Blood Type Antigens and Genetics
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Questions and Answers

Why do Group O individuals have more H antigen than the other groups?

  • Group O individuals have more precursor substances available for H antigen synthesis. (correct)
  • The O gene alters the structure of the H substance.
  • Group O individuals lack enzymes to convert H antigen to other antigens.
  • The O allele codes for an enzyme that increases the number of H antigen sites.

    • Which antigen is considered the foundation upon which A and B antigens are built?

  • A antigen
  • O antigen
  • H antigen (correct)
  • B antigen

    • In terms of the amount of H antigen present, which blood group has the least?

  • Group B
  • Group O
  • Group A1
  • Group A1B (correct)

    • Which type of precursor chains are RBC antigens primarily synthesized on?

    <p>Type 2 chains</p> Signup and view all the answers

    What does the O allele do in relation to the H substance?

    <p>It increases the number of H antigen sites.</p> Signup and view all the answers

    Which type of substances contain ABH soluble substances primarily?

    <p>Glycoproteins</p> Signup and view all the answers

    What is the main difference between the A1 and A2 antigens?

    <p>Quantitative difference in antigen sites</p> Signup and view all the answers

    Why might a crossmatch show incompatibility between A2 individuals and A1 individuals?

    <p>Differences in the conversion of H3 &amp; H4 to A</p> Signup and view all the answers

    What enzyme is produced in high concentrations due to the inheritance of an A1 gene?

    <p>N-acetylgalactosaminyl transferase</p> Signup and view all the answers

    What is the characteristic of the immunodominant sugar present on both A1 and A2 red blood cells?

    <p>N-acetyl-D-galactosamine</p> Signup and view all the answers

    Why do A2 (or A2B) individuals produce anti-A1 antibodies?

    <p>Inability to recognize A1 antigen as part of their own red blood cell makeup</p> Signup and view all the answers

    Why is anti-A1 considered clinically significant if reactive at 37°C?

    <p>Likelihood of transfusion reaction at high temperatures</p> Signup and view all the answers

    Which antigen may be hidden in Group B red blood cells?

    <p>H antigen</p> Signup and view all the answers

    Which lectin from Ulex europaeus agglutinates red blood cells of Group O and A?

    <p>Anti-H</p> Signup and view all the answers

    Which of the following A subgroups causes mixed field agglutination when polyclonal anti-A or anti-A, B is used?

    <p>A3</p> Signup and view all the answers

    Which group demonstrates weak or no agglutination with anti-B reagents?

    <p>Group B red blood cells</p> Signup and view all the answers

    Which group of discrepancies is rare according to the text?

    <p>Group I Discrepancies</p> Signup and view all the answers

    Which antigen reacts with both Group A1 and A2 red blood cells?

    <p>H antigen</p> Signup and view all the answers

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