Calcium Channel Blockers Quiz
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Questions and Answers

Which of the following statements about calcium channel blockers (CCBs) is correct?

  • Nifedipine and amlodipine do not reduce heart rate and contractility. (correct)
  • Amlodipine, a long-acting CCB, can cause myocardial hypoperfusion.
  • Short-acting nifedipine can lead to a sudden drop in blood pressure and reflex tachycardia.
  • Verapamil and diltiazem have marked effects on arteriolar vasodilatation.

Which of the following statements about potassium channel openers is incorrect?

  • They are considered first-line therapy for anti-ischemic treatment due to their potent effects. (correct)
  • They open ATP-sensitive K+ channels, leading to smooth muscle hyperpolarization.
  • They are chemically related to nitrates and act as weak NO donors, inducing venular dilation.
  • They inhibit the opening of L-type voltage-gated Ca+2 channels, producing vasodilatation.

Which of the following statements about beta-blockers is correct?

  • They are chemically related to nitrates and act as weak NO donors.
  • They decrease heart rate and contractility by blocking calcium channels.
  • They induce arteriolar vasodilatation by opening potassium channels.
  • They are considered the first choice for long-term use in reducing the incidence of sudden death. (correct)

Which of the following statements about organic nitrates is correct?

<p>They are NO donors that induce venular dilation and are chemically related to potassium channel openers. (A)</p> Signup and view all the answers

Which of the following statements about pFOX inhibitors is incorrect?

<p>They belong to the same class as beta-blockers and calcium channel blockers. (B)</p> Signup and view all the answers

Which of the following statements about the effects of calcium channel blockers is correct?

<p>Non-dihydropyridines like verapamil and diltiazem have marked effects on arteriolar vasodilatation. (D)</p> Signup and view all the answers

Which of the following statements about calcium channel blockers is correct?

<p>They selectively block L-type calcium channels in vascular smooth muscle cells, leading to vasodilation. (A)</p> Signup and view all the answers

Which of the following is NOT a pharmacological action of calcium channel blockers in the context of angina relief?

<p>Increasing heart rate (+ve chronotropism) (B)</p> Signup and view all the answers

Which of the following statements about organic nitrates is correct?

<p>They cause vasodilation by increasing the production of nitric oxide. (C)</p> Signup and view all the answers

Which of the following is a dihydropyridine calcium channel blocker?

<p>Nifedipine sustained release (B)</p> Signup and view all the answers

Which of the following statements about non-dihydropyridine calcium channel blockers is correct?

<p>They are examples of verapamil and diltiazem. (C)</p> Signup and view all the answers

Which of the following statements about beta-blockers is correct, based on the given information?

<p>They are mentioned as one of the drug classes used for angina treatment. (B)</p> Signup and view all the answers

What is the primary mechanism of action of organic nitrates in the treatment of angina?

<p>Vasodilation of veins, reducing preload and ventricular filling pressure (D)</p> Signup and view all the answers

Which of the following statements about the pharmacological actions of organic nitrates is NOT true?

<p>They inhibit the enzyme $\text{pFOX}$, leading to reduced myocardial oxygen demand (A)</p> Signup and view all the answers

Why are organic nitrates administered via sublingual, buccal, or transdermal routes?

<p>To bypass first-pass metabolism in the liver, ensuring direct systemic arrival of the drugs (D)</p> Signup and view all the answers

Which class of anti-anginal drugs acts by inhibiting calcium entry into vascular smooth muscle cells?

<p>Dihydropyridines (C)</p> Signup and view all the answers

Which of the following mechanisms of action is NOT associated with non-dihydropyridine calcium channel blockers in the treatment of angina?

<p>Activation of protein kinase G (PKG), leading to vascular smooth muscle relaxation (B)</p> Signup and view all the answers

What is the primary mechanism of action of beta-blockers in the treatment of angina?

<p>Negative chronotropic and inotropic effects, reducing myocardial oxygen demand (C)</p> Signup and view all the answers

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