B.Pharm PCG 201: Introduction to Pharmacognosy
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Questions and Answers

Which of the following is NOT a characteristic of a nutraceutical?

  • It can be used to prevent or treat disease.
  • It provides medical or health benefits.
  • It is a food or part of a food.
  • It is typically extracted from plants. (correct)
  • Which of these is an example of an organised vegetable crude drug?

  • Volatile oils
  • Ginger (correct)
  • Garlic
  • Dry latex
  • Which of the following is NOT a source of crude drugs?

  • Plants
  • Synthetic Chemicals (correct)
  • Animals
  • Minerals
  • What is the main focus of pharmacognosy?

    <p>The study of chemical compounds in plants and their uses in medicine. (D)</p> Signup and view all the answers

    What is a key difference between organised and unorganised vegetable crude drugs?

    <p>Organised drugs are extracted from plant origins with a cellular structure, while unorganised drugs are extracted from plant origins without a cellular structure. (D)</p> Signup and view all the answers

    Which of the following are traditional medicine systems that utilize natural drugs?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following is an example of a food that contains carotenoids?

    <p>Tomatoes (B)</p> Signup and view all the answers

    What percentage of the world's population is estimated to use traditional herbal medicine for primary healthcare?

    <p>80% (D)</p> Signup and view all the answers

    What is the primary reason for studying pharmacognosy?

    <p>To identify and utilize natural substances with medicinal properties. (C)</p> Signup and view all the answers

    Which of the following topics is NOT covered in the introduction to pharmacognosy?

    <p>The synthesis of new drugs from natural compounds. (D)</p> Signup and view all the answers

    What is the significance of understanding the historical development of plants in pharmacy and medicine?

    <p>It provides context for current research and practices in pharmacognosy. (A)</p> Signup and view all the answers

    Which of the following is NOT a learning outcome of a basic pharmacognosy course?

    <p>Understanding how to synthesize new drugs from natural compounds (D)</p> Signup and view all the answers

    What is the primary reason for studying adulteration and evaluation of crude drugs?

    <p>To ensure the purity and quality of natural drugs. (B)</p> Signup and view all the answers

    Which of the following is the oldest documented record of plant use for medicinal purposes?

    <p>A Neanderthal grave in Shanidar IV (D)</p> Signup and view all the answers

    What is the name of the plant species containing ephedrine?

    <p>Ephedra altissima (D)</p> Signup and view all the answers

    What is the significance of the Ebers Papyrus in the history of medicinal plant use?

    <p>It's a comprehensive medical handbook that includes both empirical and symbolic treatments. (C)</p> Signup and view all the answers

    Who is considered the "father of (Western) medicine"?

    <p>Pedanius Dioscorides (C)</p> Signup and view all the answers

    What is the Corpus Hippocraticum?

    <p>A collection of works on medical practice written by various authors influenced by Hippocrates (D)</p> Signup and view all the answers

    What is the significance of Claudius Galen's work in the history of medicine?

    <p>He summarized and consolidated Graeco-Roman pharmacy and medicine, leaving a lasting impact on the field. (A)</p> Signup and view all the answers

    What was Pliny the Elder's contribution to the understanding of natural history?

    <p>He wrote the first detailed account of natural history, including cosmology, mineralogy, and botany. (B)</p> Signup and view all the answers

    How did Taoist thought influence traditional Chinese medicine?

    <p>It integrated practices like meditation, special diets, and medicinal plants into the understanding of health. (B)</p> Signup and view all the answers

    Which of the following is NOT a definition of pharmacognosy?

    <p>It focuses on the study of the use of extracts of natural origin as medicines or health-promoting agents. (D)</p> Signup and view all the answers

    What is a key difference between phytotherapy and phytomedicine?

    <p>Phytotherapy is concerned with the study of plants, while phytomedicine is concerned with their medicinal uses. (B)</p> Signup and view all the answers

    Which of the following is NOT a common example of a botanical drug used in herbal remedies?

    <p>Mushrooms (D)</p> Signup and view all the answers

    What is the main focus of phytochemistry?

    <p>The identification and characterization of chemical compounds found in plants. (D)</p> Signup and view all the answers

    What differentiates a natural product from a synthetic compound?

