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Questions and Answers
Which process primarily forms flat bones such as those found in the skull?
Which process primarily forms flat bones such as those found in the skull?
- Intramembranous ossification (correct)
- Cartilage formation
- Endochondral ossification
- Bone remodelling
What is the first stage of bone remodelling?
What is the first stage of bone remodelling?
- Mineralization
- Formation
- Resorption
- Resting State (correct)
Which type of joint allows little to no movement and is connected by dense connective tissue?
Which type of joint allows little to no movement and is connected by dense connective tissue?
- Fibrous joints (correct)
- Elastic joints
- Cartilaginous joints
- Synovial joints
During which stage of bone remodelling do osteoclasts break down old bone tissue?
During which stage of bone remodelling do osteoclasts break down old bone tissue?
In endochondral ossification, where does the primary ossification center form?
In endochondral ossification, where does the primary ossification center form?
Which of the following statements about bone mineralization is true?
Which of the following statements about bone mineralization is true?
What characterizes a gomphosis joint?
What characterizes a gomphosis joint?
Which phase follows the reversal stage in bone remodelling?
Which phase follows the reversal stage in bone remodelling?
What type of joint is characterized by movement in one plane, such as flexion and extension?
What type of joint is characterized by movement in one plane, such as flexion and extension?
Which type of cartilage is found in the epiphyseal plates of growing bones?
Which type of cartilage is found in the epiphyseal plates of growing bones?
What type of joint allows for rotational movement around a single axis?
What type of joint allows for rotational movement around a single axis?
What is the movement of a limb away from the midline of the body called?
What is the movement of a limb away from the midline of the body called?
What kind of joint allows for gliding movements and is typically found in the wrist?
What kind of joint allows for gliding movements and is typically found in the wrist?
Which of the following terms describes the upward movement of the foot at the ankle?
Which of the following terms describes the upward movement of the foot at the ankle?
Which joint type allows movement in two planes without rotation?
Which joint type allows movement in two planes without rotation?
What type of joint is formed by bones connected by fibrocartilage, allowing slight movement?
What type of joint is formed by bones connected by fibrocartilage, allowing slight movement?
What is the primary function of diploic veins in the skull?
What is the primary function of diploic veins in the skull?
Which component of an osteon contains blood vessels and nerves?
Which component of an osteon contains blood vessels and nerves?
What type of cartilage is known for providing smooth surfaces for joint movement?
What type of cartilage is known for providing smooth surfaces for joint movement?
What role do osteoclasts play in bone tissue?
What role do osteoclasts play in bone tissue?
Which of the following types of bone matrix layers surrounds the Haversian canal?
Which of the following types of bone matrix layers surrounds the Haversian canal?
Where are osteogenic cells primarily located?
Where are osteogenic cells primarily located?
What is the primary characteristic of fibrocartilage?
What is the primary characteristic of fibrocartilage?
Which of the following structures connects adjacent Haversian canals?
Which of the following structures connects adjacent Haversian canals?
Which structure in compact bone connects the Haversian canals of different osteons?
Which structure in compact bone connects the Haversian canals of different osteons?
Which joint type allows for the greatest range of motion?
Which joint type allows for the greatest range of motion?
Which phase of bone remodeling involves the formation of new bone matrix by osteoblasts?
Which phase of bone remodeling involves the formation of new bone matrix by osteoblasts?
What is the primary cause of osteoporosis in terms of cellular activity?
What is the primary cause of osteoporosis in terms of cellular activity?
What type of medication is commonly used to manage osteoporosis by inhibiting bone resorption?
What type of medication is commonly used to manage osteoporosis by inhibiting bone resorption?
What pathological feature characterizes rheumatoid arthritis?
What pathological feature characterizes rheumatoid arthritis?
Which treatment option is NOT commonly utilized to manage rheumatoid arthritis?
Which treatment option is NOT commonly utilized to manage rheumatoid arthritis?
What function do bones play in supporting the body?
What function do bones play in supporting the body?
Which of the following lifestyle changes can aid in the management of osteoporosis?
Which of the following lifestyle changes can aid in the management of osteoporosis?
Which type of bone is primarily classified as a lever?
Which type of bone is primarily classified as a lever?
