Podcast
Questions and Answers
In the context of bone fracture healing, which statement best articulates the mechanistic divergence between primary and secondary bone healing?
In the context of bone fracture healing, which statement best articulates the mechanistic divergence between primary and secondary bone healing?
- Secondary bone healing is characterized by a complete absence of inflammatory and reparative phases, unlike primary bone healing which requires an initial inflammatory response.
- Primary bone healing achieves osseous consolidation via direct bone remodeling across the fracture line under conditions of rigid stabilization, contrasting with secondary bone healing, which involves callus formation under less rigid conditions. (correct)
- Primary bone healing necessitates callus formation as a precursor to bony union, while secondary bone healing preferentially proceeds through direct remodeling by osteoclasts and osteoblasts.
- Secondary bone healing depends on rigid stabilization to prevent callus formation, whereas primary bone healing relies on micromotion at the fracture site to stimulate callus development.
Which of the following fracture types is most likely to present with a high risk of infection, thereby necessitating surgical intervention to mitigate potential complications?
Which of the following fracture types is most likely to present with a high risk of infection, thereby necessitating surgical intervention to mitigate potential complications?
- An incomplete, greenstick fracture of the ulna, commonly observed in pediatric patients.
- A comminuted fracture of the femur, characterized by multiple bone fragments but with the skin intact.
- An open (compound) fracture of the radius, where the bone has breached the skin barrier. (correct)
- A closed, simple fracture of the tibia, resulting from a low-energy sports injury.
Given the complex interplay of mechanical forces and bone characteristics, which fracture type would be most indicative of potential child abuse, especially in pre-ambulatory children?
Given the complex interplay of mechanical forces and bone characteristics, which fracture type would be most indicative of potential child abuse, especially in pre-ambulatory children?
- A linear fracture of the humerus, consistent with a direct blow during contact sports.
- A spiral fracture of the tibia in a non-weight-bearing child, without a plausible accidental mechanism. (correct)
- A transverse fracture of the femur resulting from a fall from a significant height.
- An oblique fracture of the radius, sustained during a playground accident.
Considering the intricate process of bone remodeling, what cellular and molecular events critically determine the progression of bone strength after a fracture, distinguishing between primary and secondary bone healing?
Considering the intricate process of bone remodeling, what cellular and molecular events critically determine the progression of bone strength after a fracture, distinguishing between primary and secondary bone healing?
In evaluating a patient presenting with a pathologic fracture secondary to underlying metabolic derangement, which pre-existing condition would most dramatically alter bone's mechanical competence?
In evaluating a patient presenting with a pathologic fracture secondary to underlying metabolic derangement, which pre-existing condition would most dramatically alter bone's mechanical competence?
In the context of joint dislocations, which statement best encapsulates the biomechanical and neurovascular risks associated with a glenohumeral dislocation?
In the context of joint dislocations, which statement best encapsulates the biomechanical and neurovascular risks associated with a glenohumeral dislocation?
Given the complex interplay of forces and joint structures, which dislocation is most likely to result from forced abduction and present a heightened risk of avascular necrosis?
Given the complex interplay of forces and joint structures, which dislocation is most likely to result from forced abduction and present a heightened risk of avascular necrosis?
Considering the microstructural environment of tendons and ligaments, what key compositional variance critically influences their distinct functional attributes?
Considering the microstructural environment of tendons and ligaments, what key compositional variance critically influences their distinct functional attributes?
During the healing phase post-tendon or ligament rupture, what advanced therapeutic intervention is MOST critical in achieving optimal restoration?
During the healing phase post-tendon or ligament rupture, what advanced therapeutic intervention is MOST critical in achieving optimal restoration?
Considering the intricate cascade of pain signal transduction, what pharmacological intervention would MOST effectively target neuropathic pain arising from nerve compression due to a herniated disc?
Considering the intricate cascade of pain signal transduction, what pharmacological intervention would MOST effectively target neuropathic pain arising from nerve compression due to a herniated disc?
In the context of pain modulation, which neurophysiological mechanism accounts for the phenomenon of perceptual dominance?
In the context of pain modulation, which neurophysiological mechanism accounts for the phenomenon of perceptual dominance?