    <p>Natural products are derived from living organisms, while synthetic compounds are created in labs. (B)</p> Signup and view all the answers

    What distinguishes a semi-synthetic compound from a pure compound?

    <p>A semi-synthetic compound is partially synthesized in a lab, while a pure compound is isolated from nature. (C)</p> Signup and view all the answers

    Which of these options is a pure compound, as defined in the text?

    <p>Morphine, extracted from the opium poppy (C)</p> Signup and view all the answers

    What is the primary difference between a synthetic compound and a semi-synthetic compound?

    <p>Synthetic compounds are chemically synthesized, while semi-synthetic compounds are partially synthesized using natural compounds as starting materials. (C)</p> Signup and view all the answers

    Which of these plants is the source of the drug Taxol (Paclitaxel)?

    <p>Taxus brevifolia (C)</p> Signup and view all the answers

    What natural product is used in the production of the analgesic, morphine?

    <p>Opium poppy (Papaver somniferum) (C)</p> Signup and view all the answers

    Which of these drugs is used to treat malaria?

    <p>Quinine (B)</p> Signup and view all the answers

    What is the name of the natural product used to create the drug, Artemisinin?

    <p>Qinghao (A)</p> Signup and view all the answers

    Which of these drugs is derived from a plant species that is NOT specifically identified in the content?

    <p>Aspirin (D)</p> Signup and view all the answers

    What is the primary function of the drug Tubocurarine?

    <p>Muscle relaxation (B)</p> Signup and view all the answers

    What is Pharmacognosy?

    <p>The branch of pharmacy that focuses on drugs derived from natural sources (A)</p> Signup and view all the answers

    What is the main difference between Quinine and Artemisinin?

    <p>Quinine is a potent analgesic, Artemisinin is a potent antimalarial (C)</p> Signup and view all the answers

    What is the main focus of the earliest classical Chinese medical texts, as described in the content?

    <p>Identifying and classifying medicinal herbs (B)</p> Signup and view all the answers

    What is the primary difference between the two classical Chinese texts mentioned, 'The work' and 'Ben Cao Gang Mu'?

    <p>The number of drugs described (A)</p> Signup and view all the answers

    What is a key characteristic of the 'Ben Cao Gang Mu' text?

    <p>A detailed classification of drugs (D)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of the content provided about traditional medicine?

    <p>Traditional medicine systems are based on solely scientific principles (C)</p> Signup and view all the answers

    Which of the following is NOT a traditional system of medicine mentioned in the text?

    <p>Homeopathy (D)</p> Signup and view all the answers

    Which of the following best describes the significance of 'Ayurveda' in the context of the text?

    <p>It is recognized as the most ancient and systematized form of medicine (B)</p> Signup and view all the answers

    What is the main reason for the continued importance of plants in modern pharmacy and medicine?

    <p>Plants have historically yielded many important drugs (C)</p> Signup and view all the answers

    What is the main focus of the content regarding the importance of plants in modern pharmacy and medicine?

    <p>The scientific research conducted on plant-based treatments (C)</p> Signup and view all the answers

    Flashcards

    Nutraceuticals

    Substances from food that provide health benefits and prevent disease.

    Crude Drugs

    Vegetable drugs from plant organs without chemical modifications.

    Organised Vegetable Crude Drugs

    Therapeutic substances extracted from plant parts like leaves and roots.

    Unorganised Vegetable Crude Drugs

    Therapeutic substances extracted from plants in solid or liquid forms.

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    Examples of Nutraceuticals

    Garlic, ginger, turmeric, bilberries, and carrots known for their health benefits.

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    Artemisinin

    An important antimalarial drug derived from Artemisia annua.

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    Morphine

    A potent analgesic derived from Papaver somniferum (opium poppy).

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    Quinine

    A potent anti-malaria drug derived from cinchona bark (Cinchona succirubra).

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    Aspirin

    A nonsteroidal anti-inflammatory drug used to relieve pain, fever, and inflammation.

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    Tubocurarine

    A potent myorelaxant derived from American arrow poison (Curare).

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    Taxol

    A potent antitumor drug derived from the bark of the Pacific yew (Taxus brevifolia).

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    Physostigmine

    A drug derived from Calabar bean, used to treat antimuscarinic toxicity and glaucoma.

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    Pharmacognosy

    The branch of pharmacy studying medicinal drugs from natural sources.

