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Pathology of anemia

Learn about the bone marrow biopsy procedure, which involves taking a sample of bone marrow for examination in the histopathology lab to identify the cause of abnormal RBCs in the peripheral blood smear. This procedure is used for diagnostic purposes like aplastic anemia or leukemia, as well as therapeutic purposes such as bone marrow transplantation.

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Questions and Answers

What is the purpose of a Bone Marrow Biopsy (BMB) procedure?

To examine the normal production of cells in the histopathology lab

Why is Bone Marrow Biopsy contraindicated in patients with hemorrhagic or bone disorders?

It can cause pain and complications in those patients

How is a patient positioned for a Bone Marrow Biopsy procedure?

Lateral decubitus position

What is one of the steps involved in preparing a bone marrow sample for examination?

<p>Sterilizing the area before sample collection</p> Signup and view all the answers

How is anemia defined?

<p>A decrease in oxygentransporting capacity of blood</p> Signup and view all the answers

Why is taking a Bone Marrow Biopsy from the sternum considered very painful?

<p>Sensitivity of nerve endings near the sternum</p> Signup and view all the answers

What does a high reticulocyte index (RI) indicate?

<p>Compensatory RBC production</p> Signup and view all the answers

Which of the following is NOT a cause of aplastic anemia?

<p>Excessive RBC production</p> Signup and view all the answers

What is the main characteristic of pancytopenia?

<p>Decreased counts of red blood cells, white blood cells, and platelets</p> Signup and view all the answers

Which of the following is a symptom commonly associated with aplastic anemia?

<p>Mucosal bleeding</p> Signup and view all the answers

What is the main difference between aplastic anemia and pure red cell aplasia?

<p>Pure red cell aplasia involves pancytopenia</p> Signup and view all the answers

What is the main clinical significance of a hypocellular bone marrow with fatty infiltration?

<p>Aplastic anemia</p> Signup and view all the answers

Which type of anemia is characterized by a corrected reticulocyte count?

<p>Normocytic anemia</p> Signup and view all the answers

What condition can cause anemia due to a deficiency in or impaired use of vitamin B12 and folic acid?

<p>Pernicious anemia</p> Signup and view all the answers

Which type of anemia is characterized by deficient heme synthesis?

<p>Iron deficiency anemia</p> Signup and view all the answers

Anemia associated with chronic kidney disease is due to which factor?

<p>Erythropoietin deficiency</p> Signup and view all the answers

Which of the following is NOT a cause of microcytic anemia?

<p>Pernicious anemia</p> Signup and view all the answers

Defective globin synthesis is a feature of which type of anemia?

<p>Thalassemia</p> Signup and view all the answers

Which finding on bone marrow biopsy is characteristic of anemia due to Vitamin B12 deficiency?

<p>Horseshoe-shaped nuclei in metamyelocytes</p> Signup and view all the answers

What is the primary role of intrinsic factor (IF) in the pathogenesis of Vitamin B12 deficiency anemia?

<p>Protecting B12 from degradation by intestinal enzymes</p> Signup and view all the answers

Which clinical finding is characteristic of severe Vitamin B12 deficiency anemia?

<p>Congestive heart failure</p> Signup and view all the answers

What is the most likely cause of Vitamin B12 deficiency anemia in a patient who had a gastrectomy?

<p>Autoimmune destruction of parietal cells</p> Signup and view all the answers

How can anemia due to folate deficiency be best distinguished from anemia due to Vitamin B12 deficiency?

<p>By measuring serum and red cell folate levels</p> Signup and view all the answers

What is a common neurological symptom seen in patients with Vitamin B12 deficiency anemia?

<p>Numbness and tingling in feet and hands</p> Signup and view all the answers

Which symptom is characteristic of severe iron deficiency?

<p>Koilonychia</p> Signup and view all the answers

What can develop in iron deficiency anemia with characteristics such as dysphagia and atrophic glossitis?

<p>Plummer-Vinson syndrome</p> Signup and view all the answers

Which feature is seen in the bone marrow biopsy of a patient with impaired DNA synthesis due to B12 and folate deficiency?

