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Questions and Answers
What is the primary unit of cortical bone?
What is the primary unit of cortical bone?
- Periosteum
- Trabeculae
- Osteon (correct)
- Osteocytes
Cancellous bone is characterized by its irregular meshwork of trabeculae.
Cancellous bone is characterized by its irregular meshwork of trabeculae.
True (A)
What is the difference between woven bone in immature animals and woven bone in adult animals?
What is the difference between woven bone in immature animals and woven bone in adult animals?
Woven bone in immature animals is considered physiologic and part of normal bone growth, whereas woven bone in adult animals is considered pathologic and indicates an abnormal response to injury.
The ______ is a fibrous sheet that covers bone and has an inner osteogenic layer.
The ______ is a fibrous sheet that covers bone and has an inner osteogenic layer.
Which type of bone formation lacks a cartilage precursor?
Which type of bone formation lacks a cartilage precursor?
Cartilage is vascular in adults.
Cartilage is vascular in adults.
What is the process of bone healing where bone ends come into direct contact?
What is the process of bone healing where bone ends come into direct contact?
A ______ is a piece of dead bone separated from healthy bone during necrosis.
A ______ is a piece of dead bone separated from healthy bone during necrosis.
Match the following terms with their descriptions:
Match the following terms with their descriptions:
Which type of fracture is characterized by weakened or diseased bone?
Which type of fracture is characterized by weakened or diseased bone?
Traumatic fractures typically have sharp outlines, while pathologic fractures often have rounded edges.
Traumatic fractures typically have sharp outlines, while pathologic fractures often have rounded edges.
Explain the difference between a traumatic and a pathologic fracture.
Explain the difference between a traumatic and a pathologic fracture.
An articular fracture involves the ______ of a bone.
An articular fracture involves the ______ of a bone.
What is the term for a false joint that can form if fracture ends are not stable?
What is the term for a false joint that can form if fracture ends are not stable?
Large necrotic bone fragments (sequestra) usually resolve quickly and do not delay healing.
Large necrotic bone fragments (sequestra) usually resolve quickly and do not delay healing.
Which of the following is NOT a cause of ischemic muscle injury?
Which of the following is NOT a cause of ischemic muscle injury?
Nutritional myopathies are caused by a lack of essential nutrients, such as Vitamin E and Selenium.
Nutritional myopathies are caused by a lack of essential nutrients, such as Vitamin E and Selenium.
What are the three syndromes associated with Vitamin E/Selenium deficiency in pigs?
What are the three syndromes associated with Vitamin E/Selenium deficiency in pigs?
Seasonal Pasture Myopathy in horses is caused by the consumption of ______ and ______ trees.
Seasonal Pasture Myopathy in horses is caused by the consumption of ______ and ______ trees.
Which of the following is NOT a potential cause of Exertional Myopathy?
Which of the following is NOT a potential cause of Exertional Myopathy?
Match the following genetic myopathies with their respective causes.
Match the following genetic myopathies with their respective causes.
Polymyositis is primarily a disease affecting the skeletal muscles, with only limited involvement of the heart.
Polymyositis is primarily a disease affecting the skeletal muscles, with only limited involvement of the heart.
What are the two main muscles affected in Masticatory Myositis?
What are the two main muscles affected in Masticatory Myositis?
Which of the following is a potential trigger for Hyperkalemic Periodic Paralysis (HYPP) episodes?
Which of the following is a potential trigger for Hyperkalemic Periodic Paralysis (HYPP) episodes?
Equine Polysaccharide Storage Myopathy is characterized by an accumulation of ______ in the muscle.
Equine Polysaccharide Storage Myopathy is characterized by an accumulation of ______ in the muscle.
Malignant Hyperthermia is only seen in horses and is not found in other species.
Malignant Hyperthermia is only seen in horses and is not found in other species.
What is the primary characteristic of X-linked Muscular Dystrophy in terms of its effect on the dystrophin protein?
What is the primary characteristic of X-linked Muscular Dystrophy in terms of its effect on the dystrophin protein?
Which of the following is NOT a potential clinical sign of Exertional Myopathy?
Which of the following is NOT a potential clinical sign of Exertional Myopathy?
The accumulation of ______ in the muscle is a characteristic feature of Myofibrillary Myopathy.
The accumulation of ______ in the muscle is a characteristic feature of Myofibrillary Myopathy.
What type of pneumonia is often presented in foals aged 1-6 months due to the pathogen equi?
What type of pneumonia is often presented in foals aged 1-6 months due to the pathogen equi?
Sepsis can lead to bone infection.
Sepsis can lead to bone infection.
What is a common symptom of metaphyseal osteopathy in large breed dogs?
What is a common symptom of metaphyseal osteopathy in large breed dogs?
The condition characterized by disrupted blood supply to the femoral head is called __________.
