Blood Histology Overview

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What percentage of plasma or fluid components is made up of water?

  • 90% (correct)
  • 70%
  • 80%
  • 95%

Water contributes a minimal amount to plasma composition.

False (B)

What is the primary component of plasma?

Water

Plasma is primarily composed of _____ which makes up about 90% of its volume.

<p>water</p> Signup and view all the answers

Match the following components with their description:

<p>Water = Makes up 90% of plasma Saline = A solution of sodium chloride Dextrose = A simple sugar Plasma = Fluid component of blood</p> Signup and view all the answers

What is one reason that the cell membrane is important for red blood cells (RBCs)?

<p>It allows RBCs to squeeze through narrow capillaries. (A)</p> Signup and view all the answers

The biconcave shape of red blood cells decreases their surface area for gas exchange.

<p>False (B)</p> Signup and view all the answers

Why is the flexibility of the cell membrane crucial for RBCs when navigating through capillaries?

<p>It allows them to squeeze through narrow spaces.</p> Signup and view all the answers

The cell membrane's _____ shape increases the surface area for gas exchange.

<p>biconcave</p> Signup and view all the answers

Match the following characteristics of red blood cells to their functions:

<p>Flexible membrane = Allows passage through capillaries Biconcave shape = Increases surface area for gas exchange</p> Signup and view all the answers

What percentage of total leukocytes does the defined cell type compose?

<p>60-70% (D)</p> Signup and view all the answers

The nucleus of the cell is formed from 2-4 lobes.

<p>False (B)</p> Signup and view all the answers

What color is the cytoplasm of the cell when stained?

<p>purple</p> Signup and view all the answers

The granules of this cell type are responsible for intracellular digestion of __________ particles.

<p>phagocytized</p> Signup and view all the answers

Which of the following functions do these cells perform? (Select all that apply)

<p>Act as memory cells (A), Act as killer cells (C), Act as helper cells (D)</p> Signup and view all the answers

These cells can only act as graft rejection cells.

<p>False (B)</p> Signup and view all the answers

What cytokine inhibits viral replication?

<p>Interferon</p> Signup and view all the answers

These cells can secrete many lymphokines, including __________ which attract macrophages to the site of infection.

<p>chemostatic factor</p> Signup and view all the answers

Match the cytokines with their functions:

<p>Interferon = Inhibit viral replication Chemostatic factor = Attract macrophages Cytotoxic factors = Kill bacteria Mitogenic factors = Stimulate lymphocyte formation</p> Signup and view all the answers

What are the primary types of myeloid tissue?

<p>Red marrow and yellow marrow (B)</p> Signup and view all the answers

Lymphatic tissue includes only lymph nodes and the spleen.

<p>False (B)</p> Signup and view all the answers

Name one type of tissue involved in the immune response.

<p>Lymphatic tissue</p> Signup and view all the answers

Myeloid tissues are primarily located in the _____ marrow.

<p>bone</p> Signup and view all the answers

Match the following components with their function:

<p>Thymus = Maturation of T cells Spleen = Filtering blood and recycling iron Lymph nodes = Filtering lymph Tonsils = Protecting against pathogens entering through the throat</p> Signup and view all the answers

What contributes to the yellow color of inactive bone marrow?

<p>High contents of adipose tissue (C)</p> Signup and view all the answers

Inactive yellow bone marrow can be converted to red bone marrow under certain conditions.

<p>True (A)</p> Signup and view all the answers

What type of cells are primarily found in yellow bone marrow?

<p>Fat cells and hematopoietic stem cells</p> Signup and view all the answers

Inactive yellow bone marrow is present in the cavity of _____ bone in adults.

<p>long</p> Signup and view all the answers

Match the following descriptions with the correct features of yellow bone marrow:

<p>High adipose tissue content = Yellow color Located in adults = Cavity of long bone Fat cells and hematopoietic cells = Composition Change to red marrow = Response to severe blood loss</p> Signup and view all the answers

Flashcards

Plasma Composition

Water makes up the majority of the plasma (the fluid portion) in blood.

Saline Solutions

Saline solutions are used to replace fluids and electrolytes lost due to dehydration or blood loss.

Dextrose Solutions

Dextrose solutions provide carbohydrates as a source of energy for the body.

Saline and Dextrose Solutions

These solutions are used in medical settings to replenish fluids and electrolytes.

Signup and view all the flashcards

RBC flexibility

The cell membrane is flexible, allowing red blood cells (RBCs) to change shape and pass through narrow capillaries.

Signup and view all the flashcards

Biconcave shape of RBCs

Red blood cells have a biconcave shape, which increases their surface area for efficient gas exchange.

Signup and view all the flashcards

Increased surface area for gas exchange

The increased surface area of biconcave RBCs allows for greater oxygen and carbon dioxide exchange.

Signup and view all the flashcards

Neutrophils

A type of white blood cell that makes up 60-70% of total leukocytes in the blood.

Signup and view all the flashcards

What does the nucleus of a neutrophil look like?

The nucleus of a neutrophil is divided into segments, typically 3-5 lobes connected by thin strands.

Signup and view all the flashcards

What are the purple granules in a neutrophil?

Neutrophils contain small, purple-staining granules in their cytoplasm. These granules are lysosomes and contain enzymes.

Signup and view all the flashcards

What is the function of the enzymes in the neutrophils' granules?

These enzymes within the granules break down and digest particles that have been engulfed by the neutrophil.

Signup and view all the flashcards

What is the main function of neutrophils?

Neutrophils are essential for immune defense. They engulf and destroy bacteria, fungi, and other harmful microorganisms.

