Buspirone: Uses, Mechanism of Action, and Metabolism
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Questions and Answers

What is the primary elimination mechanism of buspirone?

  • Conjugation
  • Elimination through stool
  • Oxidative metabolism (correct)
  • Hydrolysis
  • Which receptor is buspirone known to bind optimally to?

  • Dopamine receptor
  • Serotonin receptor (correct)
  • Norepinephrine receptor
  • GABA receptor
  • Which of the following compounds has similar potency as buspirone?

  • 5-hydroxybuspirone
  • Metabolite M
  • 1-pyrimidinylpiperazine (correct)
  • Phenylpiperazine
  • What type of inhibitor can block the formation of major buspirone metabolites?

    <p>CYP3A inhibitor</p> Signup and view all the answers

    What alkyl spacer length is typically observed in buspirone analogs?

    <p>Chain of 2-5 methylene groups</p> Signup and view all the answers

    What is the typical aryl portion in buspirone analogs?

    <p>Phenyl, substituted phenyl, or a heteroaryl group</p> Signup and view all the answers

    What is the analysis method used to determine the amount of buspirone present in a sample?

    <p>Spectrophotometric analysis</p> Signup and view all the answers

    What color is produced due to the oxidation reaction of buspirone with alkaline potassium permanganate?

    <p>Bluish green</p> Signup and view all the answers

    Which atom is typically found in the terminus of buspirone analogs?

    <p>Nitrogen</p> Signup and view all the answers

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