When developing a comprehensive, multimodal treatment regimen for chronic lower back pain (LBP), what critical consideration should guide the selection and sequencing of interventions to optimize patient outcomes?
When developing a comprehensive, multimodal treatment regimen for chronic lower back pain (LBP), what critical consideration should guide the selection and sequencing of interventions to optimize patient outcomes?
In a patient presenting with suspected primary osteoporosis, what specific bone quality parameters, beyond bone mineral density (BMD), would be most valuable in predicting fracture risk and guiding personalized treatment strategies?
In a patient presenting with suspected primary osteoporosis, what specific bone quality parameters, beyond bone mineral density (BMD), would be most valuable in predicting fracture risk and guiding personalized treatment strategies?
Given the complex interplay of hormonal regulation in bone metabolism, what specific intervention would selectively counteract increased osteoclast activity in postmenopausal osteoporosis?
Given the complex interplay of hormonal regulation in bone metabolism, what specific intervention would selectively counteract increased osteoclast activity in postmenopausal osteoporosis?
In the context of osteomalacia pathophysiology, what specific mechanism explains the generalized bone pain?
In the context of osteomalacia pathophysiology, what specific mechanism explains the generalized bone pain?
How do the pathophysiological mechanisms of calcipenic and phosphopenic rickets differ, and how would these differences manifest clinically and diagnostically?
How do the pathophysiological mechanisms of calcipenic and phosphopenic rickets differ, and how would these differences manifest clinically and diagnostically?
In a patient diagnosed with osteomyelitis, what advanced imaging modality would discriminate between sequestrum and involucrum formation, guiding surgical debridement?
In a patient diagnosed with osteomyelitis, what advanced imaging modality would discriminate between sequestrum and involucrum formation, guiding surgical debridement?
What factors are the most critical determinants in the pathogenesis of acute hematogenous osteomyelitis in children versus adults?
What factors are the most critical determinants in the pathogenesis of acute hematogenous osteomyelitis in children versus adults?
Given the heterogeneity of bone tumors what features serve to differentiate osteosarcoma from Ewing sarcoma in adolescents?
Given the heterogeneity of bone tumors what features serve to differentiate osteosarcoma from Ewing sarcoma in adolescents?
During the progressive stages of osteoarthritis (OA), what complex interplay of cellular and molecular events drives irreversible articular cartilage degradation and aberrant subchondral bone remodeling?
During the progressive stages of osteoarthritis (OA), what complex interplay of cellular and molecular events drives irreversible articular cartilage degradation and aberrant subchondral bone remodeling?
Considering the multifaceted pathophysiology of osteoarthritis, what therapeutic intervention is most effective to halt the progressive degradation of articular cartilage?
Considering the multifaceted pathophysiology of osteoarthritis, what therapeutic intervention is most effective to halt the progressive degradation of articular cartilage?
When approaching a patient presenting with suspected rheumatoid arthritis (RA), what serologic and inflammatory markers would provide the strongest evidence?
When approaching a patient presenting with suspected rheumatoid arthritis (RA), what serologic and inflammatory markers would provide the strongest evidence?
How is the mechanism of pannus formation related to joint destruction and the resulting physical manifestations in Rheumatoid Arthritis?
How is the mechanism of pannus formation related to joint destruction and the resulting physical manifestations in Rheumatoid Arthritis?
What pathophysiological event is directly responsible for acute inflammation and pain in gout?
What pathophysiological event is directly responsible for acute inflammation and pain in gout?
What distinguishes gout from pseudogout?
What distinguishes gout from pseudogout?
Given the significance of genetics in disorders such as gout and rheumatoid arthritis, what role does precision medicine play in the understanding of these conditions?
Given the significance of genetics in disorders such as gout and rheumatoid arthritis, what role does precision medicine play in the understanding of these conditions?
How does Long Covid (post-acute sequelae of COVID-19) most likely impact musculoskeletal system?
How does Long Covid (post-acute sequelae of COVID-19) most likely impact musculoskeletal system?
What is a good way to distinguish Long Covid (post-acute sequelae of COVID-19) and Lyme's.
What is a good way to distinguish Long Covid (post-acute sequelae of COVID-19) and Lyme's.
What features allow osteocytes to remain fully functioning?