The condition characterized by disrupted blood supply to the femoral head is called __________.
Match the following joint conditions with their causes:
Match the following joint conditions with their causes:
Which breed of dog is genetically predisposed to panosteitis?
Which breed of dog is genetically predisposed to panosteitis?
Articular cartilage has a rich supply of nerves and vessels.
Articular cartilage has a rich supply of nerves and vessels.
What leads to the erosion of articular cartilage?
What leads to the erosion of articular cartilage?
In cases of osteomyelitis, bone infection can occur due to __________.
In cases of osteomyelitis, bone infection can occur due to __________.
What radiographic feature is associated with metaphyseal osteopathy?
What radiographic feature is associated with metaphyseal osteopathy?
Which condition can cause abortion or stillbirths in animals?
Which condition can cause abortion or stillbirths in animals?
Feline calicivirus is associated with immune-complex pathogenesis in Feline 'Limping Syndrome'.
Feline calicivirus is associated with immune-complex pathogenesis in Feline 'Limping Syndrome'.
What is a common cause of bird arthritis?
What is a common cause of bird arthritis?
Arthritis in reptiles and birds is often associated with high ________ diet.
Arthritis in reptiles and birds is often associated with high ________ diet.
Match the following diseases with their associated characteristics:
Match the following diseases with their associated characteristics:
What is the recommended action if an outbreak of Poultry Viral Arthritis occurs?
What is the recommended action if an outbreak of Poultry Viral Arthritis occurs?
Immune-complex deposition in the synovium is associated with immune-mediated polyarthritis.
Immune-complex deposition in the synovium is associated with immune-mediated polyarthritis.
What condition is often a primary concern in animals producing uric acid?
What condition is often a primary concern in animals producing uric acid?
Fibrinous arthritis with synovial hyperplasia is often diagnosed in ________ syndrome.
Fibrinous arthritis with synovial hyperplasia is often diagnosed in ________ syndrome.
Which of the following is NOT a typical symptom of Degenerative joint disease?
Which of the following is NOT a typical symptom of Degenerative joint disease?
What is the most common eyelid neoplasm in dogs?
What is the most common eyelid neoplasm in dogs?
Blepharitis is an inflammation of the cornea.
Blepharitis is an inflammation of the cornea.
What condition is characterized by the rolling inward of the eyelid?
What condition is characterized by the rolling inward of the eyelid?
The main cause of chemosis is __________.
The main cause of chemosis is __________.
Match the eyelid diseases with their descriptions:
Match the eyelid diseases with their descriptions:
Which of the following is a common cause of conjunctivitis in cats?
Which of the following is a common cause of conjunctivitis in cats?
The tear film is composed of three layers: lipid, aqueous, and mucin.
The tear film is composed of three layers: lipid, aqueous, and mucin.
What is the primary cause of glaucoma?
What is the primary cause of glaucoma?
Name one type of neoplasia that commonly affects the eyelids in cats.
Name one type of neoplasia that commonly affects the eyelids in cats.
The __________ produces the mucin portion of tears.
The __________ produces the mucin portion of tears.
Normal intraocular pressure (IOP) ranges from 5-15 mmHg.
Normal intraocular pressure (IOP) ranges from 5-15 mmHg.
What is goniodysgenesis?
What is goniodysgenesis?
Which layer of the cornea is 90% of its thickness?
Which layer of the cornea is 90% of its thickness?
Keratoconjunctivitis sicca is also known as dry eye disease.
Keratoconjunctivitis sicca is also known as dry eye disease.
The presence of __________ in the anterior chamber indicates anterior uveitis.
The presence of __________ in the anterior chamber indicates anterior uveitis.
Match the following conditions with their definitions:
Match the following conditions with their definitions:
What does SCC stand for in relation to eyelid neoplasia in cats?
What does SCC stand for in relation to eyelid neoplasia in cats?
Which of the following is NOT a symptom of anterior uveitis?
Which of the following is NOT a symptom of anterior uveitis?
The anterior layer of the tear film is known as the __________ layer.
The anterior layer of the tear film is known as the __________ layer.
Which abnormality is most associated with the merle gene in dogs?
Which abnormality is most associated with the merle gene in dogs?
Secondary glaucoma can occur due to uveitis.
Secondary glaucoma can occur due to uveitis.
What causes the iris to appear congested in cases of iritis?
What causes the iris to appear congested in cases of iritis?
The __________ is responsible for preventing the movement of proteins in the eye.
The __________ is responsible for preventing the movement of proteins in the eye.
What effect does chronic glaucoma have on the eye's structure?
What effect does chronic glaucoma have on the eye's structure?
Hyphema refers to the presence of proteins in the anterior chamber.
Hyphema refers to the presence of proteins in the anterior chamber.
What role do zonule fibers play in relation to the lens?
