Pathology of anemia

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Questions and Answers

What is the purpose of a Bone Marrow Biopsy (BMB) procedure?

  • To examine the normal production of cells in the histopathology lab (correct)
  • To examine the respiratory capacity of blood
  • To transplant bone marrow for therapeutic purposes
  • To diagnose bone disorders

Why is Bone Marrow Biopsy contraindicated in patients with hemorrhagic or bone disorders?

  • It can cause pain and complications in those patients (correct)
  • It is ineffective in diagnosing anemia
  • It is an unnecessary diagnostic procedure
  • It can lead to further abnormalities in RBCs

How is a patient positioned for a Bone Marrow Biopsy procedure?

  • Supine position
  • Lithotomy position
  • Prone position
  • Lateral decubitus position (correct)

What is one of the steps involved in preparing a bone marrow sample for examination?

<p>Sterilizing the area before sample collection (C)</p> Signup and view all the answers

How is anemia defined?

<p>A decrease in oxygentransporting capacity of blood (A)</p> Signup and view all the answers

Why is taking a Bone Marrow Biopsy from the sternum considered very painful?

<p>Sensitivity of nerve endings near the sternum (D)</p> Signup and view all the answers

What does a high reticulocyte index (RI) indicate?

<p>Compensatory RBC production (C)</p> Signup and view all the answers

Which of the following is NOT a cause of aplastic anemia?

<p>Excessive RBC production (C)</p> Signup and view all the answers

What is the main characteristic of pancytopenia?

<p>Decreased counts of red blood cells, white blood cells, and platelets (D)</p> Signup and view all the answers

Which of the following is a symptom commonly associated with aplastic anemia?

<p>Mucosal bleeding (B)</p> Signup and view all the answers

What is the main difference between aplastic anemia and pure red cell aplasia?

<p>Pure red cell aplasia involves pancytopenia (A)</p> Signup and view all the answers

What is the main clinical significance of a hypocellular bone marrow with fatty infiltration?

<p>Aplastic anemia (A)</p> Signup and view all the answers

Which type of anemia is characterized by a corrected reticulocyte count?

<p>Normocytic anemia (A)</p> Signup and view all the answers

What condition can cause anemia due to a deficiency in or impaired use of vitamin B12 and folic acid?

<p>Pernicious anemia (D)</p> Signup and view all the answers

Which type of anemia is characterized by deficient heme synthesis?

<p>Iron deficiency anemia (C)</p> Signup and view all the answers

Anemia associated with chronic kidney disease is due to which factor?

<p>Erythropoietin deficiency (B)</p> Signup and view all the answers

Which of the following is NOT a cause of microcytic anemia?

<p>Pernicious anemia (D)</p> Signup and view all the answers

Defective globin synthesis is a feature of which type of anemia?

<p>Thalassemia (D)</p> Signup and view all the answers

Which finding on bone marrow biopsy is characteristic of anemia due to Vitamin B12 deficiency?

<p>Horseshoe-shaped nuclei in metamyelocytes (C)</p> Signup and view all the answers

What is the primary role of intrinsic factor (IF) in the pathogenesis of Vitamin B12 deficiency anemia?

<p>Protecting B12 from degradation by intestinal enzymes (D)</p> Signup and view all the answers

Which clinical finding is characteristic of severe Vitamin B12 deficiency anemia?

<p>Congestive heart failure (C)</p> Signup and view all the answers

What is the most likely cause of Vitamin B12 deficiency anemia in a patient who had a gastrectomy?

<p>Autoimmune destruction of parietal cells (A)</p> Signup and view all the answers

How can anemia due to folate deficiency be best distinguished from anemia due to Vitamin B12 deficiency?

<p>By measuring serum and red cell folate levels (C)</p> Signup and view all the answers

What is a common neurological symptom seen in patients with Vitamin B12 deficiency anemia?

<p>Numbness and tingling in feet and hands (A)</p> Signup and view all the answers

Which symptom is characteristic of severe iron deficiency?

<p>Koilonychia (C)</p> Signup and view all the answers

What can develop in iron deficiency anemia with characteristics such as dysphagia and atrophic glossitis?

<p>Plummer-Vinson syndrome (B)</p> Signup and view all the answers

Which feature is seen in the bone marrow biopsy of a patient with impaired DNA synthesis due to B12 and folate deficiency?

