Body Systems and Regional Anatomy Overview

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Questions and Answers

Which germ layer is responsible for forming the nervous system?

  • Mesoderm
  • Neural crest
  • Endoderm
  • Ectoderm (correct)

What critical process begins on day 20 of embryonic development?

  • Neurulation (correct)
  • Gastrulation
  • Organogenesis
  • Implantation

What is the function of the notochord during neural tube formation?

  • Instructs the development of the neural crest
  • Directs the formation of the cranial neuropore
  • Facilitates the closure of the neural folds
  • Acts as an organizer for the neural tube's lower half (correct)

During which stage of embryonic development do primary brain vesicles differentiate into secondary brain vesicles?

<p>Organogenesis (D)</p> Signup and view all the answers

What cell type gives rise to peripheral nervous system structures during development?

<p>Neural crest cells (B)</p> Signup and view all the answers

Which of the following factors can contribute to bone-joint inflammation?

<p>Mechanical imbalances (B)</p> Signup and view all the answers

What is the main purpose of fixation in tissue processing?

<p>To preserve structural integrity (C)</p> Signup and view all the answers

In the context of vertebrates, how does the length of distal limb segments affect locomotion?

<p>Longer segments cover more distance with the same energy. (B)</p> Signup and view all the answers

What is histology primarily concerned with?

<p>Study of body cells and tissue organization (B)</p> Signup and view all the answers

Which of the following step is NOT part of the tissue processing procedure?

<p>Modelling (A)</p> Signup and view all the answers

What adaptation do jumping animals have in their lower limbs for improved locomotion?

<p>Larger feet and highly flexed limbs (D)</p> Signup and view all the answers

Why would a species with a long-distance locomotion strategy typically have reduced digits?

<p>To reduce energy required during movement (A)</p> Signup and view all the answers

What is the primary focus of pathology as compared to histology?

<p>Examining diseased tissues (C)</p> Signup and view all the answers

What are tendons primarily responsible for?

<p>Attaching muscles to bones (C)</p> Signup and view all the answers

Which type of muscle shape is characterized by fibers that insert at an angle to the tendon?

<p>Pennate (D)</p> Signup and view all the answers

Which of the following is NOT a factor contributing to issues like muscular overuse or trauma?

<p>Proper biomechanics (C)</p> Signup and view all the answers

What distinguishes intrinsic muscles from extrinsic muscles?

<p>Intrinsic muscles have attachments entirely within one area of the body (C)</p> Signup and view all the answers

What type of connective tissue is the periosteum composed of?

<p>Dense irregular connective tissue (C)</p> Signup and view all the answers

How do Sharpey’s fibers function in the skeletal system?

<p>They embed collagen fibers into the bone matrix (A)</p> Signup and view all the answers

What is a key characteristic of fusiform muscle shape?

<p>Spindle-shaped with fibers running parallel (D)</p> Signup and view all the answers

What are the main functions of ligaments in the body?

<p>Connect bones to bones (A)</p> Signup and view all the answers

What type of muscle shape is described as having broad and narrow attachments?

<p>Convergent (A)</p> Signup and view all the answers

Which of these factors is not mentioned as a mechanical advantage of joints?

<p>Flexibility (D)</p> Signup and view all the answers

What is the purpose of adding growth factors to stem cells in neural studies?

<p>To initiate the proliferation and differentiation into neurons (C)</p> Signup and view all the answers

What describes the term 'contralateral' in relation to body structures?

<p>Structures compared on opposite sides of the body (D)</p> Signup and view all the answers

Which of the following characteristics best describes arteries?

<p>Firm, elastic, and thick muscular walls (A)</p> Signup and view all the answers

What developmental aspect can be studied through dorsal patterning?

<p>Sensory neuron and motor neuron development (C)</p> Signup and view all the answers

What is the primary role of signaling pathways in neural differentiation?

<p>To facilitate cell migration and communication (B)</p> Signup and view all the answers

Which of the following best describes the brain's physical characteristics?

<p>Structured like a wrinkled walnut with a consistency similar to jelly (A)</p> Signup and view all the answers

Which of these statements accurately defines 'ipsilateral'?

<p>Comparison of two structures on the same side of the body (B)</p> Signup and view all the answers

What unique features does the gallbladder exhibit?

<p>Small and green, resembling a deflated balloon or small pear (C)</p> Signup and view all the answers

What distinguishes embryonic stem cells from adult stem cells?

<p>Embryonic stem cells are pluripotent while adult stem cells are multipotent. (B)</p> Signup and view all the answers

Which of the following best describes progenitor cells?

