BMD427 Lecture 2: Genomic Data Acquisition and Quality Control Quiz
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Questions and Answers

What is the main challenge associated with sequencing data?

  • Monitoring quality control metrics over all stages of the data processing pipeline (correct)
  • Economical and practical diagnostic approach
  • Selecting and analyzing genes related to a specific disease
  • Analyzing the entire genome

What percentage of the human genome do exonic regions comprise?

  • 15%
  • 50%
  • 85%
  • 2% (correct)

What genetic information does targeted sequencing provide?

  • Genes related to a specific disease or disease group (correct)
  • Only noncoding region sequences
  • Entire genome analysis
  • Functional variants detection

What does WGS involve the analysis of?

<p>Entire genome (D)</p> Signup and view all the answers

What does WES exhibit low sensitivity to?

<p>Structural variations (A)</p> Signup and view all the answers

What is the purpose of demultiplexing in DNA sequencing?

<p>To sort sequenced reads into separate files for each sample in a sequenced run based on unique sequences ligated to each sample's genetic material (A)</p> Signup and view all the answers

What is the main reason for performing quality control (QC) in DNA sequencing?

<p>To save time, effort, and money by screening for data with quality issues (C)</p> Signup and view all the answers

What are the universal QC metrics used in DNA sequencing?

<p>Demultiplexing, base call quality, adapter content, mapping quality (B)</p> Signup and view all the answers

What is the purpose of quality encoding in DNA sequencing?

<p>To convert ASCII table into quality scores for sequenced reads (B)</p> Signup and view all the answers

What is the significance of QC in the overall workflow of DNA sequencing data?

<p>To exclude data with serious quality issues and flag data with questionable quality (B)</p> Signup and view all the answers

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