Bone Physiology Quiz

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Questions and Answers

Which process primarily forms flat bones such as those found in the skull?

  • Intramembranous ossification (correct)
  • Cartilage formation
  • Endochondral ossification
  • Bone remodelling

What is the first stage of bone remodelling?

  • Mineralization
  • Formation
  • Resorption
  • Resting State (correct)

Which type of joint allows little to no movement and is connected by dense connective tissue?

  • Fibrous joints (correct)
  • Elastic joints
  • Cartilaginous joints
  • Synovial joints

During which stage of bone remodelling do osteoclasts break down old bone tissue?

<p>Resorption (C)</p> Signup and view all the answers

In endochondral ossification, where does the primary ossification center form?

<p>Diaphysis (A)</p> Signup and view all the answers

Which of the following statements about bone mineralization is true?

<p>It restores bone strength by depositing calcium and phosphate. (A)</p> Signup and view all the answers

What characterizes a gomphosis joint?

<p>A joint formed by pegs fitting into sockets (D)</p> Signup and view all the answers

Which phase follows the reversal stage in bone remodelling?

<p>Formation (A)</p> Signup and view all the answers

What type of joint is characterized by movement in one plane, such as flexion and extension?

<p>Hinge Joint (A)</p> Signup and view all the answers

Which type of cartilage is found in the epiphyseal plates of growing bones?

<p>Hyaline cartilage (C)</p> Signup and view all the answers

What type of joint allows for rotational movement around a single axis?

<p>Pivot Joint (B)</p> Signup and view all the answers

What is the movement of a limb away from the midline of the body called?

<p>Abduction (A)</p> Signup and view all the answers

What kind of joint allows for gliding movements and is typically found in the wrist?

<p>Gliding Joint (C)</p> Signup and view all the answers

Which of the following terms describes the upward movement of the foot at the ankle?

<p>Dorsiflexion (A)</p> Signup and view all the answers

Which joint type allows movement in two planes without rotation?

<p>Condyloid Joint (C)</p> Signup and view all the answers

What type of joint is formed by bones connected by fibrocartilage, allowing slight movement?

<p>Symphysis (B)</p> Signup and view all the answers

What is the primary function of diploic veins in the skull?

<p>To drain blood from cranial bones (D)</p> Signup and view all the answers

Which component of an osteon contains blood vessels and nerves?

<p>Haversian canal (C)</p> Signup and view all the answers

What type of cartilage is known for providing smooth surfaces for joint movement?

<p>Hyaline cartilage (C)</p> Signup and view all the answers

What role do osteoclasts play in bone tissue?

<p>Responsible for bone resorption (A)</p> Signup and view all the answers

Which of the following types of bone matrix layers surrounds the Haversian canal?

<p>Concentric lamellae (D)</p> Signup and view all the answers

Where are osteogenic cells primarily located?

<p>Endosteum and periosteum (B)</p> Signup and view all the answers

What is the primary characteristic of fibrocartilage?

<p>Resists compression and tension (A)</p> Signup and view all the answers

Which of the following structures connects adjacent Haversian canals?

<p>Volkmann's canals (B)</p> Signup and view all the answers

Which structure in compact bone connects the Haversian canals of different osteons?

<p>Volkmann's canals (A)</p> Signup and view all the answers

Which joint type allows for the greatest range of motion?

<p>Ball-and-socket joint (A)</p> Signup and view all the answers

Which phase of bone remodeling involves the formation of new bone matrix by osteoblasts?

<p>Formation (D)</p> Signup and view all the answers

What is the primary cause of osteoporosis in terms of cellular activity?

<p>Imbalance favoring osteoclast activity (D)</p> Signup and view all the answers

What type of medication is commonly used to manage osteoporosis by inhibiting bone resorption?

<p>Bisphosphonates (B)</p> Signup and view all the answers

What pathological feature characterizes rheumatoid arthritis?

<p>Inflammation of the synovial membrane (A)</p> Signup and view all the answers

Which treatment option is NOT commonly utilized to manage rheumatoid arthritis?

<p>Bone density scans (C)</p> Signup and view all the answers

What function do bones play in supporting the body?

