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By @juniperphoton

Blood Group I.LEWIS System Overview

Created by SecureGlacier

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Questions and Answers

What is the main source of the Lewis antigen?

Gastrointestinal tract

Which chromosome houses the gene responsible for fucosyltransferases in the Lewis antigen system?

Chromosome 19

In which individuals is the Le (a+b+) genotype possible?

Asians

What are the possible genotypes in the Lewis antigen system?

<p>Le (a+b-), Le (a-b+), Le (a-b-), Le (a+b+)</p> Signup and view all the answers

What type of antibodies are associated with the Bombay Parabombay phenotype?

<p>Anti-Lea, Anti-Leb</p> Signup and view all the answers

Which infection is Leb associated with?

<p>Helicobacter pylori infection</p> Signup and view all the answers

What is the significance of the dosage effect in MNSs antigens?

<p>Antibodies react more strongly with homozygous RBCs (MM) than heterozygous RBCs (MN).</p> Signup and view all the answers

How do MN antigens on Glycophorin A differ?

<p>They differ at amino acids at position 1 & 5.</p> Signup and view all the answers

What is the significance of the U phenotype in MNSs antigens?

<p>It is formed when an individual is S+s+ (U = Universal).</p> Signup and view all the answers

Describe the characteristics of anti-M and anti-N antibodies.

<p>Cold reacting, naturally occurring, IgG/IgM antibodies enhanced at acidic pH (6.5).</p> Signup and view all the answers

What is the nature of anti-S & anti-s antibodies?

<p>They are IgG in nature and found in S-s- individuals.</p> Signup and view all the answers

Which disease is associated with GPA and GPB antigens?

<p>GPA - receptor for Escherichia coli; GPA & GPB - receptor for Plasmodium falciparum.</p> Signup and view all the answers

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