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Buspirone: Uses, Mechanism of Action, and Metabolism

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Buspirone: Uses, Mechanism of Action, and Metabolism

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Questions and Answers

What is the primary elimination mechanism of buspirone?

Conjugation

Elimination through stool

Oxidative metabolism (correct)

Hydrolysis

Which receptor is buspirone known to bind optimally to?

Dopamine receptor

Serotonin receptor (correct)

Norepinephrine receptor

GABA receptor

Which of the following compounds has similar potency as buspirone?

5-hydroxybuspirone

Metabolite M

1-pyrimidinylpiperazine (correct)

Phenylpiperazine

What type of inhibitor can block the formation of major buspirone metabolites?

CYP3A inhibitor Signup and view all the answers

What alkyl spacer length is typically observed in buspirone analogs?

Chain of 2-5 methylene groups Signup and view all the answers

What is the typical aryl portion in buspirone analogs?

Phenyl, substituted phenyl, or a heteroaryl group Signup and view all the answers

What is the analysis method used to determine the amount of buspirone present in a sample?

Spectrophotometric analysis Signup and view all the answers

What color is produced due to the oxidation reaction of buspirone with alkaline potassium permanganate?

Bluish green Signup and view all the answers

Which atom is typically found in the terminus of buspirone analogs?

Nitrogen Signup and view all the answers