Signup and view all the flashcards

Myeloid tissue

Tissue responsible for generating blood cells.

Signup and view all the flashcards

Lymphatic tissue

Specialized tissue that generates and stores immune cells.

Signup and view all the flashcards

Lymph node

A type of lymphatic organ, filters lymph fluid and houses white blood cells.

Signup and view all the flashcards

Thymus

A primary lymphatic organ responsible for T cell maturation.

Signup and view all the flashcards

Spleen

A large lymphatic organ that filters blood, stores white blood cells, and removes old red blood cells.

Signup and view all the flashcards

Graft Rejection Cells

T lymphocytes that are responsible for recognizing and attacking cells that express foreign antigens, such as those found on transplanted organs or infected cells.

Signup and view all the flashcards

Memory Cells

A type of T lymphocyte that retains memory of specific antigens it has encountered, allowing for a quicker and more effective immune response upon subsequent exposure.

Signup and view all the flashcards

Helper Cells

T helper cells (Th cells) are a type of T lymphocyte that play a critical role in regulating the adaptive immune response by activating other immune cells, such as cytotoxic T cells and B cells.

Signup and view all the flashcards

Killer Cells

T lymphocytes that directly kill infected cells or tumor cells by releasing cytotoxic factors.

Signup and view all the flashcards

Interferon

A potent protein produced by T lymphocytes that can inhibit viral replication and help control viral infections.

Signup and view all the flashcards

What is yellow bone marrow?

Yellow bone marrow is a type of tissue found in the cavities of long bones in adults. It's primarily made up of fat cells, but also contains some stem cells that can create blood cells. It gives the marrow its yellow color.

Signup and view all the flashcards

What makes yellow bone marrow yellow?

Yellow bone marrow is mostly made up of fat cells, which are essential for energy storage.

Signup and view all the flashcards

What's the function of stem cells in yellow bone marrow?

Although yellow bone marrow mainly stores fat, it also contains some stem cells. These cells are important because they can differentiate into blood cells.

Signup and view all the flashcards

How can yellow bone marrow change?

In extreme situations like significant blood loss, the body can convert yellow bone marrow into red bone marrow. Red bone marrow is responsible for producing blood cells.

Signup and view all the flashcards

Where is yellow bone marrow located?

Yellow bone marrow is found in the cavities of long bones of adults, such as the femur (thigh bone) and humerus (upper arm bone).

Signup and view all the flashcards

Study Notes

Blood Histology

  • Blood is a fluid connective tissue composed of cells, fibers, and plasma
  • Blood constitutes 55% of the total blood volume
  • Plasma is a yellowish fluid acting as a medium for circulating cells and metabolic substances
  • Plasma is composed of approximately 90% water, 7% proteins (albumin, fibrinogen, globulins), and traces of other organic molecules like vitamins, lipids, and hormones.

Cellular Components of Blood

  • Erythrocytes (RBCs):
    • Number: 5-5.5 million per cubic millimeter in males, 4.5-5 million in females
    • Functions: transport oxygen and carbon dioxide
    • Shape: biconcave discs, lacking a nucleus in mature form
    • Life span: ~120 days
    • Abnormalities: Anemia (decreased number), types include deficiency, hemorrhagic, and hemolytic anemia
  • Leukocytes (WBCs):
    • Types:
      • Granulocytes (neutrophils, eosinophils, basophils)
      • Agranulocytes (lymphocytes, monocytes)
  • Platelets (thrombocytes):
    • Functions: blood clotting
    • Origin: megakaryocytes in bone marrow
    • Lifespan: 7-10 days

Action of Erythropoietin

  • Erythropoietin is a hormone that regulates red blood cell production
  • When oxygen levels in the blood are low, the kidneys release erythropoietin
  • Erythropoietin stimulates the red bone marrow to produce more red blood cells
  • Increased red blood cells increase the oxygen-carrying ability of the blood
  • This results in a reversal of the initial low oxygen condition.

Hematopoiesis

  • Hematopoiesis is the process of blood cell formation
  • Occurs in specialized tissues in the body like bone marrow
  • Myeloid tissue consists of two types, Yellow bone marrow, and Red bone marrow
  • Yellow bone marrow is mostly inactive, containing mostly adipose tissue.
  • Red bone marrow contains hematopoietic stem cells which are responsible for the production of blood cells.
  • In adults, most bone marrow is yellow except vertebrae, sternum, epiphyses of long bones where red marrow is found.
  • Embryonic Blood Elements Development:
    • Mesoblastic phase (first two months) occurs in mesenchymal areas of vascular and placental tissue
    • Hepatic phase (months 2-5) takes place in the liver
  • The various types of blood cells are formed from pluripotent stem cells in the bone marrow
  • The stroma is composed of fixed cells including: reticular cells, osteogenic cells, fat cells, and endothelial cells
  • Blood sinusoids are spaces within the bone marrow that allow developing blood cells access to systemic circulation
  • Free cells are developing blood cells in various stages, originating from CFUs (colony forming units)

Other Blood Components

  • Reticulocytes: immature RBCs, still have some organelles
  • Certain congenital abnormalities in cell membrane of RBCs can lead to spherocytosis and sickle cell anemia
  • Different types of leukocytes exist differentiated by their staining properties and nuclei shapes
  • Natural Killer Cells (NK cells): Lymphocytes capable of killing abnormal cells. They differentiate in the lymphoid organs rather than the bone marrow.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Related Documents

Histology Blood PDF - 2024

More Like This

Use Quizgecko on...
Browser
Browser