What is the primary role of red marrow in bones?
What is the primary role of red marrow in bones?
Which function allows bones to protect internal organs?
Which function allows bones to protect internal organs?
What type of bone would you classify the patella as?
What type of bone would you classify the patella as?
What is the significance of mineral storage in bones?
What is the significance of mineral storage in bones?
Which type of bones are characterized by their complex shapes?
Which type of bones are characterized by their complex shapes?
How does yellow marrow function within the bones?
How does yellow marrow function within the bones?
Flashcards
Intramembranous Ossification
Intramembranous Ossification
Bone formation process where mesenchymal cells differentiate into osteoblasts, which secrete bone matrix that calcifies into spongy bone, forming flat bones like those in the skull and clavicles.
Endochondral Ossification
Endochondral Ossification
Bone formation process involving the replacement of hyaline cartilage by bone tissue, resulting in the development of long bones.
Bone Remodelling
Bone Remodelling
A continuous process of bone resorption by osteoclasts and bone formation by osteoblasts, maintaining bone strength and mineral balance.
Resting State (Bone Remodelling)
Resting State (Bone Remodelling)
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Resorption (Bone Remodelling)
Resorption (Bone Remodelling)
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Reversal (Bone Remodelling)
Reversal (Bone Remodelling)
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Formation (Bone Remodelling)
Formation (Bone Remodelling)
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Mineralization (Bone Remodelling)
Mineralization (Bone Remodelling)
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Synchondrosis
Synchondrosis
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Symphysis
Symphysis
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Synovial Joint
Synovial Joint
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Hinge Joint
Hinge Joint
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Gliding Joint
Gliding Joint
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Pivot Joint
Pivot Joint
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Saddle Joint
Saddle Joint
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Condyloid Joint
Condyloid Joint
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Ball-and-Socket Joint
Ball-and-Socket Joint
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Bone Support Function
Bone Support Function
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Bone Protection Function
Bone Protection Function
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Bone Movement Function
Bone Movement Function
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Bone Mineral Storage Function
Bone Mineral Storage Function
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Bone Triglyceride Storage Function
Bone Triglyceride Storage Function
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Bone Blood Cell Production Function
Bone Blood Cell Production Function
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What are Long Bones?
What are Long Bones?
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What are Irregular Bones?
What are Irregular Bones?
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What connects Haversian canals?
What connects Haversian canals?
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What type of joint has the most movement?
What type of joint has the most movement?
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Which phase of bone remodeling involves building new bone?
Which phase of bone remodeling involves building new bone?
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How does an imbalance of osteoclasts and osteoblasts lead to osteoporosis?
How does an imbalance of osteoclasts and osteoblasts lead to osteoporosis?
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What is the pathological process in rheumatoid arthritis?
What is the pathological process in rheumatoid arthritis?
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How can we manage osteoporosis?
How can we manage osteoporosis?
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How can we manage rheumatoid arthritis?
How can we manage rheumatoid arthritis?
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What connects osteocytes within bone?
What connects osteocytes within bone?
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What are Diploic Veins?
What are Diploic Veins?
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What is an Osteon?
What is an Osteon?
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What is the Haversian Canal?
What is the Haversian Canal?
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What are Volkmann's Canals?
What are Volkmann's Canals?
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What are Canaliculi?
What are Canaliculi?
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What are Osteogenic Cells?
What are Osteogenic Cells?
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What are Osteoblasts?
What are Osteoblasts?
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What are Osteocytes?
What are Osteocytes?