What features allow osteocytes to remain fully functioning?
How does diabetes promote/impact arthritis?
How does diabetes promote/impact arthritis?
How do rheumatoid factors support joint dysfunction?
How do rheumatoid factors support joint dysfunction?
What can contribute to osteomalacia and vitamin D deficiency?
What can contribute to osteomalacia and vitamin D deficiency?
Where do infections deposit in osteomyelitis?
Where do infections deposit in osteomyelitis?
Rank the likelihood of infections in osteomyelitis?
Rank the likelihood of infections in osteomyelitis?
From Long Covid which of these is most common?
From Long Covid which of these is most common?
Which are bone tumor classification?
Which are bone tumor classification?
What is the hallmark of bone tumor aggression?
What is the hallmark of bone tumor aggression?
Considering the multifaceted nature of nociception, which statement best encapsulates the role of Aδ and C fibers in the transmission of pain signals from a peripheral injury site to the central nervous system?
Considering the multifaceted nature of nociception, which statement best encapsulates the role of Aδ and C fibers in the transmission of pain signals from a peripheral injury site to the central nervous system?
In the context of pain modulation, consider the complex interaction between descending inhibitory pathways and neurotransmitters. Which of the following statements best explains the role of endogenous opioids in reducing pain transmission?
In the context of pain modulation, consider the complex interaction between descending inhibitory pathways and neurotransmitters. Which of the following statements best explains the role of endogenous opioids in reducing pain transmission?
Given the interplay of mechanical forces and bone characteristics, which injury would most strongly suggest an underlying pathological condition affecting bone integrity, especially in the absence of significant trauma?
Given the interplay of mechanical forces and bone characteristics, which injury would most strongly suggest an underlying pathological condition affecting bone integrity, especially in the absence of significant trauma?
When considering fracture patterns in pediatric patients, which type is MOST indicative of non-accidental trauma, necessitating immediate safeguarding measures and a thorough investigation into the child's living environment?
When considering fracture patterns in pediatric patients, which type is MOST indicative of non-accidental trauma, necessitating immediate safeguarding measures and a thorough investigation into the child's living environment?
Within the context of articular cartilage degradation in osteoarthritis (OA), which of the following elements most intricately orchestrates the matrix metalloproteinase (MMP)-mediated breakdown of type II collagen, leading to irreversible joint damage?
Within the context of articular cartilage degradation in osteoarthritis (OA), which of the following elements most intricately orchestrates the matrix metalloproteinase (MMP)-mediated breakdown of type II collagen, leading to irreversible joint damage?
In scenarios of suspected primary hyperparathyroidism contributing to osteoporosis, what intervention most directly addresses the underlying pathophysiology of increased osteoclastic bone resorption, thus mitigating skeletal fragility?
In scenarios of suspected primary hyperparathyroidism contributing to osteoporosis, what intervention most directly addresses the underlying pathophysiology of increased osteoclastic bone resorption, thus mitigating skeletal fragility?
What specific pathomechanism is most immediately responsible for the diffuse bone pain experienced by individuals afflicted with osteomalacia, thereby distinguishing it from other metabolic bone disorders?
What specific pathomechanism is most immediately responsible for the diffuse bone pain experienced by individuals afflicted with osteomalacia, thereby distinguishing it from other metabolic bone disorders?
In contrasting the etiologies of calcipenic and phosphopenic rickets, which statement best captures the fundamental distinction in their respective pathophysiologies and downstream clinical or diagnostic ramifications?
In contrasting the etiologies of calcipenic and phosphopenic rickets, which statement best captures the fundamental distinction in their respective pathophysiologies and downstream clinical or diagnostic ramifications?
To optimally differentiate between a sequestrum and involucrum in osteomyelitis, which imaging modality should be employed to provide the highest resolution to observe the vascular supply to guide surgical planning?
To optimally differentiate between a sequestrum and involucrum in osteomyelitis, which imaging modality should be employed to provide the highest resolution to observe the vascular supply to guide surgical planning?
Concerning the pathogenesis of acute hematogenous osteomyelitis, what delineates the most critical difference influencing the infectious pathway between pediatric and adult populations?