<p>They provide a rigid framework that supports the body. (C)</p> Signup and view all the answers

Which of the following lifestyle changes can aid in the management of osteoporosis?

<p>Calcium and vitamin D supplementation (A)</p> Signup and view all the answers

Which type of bone is primarily classified as a lever?

<p>Long bones (A)</p> Signup and view all the answers

What is the primary role of red marrow in bones?

<p>Production of blood cells (A)</p> Signup and view all the answers

Which function allows bones to protect internal organs?

<p>Hard barrier formation (D)</p> Signup and view all the answers

What type of bone would you classify the patella as?

<p>Sesamoid bone (D)</p> Signup and view all the answers

What is the significance of mineral storage in bones?

<p>It facilitates nerve conduction and muscle contraction. (B)</p> Signup and view all the answers

Which type of bones are characterized by their complex shapes?

<p>Irregular bones (B)</p> Signup and view all the answers

How does yellow marrow function within the bones?

<p>It serves as an energy reserve. (C)</p> Signup and view all the answers

Flashcards

Intramembranous Ossification

Bone formation process where mesenchymal cells differentiate into osteoblasts, which secrete bone matrix that calcifies into spongy bone, forming flat bones like those in the skull and clavicles.

Endochondral Ossification

Bone formation process involving the replacement of hyaline cartilage by bone tissue, resulting in the development of long bones.

Bone Remodelling

A continuous process of bone resorption by osteoclasts and bone formation by osteoblasts, maintaining bone strength and mineral balance.

Resting State (Bone Remodelling)

The resting phase of bone remodelling where no resorption or formation occurs.

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Resorption (Bone Remodelling)

Phase of bone remodelling where osteoclasts break down old bone, creating resorption bays.

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Reversal (Bone Remodelling)

Phase of bone remodelling where mononuclear cells prepare the bone surface for new bone formation.

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Formation (Bone Remodelling)

Phase of bone remodelling where osteoblasts lay down new bone matrix, filling in the resorption bays.

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Mineralization (Bone Remodelling)

Phase of bone remodelling where the newly formed bone matrix becomes mineralized with calcium and phosphate, restoring bone strength.

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Synchondrosis

A joint where bones are connected by hyaline cartilage, allowing for limited movement. Examples include the epiphyseal plates in growing bones.

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Symphysis

A joint where bones are connected by fibrocartilage, allowing for slight movement. Examples include the pubic symphysis and intervertebral discs.

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Synovial Joint

The most movable type of joint in the body. These joints have a fluid-filled cavity that allows for a wide range of movements.

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Hinge Joint

A type of synovial joint that allows movement in one plane, such as flexion and extension. Examples include the elbow and knee.

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Gliding Joint

A type of synovial joint that allows sliding or gliding movements. Found in the carpals of the wrist.

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Pivot Joint

A synovial joint that allows rotational movement around a single axis. An example is the atlantoaxial joint between the first and second cervical vertebrae, which allows for head rotation.

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Saddle Joint

A type of synovial joint that allows movement in two planes (flexion-extension and abduction-adduction). The thumb joint (carpometacarpal joint) is a good example.

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Condyloid Joint

A synovial joint that allows movement in two planes without rotation. The wrist joint is an example.

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Ball-and-Socket Joint

A type of synovial joint that allows movement in multiple planes and rotation. Examples include the shoulder and hip joints.

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Bone Support Function

Bones provide a rigid framework that supports the body and helps maintain its shape. This is essential for posture and the attachment of muscles for movement.

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Bone Protection Function

Bones protect vital organs by forming hard barriers. Examples include the skull protecting the brain, the rib cage protecting the heart and lungs, and vertebrae protecting the spinal cord.

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Bone Movement Function

Bones work as levers that muscles pull on to create movement. Joints, where bones meet, allow for a range of motions, leading to skeletal movement.

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Bone Mineral Storage Function

Bones store essential minerals like calcium and phosphorus. These minerals can be released into the bloodstream when needed to maintain mineral balance and support physiological processes like nerve conduction and muscle contraction.