<p>They are less mature cells that can differentiate or replicate. (B)</p> Signup and view all the answers

What is the role of growth factors in cell identity?

<p>They stimulate differentiation and proliferation of cells. (D)</p> Signup and view all the answers

What is the significance of molecular markers in cell identification?

<p>They reflect the molecular identity of the cell through proteins and genes. (B)</p> Signup and view all the answers

Which type of stem cell is induced pluripotent?

<p>Somatic body cells that are genetically reprogrammed. (B)</p> Signup and view all the answers

What is a characteristic of blood stem cells?

<p>They can turn into multipotent cell types and form various blood components. (A)</p> Signup and view all the answers

What is a key limitation of identifying cell types solely based on phenotype?

<p>Different cell types can exhibit very similar appearances. (C)</p> Signup and view all the answers

What is the first stage of the zygote's development process?

<p>Zygote cleavage (B)</p> Signup and view all the answers

Which statement correctly describes terminally differentiated cells?

<p>They cannot differentiate into any other cell types. (A)</p> Signup and view all the answers

What structure surrounds the zygote and plays a protective role?

<p>Zona pellucida (B)</p> Signup and view all the answers

Which hormone is primarily responsible for preparing the uterus for embryo implantation?

<p>Progesterone (C)</p> Signup and view all the answers

What is the primary purpose of the trophoblast cells during early pregnancy?

<p>To invade the uterine wall and form the placenta (B)</p> Signup and view all the answers

At what stage do the cell populations of the inner cell mass begin to segregate?

<p>Blastocyst stage (A)</p> Signup and view all the answers

Which layer of the bilaminar disc forms the embryo?

<p>Primitive ectoderm (Epiblast) (A)</p> Signup and view all the answers

Which process begins with the formation of the primitive streak?

<p>Gastrulation (A)</p> Signup and view all the answers

What does the inner cell mass of the blastocyst differentiate into?

<p>Embryo and supportive tissues (A)</p> Signup and view all the answers

When does the embryo typically implant into the uterine wall?

<p>Day 6/7 (C)</p> Signup and view all the answers

What type of cells do hypoblasts ultimately differentiate into?

<p>Multipotent cells (B)</p> Signup and view all the answers

Flashcards

Bone-joint inflammation factors

Bone-joint inflammation is caused by imbalanced joint tissue repair/destruction/remodelling, mechanical factors, and metabolic factors.

Human teeth

Human teeth are unspecialized.

Bony pelvis

The bony pelvis is composed of hip bones and the sacrum.

Lower limb similarities

Across different species, the lower limbs are generally used for locomotion.

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Quadrupedal mammals & lower limbs

In quadrupedal mammals, weight-bearing typically occurs on the lower limbs.

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Distal limb segments & distance covered

Increasing the length of distal limb segments increases the distance covered by a stride while running.

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Histology

Histology is the study of the body's cells and tissues, and how tissues are organised into organs.

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Histology vs. Pathology

Histology studies healthy tissues, while pathology studies abnormal or diseased tissues.

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Specimen Acquisition

The first step in tissue processing, involving obtaining fresh tissue.

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Tissue Fixation

Tissue fixation preserves the structure of the tissue.

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Tissue dehydration

Tissue dehydration removes water from the tissue.

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Skeletal Muscle Attachment

Muscles attach to bones using tendons or aponeuroses. Contraction brings the attachment points closer together.

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Tendon vs. Ligament

Tendons connect muscles to bones, whereas ligaments connect bones to bones. They're both fibrous tissues, but tendons allow movement and ligaments stabilize joints.

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Intrinsic Muscle

A muscle whose attachments are entirely within the same region of the body.

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Extrinsic Muscle

A muscle with one attachment point is within one area of the body, the other is in a different area.

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Muscle Shape: Pennate

Feather-like muscle fibers that attach to a tendon at an angle, increasing the number of fibers that can be packed into a given space.

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Muscle Shape: Fusiform

Spindle-shaped muscle with a wider belly and tapered ends; allows for greater contraction.

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Muscle Shape: Convergent

Muscle with a broad origin and a narrow insertion; allows for varied contraction direction and a strong pull.

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Muscle Shape: Circular

Muscle fibers arranged in concentric circles forming a sphincter around an opening.

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Muscle Shape: Multiheaded/Multibellied

Muscles with multiple heads (origins) or multiple bellies (muscle segments).

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Sharpey's Fibers

Collagen fibers that connect tendons and ligaments to bone, embedding into the periosteum.

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Muscle Overuse

Repetitive stress or excessive use of a muscle leading to injury.

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Oocyte

The female gamete, a haploid cell containing 23 chromosomes, released from the ovaries.