<p>Horseshoe-shaped nuclei of neutrophils (D)</p> Signup and view all the answers

Which symptom is a result of the depletion of essential iron-containing enzymes in severe iron deficiency?

<p>Alopecia (C)</p> Signup and view all the answers

What underlying cause results in hypersegmented neutrophils in peripheral blood smear due to impaired DNA synthesis?

<p>Folate Deficiency (C)</p> Signup and view all the answers

Which clinical finding is associated with celiac disease or after gastrectomy?

<p>Thinning of part in the esophagus due to mucosal damage (A)</p> Signup and view all the answers

What term describes the average volume per red cell, expressed in femtoliters?

<p>Mean cell volume (D)</p> Signup and view all the answers

Which red blood cell morphology resembles a shooting target with a dark center surrounded by a white ring?

<p>Target Cell (Codocyte) (A)</p> Signup and view all the answers

What term describes red blood cells with a crescent shape that occurs under low oxygen conditions?

<p>Sickle Cell (A)</p> Signup and view all the answers

Which term describes red blood cells with thorny spike-like projections?

<p>Acanthocyte (spur cell) (B)</p> Signup and view all the answers

What is the term for the coefficient of variation of red cell volume?

<p>Red cell distribution width (B)</p> Signup and view all the answers

Which term describes small, spherical red blood cells without central pallor?

<p>Spherocyte (B)</p> Signup and view all the answers

What term describes elongated fade in the center of a red blood cell?

<p>Stomatocyte (A)</p> Signup and view all the answers

Which type of red blood cells have a slit-like or coffee bean shape?

<p>Sickle Cell (B)</p> Signup and view all the answers

'Acanthocytes' refer to RBCs with thorny spike-like projections and can occur in which condition?

<p>In iron deficiency anemia (B)</p> Signup and view all the answers

Which type of red blood cell morphology is characterized by fragmented cells and can be seen in patients with thalassemia?

<p>Schistocytes (C)</p> Signup and view all the answers

What is the term for red blood cells that have spine projections and smaller, more uniform projections than acanthocytes?

<p>Echinocytes (D)</p> Signup and view all the answers

Which of the following descriptive terms is associated with a red blood cell having a central pallor that exceeds one-third of the cell diameter?

<p>Hypochromia (D)</p> Signup and view all the answers

Which process involves the mechanical squeezing of a red blood cell causing it to 'shed a tear' and acquire a teardrop shape?

<p>Echinocytosis (B)</p> Signup and view all the answers

What term describes a red blood cell with elongated, cigar or sausage shape due to mutations in genes encoding RBC membrane proteins?

<p>Elliptocyte (A)</p> Signup and view all the answers

What is the morphology of an RBC when it shows Cabot’s ring?

<p>Ring shape or figure-8 structure in the RBC (B)</p> Signup and view all the answers

Which of the following describes basophilic stippling in red blood cells?

<p>Deep blue granules of variable size in the RBC (D)</p> Signup and view all the answers

What is the characteristic appearance of Howell-Jolly bodies in red blood cells?

<p>Round solid dark inclusion in the RBC (A)</p> Signup and view all the answers

Which condition results in agglutination of red blood cells?

<p>Immune system disease (B)</p> Signup and view all the answers

What does it mean when red blood cells are said to form Rouleaux?

<p>RBCs aggregate due to antibacterial proteins (B)</p> Signup and view all the answers

Agglutination and Rouleaux formation in red blood cells cannot occur simultaneously due to what reason?

<p>Mutually exclusive mechanisms governing each process (D)</p> Signup and view all the answers

What term is used to describe red blood cells that have a slit-like or coffee bean shape?

<p>Stomatocytes (C)</p> Signup and view all the answers

Which of the following terms refers to red blood cells that resemble a shooting target with a dark center surrounded by a white ring?

<p>Codocytes (B)</p> Signup and view all the answers

What is the term for red blood cells that have thorny spike-like projections?

<p>Acanthocytes (C)</p> Signup and view all the answers

Which term describes small, spherical red blood cells without central pallor?

<p>Spherocytes (A)</p> Signup and view all the answers

What is the term for red blood cells that exhibit elongated fade in the center?

<p>Echinocytes (D)</p> Signup and view all the answers

Which term is used to describe the coefficient of variation of red cell volume?

<p>RDW (D)</p> Signup and view all the answers

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