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Study Notes
Bone Physiology
- Bone physiology is crucial for understanding how bones and cartilage contribute to the overall function of the human body
- This unit examines bone structure, function, and dynamics, along with cartilage types, and joints, which enable movement and provide support
Functions of Bone and Cartilage
- Support: Bones provide a rigid framework, supporting the body and maintaining shape. This structural support is important for posture and muscle attachment, enabling movement
- Protection: Bones form hard barriers, protecting vital organs. Examples of this protection include the skull sheltering the brain, ribs protecting the heart & lungs, and vertebrae protecting the spinal cord
- Movement: Bones act as levers that muscles pull on to produce movement. Joints where bones meet allow a range of motions, essential for skeletal movement
- Mineral Storage: Bones store essential minerals (calcium and phosphorus), which can be released into the bloodstream, maintaining mineral balance. This supports physiological processes such as nerve conduction and muscle contractions
- Triglyceride Storage: Yellow marrow in the medullary cavities of long bones stores triglycerides, acting as an energy reserve for the body
- Blood Cell Production: Red marrow within certain bones is responsible for hematopoiesis (production of blood cells). This includes red blood cells, white blood cells, and platelets
Gross Anatomy of the Bone
- Types of Bones: Bones are classified by shape
- Long Bones: Longer than wide, acting primarily as levers (examples: femur, humerus)
- Short Bones: Nearly equal in length and width, providing stability and limited movement (examples: carpals, tarsals)
Microanatomy of the Bone
- Osteon (Haversian System): The fundamental functional unit of compact bone. It consists of concentric rings (lamellae) surrounding a central Haversian canal
- Haversian Canal: Contains blood vessels and nerves, supplying bone cells
- Volkmann's Canals: Connect adjacent Haversian canals, allowing for the passage of blood vessels and nerves
- Canaliculi: Small channels extending from lacunae, connecting osteocytes, facilitating nutrient and waste exchange between osteocytes and vessels
- Lamellae: Layers of bone matrix within an osteon: concentric (surrounding Haversian Canal), interstitial (between osteons), circumferential (encircle entire bone)
- Bone Cells:
- Osteogenic Cells: Precursor cells differentiating into osteoblasts. Found in periosteum and endosteum; crucial in bone growth and repair
- Osteoblasts: Bone-forming cells, synthesizing and secreting bone matrix. Once trapped in the matrix, they become osteocytes
- Osteocytes: Mature bone cells maintaining bone matrix. Reside in lacunae, communicating with one another and the bone surface via canaliculi
- Osteoclasts: Large, multinucleated cells responsible for bone resorption. Secrete acids and enzymes, releasing calcium and other minerals into the bloodstream
Cartilage
- Hyaline Cartilage: Most common type, providing smooth surfaces for joint movement, flexibility, and support (found in nose, trachea, larynx, ends of long bones)
- Fibrocartilage: Dense, tough cartilage resisting compression and tension (found in intervertebral discs, pubic symphysis, menisci of knee)
- Elastic Cartilage: Flexible; maintaining shape and structure while allowing movement (found in external ear, epiglottis, Eustachian tubes)
Embryonic Bone Formation
- Intramembranous Ossification: Forms flat bones (skull, clavicles). Mesenchymal cells differentiate into osteoblasts, secreting bone matrix
- Endochondral Ossification: Most bones are formed through cartilage replacement. Begins with cartilage model, gradually replaced by bone tissue
Bone Remodelling
- Continuous process involving resorption of old bone and formation of new bone. Maintaining bone strength and mineral balance
- Stages:
- Resting: Inactive surface
- Resorption: Osteoclasts break down old bone
- Reversal: Cells prepare for formation
- Formation: Osteoblasts create new bone matrix
- Mineralization: Calcium and phosphate deposition strengthens new matrix
- Stages:
Types of Joints
- Fibrous Joints: Connected by dense connective tissue; little to no movement
- Sutures (skull), Gomphosis (teeth), Syndesmosis (tibiofibular)
- Cartilaginous Joints: Connected by cartilage; limited movement
- Synchondrosis (epiphyseal plates), Symphysis (pubic symphysis, intervertebral discs)
- Synovial Joints: Most movable; characterized by a fluid-filled joint cavity
- Hinge (elbow), Gliding (wrist), Pivot (atlantoaxial), Saddle (thumb), Condyloid (wrist), Ball-and-socket (shoulder, hip)
Movements of Joints
- Flexion/Extension: Bending/straightening; changing angle between bones
- Abduction/Adduction: Movement away/towards body midline
- Rotation: Movement around central axis
- Circumduction: Circular movement combining flexion, extension, abduction, and adduction
- Supination/Pronation: Forearm rotation; palm up/down
- Inversion/Eversion: Foot movement; sole inward/outward
- Dorsiflexion/Plantarflexion: Ankle movement; raising/lowering foot
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