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Fertilization

The process where a sperm unites with an oocyte, forming a zygote.

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Zygote

A single cell formed after fertilization, containing a diploid set of 46 chromosomes (one set from each parent).

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Zona Pellucida

A protective layer surrounding the zygote, crucial for early development and preventing polyspermy (multiple sperm fertilizing the egg).

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Cleavage

A series of rapid mitotic divisions the zygote undergoes while traveling down the fallopian tube.

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Morula

A solid ball of cells formed during embryonic development (16-32 cells), resulting from the cleavage process.

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Blastocyst

A hollow ball of cells formed from the morula, consisting of the inner cell mass and trophoblast.

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Inner Cell Mass (ICM)

The inner group of cells within the blastocyst, which will give rise to the embryo and its supporting tissues (e.g., yolk sac).

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Trophoblast

The outer layer of cells in the blastocyst, that will form the placenta and other extra-embryonic tissues.

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Implantation

The process where the blastocyst embeds itself into the uterine wall.

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Gastrulation

The process forming the three primary germ layers (ectoderm, mesoderm, endoderm) from the blastula's inner cell mass.

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Germ Layers

The three primary layers – ectoderm, mesoderm, and endoderm – formed during gastrulation, that give rise to all tissues of the body.

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Placenta

A temporary organ that develops during pregnancy and provides nutrients and oxygen to the growing fetus.

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Ectoderm function

Forms the nervous system, skin, hair, and nails during embryonic development.

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Mesoderm function

Creates bone, blood vessels, blood, heart, and muscles in embryos.

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Endoderm function

Develops into the epithelial lining of glands, respiratory, and GI tracts.

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Embryonic left-right axis

Established by cells in the node, creating a directional pattern in the embryo.

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Primitive node/pit

A cluster of cells with cilia (hair-like structures) that rotate the embryo, setting the left-right axis.

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Neurulation

The process where the neural plate folds into a neural tube, forming the central nervous system.

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Neural tube formation steps

Ectoderm thickens, folds, closes creating the hollow neural tube - precursor to CNS.

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Notochord

A signaling structure that influences development of the bottom half of the neural tube.

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Neural crest cells

Form the peripheral nervous system and other structures like melanocytes (skin pigment).

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Brain vesicles

Primary vesicles formed during development, differentiate to secondary brain vesicles.

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Somatic cells

Highly specialized body cells.

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Progenitor cells

Less mature cells that can differentiate and replicate.

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Differentiation

The process of a cell changing into another cell type.

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Stem cells

Undifferentiated cells that can turn into many different cell types.

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Potency

Ability of a cell to differentiate into different cell types.

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Pluripotent cells

Cells with the ability to differentiate into almost any cell type.

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Embryonic stem cells

Stem cells derived from the inner cell mass of a blastocyst.

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Adult stem cells

Stem cells found in developed organs.

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Induced pluripotent stem cells

Somatic cells reprogrammed to be pluripotent.

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Multipotent cells

Cells that can differentiate into a limited number of cell types.

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Blood stem cells

Stem cells that differentiate into various blood components.

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Growth factors

Molecules stimulating cell differentiation and proliferation.

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Molecular Markers

Proteins and genes that identify cell types.

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Stem cell differentiation to neurons

Adding growth factors to stem cells can transform them into neurons.

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Neural plate differentiation

The neural plate develops into definitive ectoderm, proliferating and forming layers.

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Growth factors in stem cells

Adding specific growth factors to stem cells influences cell proliferation and differentiation.

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Signaling pathways in development

Understanding how cells communicate to guide migration, proliferation, and differentiation in development.

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Nervous system patterning

The development of specific structures and arrangements in the nervous system, using growth factors in development.

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Sensory neuron development

Growth factors can induce the development of sensory neurons from a source structure in the nervous system.

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Motor neuron development

Growth factors can induce the development of motor neurons from a source structure in the nervous system.

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Bilateral structure

Paired structures on either side of the body.

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Unilateral structure

Structure present on only one side of the body.

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Ipsilateral structures

Two structures on the same side of the body.

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Contralateral structures

Two structures on opposite sides of the body.

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Heart description

Approximately the size of a large apple or fist, pear-shaped, marbled texture.

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Brain description

Wrinkled walnut-like appearance, soft pinkish cauliflower consistency.

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Lung description

Spongy balloon-like, pinkish-grey, branching bronchial tree.

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Stomach description

Deflated balloon, bagpipe, or soft wrinkled leather pouch.

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Kidney description

Bean-shaped, similar size to a smartphone, rubbery consistency.

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Large intestine description

Long bumpy tube, like a coiled hose, or a horseshoe shape.