Concerning the pathogenesis of acute hematogenous osteomyelitis, what delineates the most critical difference influencing the infectious pathway between pediatric and adult populations?
How might precision medicine improve the understanding of genetics in the pathology of disorders like rheumatoid arthritis (RA) and gout?
How might precision medicine improve the understanding of genetics in the pathology of disorders like rheumatoid arthritis (RA) and gout?
Considering the intricate balance of osteoblastic and osteoclastic activity, which of the following best describes the effect of estrogen on bone homeostasis in postmenopausal women?
Considering the intricate balance of osteoblastic and osteoclastic activity, which of the following best describes the effect of estrogen on bone homeostasis in postmenopausal women?
In the context of hip dislocations, especially those resulting from high-energy trauma, which vascular structure is MOST vulnerable to injury?
In the context of hip dislocations, especially those resulting from high-energy trauma, which vascular structure is MOST vulnerable to injury?
What cellular mechanism explains the primary difference between bone spurs of osteoarthritis and bone formation in osteomalacia?
What cellular mechanism explains the primary difference between bone spurs of osteoarthritis and bone formation in osteomalacia?
What are the diagnostic criteria that are used to differentiate osteosarcoma from Ewing sarcoma in adolescents?
What are the diagnostic criteria that are used to differentiate osteosarcoma from Ewing sarcoma in adolescents?
Flashcards
Complete Fracture
Complete Fracture
Bone is broken entirely into two or more separate pieces.
Incomplete Fracture
Incomplete Fracture
Partial bone damage due to bending or lower-impact force.
Open (Compound) Fracture
Open (Compound) Fracture
Bone breaks through the skin, increasing infection risk.
Closed (Simple) Fracture
Closed (Simple) Fracture
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Comminuted Fracture
Comminuted Fracture
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Linear Fracture
Linear Fracture
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Oblique Fracture
Oblique Fracture
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Spiral Fracture
Spiral Fracture
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Transverse Fracture
Transverse Fracture
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Greenstick Fracture
Greenstick Fracture
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Torus (Buckle) Fracture
Torus (Buckle) Fracture
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Bowing Fracture
Bowing Fracture
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Pathologic Fracture
Pathologic Fracture
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Stress Fracture
Stress Fracture
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Fatigue Fracture
Fatigue Fracture
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Transchondral Fracture
Transchondral Fracture
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Primary (Direct) Bone Healing
Primary (Direct) Bone Healing
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Secondary (Indirect) Bone Healing
Secondary (Indirect) Bone Healing
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Hematoma Formation
Hematoma Formation
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Procallus Formation
Procallus Formation
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Knee Dislocation
Knee Dislocation
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Elbow Dislocation (Adults)
Elbow Dislocation (Adults)
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Pain Sign of Dislocation
Pain Sign of Dislocation
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Joint Deformity
Joint Deformity
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Limited range of motion
Limited range of motion
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Tendon
Tendon
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Ligament
Ligament
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Strain
Strain
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Sprain
Sprain
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Proper Healing for tendon
Proper Healing for tendon
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Substance P
Substance P
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Enkephalins
Enkephalins
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Excitatory Neurotransmitters
Excitatory Neurotransmitters
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Gamma-Aminobutyric Acid (GABA)
Gamma-Aminobutyric Acid (GABA)
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Nociceptors
Nociceptors
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Aδ fibers
Aδ fibers
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Perceptual Dominance
Perceptual Dominance
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Acute Pain
Acute Pain
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Chronic Pain
Chronic Pain
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Referred Pain
Referred Pain
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Pain Mechanisms
Pain Mechanisms
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Degenerative Changes
Degenerative Changes
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Bone Mineral Density
Bone Mineral Density
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Estrogen Deficiency
Estrogen Deficiency
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OPG-Osteoprotegerin
OPG-Osteoprotegerin
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Osteosarcoma
Osteosarcoma
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Tumor
Tumor
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Moth-eaten bone destruction
Moth-eaten bone destruction
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Chondroma
Chondroma
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Fibrosarcoma
Fibrosarcoma
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Giant Cell Tumor
Giant Cell Tumor
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Slow cortical erosion
Slow cortical erosion
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Ewing Sarcoma
Ewing Sarcoma
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Exogenous Osteomyelitis
Exogenous Osteomyelitis
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Endogenous Osteomyelitis
Endogenous Osteomyelitis
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Joint Effusion
Joint Effusion
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Study Notes
Fracture Types
- Complete fractures involve a bone broken entirely into two or more separate pieces, potentially needing surgery or immobilization based on severity.
