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Which treatment modality is mandatory for local recurrence prevention in Breast Conserving Surgery (BCS)?
A Mastectomy typically results in a higher local recurrence rate compared to Breast Conserving Surgery.
False
What percentage of breast volume resection is considered volume displacement in oncoplasty?
10-15%
In breast oncoplasty, a resection of _____% or more of breast volume is classified as volume replacement.
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Match the type of surgical treatment with its definition:
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Which technique combines blue dye and radionuclide for the best identification of hot nodes?
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The Indocyanine Green Technique involves the use of radiation for lymph node visualization.
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What is the primary advantage of the Sentimag Technique?
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In the Radionuclide Technique, ________ tagged sulphur colloid is injected.
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Match the following techniques with their primary features:
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What is the primary purpose of lymphedema massages after breast surgery?
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Phantom breast syndrome occurs because patients feel pain in the area where the breast was removed.
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What is one major advantage of the DIEP flap compared to the TRAM flap?
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The condition where the cancer covers the chest wall like armor is referred to as _____ en cuirasse.
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Match the following conditions or procedures with their descriptions:
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What is a common risk factor that increases the incidence of post-mastectomy lymphedema?
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Flap necrosis is primarily caused by infection.
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What is the most common complication after mastectomy related to fluid accumulation?
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The _____ nerve injury can lead to winging of the scapula.
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Match the following complications with their descriptions:
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What is the primary purpose of a Sentinel Lymph Node Biopsy (SLNB)?
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SLNB is commonly used for all types of cancer.
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What common nerve is often injured during the Sentinel Lymph Node Biopsy procedure?
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The __________ technique involves injecting methylene blue into the subcutaneous plane during SLNB.
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Match the type of cancer with its inclusion for SLNB:
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What is the typical radiation dose for Whole Breast Irradiation (WBI)?
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Accelerated Partial Breast Irradiation (APBI) is indicated for tumors that are unifocal and have negative lymphovascular invasion.
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What type of hormonal therapy is typically used in pre-menopausal women with breast cancer?
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Tamoxifen must be taken for _____ years before a patient can consider pregnancy.
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Match the following hormonal therapy drugs with their respective categories:
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What is the main purpose of a chemoport?
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Chemotherapy should be avoided in patients with a poor performance status.
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Name one chemotherapy regimen currently used for Her 2 neu negative breast cancer.
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The Oncotype Dx is a _____ assay used to determine the risk of recurrence.
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Match the following chemotherapy drugs with their correct category:
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Which of the following is NOT an indication for chemotherapy?
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HER 2 neu positive tumors can benefit from neoadjuvant chemotherapy.
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What is the primary objective of using RECIST criteria in chemotherapy?
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The abbreviation PCR stands for _____ in the context of tumor response.
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Match the response evaluation criteria to their definitions:
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Which type of mastectomy removes the entire breast along with the nipple areola complex and lymph nodes?
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Nipple-sparing mastectomy preserves the nipple and areola.
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What structure is typically not removed during a simple mastectomy?
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A modified radical mastectomy uses an __________ incision.
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Which structures are included in the removal during a radical mastectomy?
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Match the following types of mastectomy with their characteristics:
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The technique known as Auchincloss - Patey - Scanlon is used in some types of mastectomies.
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How many lymph nodes are generally removed during axillary clearance?
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Which of the following is an absolute contraindication for Breast Conserving Surgery?
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Breast Conserving Surgery can be performed after neoadjuvant chemotherapy.
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Name one relative contraindication for Breast Conserving Surgery.
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The technique involves the presence of large tumors relative to the breast, termed ______.
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Match the following types of tumors with their respective categories:
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Study Notes
Breast Cancer Treatment Modalities
- Surgery, Chemotherapy, Radiotherapy (RT), Hormonal Therapy (HT) are the primary modalities used to treat breast cancer.
- Surgical options involve Breast Conserving Surgery (BCS) and Mastectomy.
- BCS leads to a 3-4% local recurrence rate, making RT mandatory.
- Mastectomy has a 1% local recurrence rate.
- Oncoplasty combines cancer surgery with plastic surgery techniques.
- Two types of Oncoplasty are Volume Displacement and Volume Replacement.
- Volume Displacement removes 10-15% of breast volume.
- Volume Replacement removes ≥ 15% of breast volume.
Managing Breast Cancer Treatment Side Effects
- Skin care, lymphedema massages and stockings are important for post-operative recovery.
- Regular exercise can promote lymphatic drainage and reduce the risk of lymphedema.
Local Recurrence
- Repeat biopsy is crucial to confirm diagnosis.
- Immunohistochemistry (IHC) marker analysis helps identify changes in tumor expression.
- Extensive local recurrences can lead to Cancer en cuirasse, a condition where the chest wall is covered by tumor.
Phantom Breast Syndrome
- Patients experience the sensation of the breast being present.
- Caused by Intercostobrachial Nerve (ICBN) entrapment.
- Associated with pain.
Reconstructive Surgery
- TRAM and DIEP flaps are common techniques.
