Calviello Metabolic Maps: Atherosclerosis
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Questions and Answers

What is the result of the interaction between oxidised LDL and INFgamma M1 activation in the early phase of atherosclerotic lesion development?

  • NETosis of foam cells by contact with histones of DNA trap (correct)
  • Proliferative response of local SMCs of the plaque
  • Formation of fibroblast-like SMCs
  • Recruitment of BM-derived SMCs progenitor synthesis of proteoglycans

What is the consequence of the pro-atherogenic vicious circle between lipids and cell components implicated in the inflammatory process?

  • Aortic Aneurysm enlargement
  • Cerebral Infarction/Stroke
  • Peripheral Arteriopathies
  • All of the above (correct)

What is the effect of modified LDL on endothelium?

  • No response
  • Unknown response
  • Anti-inflammatory response
  • Pro-inflammatory response (correct)

Why are younger males more affected by atherosclerosis?

<p>Due to hormonal reasons (B)</p> Signup and view all the answers

What is the result of the recruitment of BM-derived SMCs progenitor synthesis of proteoglycans?

<p>Advances in the atherosclerotic lesion development (C)</p> Signup and view all the answers

What is the role of smooth muscle cells in the advanced phase of atherosclerotic lesion development?

<p>Participation in the formation of the cap of the plaque (B)</p> Signup and view all the answers

What is the effect of hypertension and smoking on atherosclerosis?

<p>Environmental/Modifiable risk factors (C)</p> Signup and view all the answers

What is the effect of overweight and obesity on atherosclerosis?

<p>Environmental/Modifiable risk factors (D)</p> Signup and view all the answers

What is the reason for the higher incidence of atherosclerosis in African and Asian populations compared to Caucasian populations?

<p>Ethnicity-related factors (B)</p> Signup and view all the answers

What is the result of the formation of fibroblast-like SMCs?

<p>Advances in the atherosclerotic lesion development (D)</p> Signup and view all the answers

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