- Incomplete fractures cause partial bone damage, are often due to bending or low impact, and are more common in children because their bones are more flexible; they usually heal well with immobilization.
- Open (Compound) fractures occur with high-energy trauma which results in the bone breaking through the skin, which increases infection risk and typically requires surgical intervention.
- Closed (Simple) fractures involve bone breaks that do not puncture the skin, often treated with casting or splinting, and are usually moderately difficult to treat.
- Comminuted fractures result from severe trauma causing the bone to shatter into three or more pieces, a high difficulty injury often requiring surgery and hardware for fixation, and frequently occur in the elderly.
- Linear fractures result from direct impact parallel to the bone axis which are often moderate in severity, and may heal with immobilization, more common in people of all ages.
- Oblique fractures are a result of slanted force applied to the bone and often occur at an angle to the bone shaft which may need surgical fixation.
- Spiral fractures are due to twisting force on the bone, often encircling it, and are difficult to treat due to misalignment, frequently requiring surgery, and more common in children and athletes.
- Transverse fractures are caused by direct impact perpendicular to the bone, running straight across at a 90-degree angle and requires surgical stabilization to treat.
- Greenstick fractures happen due to bending force on soft bones, breaking one side while bending the other with treatment involving use of a cast.
- Torus (Buckle) fractures are due to compressive force causing buckling of the bone cortex without a complete break, a condition typically seen in children resolving with immobilization.
Other Fracture Considerations
- Bowing Fracture: Longitudinal force is the cause, with one bone bending the other fracturing completely, more common in children.
- Pathologic Fracture: Occurs secondary to disease weakening it and can lead to angular deformity, painless swelling, or generalized bone pain.
- Stress Fracture: Repetitive strain from activity causes small cracks, more common in athletes, runners or any person doing repetitive physical activities.
- Fatigue Fracture: Overuse leading to microfractures, and requires activity modification.
- Transchondral Fracture: Repetitive microtrauma or sudden force that damages cartilage, and depending on where the injury is the treatment ranges from easy to difficult.
General Info on Fractures
- Fractures of healthy bones, especially the tibia, clavicle, and lower humerus, usually occur in young people as a result of trauma.
- Fractures of hand and foot bones are often caused by accidents in the workplace
- Fractures of the upper femur, upper humerus, vertebrae, and pelvis occur more frequently in older adults and are often linked to osteoporosis.
- Hip fractures, the most serious result of osteoporosis, exhibit significant geographical variations.
- Stress fractures are painful due to increased remodeling; initially pain only occurs during activity and is usually relieved by rest and soft tissue swelling.
- Transchondral fractures may be asymptomatic, or painful during movement.
Types of Bone Healing
-
Primary bone healing occurs when fracture ends are stabilized
-
Secondary bone healing occurs when there is movement at the fracture sites.
Primary Direct Bone Healing
- Bone heals direct remodeling
- Requires rigid stabilization like surgical fixation
- has no callus formation
- and is generally faster
Secondary Indirect Bone Healing
- Bone goes through inflammatory, reparative and remodeling phases
- Can use non-rigid fixation like casting
- Involves callus formation
- Takes longer to heal
Bone Healing Process Flowchart
- Bones break, disrupting the periosteum, blood vessels, and surrounding soft tissues resulting in damaged bone ends that bleed into nearby soft tissue
- A blood clot forms creating a hematoma in between fractured ends and beneath the periosteum
- Dead tissue and debris trigger inflammation with vasodilation, plasma exudation, and infiltration of leukocytes.
- New blood vessels from soft tissue and marrow invade the area increasing blood flow
- Bone cells are activated and procallus forms along bone shaft and covers fractures
- Subperiosteal procallus forms along the bone's outer surface.
- The matrix mineralizes and hard callus forms as osteoblasts synthesize collagen and matrix in procallus.
- The unnecessary callus is resorbed while creating new areas of stress.