What role do zonule fibers play in relation to the lens?
Increased intraocular pressure can lead to __________ and permanent blindness.
Increased intraocular pressure can lead to __________ and permanent blindness.
In terms of lens diseases, what is nuclear sclerosis?
In terms of lens diseases, what is nuclear sclerosis?
Flashcards
Compact Bone
Compact Bone
The outer layer of bone, containing osteons which are the primary units. Known for its strength.
Cancellous Bone
Cancellous Bone
The inner layer of bone, containing trabeculae that form an irregular meshwork. It contains hematopoietic tissue and/or adipose tissue.
Woven Bone
Woven Bone
Immature bone tissue that's physiologically present in young animals and pathologically in adults.
Osteoblasts
Osteoblasts
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Osteoclasts
Osteoclasts
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Osteocytes
Osteocytes
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Periosteum
Periosteum
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Intramembranous Ossification
Intramembranous Ossification
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Endochondral Ossification
Endochondral Ossification
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Bone Infarction
Bone Infarction
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Sequestrum
Sequestrum
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Traumatic Fracture
Traumatic Fracture
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Pathologic Fracture
Pathologic Fracture
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Articular Fracture
Articular Fracture
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Avulsion Fracture
Avulsion Fracture
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Equine Rhodococcus Equi Infection
Equine Rhodococcus Equi Infection
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Metaphyseal Osteopathy
Metaphyseal Osteopathy
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Panosteitis
Panosteitis
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Necrosis of the Femoral Head
Necrosis of the Femoral Head
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Articular Cartilage
Articular Cartilage
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Synovial Membrane
Synovial Membrane
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Articular Cartilage Damage
Articular Cartilage Damage
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Supporting Bone Response to Injury
Supporting Bone Response to Injury
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Synovial Villous Hyperplasia
Synovial Villous Hyperplasia
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Pannus Formation
Pannus Formation
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Canine Osteosclerosis
Canine Osteosclerosis
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Caprine Arthritis Encephalitis
Caprine Arthritis Encephalitis
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Feline Limping Syndrome
Feline Limping Syndrome
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Poultry Viral Arthritis
Poultry Viral Arthritis
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Immune-mediated Polyarthritis (IMPA)
Immune-mediated Polyarthritis (IMPA)
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Degenerative Joint Disease (DJD, aka Osteoarthritis)
Degenerative Joint Disease (DJD, aka Osteoarthritis)
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Articular Gout
Articular Gout
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Bacterial Arthritis in Pigs
Bacterial Arthritis in Pigs
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Tenosynovitis
Tenosynovitis
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Goniodysgenesis
Goniodysgenesis
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Glaucoma
Glaucoma
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What is the normal IOP range?
What is the normal IOP range?
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What causes glaucoma?
What causes glaucoma?
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Primary Glaucoma
Primary Glaucoma
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Gonioscopy
Gonioscopy
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Blood Ocular Barrier
Blood Ocular Barrier
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Uveitis
Uveitis
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Anterior Uveitis
Anterior Uveitis
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Aqueous Flare
Aqueous Flare
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Miosis
Miosis
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Hypopyon
Hypopyon
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Hyphema
Hyphema
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Keratic Precipitates (KP)
Keratic Precipitates (KP)
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Rubeosis Iridis
Rubeosis Iridis
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Dermoid or Choristoma
Dermoid or Choristoma
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Blepharitis
Blepharitis
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Meibomitis
Meibomitis
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Chalazion
Chalazion
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Meibomian Gland Adenoma
Meibomian Gland Adenoma
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Conjunctivitis
Conjunctivitis
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Chemosis
Chemosis
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Cornea
Cornea
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Sclera
Sclera
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Limbus
Limbus
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Descemet's Membrane Detachment
Descemet's Membrane Detachment
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Ulcerative Keratitis
Ulcerative Keratitis
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Indolent Ulcer
Indolent Ulcer
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Infected Ulcer
Infected Ulcer
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Descemetocele
Descemetocele
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Pannus
Pannus
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Malignant Edema
Malignant Edema
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Thromboembolism-induced Muscle Necrosis
Thromboembolism-induced Muscle Necrosis
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External Pressure Muscle Injury
External Pressure Muscle Injury
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Internal Pressure Muscle Injury
Internal Pressure Muscle Injury
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Vitamin E/Selenium Deficiency Myopathy
Vitamin E/Selenium Deficiency Myopathy
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Selenium Deficiency in Horses
Selenium Deficiency in Horses
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Equine Motor Neuron Disease
Equine Motor Neuron Disease
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Vitamin E/Selenium Deficiency in Pigs
Vitamin E/Selenium Deficiency in Pigs
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White Muscle Disease in Pigs
White Muscle Disease in Pigs
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Mulberry Heart Disease
Mulberry Heart Disease
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Hepatosis Dietetica
Hepatosis Dietetica
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Plant-induced Toxic Myopathies
Plant-induced Toxic Myopathies
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Seasonal Pasture Myopathy in Horses
Seasonal Pasture Myopathy in Horses
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Ionophore-induced Myopathies
Ionophore-induced Myopathies
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Exertional Myopathy
Exertional Myopathy
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Genetic Myopathies
Genetic Myopathies
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Study Notes
Bone Pathology
- Anatomy & Response to Injury:
- Compact bone is the outer layer, cortical bone is the primary unit of lamellar bone.
