13 Questions
Which complement components bind to specific receptors on erythrocytes, neutrophils, monocytes, and macrophages to facilitate phagocytosis?
C4b, C3b, and iC3b
What is the consequence of binding C5a to monocytes?
Oxidative burst with increased production of hydrolytic enzymes
List three cases where complement can be harmful.
- Gram-negative septicaemia, 2. Tissue necrosis like myocardial infarction, 3. Lysis of red cells
What is the main function of the Membrane Inhibitor of Reactive Lysis (MIRL)?
To bind to C8 and prevent insertion of C9 into host cell membranes.
What prevents lysis from occurring despite the binding of C8 and C9?
Binding of S protein to the C5b67 complex.
What is another name for the S protein?
Vitronectin.
What is the significance of the activation of complement in biological manifestations?
It is a very effective means of amplifying the inflammatory response to destroy and clear foreign antigens.
Where is the Membrane Inhibitor of Reactive Lysis (MIRL) widely distributed?
On the cell membranes of all circulating blood cells, including red blood cells, and on endothelial, epithelial, and many other types of cells.
What is the role of complement receptors found on host cells?
They amplify and enhance the immune response by augmenting phagocytosis and stimulating accessory cells.
What does the S protein interact with as it forms in the fluid phase?
C5b67 complex.
What does the Membrane Inhibitor of Reactive Lysis (MIRL) prevent from forming?
Membrane attack complex.
What are the consequences of binding C5a to monocytes?
Not provided in the text.
What serves as a means of linking innate and natural immunity?
Complement proteins.
Test your knowledge on the structure and function of the C1 complex in immunology. Learn about the subunits C1q, C1r, and C1s and their roles in the immune response cascade.
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