18 Questions
Which subunit of the voltage-gated calcium channel do Calcium Antagonists bind to?
Alpha1
What is the mechanism of action of Calcium Antagonists in preventing the diffusion of Ca2+ through the pore in an open channel?
Indirectly preventing diffusion by binding to the alpha1 subunit
Which type of Calcium Channel Blocker is preferentially acting on the heart?
Verapamil
What is one example of a Benzothiazepine Calcium Channel Blocker?
Diltiazem
In which type of angina would reducing coronary artery spasm be beneficial?
Variant angina
What is the main pharmacological effect in smooth muscles caused by Calcium Channel Blockers?
Arterial vasodilation
What is the primary reason for the contraindication of Calcium Channel Blockers (CCB) in heart failure?
They can worsen cardiac contractility.
What is the mechanism behind the reflex increase in sympathetic activity caused by Calcium Channel Blockers (CCB)?
Vasodilation-induced baroreceptor reflex.
Which of the following is an adverse drug reaction associated with Calcium Channel Blockers?
Peripheral edema.
How does grapefruit interact with Calcium Channel Blockers?
It decreases CCB metabolism.
Which of the following statements is true regarding the clinical use of Dihydropyridine Calcium Channel Blockers?
They protect ischemic tissues effectively.
What is a characteristic of Calcium Antagonists' pharmacokinetics?
Well absorbed when taken orally except in special circumstances.
What is a contraindication for all calcium channel blockers in the presence of overt heart failure?
Congestive heart failure
What adverse drug reaction is most frequently associated with nifedipine among the calcium channel blockers?
Peripheral edema
Which calcium antagonist does not increase mortality in patients with heart failure due to nonischemic left ventricular systolic dysfunction?
Amlodipine
What type of interaction occurs between calcium channel blockers and grapefruit?
Synergistic interaction
Which clinical condition is not a common use for calcium channel blockers?
Heart failure
Which calcium antagonist has a long half-life and is typically dosed once daily?
Amlodipine
Test your knowledge on Calcium Channel Blockers including the classes, mechanisms of action, and pharmacological effects of calcium antagonists such as phenylalkylamines, dihydropyridines, and benzothizepines.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
