Calcium Channel Blockers Mechanism of Action and Uses
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Questions and Answers

Which of the following is a characteristic of the drug class 'Organic Nitrates'?

  • They have a narrow therapeutic window, with the effective dose close to the toxic dose
  • They work directly on smooth muscle to promote dilation of veins, decreasing oxygen demand (correct)
  • They have a unique lupus-like syndrome as an adverse effect
  • They are used to treat hypertensive crisis in African American populations

    • What is a common adverse effect associated with the use of quinidine, a sodium channel blocker?

  • Headache and orthostatic hypotension
  • Central nervous system and gastrointestinal effects (correct)
  • Anorexia as an early sign of toxicity
  • Lupus-like syndrome

    • Which of the following is a characteristic of the 'Potassium channel blocker' drug class?

  • They are considered first-line for treating hypertension in African American populations
  • They are used less frequently now (correct)
  • They work directly on smooth muscle to promote dilation of veins
  • They have many drug interactions, including with grapefruit juice

    • What is the chemical relationship between nitroglycerin and explosives?

    <p>Nitroglycerin is the same as the nitro in explosives</p> Signup and view all the answers

    What is a common adverse effect associated with the use of organic nitrates?

    <p>Headache and orthostatic hypotension</p> Signup and view all the answers

    Which drug class is considered first-line for treating hypertension, heart failure, and hypertensive crisis in African American populations?

    <p>Sodium channel blockers</p> Signup and view all the answers

    What is the primary mechanism of action of calcium channel blockers (CCBs)?

    <p>Preventing calcium from entering cells, especially in the heart and blood vessels</p> Signup and view all the answers

    Which of the following is NOT a therapeutic use of calcium channel blockers?

    <p>Heart failure</p> Signup and view all the answers

    Which of the following adverse effects is NOT associated with calcium channel blockers?

    <p>Nausea and vomiting</p> Signup and view all the answers

    Which of the following calcium channel blockers is specifically mentioned as affecting the heart?

    <p>Verapamil</p> Signup and view all the answers

    Which of the following drugs is used in severe hypertension, but can have serious side effects?

    <p>Minoxidil</p> Signup and view all the answers

    Which of the following statements is true about digoxin?

    <p>It is used less frequently now because it has not been proven to prolong life</p> Signup and view all the answers

    What is considered the 'second line' of drug classes for the treatment of various cardiovascular conditions?

    <p>Beta adrenergic blockers</p> Signup and view all the answers

    What is a unique adverse effect associated with the use of quinidine, a sodium channel blocker?

    <p>Lupus-like syndrome</p> Signup and view all the answers

    What is the primary mechanism of action for organic nitrates?

    <p>Directly promote dilation of veins, reducing oxygen demand</p> Signup and view all the answers

    Which of the following is an important consideration when using organic nitrates?

    <p>Organic nitrates degrade easily with exposure to light, heat, or moisture</p> Signup and view all the answers

    Which drug class is considered first-line for treating hypertension, heart failure, and hypertensive crisis in African American populations?

    <p>Sodium channel blockers</p> Signup and view all the answers

    What is a common adverse effect associated with the use of organic nitrates?

    <p>Headache</p> Signup and view all the answers

    What is the primary mechanism of action of calcium channel blockers (CCBs)?

    <p>Prevents calcium from entering cells, especially at the heart and blood vessels, leading to decreased heart rate and myocardial contraction</p> Signup and view all the answers

    Which of the following calcium channel blockers is specifically mentioned as affecting the heart?

    <p>Verapamil</p> Signup and view all the answers

    Which drug class is considered first-line for treating hypertension, heart failure, and hypertensive crisis in African American populations?

    <p>Hydralazine</p> Signup and view all the answers

    Which of the following is a therapeutic use of calcium channel blockers?

    <p>All of the above</p> Signup and view all the answers

    What is a common adverse effect associated with the use of calcium channel blockers?

    <p>All of the above</p> Signup and view all the answers

    Which of the following drugs is used in severe hypertension, but can have serious side effects?

    <p>Minoxidil</p> Signup and view all the answers

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