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    Phytotherapy

    Study of using natural extracts as medicines or health agents.

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    Phytomedicine

    Herbal medicine with therapeutic properties derived from plants.

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    Phytochemistry

    Study of chemicals and compounds found in plants.

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    Natural products

    Compounds isolated from natural sources like plants and fungi.

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    Pure compound

    A single chemical entity with specific structure isolated from nature.

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    Synthetic compounds

    Chemically synthesized substances based on natural compounds.

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    Semi-synthetic compounds

    Partially synthesized substances using natural compounds as starting points.

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    Traditional Chinese Medicine (TCM)

    An ancient medical system including herbal and natural remedies, widely used today.

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    Ben Cao Gang Mu

    A 16th-century Chinese herbal text by Li Shizhen containing 1892 drugs.

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    Ayurveda

    Ancient Indian system of medicine, meaning 'knowledge of life'.

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    Four Temperatures

    Classification system in TCM based on the temperature characteristics of drugs.

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    Five Tastes

    Classification in TCM based on flavors: sweet, sour, bitter, spicy, salty.

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    Natural Product Research

    Scientific exploration of natural substances for new drugs.

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    Cinchona officinalis

    A South American plant known for yielding quinine, used as an anti-malarial.

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    Adulteration

    The process of adding impurities to natural drugs.

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    Cytomorphology

    The study of cell structure and form.

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    Traditional Medicine

    Historical healthcare practices using natural products.

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    WHO Statistic

    WHO states 80% of the global population uses herbal medicine.

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    Collection & Preparation

    Methods for obtaining and formulating natural drugs.

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    Ebers Papyrus

    A medical handbook from ancient Egypt, circa 1500 BC, covering various illnesses and treatments.

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    Pedanius Dioscorides

    Greek scholar known as the 'father of Western medicine' for his influential works on pharmacognosy.

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    Corpus Hippocraticum

    A collection of ancient Greek medical texts attributed to Hippocrates and his followers.

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    Galenical

    Refers to medicines or preparations associated with Claudius Galen, a key figure in Graeco-Roman medicine.

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    Shen Nong Ben Cao Jing

    An important Chinese text on medicinal plants that reflects Taoist thought on health.

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    Pliny the Elder

    Roman author known for his work in natural history, including medicinal plants and products.

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    Neanderthal medicine

    Earliest documented medical practices dating back to 60,000 BC found in Shanidar IV.

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    Study Notes

    B.Pharm PCG 201: Introduction to Pharmacognosy

    • Course title: B.Pharm PCG 201: Introduction to Pharmacognosy
    • Lecturer: Dr. Ibrahim Malami
    • Affiliation: Department of Pharmacognosy & Ethnopharmacy, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University, Sokoto, Nigeria.
    • Additional Affiliation: Centre For Advanced Medical Research and Training (CAMRET), Usmanu Danfodiyo University, Sokoto, Nigeria.

    Highlights

    • Topics covered: Introduction to Pharmacognosy, Microscopy, Cytomorphology, Cytology and Cytogenesis, Cell inclusions.
    • Hour allocation: Introduction to Pharmacognosy - 10 hours, Microscopy - 13 hours, Cytomorphology - 7 hours

    Objectives

    • Introduce the scope, significance, and applications of pharmacognosy.
    • Highlight important natural products and phytomedicines in medicine and pharmacy.
    • Detail different classifications of natural drugs.
    • Explain the collection and preparation of natural drugs.
    • Explain adulteration and evaluation of crude drugs.
    • Provide various publications in pharmacognosy.

    Learning Outcomes

    • Provide a general scientific overview of pharmacognosy and its key applications.
    • Give a historical overview of plant use in pharmacy and medicine.
    • Discuss the collection, preparation, and potential adulteration of natural drugs.
    • Establish pharmacognosy as a crucial discipline within pharmacy and medicine.