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Bone Triglyceride Storage Function

The yellow marrow found in the cavities of long bones stores triglycerides, which serve as an energy reserve for the body.

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Bone Blood Cell Production Function

The red marrow inside certain bones is responsible for hematopoiesis, the production of blood cells like red blood cells, white blood cells, and platelets.

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What are Long Bones?

Long bones are longer than they are wide, primarily serving as levers. Examples include the femur and humerus.

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What are Irregular Bones?

These bones have complex shapes that don't fit into any of the other categories, such as the vertebrae and some facial bones.

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What connects Haversian canals?

Volkmann's canals connect to Haversian canals, allowing blood vessels and nerves to reach the interior of bone. They are channels that run perpendicular to the long axis of the bone, linking the Haversian canals.

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What type of joint has the most movement?

Ball-and-socket joints offer the widest range of motion, enabling movement in multiple planes, including rotation. Examples include the shoulder and hip joints.

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Which phase of bone remodeling involves building new bone?

Bone formation involves the creation of new bone matrix by osteoblasts. This process is part of bone remodeling, which involves the replacement of old bone tissue with new bone tissue.

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How does an imbalance of osteoclasts and osteoblasts lead to osteoporosis?

Osteoporosis occurs when osteoclasts, which break down bone, work more efficiently than osteoblasts, which build bone. This leads to weakened bones and increased fracture risk.

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What is the pathological process in rheumatoid arthritis?

Rheumatoid arthritis, an autoimmune disease, attacks the synovial membrane of joints, causing inflammation, cartilage destruction, and bone erosion. This leads to pain, stiffness, and joint deformity.

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How can we manage osteoporosis?

Osteoclast activity can be reduced by bisphosphonates, calcium and vitamin D supplementation, and weight-bearing exercise, all of which can help manage osteoporosis.

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How can we manage rheumatoid arthritis?

Anti-inflammatory medications, DMARDs, and physical therapy can help manage rheumatoid arthritis by reducing inflammation, slowing disease progression, and preserving joint function.

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What connects osteocytes within bone?

Canaliculi are microscopic channels that connect osteocytes within the lacunae. They allow the exchange of nutrients and waste products between osteocytes and blood vessels.

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What are Diploic Veins?

Large, valveless veins found within the spongy bone of the skull, they drain blood from the cranial bones and connect to the venous sinuses of the brain.

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What is an Osteon?

The 'building block' of compact bone, consisting of concentric rings of calcified matrix (lamellae) surrounding a central Haversian canal containing blood vessels and nerves.

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What is the Haversian Canal?

The central canal of an osteon, containing blood vessels and nerves that supply the bone cells.

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What are Volkmann's Canals?

Horizontal canals connecting adjacent Haversian canals, allowing blood vessels and nerves to pass between osteons.

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What are Canaliculi?

Small channels that connect osteocytes within the lamellae, facilitating nutrient exchange and waste removal.

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What are Osteogenic Cells?

Precursor cells that differentiate into osteoblasts; found in the periosteum and endosteum, crucial for bone growth and repair.

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What are Osteoblasts?

Bone-forming cells responsible for synthesizing and secreting bone matrix, differentiating into osteocytes when trapped in the matrix.

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What are Osteocytes?

Mature bone cells responsible for maintaining the bone matrix, residing in lacunae and communicating with each other and the bone surface through canaliculi.

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Study Notes

Bone Physiology

  • Bone physiology is crucial for understanding how bones and cartilage contribute to the overall function of the human body
  • This unit examines bone structure, function, and dynamics, along with cartilage types, and joints, which enable movement and provide support

Functions of Bone and Cartilage

  • Support: Bones provide a rigid framework, supporting the body and maintaining shape. This structural support is important for posture and muscle attachment, enabling movement
  • Protection: Bones form hard barriers, protecting vital organs. Examples of this protection include the skull sheltering the brain, ribs protecting the heart & lungs, and vertebrae protecting the spinal cord
  • Movement: Bones act as levers that muscles pull on to produce movement. Joints where bones meet allow a range of motions, essential for skeletal movement
  • Mineral Storage: Bones store essential minerals (calcium and phosphorus), which can be released into the bloodstream, maintaining mineral balance. This supports physiological processes such as nerve conduction and muscle contractions
  • Triglyceride Storage: Yellow marrow in the medullary cavities of long bones stores triglycerides, acting as an energy reserve for the body
  • Blood Cell Production: Red marrow within certain bones is responsible for hematopoiesis (production of blood cells). This includes red blood cells, white blood cells, and platelets