- Cancellous bone is the inner cavity made of spongy bone with trabeculae. Woven bone (in immature animals) eventually progresses to lamellar bone. Abnormal woven bone in adults is pathological.
- Osteoblasts create new bone, forming osteoid (non-mineralized bone matrix).
- Osteoclasts break down bone. Osteocytes are living mature bone cells formed when osteoblasts are trapped within lacunae, and are involved in bone remodeling.
- Periosteum, a fibrous sheet covering bone, has two layers: an inner osteogenic layer which produces bone (intramembranous ossification) and a non-specific in response to injury (pathologically). Woven bone is replaced with bone in this process.
- Intramembranous ossification creates bone directly from osteoblasts, lacking cartilage precursors and is utilized for flat bones of skull.
- Endochondral ossification utilizes cartilage precursors to produce bone, increasing the length of long bones and vertebra.
- Young animals are more prone to joint infections due to capillary loop development within cartilage.
- Blood vessels supply the avascular cartilage in adults: nutrient, metaphyseal, periosteal, and epiphyseal.
Bone Injury: Fractures
- Infarction:
- Blood loss causes wedge shape pallor and necrosis.
- Sequestrum is the infected bone surrounded by viable bone, resulting from inflammation and an accumulation of purulent exudate, leading to pathologic fracture of diseased bone.
Bone Injury: Physeal Fractures
- Bone Healing: The primary contact healing through osteon system and cutting cones of osteoclasts, followed by secondary non-rigid fixation. Four phases: hematoma (2 weeks), granulation tissue to fibrocartilage soft callus (2-6 weeks), hard callus with osteoblast and osteoclast recruitment (6-8 weeks), and bone remodeling (months to years). Stability and close proximity of fracture ends is critical for healing (can result in pseudoarthrosis - false joint), as well as removal of necrotic fragments. Infection delays healing.
Non neoplastic bone proliferation
- Exostosis: Bone/cartilage growth on the outer surface of bone.
- Enostosis: Bone/cartilage growth on the inner surface of bone. Usually secondary to inflammation.
- Osteophyte: Growth of bone in the joint capsule margin, often seen in arthritis.
- Enthesophyte: Growth at tendon or ligament insertion site.
- Osteochondroma: A defect in skeletal development. Usually inherited. Multiple exostoses often seen in cartilage.
Hypertrophic Osteopathy
- Can transform into osteosarcoma/chondrosarcoma. Spreads from periosteal formation along diaphysis of long bone. Intrathoracic disease can be a factor, such as pulmonary carcinoma, which leads to altered vasovagal input with intrathoracic dz. Not an inherited disorder.
Growth Disorders and Retards
- Description and causes of specific growth retardations and arrest
Osteogenesis Imperfecta, Osteopetrosis, Osteosclerosis
- Description and causes of specific growth disorders and bone diseases.
Craniomandibular Osteopathy
- Autosomal recessive: Occurs in young dogs (4-7 months).
- Symptoms: Painful mastication affecting eating ability.
Chondrodysplasia
- Inherited defects: in endochondral ossification (in epiphyseal and metaphyseal regions).
Osteochondrosis
- Acquired defect in endochondral ossification: impaired vascular supply to physis, leading to necrosis & retained necrotic cartilage.
- Multiple factors: Large size, growth rate, diet (high copper) & genetic factors cause cartilage failure to mineralize and bone to replace it.
Cervical Vertebral Myelopathy
- Two forms: Static (narrowed spinal canal) and dynamic (instability). Congenital disorders in horses & dogs often have symptoms related to the narrowing of the spinal canal in the cervical region.
Epiphysiolysis
- Impaired endochondral ossification: causing weak epiphysis, and separation from metaphysis. Often seen in pigs, dogs, and cats. The affected animals may have other specific underlying diseases.
Metabolic and Growth Disorders: Bone Growth Disorders
- Primary physis and metaphyseal (injury/development): affects the growth of the bone.
- Vessels in beams allow osteoblasts to enter & remodel primary trabeculae to create secondary trabeculae.
Infectious Arthritis
- Route of entry: Hematogenous, extension of osteomyelitis, soft tissue extension, iatrogenic procedures, and direct penetrating injury.
- Some infections come from elsewhere in the body to the joint cavity.
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