- TRAM (Transverse rectus abdominus myocutaneous flap) involves removing skin, fat, and muscle, increasing the risk of incisional hernia.
- DIEP (Deep inferior epigastric artery perforator flap) involves removing skin and fat, minimizing abdominal complications as muscle is not removed.
Sentinel Lymph Node Biopsy (SLNB)
- Developed for penile cancer.
- Identifies the first lymph node draining from the cancer site.
- Usually located in level 1 of the axilla.
- ICBN is a commonly injured nerve during this procedure.
SLNB - Applications & Techniques
- SLNB is utilized for various cancers, including malignant melanoma, breast cancer, penile cancer, vulvar carcinoma, and head & neck cancer.
- Blue dye technique involves injecting methylene blue/isosulfan blue into the periareolar region to localize lymph nodes.
Axillary Clearance
- Not required for some cancers, reducing the incidence of lymphedema.
SLNB Complications
- Skin tattooing, anaphylaxis, bluish discoloration of urine, and skin necrosis are potential complications.
Radiotherapy in Breast Cancer
- Indications: Positive lymph nodes, tumor size > 5 cm, locally advanced breast carcinoma, after breast conserving surgery.
- Types of RT: Whole Breast Irradiation (WBI) and Accelerated Partial Breast Irradiation (ABPI).
- ABPI is suitable for T1, ER, PR-positive, negative lymphovascular invasion, unifocal tumors with negative margins and patients over 250 years old.
Hormonal Therapy
- Indications: ER/PR-positive tumors.
- Pre-menopausal: Tamoxifen (SERM) for 5 years, can be extended to 10 years.
- Post-menopausal: Aromatase inhibitors (Letrozole, Anastrozole) for 5-10 years.
Pregnancy Planning with Tamoxifen
- 2 years of continuous Tamoxifen therapy are required before pregnancy planning.
- Tamoxifen should be stopped 3 months before conception.
Different Types of Mastectomy
- Simple mastectomy: Removes the breast and nipple-areola complex, but not lymph nodes.
- Modified radical mastectomy (MRM): Removes the breast, nipple-areola complex, pectoral fascia, and level 1, 2, 3 axillary lymph nodes.
- Radical mastectomy: Removes the breast, nipple-areola complex, pectoral major and minor muscles, and level 1, 2, 3 axillary lymph nodes.
Additional Mastectomy Techniques
- Nipple-sparing mastectomy preserves the nipple and areola.
- Skin-sparing mastectomy preserves the skin.
Axillary Clearance Boundaries
- Medial boundary: Halstead Ligament
- Lateral boundary: Thoraco-dorsal pedicle
- Superior boundary: Axillary vein
- Inferior boundary: Angular vein
- Long thoracic nerve: Saved, not a boundary.
Chemoport
- Inserted below the clavicle.
- Delivers chemotherapy drugs.
- Reduces risk of thrombophlebitis.
Chemotherapy Regimens
- CAF/CMF: Not currently used.
- Her 2 neu-negative: 4 cycles of AC/EC followed by paclitaxel.
- Her 2 neu-positive: 6 cycles of TCH + P.
Avoiding Chemotherapy
- Patients with poor performance status.
- Tumors with specific characteristics: T₁ or T₂ and ER, PR, or HER2 status.
Molecular Testing for Breast Cancer
- Predicts risk of recurrence.
- Low risk: Avoid chemotherapy.
- High risk: Chemotherapy is recommended.
- Available tests: Oncotype Dx, PAM 50, mammo print, Endopredict, and CAN assist (Indian test)
Chemotherapy and Radiotherapy
- Indications for Chemotherapy: Positive lymph nodes, locally advanced breast cancers, ER, PR-negative tumors, HER 2 neu-positive tumors, metastasis.
- Neoadjuvant Chemotherapy (NACT) Indications: Locally advanced breast cancer, triple-negative breast cancer, HER 2 neu-positive tumors, large tumors with patient desiring breast conservation surgery.
- NACT Advantages: Downstages/downsizes the tumor, reduces micrometastasis, provides an in vivo indicator of chemosensitivity.
- RECIST Criteria: Standardized evaluation criteria for assessing tumor response to chemotherapy.
Contraindications for Breast Conserving Surgery (BCS)
- Absolute Contraindication: Pregnancy.
- Relative Contraindications: Previous radiation therapy to the chest wall, collagen vascular diseases, multifocal tumors, diffuse microcalcifications/DCIS, locally advanced breast cancer, large tumor: breast ratio.
Technical Considerations for BCS
- Multicentric tumors, multifocal tumors, diffuse microcalcifications/DCIS, locally advanced breast cancer, large tumor: breast ratio.
- BCS can be performed after neoadjuvant chemotherapy.
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Description
This quiz focuses on the various treatment modalities for breast cancer, including surgery, chemotherapy, radiotherapy, and hormonal therapy. It also explores oncoplasty techniques and the management of treatment side effects. Test your knowledge on the effectiveness and recurrence rates of different surgical options.