Brugada Syndrome: Cardiac Arrhythmia

Brugada syndrome is characterized by ST-segment elevation in which of the following ECG leads?

Patients with Brugada syndrome are at high risk of sudden cardiac death due to bradycardia.

In what year was Brugada syndrome first described?

Brugada syndrome was initially thought to be inherited as a monogenic, autosomal dominant disease, it is now considered more likely to encompass an ______ or polygenic inheritance.

Match the following aspects of Brugada syndrome with their descriptions:

Which of the following best describes the inheritance pattern of Brugada syndrome, as understood currently?

All patients with Brugada syndrome have a detectable mutation in the SCN5A gene.

The SCN5A gene encodes the alpha subunit of which cardiac ion channel?

Mutations in the SCN5A gene result in defective Nav1.5 channels in the cardiac cell membrane, which play a crucial role in the initial ______ phase of the cardiac action potential.

Match the following cardiac conditions with the SCN5A gene mutations that are also implicated in Brugada syndrome

Which phase of the cardiac action potential is directly affected by mutations in the SCN5A gene in Brugada syndrome?

The repolarization and depolarization disorder models in Brugada syndrome emphasize the involvement of the left ventricle.

What part of the right ventricle is particularly implicated in the pathophysiology of Brugada syndrome?

In Brugada syndrome, the distinctive ECG changes are observed in the right precordial leads, specifically leads ______ to V3.

Match the following characteristics with their prevalence in Brugada syndrome

Which of the following demographic groups has the highest reported prevalence of Brugada syndrome?

Brugada syndrome is equally prevalent among males and females.

In which region of Asia is Brugada syndrome particularly prevalent?

Mutations in the SCN5A gene result in defective Nav1.5 channels in the cardiac cell membrane, which results in a delayed phase ______, causing slower conduction

Match the hypothesis regarding Brugada syndrome's pathophysiology with their mechanisms

Which of the following describes the role of the SCN5A gene in Brugada Syndrome?

Brugada syndrome exclusively involves mutations in the SCN5A gene.

What type of ventricular arrhythmia is commonly associated with sudden cardiac death in Brugada syndrome?

The loss of function of Nav1.5 channels due to SCN5A mutations leads to a ______ phase zero, causing slower conduction in the heart.

Match the following characteristics with their description

Which of the following is NOT generally considered a risk factor for Brugada syndrome?

The precise mechanism of Brugada syndrome is fully understood.

Name one syndrome, other than Brugada syndrome, in which mutations of the SCN5A gene are implicated.

In the context of Brugada syndrome, polymorphic ventricular tachycardia (VT) can lead to ______.

Match the descriptions with the terminology

In Brugada syndrome, which of the following ECG findings is most indicative of the condition?

Brugada Syndrome is more common in females than males

Name the primary genetic defect involved with Brugada syndrome.

The distinctive ECG changes observed in the right precordial leads (V1-V3) are due to the involvement of the ______.

Match the following

In individuals with Brugada Syndrome, what cardiac event poses the greatest risk?

All mutations of the SCN5A gene are considered pathogenic in Brugada Syndrome

What is the function of wild-type SCN5A?

The loss of function of Nav1.5 channels due to SCN5A mutations can result in a delayed phase zero, leading to slower conduction and increasing risk of ______.

Match the concepts with their description regarding Brugada Syndrome