Podcast
Questions and Answers
What is the main function of the Type IV Secretion System (T4SS) in Brucella?
What is the main function of the Type IV Secretion System (T4SS) in Brucella?
- Promote replication in eBCVs
- Trigger autophagy in the host cells
- Induce acidity in phagolysosomes
- Control intracellular trafficking in host macrophages (correct)
What is the role of the acidified phagosomal compartments (eBCVs) in host cells?
What is the role of the acidified phagosomal compartments (eBCVs) in host cells?
- Maintain the acidity for bacterial survival
- Provide a replicative environment for Brucella
- Support bacterial egress and cell-to-cell spread
- Initiate expression of T4SS genes (correct)
Where does Brucella sustain chronic intracellular persistence in the host?
Where does Brucella sustain chronic intracellular persistence in the host?
- Phagolysosomes
- Autophagic BCVs (aBCVs)
- Replicative BCVs (rBCVs) (correct)
- Endoplasmic reticulum (ER)
What leads to the formation of autophagic BCVs (aBCVs) in Brucella infection?
What leads to the formation of autophagic BCVs (aBCVs) in Brucella infection?
How do T4SS effectors contribute to Brucella immunosuppression?
How do T4SS effectors contribute to Brucella immunosuppression?
What is the role of the O-chain in Brucella's virulence?
What is the role of the O-chain in Brucella's virulence?
Which pathway does the O-chain facilitate for Brucella's entry into host cells?
Which pathway does the O-chain facilitate for Brucella's entry into host cells?
Why is the Lipid A of Brucella important for immune evasion?
Why is the Lipid A of Brucella important for immune evasion?
In what way do O-chains contribute to the formation of rBCV?
In what way do O-chains contribute to the formation of rBCV?
How do O-chains help in immune evasion by Brucella?
How do O-chains help in immune evasion by Brucella?
What is the main function of dendritic cells?
What is the main function of dendritic cells?
Which Brucella outer membrane protein inhibits dendritic cells from maturing?
Which Brucella outer membrane protein inhibits dendritic cells from maturing?
How does Omp19 contribute to Brucella's virulence?
How does Omp19 contribute to Brucella's virulence?
Which T4SS effector proteins of Brucella are known to block cytokine production?
Which T4SS effector proteins of Brucella are known to block cytokine production?
What is the role of Cyclic B Glucan (CBG) in relation to dendritic cells?
What is the role of Cyclic B Glucan (CBG) in relation to dendritic cells?
What is the role of the T4SS effector VceC in infected cells?
What is the role of the T4SS effector VceC in infected cells?
Which cytokine is stimulated by the unfolded protein response (UPR) triggered by Brucella infection?
Which cytokine is stimulated by the unfolded protein response (UPR) triggered by Brucella infection?
What immunological structure is rich in macrophages and characterized by a lymphocytic cuff made of B and T cells?
What immunological structure is rich in macrophages and characterized by a lymphocytic cuff made of B and T cells?
What is the consequence of macrophages producing inflammatory cytokines in response to Brucella infection?
What is the consequence of macrophages producing inflammatory cytokines in response to Brucella infection?
Which cellular transformation can macrophages undergo within a granuloma?
Which cellular transformation can macrophages undergo within a granuloma?
What is the role of VceC effector in Brucella infection?
What is the role of VceC effector in Brucella infection?
How do T4SS effectors like BtpA and BtpB contribute to Brucella survival?
How do T4SS effectors like BtpA and BtpB contribute to Brucella survival?
Why is the ability of T4SS effectors to over stimulate and suppress the host immune response crucial for Brucella survival?
Why is the ability of T4SS effectors to over stimulate and suppress the host immune response crucial for Brucella survival?
What is the role of lipopolysaccharide in Brucella strains?
What is the role of lipopolysaccharide in Brucella strains?
How do Brucella spp. modulate the host immune response for their long-term survival?
How do Brucella spp. modulate the host immune response for their long-term survival?
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