Blood Type Antigens and Genetics

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Why do Group O individuals have more H antigen than the other groups?

Group O individuals have more precursor substances available for H antigen synthesis. (correct)

The O gene alters the structure of the H substance.

Group O individuals lack enzymes to convert H antigen to other antigens.

The O allele codes for an enzyme that increases the number of H antigen sites.

Which antigen is considered the foundation upon which A and B antigens are built?

A antigen

O antigen

H antigen (correct)

B antigen

In terms of the amount of H antigen present, which blood group has the least?

Group B

Group O

Group A1

Group A1B (correct)

Which type of precursor chains are RBC antigens primarily synthesized on?

Type 2 chains Signup and view all the answers

What does the O allele do in relation to the H substance?

It increases the number of H antigen sites. Signup and view all the answers

Which type of substances contain ABH soluble substances primarily?

Glycoproteins Signup and view all the answers

What is the main difference between the A1 and A2 antigens?

Quantitative difference in antigen sites Signup and view all the answers

Why might a crossmatch show incompatibility between A2 individuals and A1 individuals?

Differences in the conversion of H3 & H4 to A Signup and view all the answers

What enzyme is produced in high concentrations due to the inheritance of an A1 gene?

N-acetylgalactosaminyl transferase Signup and view all the answers

What is the characteristic of the immunodominant sugar present on both A1 and A2 red blood cells?

N-acetyl-D-galactosamine Signup and view all the answers

Why do A2 (or A2B) individuals produce anti-A1 antibodies?

Inability to recognize A1 antigen as part of their own red blood cell makeup Signup and view all the answers

Why is anti-A1 considered clinically significant if reactive at 37°C?

Likelihood of transfusion reaction at high temperatures Signup and view all the answers

Which antigen may be hidden in Group B red blood cells?

H antigen Signup and view all the answers

Which lectin from Ulex europaeus agglutinates red blood cells of Group O and A?

Anti-H Signup and view all the answers

Blood Type Antigens and Genetics

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Questions and Answers

Why do Group O individuals have more H antigen than the other groups?

Which antigen is considered the foundation upon which A and B antigens are built?

In terms of the amount of H antigen present, which blood group has the least?

Which type of precursor chains are RBC antigens primarily synthesized on?

What does the O allele do in relation to the H substance?

Which type of substances contain ABH soluble substances primarily?

What is the main difference between the A1 and A2 antigens?

Why might a crossmatch show incompatibility between A2 individuals and A1 individuals?

What enzyme is produced in high concentrations due to the inheritance of an A1 gene?

What is the characteristic of the immunodominant sugar present on both A1 and A2 red blood cells?

Why do A2 (or A2B) individuals produce anti-A1 antibodies?

Why is anti-A1 considered clinically significant if reactive at 37°C?

Which antigen may be hidden in Group B red blood cells?

Which lectin from Ulex europaeus agglutinates red blood cells of Group O and A?

Which of the following A subgroups causes mixed field agglutination when polyclonal anti-A or anti-A, B is used?

Which group demonstrates weak or no agglutination with anti-B reagents?

Which group of discrepancies is rare according to the text?

Which antigen reacts with both Group A1 and A2 red blood cells?

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