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Small intestine description

Long, tightly coiled hose, like a bundle of cooked spaghetti.

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Pancreas description

Lumpy banana shape, fish fillet (wider head, narrow tail), like a long pine cone.

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Gallbladder description

Small green pear-like, or deflated balloon.

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Artery description

Firm, elastic, thick-walled, larger than veins and nerves, often red.

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Study Notes

Summary of Body Systems

  • The body has eleven major systems working together for overall function
  • Integumentary, Muscular, Skeletal, Nervous, Cardiovascular, Endocrine, Lymphatic, Respiratory, Digestive, Urinary, and Reproductive systems
  • Each system has a specific role in maintaining overall health and function
  • Some systems work together closely, like muscular and skeletal
  • Other systems have less interaction, but still contribute to the whole body

Summary of Regional Anatomy

  • Structures located together within a defined region of the body are studied under regional anatomy
  • The body has distinct cavities, e.g. cranial, thoracic, abdominal, pelvic cavities
  • Each region contains different organs and structures, all working in coordinated function
  • Structures in one region don't always directly affect others
  • It's difficult in many areas to separate the structural function of one region from another

Summary of Viscera

  • Viscera means 'internal organ'
  • Viscera typically protected by superficial bone, muscles, or fat.
  • They may be hollow or solid paired or unpaired
  • Viscera function in a variety of ways
  • They are vital for maintaining life in many cases

Summary of Forensic Lecture

  • Forensic workers (coroners, pathologists, dentists, anthropologists, mortuary technicians, radiographers, and social workers) have specific roles to identify, study and preserve bodies for further investigation.
  • Biological profiling, using characteristics such as ancestry, sex, and age, which help determine the identity and circumstances of a body
  • Accurate estimation of postmortem intervals (PMIs) is vital in many forensic cases

Summary of Histology and Pathology

  • Histology is the study of normal body tissues
  • Pathology is the study of abnormal/diseased tissues
  • Histology focuses on cell and tissue design
  • Methods developed to achieve this include specimen acquisition and preparation

Summary of Joints

  • Joints are where bones meet
  • Fibrous joints are held in place by connective tissue, little to no movement.
  • Cartilaginous joints are connected by cartilage (hyaline or fibrocartilage), slight movement.
  • Synovial joints are freely movable, containing a joint capsule and fluid.
  • Osteoarthritis is a joint inflammation that occurs due to imbalanced joint tissue. This can be caused by several factors: mechanical, inflammatory, or metabolic.

Summary of Bone Classification and Function

  • Bone types are based on shape, size and location in the body
  • Bone types include long, short, flat and irregular
  • Bone function includes support, protection, movement, and production of blood cells.
  • Various bone features, like crests, foramens, fossae and tuberculosities, serve different purposes, e.g. muscle attachment.
  • Axial skeleton bones form the axis of the body
  • Appendicular skeleton bones aid in movement

Summary of Muscles

  • Muscles enable movement in the body
  • Various types of muscles, including flat, parallel, fusiform, convergent, unipennate, bipennate, and multipennate exist due to their varied functions and locations.
  • Understanding muscle location within the body is important for understanding function
  • Intrinsic muscles are where attachments are entirely within the area
  • Extrinsic muscles cross a joint to cause movement.

Summary of Nerves

  • Nerves enable communication between the brain and the body.
  • Nerves transmit signals between body and brain.
  • The nervous system can be classified according to region; -e.g. peripheral nervous system
  • The nervous system transmits messages
  • Nerves vary in shape or appearance depending on their location and function.

Summary of Comparative Anatomy

  • Studying similarities and differences between different species, especially in relation to their anatomy and behaviour
  • Understanding bone types, teeth structure and body architecture in relation to their function (e.g. in different animals), as well as implications for humans
  • Understanding bone-related systems like the hip bone and pelvis

Summary of Embryonic Development

  • Fertilization involves the fusion of a sperm and egg.
  • Embryonic implantation is the embedding of the embryo into the uterine wall during implantation
  • Different stages exist from fertilization to eventual development of the embryo and fetus.
  • Stages include: Zygote, Blastocyst, Gastrulation, Neurulation.
  • Different stages and factors effect development of offspring
  • Various cell signals including autocrine, paracrine and hormonal signaling also directly affect growth, differentiation and patterning.

Summary of Stem Cells

  • Stem cells are undifferentiated cells capable of developing into other cell types
  • Embryonic stem cells are derived from the early embryo, pluripotent
  • Adult stem cells are found in various tissues throughout the body, multipotent
  • Stem cells are currently used for research in understanding and treating diseases and the overall development process.

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