

    <p>Increased risk of mutation and carcinogenesis</p> Signup and view all the answers

    What is the characteristic of the effect of oncogenes on cell growth?

    <p>Dominant</p> Signup and view all the answers

    What is the result of DNA damage in normal cells?

    <p>Mutations can be repaired or go unnoticed.</p> Signup and view all the answers

    What is the role of genome instability in cancer development?

    <p>It promotes cancer formation.</p> Signup and view all the answers

    What is the function of p53 in the cell cycle?

    <p>To inhibit cell growth and tumour formation</p> Signup and view all the answers

    What is a common characteristic of tumor suppressor genes?

    <p>They inhibit cell growth</p> Signup and view all the answers

    What is the relationship between carcinogens and mutagens?

    <p>All carcinogens are mutagens, but not all mutagens are carcinogens.</p> Signup and view all the answers

    What is the role of the Retinoblastoma (Rb) gene in cell cycle regulation?

    <p>It inhibits cell cycle progression</p> Signup and view all the answers

    What is the function of Ras proteins in signal transduction?

    <p>They are inner membrane-bound signal transducers</p> Signup and view all the answers

    What is the correlation between UV exposure and cancer?

    <p>UV exposure increases the risk of skin cancer</p> Signup and view all the answers

    What is the result of unrepaired or incorrectly repaired DNA damage?

    <p>DNA mutations</p> Signup and view all the answers

    What is the role of transcription factors in gene expression?

    <p>They activate or repress gene expression</p> Signup and view all the answers

    What is the function of protein phosphatases in cell signaling?

    <p>They remove phosphates from proteins</p> Signup and view all the answers

    What is the result of mutations occurring in genes involved in DNA repair?

    <p>Decreased DNA repair capacity</p> Signup and view all the answers

    What is the definition of a mutagen?

    <p>A substance that causes DNA mutations</p> Signup and view all the answers

    What is the consequence of genomic instability in cancer cells?

    <p>Accumulation of mutations</p> Signup and view all the answers

    What is the role of Cyclins and associated cyclin-dependent kinases in regulating Rb gene activity?

    <p>They phosphorylate Rb gene</p> Signup and view all the answers

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