Body Compartments Quiz
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Questions and Answers

In the one-compartment open model, what does the plot of drug concentration (C) versus time (t) look like on a linear paper?

  • Exponential
  • Logarithmic
  • Linear
  • Curvelinear (correct)
  • What is the unit of the elimination rate constant (Ke)?

  • mg/min
  • mg/L
  • min^-1 (correct)
  • L/min
  • What does a linear plot of drug concentration (C) versus time (t) on a semi-log paper indicate?

  • Logarithmic decay
  • Exponential growth
  • Logarithmic growth
  • Exponential decay (correct)
  • What characterizes the elimination phase in the one-compartment open model?

    <p>Three parameters</p> Signup and view all the answers

    What happens to the drug concentration in plasma during intravenous (IV) infusion at a zero-order rate?

    <p>Reaches a plateau or steady state level</p> Signup and view all the answers

    What is the time required to reach steady-state drug concentration in the blood primarily dependent on in the one-compartment open model?

    <p>Elimination half-life</p> Signup and view all the answers

    What happens to the time needed to reach steady state if a higher infusion rate is used in the one-compartment open model?

    <p>Remains the same</p> Signup and view all the answers

    What occurs when the rate of infusion equals the rate of elimination during IV infusion?

    <p>Concentration of drug in plasma approaches a constant value</p> Signup and view all the answers

    What happens to the amount of drug in the body when a constant rate of infusion is started and there is no elimination?

    <p>Rises gradually</p> Signup and view all the answers

    What is the primary advantage of giving a drug by intravenous infusion at a zero-order rate?

    <p>Prevents fluctuating peak and valley blood levels</p> Signup and view all the answers

    What is the time required to reach steady-state drug concentration in the blood if the rate of infusion is increased?

    <p>Remains the same</p> Signup and view all the answers

    What does the plateau level during IV infusion at a constant rate indicate?

    <p>Steady-state concentration</p> Signup and view all the answers

    What is a compartment in the context of body composition?

    <p>A tissue or group of tissues with similar blood flow and drug affinity</p> Signup and view all the answers

    What does the simplest model predict the body as?

    <p>A single, kinetically homogenous unit with no barriers to movement of drug</p> Signup and view all the answers

    What does the one compartment open model assume about changes in plasma levels of a drug?

    <p>They reflect proportional changes in tissue drug levels</p> Signup and view all the answers

    What does 'open' reflect in the one compartment open model?

    <p>Absorption and elimination are unidirectional</p> Signup and view all the answers

    In the context of various one compartment open models, what does 'intravenous adm' stand for?

    <p>Intravenous administration</p> Signup and view all the answers

    What is the main characteristic of a compartment in the body?

    <p>Tissue or group of tissues with similar blood flow and drug affinity</p> Signup and view all the answers

    What is the key feature of the simplest model for body composition?

    <p>No barriers to movement of drug</p> Signup and view all the answers

    What is the assumption of the one compartment open model about drug concentration in plasma and other body tissues?

    <p>They are not equal</p> Signup and view all the answers

    What does 'open' imply in the one compartment open model?

    <p>Unidirectional absorption and elimination</p> Signup and view all the answers

    What is the meaning of 'intravenous adm' in the context of various one compartment open models?

    <p>Intravenous administration</p> Signup and view all the answers

    Which statement best describes a compartment in the body?

    <p>A tissue or group of tissues with similar blood flow and drug affinity</p> Signup and view all the answers

    What is the primary implication of the simplest model for body composition?

    <p>No barriers to movement of drug</p> Signup and view all the answers

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