Body Compartments Quiz

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Questions and Answers

In the one-compartment open model, what does the plot of drug concentration (C) versus time (t) look like on a linear paper?

  • Exponential
  • Logarithmic
  • Linear
  • Curvelinear (correct)

What is the unit of the elimination rate constant (Ke)?

  • mg/min
  • mg/L
  • min^-1 (correct)
  • L/min

What does a linear plot of drug concentration (C) versus time (t) on a semi-log paper indicate?

  • Logarithmic decay
  • Exponential growth
  • Logarithmic growth
  • Exponential decay (correct)

What characterizes the elimination phase in the one-compartment open model?

<p>Three parameters (B)</p> Signup and view all the answers

What happens to the drug concentration in plasma during intravenous (IV) infusion at a zero-order rate?

<p>Reaches a plateau or steady state level (A)</p> Signup and view all the answers

What is the time required to reach steady-state drug concentration in the blood primarily dependent on in the one-compartment open model?

<p>Elimination half-life (B)</p> Signup and view all the answers

What happens to the time needed to reach steady state if a higher infusion rate is used in the one-compartment open model?

<p>Remains the same (C)</p> Signup and view all the answers

What occurs when the rate of infusion equals the rate of elimination during IV infusion?

<p>Concentration of drug in plasma approaches a constant value (A)</p> Signup and view all the answers

What happens to the amount of drug in the body when a constant rate of infusion is started and there is no elimination?

<p>Rises gradually (A)</p> Signup and view all the answers

What is the primary advantage of giving a drug by intravenous infusion at a zero-order rate?

<p>Prevents fluctuating peak and valley blood levels (B)</p> Signup and view all the answers

What is the time required to reach steady-state drug concentration in the blood if the rate of infusion is increased?

<p>Remains the same (A)</p> Signup and view all the answers

What does the plateau level during IV infusion at a constant rate indicate?

<p>Steady-state concentration (A)</p> Signup and view all the answers

What is a compartment in the context of body composition?

<p>A tissue or group of tissues with similar blood flow and drug affinity (B)</p> Signup and view all the answers

What does the simplest model predict the body as?

<p>A single, kinetically homogenous unit with no barriers to movement of drug (C)</p> Signup and view all the answers

What does the one compartment open model assume about changes in plasma levels of a drug?

<p>They reflect proportional changes in tissue drug levels (D)</p> Signup and view all the answers

What does 'open' reflect in the one compartment open model?

<p>Absorption and elimination are unidirectional (C)</p> Signup and view all the answers

In the context of various one compartment open models, what does 'intravenous adm' stand for?

<p>Intravenous administration (D)</p> Signup and view all the answers

What is the main characteristic of a compartment in the body?

<p>Tissue or group of tissues with similar blood flow and drug affinity (A)</p> Signup and view all the answers

What is the key feature of the simplest model for body composition?

<p>No barriers to movement of drug (B)</p> Signup and view all the answers

What is the assumption of the one compartment open model about drug concentration in plasma and other body tissues?

<p>They are not equal (A)</p> Signup and view all the answers

What does 'open' imply in the one compartment open model?

<p>Unidirectional absorption and elimination (B)</p> Signup and view all the answers

What is the meaning of 'intravenous adm' in the context of various one compartment open models?

<p>Intravenous administration (C)</p> Signup and view all the answers

Which statement best describes a compartment in the body?

<p>A tissue or group of tissues with similar blood flow and drug affinity (C)</p> Signup and view all the answers

What is the primary implication of the simplest model for body composition?

<p>No barriers to movement of drug (C)</p> Signup and view all the answers

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