    Introduction

    • Natural drugs (especially terrestrial higher plants) have historically been alternatives to anti-infectives.
    • These played a significant role in ancient traditional medicine systems, for example:
      • Traditional Chinese Medicine (Chinese)
      • Ayurvedic Medicine (Indians)
      • Egyptian Traditional Medicine (Ancient Egyptian)

    Importance of Plants in Modern Pharmacy and Medicine

    • WHO data: Up to 80% of the global population uses traditional herbal medicine for primary healthcare.
    • Modern medicine: Approximately 50% of modern medicines are either derived from natural origins or based on natural products.
    • Recent drug development: The majority of recently introduced natural product-derived drugs resulted from:
      • Terrestrial microbe sources
      • Higher plants
      • Marine animal origins

    Examples of Natural Drugs

    • Atropine – Atropa belladonna
    • Aspirin – Salix spp
    • Quinine – Cinchona spp
    • Paclitaxel – Taxus brevifolia
    • Penicillin – Penicillium spp
    • Doxorubicin – Streptomyces spp
    • Streptomycin – Streptomyces spp
    • Morphine – Papaver somniferum
    • Artemisinin – Artemisia annua
    • Vinca alkaloids – Catharanthus roseus

    Pharmacognosy's History

    • Definition: Coined in the early 19th century by Johann Adam Schmidt, the term derives from "pharmakon" (remedy) and "gignosco" (knowledge).
    • Established field: A crucial pharmaceutical science within pharmacy education for over a century.
    • Evolution of focus: Shifted focus from mainly 19th and early 20th century focus on chemical and biological focus over 60 years.
    • Key historical concepts:
      • Historical studies are essential to gaining a better understanding of medicines and diseases
      • The methods of understanding are archaeology and documented records
      • Examples: Ephedra altissima (ephedrine), Egyptian Ebers Papyrus (~1500 BC), and Greek medicine (Dioscorides, Hippocrates and Galen)

    Modern Aspects of Pharmacognosy

    • Evolved to include phytotherapy, phytomedicine, phytochemistry, and nutraceuticals.
    • Increased relevance: A significant increase in the use of herbal remedies by the public, particularly in Europe, North America, and Australasia.

    Phytotherapy

    • Definition: Primarily focused on using natural extracts as healthcare or health-enhancing agents.
    • Role: Integral part of traditional medicine, often a treatment method for common illnesses.

    Phytomedicine

    • Definition: Herbal medicine with strong therapeutic properties which form a basis for herbal remedies.
    • Examples: Aerial parts, leaves, flowers, roots, barks, rhizomes.

    Phytochemistry

    • Definition: Study of the chemical constituents of plants and their compounds, like morphine, taxol, and artemisinin.

    Other Key Concepts

    • Natural products: Isolated compounds originated from natural sources including bacteria, fungi, plants, and animals .
    • Pure compounds: A single chemical entity, well-defined structure and composition, isolated and purified from natural sources.
    • Synthetic compounds: Chemically synthesized substances originating from natural substances.
    • Semi-synthetic compounds: Substances partly synthesized in the laboratory using natural compounds as raw materials.
    • Nutraceuticals: A substance or part of a food, providing health advantages and preventative effects (e.g, spices, certain plants).
    • Crude drugs: Plant-derived substances (or exudates) unmodified in chemical composition, prepared from plant organs.
    • Crude drug sources: Plants (e.g., leaves, stems, roots, bark, seeds), animals, and minerals.
    • Organized/Unorganized crude drug types: Organized are therapeutic substances from plants. Unorganized are substances like dry latex, gums, resins etc, typically extracted from plants.

    Notable Figures and Discoveries

    • Artemisinin: A significant antimalarial, discovered by Youyou Tu who was awarded a Nobel Prize for her research.
    • Morphine: Derived from opium poppy, a potent analgesic and smooth muscle relaxant.
    • Quinine: Derived from Cinchona bark, effective anti-malaria agent.
    • Aspirin: Salix spp, the basis of nonsteroidal anti-inflammatory drug, used for pain, fever, and inflammation relief.
    • Tubocurarine: Derived from American arrow poison, potent analgesic and myorelaxant, used in anesthesiology.
    • Taxol: Derived from Pacific yew tree bark, a notable anticancer drug for breast, lung, and ovarian cancer.
    • Physostigmine: Derived from Calabar bean, effective in managing anti-muscarinic toxicity and glaucoma.

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    Description

    This quiz covers key concepts in Pharmacognosy as part of the B.Pharm PCG 201 course. Topics include Microscopy, Cytomorphology, and the significance of natural products in medicine. Students will demonstrate their understanding of drug classification and preparation processes.

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