Questions and Answers
In the one-compartment open model, what does the plot of drug concentration (C) versus time (t) look like on a linear paper?
Curvelinear
What is the unit of the elimination rate constant (Ke)?
min^-1
What does a linear plot of drug concentration (C) versus time (t) on a semi-log paper indicate?
Exponential decay
What characterizes the elimination phase in the one-compartment open model?
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What happens to the drug concentration in plasma during intravenous (IV) infusion at a zero-order rate?
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What is the time required to reach steady-state drug concentration in the blood primarily dependent on in the one-compartment open model?
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What happens to the time needed to reach steady state if a higher infusion rate is used in the one-compartment open model?
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What occurs when the rate of infusion equals the rate of elimination during IV infusion?
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What happens to the amount of drug in the body when a constant rate of infusion is started and there is no elimination?
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What is the primary advantage of giving a drug by intravenous infusion at a zero-order rate?
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What is the time required to reach steady-state drug concentration in the blood if the rate of infusion is increased?
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What does the plateau level during IV infusion at a constant rate indicate?
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What is a compartment in the context of body composition?
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What does the simplest model predict the body as?
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What does the one compartment open model assume about changes in plasma levels of a drug?
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What does 'open' reflect in the one compartment open model?
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In the context of various one compartment open models, what does 'intravenous adm' stand for?
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What is the main characteristic of a compartment in the body?
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What is the key feature of the simplest model for body composition?
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What is the assumption of the one compartment open model about drug concentration in plasma and other body tissues?
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What does 'open' imply in the one compartment open model?
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What is the meaning of 'intravenous adm' in the context of various one compartment open models?
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Which statement best describes a compartment in the body?
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What is the primary implication of the simplest model for body composition?
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