Types of Joint Dislocations
- Shoulder (Glenohumeral Joint) causes glenohumeral dislocation resulting from general trauma with the shoulder being the most dislocated joint in the body
- Elbow (Radial Head), pulling on the hand or forearm the radial head can slip out, also known as "nursemaid's elbow"
- Elbow dislocation can be traumatic with broken bones commonly occurring, and the ulna or radial head bones can get dislocated in the joint
- Wrist, falling on a hyper extended hand causes dislocation of carpal bones
- Hand dislocation occurs due to hyperextension, is common in contact sports
- Hip are posterior from car accidents
- Hip anterior occurs from forced abduction rare in healthy individuals from falling from high altitudes
- Knee dislocations are unstable joints of various types such as anterior, posterior, medial, lateral, and rotary caused by hyperextension
Other disclocation information
- Shoulder dislocations may damage the capsule and nerves
- Nerve damage can disrupt the nerve sensory and paralyze deltoid muscle
- Disrupting circulation can lead to ischemia and permanent disability
- In hip can cause avascular necrosis of the femoral head
General Signs and Symptoms of Dislocation
- Pain from inflammatory
- Swelling due to joint deformity and muscle contractions
- Limited range of motion and broken bones
Dislocations - Symptoms and Limitations
- Shoulder dislocation happens with severe arm pain and limits its movement.
- Elbow dislocation in kids limits pain at rest but hurts to move the arm
- Adult Elbow dislocation also causes severe arm pain and resistance to movement, and can also cause joint deformity
- Wrist dislocation causes lots of pain and inhibits bearing any weight
- Painful finger dislocation
- Car accidents causing pain and in the thigh or inguinal region causing immobility, resulting in the leg appearing shortened
- Anterior hip has lots of pain and you cant move or rotate flexing the leg
- Various knee dislocations also cause pain and immobility
General Information for Ligaments and Tendons
- Tendons- muscles to bones enabling movement
- Ligaments- connect bone to joint
- Injuries to tendon or ligaments include sprains, strains and ruptures
- Ligaments are in knee elbow and ankle for stability
- Tendons are throughout body handling lots of movement like the achilles tendon
General Tendon Notes
- Tendon is muscle to bone
- Ligaments are bone to bone - Their difference is in function not structure
- Sprains are ligament injury with stretching and tearing
- wrist ankle elbow and knee commonly injured
- Avulsion injuries separate soft tissues from attachment is sports
- Strains are in tendons and ruptures with stretching and tearing
- hands feet knee and arm are usually injured
- Injuries can be due to heavy strain trauma
- Also can be from arthritis, lupus or injections, antibiotics
Strains
- First degree - fibers are stretched and functional with a stable joint
- Second degree - partial tearing occurs with muscle contraction
- Third degree - theres improper contraction because the muscle is completely torn
Healing
- Torn area with bleeding
- Formation with collagen in ligaments over 3-4 days
- Muscle tissues align with collagen that interweaves
- Collagen fibres attach and connect to the bones restoring joints
- Injuries are also more susceptible to joint dislocations
Other joint injuries
- commonly seen in finger and elbow sprains with the inability to function
- the injuries limit mobility and cause lots of pain
The step by step for pain transmission
- Noxious stimulus activates pain receptors that convert to electrical signals
- these receptors cause a response using stimuli
- signals travel through spinal cord to neurons through brain using Ad fibers with well localized fast pain
- slow transmissions are through unmyelinated C fibers which transmit slow pain
- Spinothalamic tracts carry this signal through brain which sends signals to cerebral cortex to control the location of pain
- pain is understood with 3 systems
- sensoring which uses the somatosensory cortex to identify
- affective- motivational is limbic feeling and the brainstem
- cognitive is modified experience which modify thoughts
- all of this information gets enhanced and suppressed as well and transmitted using enkephalins, endorphins
Role for pain modulation
- The body regulates pain using signals that is regulated using a pain threshold with neuromodulator which gets raised using certain actions like exercising and such
- Different methods of inhibitory for the body is to increase and decrease pain by releasing chemicals like prostaglandins histamines
Pain Modulations
- Are by means of chemical modulators like releasing chemicals that increase pain
- Other factors like endorphins also affect this
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