Blood Type Antigens and Genetics
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Questions and Answers

Why do Group O individuals have more H antigen than the other groups?

  • Group O individuals have more precursor substances available for H antigen synthesis. (correct)
  • The O gene alters the structure of the H substance.
  • Group O individuals lack enzymes to convert H antigen to other antigens.
  • The O allele codes for an enzyme that increases the number of H antigen sites.

Which antigen is considered the foundation upon which A and B antigens are built?

  • A antigen
  • O antigen
  • H antigen (correct)
  • B antigen

In terms of the amount of H antigen present, which blood group has the least?

  • Group B
  • Group O
  • Group A1
  • Group A1B (correct)

Which type of precursor chains are RBC antigens primarily synthesized on?

<p>Type 2 chains (B)</p> Signup and view all the answers

What does the O allele do in relation to the H substance?

<p>It increases the number of H antigen sites. (C)</p> Signup and view all the answers

Which type of substances contain ABH soluble substances primarily?

<p>Glycoproteins (A)</p> Signup and view all the answers

What is the main difference between the A1 and A2 antigens?

<p>Quantitative difference in antigen sites (A)</p> Signup and view all the answers

Why might a crossmatch show incompatibility between A2 individuals and A1 individuals?

<p>Differences in the conversion of H3 &amp; H4 to A (D)</p> Signup and view all the answers

What enzyme is produced in high concentrations due to the inheritance of an A1 gene?

<p>N-acetylgalactosaminyl transferase (A)</p> Signup and view all the answers

What is the characteristic of the immunodominant sugar present on both A1 and A2 red blood cells?

<p>N-acetyl-D-galactosamine (B)</p> Signup and view all the answers

Why do A2 (or A2B) individuals produce anti-A1 antibodies?

<p>Inability to recognize A1 antigen as part of their own red blood cell makeup (D)</p> Signup and view all the answers

Why is anti-A1 considered clinically significant if reactive at 37°C?

<p>Likelihood of transfusion reaction at high temperatures (B)</p> Signup and view all the answers

Which antigen may be hidden in Group B red blood cells?

<p>H antigen (D)</p> Signup and view all the answers

Which lectin from Ulex europaeus agglutinates red blood cells of Group O and A?

<p>Anti-H (B)</p> Signup and view all the answers

Which of the following A subgroups causes mixed field agglutination when polyclonal anti-A or anti-A, B is used?

<p>A3 (B)</p> Signup and view all the answers

Which group demonstrates weak or no agglutination with anti-B reagents?

<p>Group B red blood cells (C)</p> Signup and view all the answers

Which group of discrepancies is rare according to the text?

<p>Group I Discrepancies (B)</p> Signup and view all the answers

Which antigen reacts with both Group A1 and A2 red blood cells?

<p>H antigen (A)</p> Signup and view all the answers
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