Gross Anatomy of the Bone

  • Types of Bones: Bones are classified by shape
    • Long Bones: Longer than wide, acting primarily as levers (examples: femur, humerus)
    • Short Bones: Nearly equal in length and width, providing stability and limited movement (examples: carpals, tarsals)

Microanatomy of the Bone

  • Osteon (Haversian System): The fundamental functional unit of compact bone. It consists of concentric rings (lamellae) surrounding a central Haversian canal
    • Haversian Canal: Contains blood vessels and nerves, supplying bone cells
    • Volkmann's Canals: Connect adjacent Haversian canals, allowing for the passage of blood vessels and nerves
    • Canaliculi: Small channels extending from lacunae, connecting osteocytes, facilitating nutrient and waste exchange between osteocytes and vessels
    • Lamellae: Layers of bone matrix within an osteon: concentric (surrounding Haversian Canal), interstitial (between osteons), circumferential (encircle entire bone)
  • Bone Cells:
    • Osteogenic Cells: Precursor cells differentiating into osteoblasts. Found in periosteum and endosteum; crucial in bone growth and repair
    • Osteoblasts: Bone-forming cells, synthesizing and secreting bone matrix. Once trapped in the matrix, they become osteocytes
    • Osteocytes: Mature bone cells maintaining bone matrix. Reside in lacunae, communicating with one another and the bone surface via canaliculi
    • Osteoclasts: Large, multinucleated cells responsible for bone resorption. Secrete acids and enzymes, releasing calcium and other minerals into the bloodstream

Cartilage

  • Hyaline Cartilage: Most common type, providing smooth surfaces for joint movement, flexibility, and support (found in nose, trachea, larynx, ends of long bones)
  • Fibrocartilage: Dense, tough cartilage resisting compression and tension (found in intervertebral discs, pubic symphysis, menisci of knee)
  • Elastic Cartilage: Flexible; maintaining shape and structure while allowing movement (found in external ear, epiglottis, Eustachian tubes)

Embryonic Bone Formation

  • Intramembranous Ossification: Forms flat bones (skull, clavicles). Mesenchymal cells differentiate into osteoblasts, secreting bone matrix
  • Endochondral Ossification: Most bones are formed through cartilage replacement. Begins with cartilage model, gradually replaced by bone tissue

Bone Remodelling

  • Continuous process involving resorption of old bone and formation of new bone. Maintaining bone strength and mineral balance
    • Stages:
      • Resting: Inactive surface
      • Resorption: Osteoclasts break down old bone
      • Reversal: Cells prepare for formation
      • Formation: Osteoblasts create new bone matrix
      • Mineralization: Calcium and phosphate deposition strengthens new matrix

Types of Joints

  • Fibrous Joints: Connected by dense connective tissue; little to no movement
    • Sutures (skull), Gomphosis (teeth), Syndesmosis (tibiofibular)
  • Cartilaginous Joints: Connected by cartilage; limited movement
    • Synchondrosis (epiphyseal plates), Symphysis (pubic symphysis, intervertebral discs)
  • Synovial Joints: Most movable; characterized by a fluid-filled joint cavity
    • Hinge (elbow), Gliding (wrist), Pivot (atlantoaxial), Saddle (thumb), Condyloid (wrist), Ball-and-socket (shoulder, hip)

Movements of Joints

  • Flexion/Extension: Bending/straightening; changing angle between bones
  • Abduction/Adduction: Movement away/towards body midline
  • Rotation: Movement around central axis
  • Circumduction: Circular movement combining flexion, extension, abduction, and adduction
  • Supination/Pronation: Forearm rotation; palm up/down
  • Inversion/Eversion: Foot movement; sole inward/outward
  • Dorsiflexion/Plantarflexion: Ankle movement; raising/lowering foot

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