18 Questions
What is bronchiectasis?
Bronchiectasis is a chronic lung disease characterized by repeated episodes of infection and chronic inflammation.
How many new cases of bronchiectasis are estimated to be diagnosed annually?
Almost 20,000 new cases
What is the key question addressed in the study related to bronchiectasis and cardiovascular comorbidities?
Do people with bronchiectasis have more cardiovascular comorbidities compared with the general population and are they at increased risk of incident cardiovascular events?
What common risk factors of cardiovascular disease do individuals with bronchiectasis share?
Hypoxia and systemic inflammation
What is the bottom line regarding cardiovascular comorbidities in bronchiectasis patients?
There are limited data on the extent
How many people in the UK currently have a diagnosis of bronchiectasis?
Over 300,000 people
What is the prevalence of individuals with bronchiectasis who had a diagnosis of CHD or stroke?
2417 individuals
What was the median time between recording of the CHD event and the index date for people with bronchiectasis?
8.3 years
After adjusting for various factors, by what percentage were the odds of CHD higher in people with bronchiectasis compared to those without?
33%
What comorbidities associated with the aetiology of the disease were found in people with bronchiectasis?
Historical cohort study (8.5) (10.5) (24.2) (28.7) (28.2)
What was the prevalence of risk factors for CHD or stroke in people with bronchiectasis?
Higher
How many individuals with bronchiectasis had a history of stroke prior to the index date?
9.2%
What statistical method was used to quantify the association between bronchiectasis and recorded diagnoses of CHD or stroke in the cross-sectional study?
Logistic regression
In the cross-sectional study, what were the odds ratios for pre-existing diagnoses of CHD and stroke in people with bronchiectasis compared to those without bronchiectasis?
CHD OR 1.33, Stroke OR 1.92
What type of regression was used in the cohort study to investigate if individuals with bronchiectasis are at increased risk of incident CHD and stroke events?
Cox regression
What were the hazard ratios for first CHD and stroke in people with bronchiectasis compared to the general population?
HR for CHD 1.44, HR for stroke 1.71
What were the variables adjusted for in the analysis of incident CHD and stroke in individuals with bronchiectasis?
Age, sex, smoking habit, risk factors for cardiovascular disease
What conclusion was drawn regarding the risk of CHD and stroke in people with bronchiectasis compared to the general population?
The risk of CHD and stroke is higher in people with bronchiectasis compared to the general population
Test your knowledge on bronchiectasis, a chronic lung disease characterized by infection and inflammation, and its relationship with cardiovascular comorbidities. Explore the need for increased awareness and integrated care for patients with this condition.
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