<p>Horseshoe-shaped nuclei of neutrophils</p> Signup and view all the answers

Which symptom is a result of the depletion of essential iron-containing enzymes in severe iron deficiency?

<p>Alopecia</p> Signup and view all the answers

What underlying cause results in hypersegmented neutrophils in peripheral blood smear due to impaired DNA synthesis?

<p>Folate Deficiency</p> Signup and view all the answers

Which clinical finding is associated with celiac disease or after gastrectomy?

<p>Thinning of part in the esophagus due to mucosal damage</p> Signup and view all the answers

What term describes the average volume per red cell, expressed in femtoliters?

<p>Mean cell volume</p> Signup and view all the answers

Which red blood cell morphology resembles a shooting target with a dark center surrounded by a white ring?

<p>Target Cell (Codocyte)</p> Signup and view all the answers

What term describes red blood cells with a crescent shape that occurs under low oxygen conditions?

<p>Sickle Cell</p> Signup and view all the answers

Which term describes red blood cells with thorny spike-like projections?

<p>Acanthocyte (spur cell)</p> Signup and view all the answers

What is the term for the coefficient of variation of red cell volume?

<p>Red cell distribution width</p> Signup and view all the answers

Which term describes small, spherical red blood cells without central pallor?

<p>Spherocyte</p> Signup and view all the answers

What term describes elongated fade in the center of a red blood cell?

<p>Stomatocyte</p> Signup and view all the answers

Which type of red blood cells have a slit-like or coffee bean shape?

<p>Sickle Cell</p> Signup and view all the answers

'Acanthocytes' refer to RBCs with thorny spike-like projections and can occur in which condition?

<p>In iron deficiency anemia</p> Signup and view all the answers

Which type of red blood cell morphology is characterized by fragmented cells and can be seen in patients with thalassemia?

<p>Schistocytes</p> Signup and view all the answers

What is the term for red blood cells that have spine projections and smaller, more uniform projections than acanthocytes?

<p>Echinocytes</p> Signup and view all the answers

Which of the following descriptive terms is associated with a red blood cell having a central pallor that exceeds one-third of the cell diameter?

<p>Hypochromia</p> Signup and view all the answers

Which process involves the mechanical squeezing of a red blood cell causing it to 'shed a tear' and acquire a teardrop shape?

<p>Echinocytosis</p> Signup and view all the answers

What term describes a red blood cell with elongated, cigar or sausage shape due to mutations in genes encoding RBC membrane proteins?

<p>Elliptocyte</p> Signup and view all the answers

What is the morphology of an RBC when it shows Cabot’s ring?

<p>Ring shape or figure-8 structure in the RBC</p> Signup and view all the answers

Which of the following describes basophilic stippling in red blood cells?

<p>Deep blue granules of variable size in the RBC</p> Signup and view all the answers

What is the characteristic appearance of Howell-Jolly bodies in red blood cells?

<p>Round solid dark inclusion in the RBC</p> Signup and view all the answers

Which condition results in agglutination of red blood cells?

<p>Immune system disease</p> Signup and view all the answers

What does it mean when red blood cells are said to form Rouleaux?

<p>RBCs aggregate due to antibacterial proteins</p> Signup and view all the answers

Agglutination and Rouleaux formation in red blood cells cannot occur simultaneously due to what reason?

<p>Mutually exclusive mechanisms governing each process</p> Signup and view all the answers

What term is used to describe red blood cells that have a slit-like or coffee bean shape?

<p>Stomatocytes</p> Signup and view all the answers

Which of the following terms refers to red blood cells that resemble a shooting target with a dark center surrounded by a white ring?

<p>Codocytes</p> Signup and view all the answers

What is the term for red blood cells that have thorny spike-like projections?

<p>Acanthocytes</p> Signup and view all the answers

Which term describes small, spherical red blood cells without central pallor?

<p>Spherocytes</p> Signup and view all the answers

What is the term for red blood cells that exhibit elongated fade in the center?

<p>Echinocytes</p> Signup and view all the answers

Which term is used to describe the coefficient of variation of red cell volume?

<p>RDW</p> Signup and view all the answers

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