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Questions and Answers
What is the mechanism of action of nitrates in the treatment of angina pectoris?
What is the mechanism of action of nitrates in the treatment of angina pectoris?
- Increase oxygen demand and decrease oxygen supply
- Decrease work done by the heart and increase preload
- Decrease oxygen demand and increase oxygen supply (correct)
- Increase work done by the heart and increase afterload
Which type of preparation of nitrates has the longest duration of action?
Which type of preparation of nitrates has the longest duration of action?
- Transdermal patch
- Sublingual tablets
- Oral slow-release preparation (correct)
- Intravenous injection
What are the adverse reactions associated with organic nitrates?
What are the adverse reactions associated with organic nitrates?
- Throbbing headache, flushing (correct)
- Nausea, vomiting
- Dizziness, blurred vision
- Joint pain, muscle cramps
How do nitrates affect coronary blood flow in the treatment of angina pectoris?
How do nitrates affect coronary blood flow in the treatment of angina pectoris?
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In what type of emergency is the sublingual (SL) tablet preparation of nitrates used?
In what type of emergency is the sublingual (SL) tablet preparation of nitrates used?
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Study Notes
Nitrates in Angina Pectoris
- Mechanism of action: Nitrates cause systemic vasodilation, leading to a decrease in preload and afterload. This reduces the workload of the heart, allowing for improved blood flow to the heart muscle.
- Duration of action: Nitrates are available in various formulations, with varying durations of action. Transdermal patches have the longest duration of action, lasting for 12-24 hours.
- Adverse reactions: Commonly observed adverse reactions include headaches, dizziness, hypotension, and flushing. In rare cases, more serious reactions such as methemoglobinemia can occur.
- Effect on coronary blood flow: While nitrates cause systemic vasodilation, they also cause preferential vasodilation of coronary arteries, leading to an increase in coronary blood flow.
- Sublingual (SL) tablet preparation: The SL tablet preparation of nitrates is employed in emergencies associated with acute anginal episodes.
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Description
Test your knowledge on antianginal drugs with this quiz covering mechanisms of action, adverse effects, and classifications of nitrates and calcium channel blockers.
