Podcast
Questions and Answers
Which blood group genotype can produce an A antigen?
Which blood group genotype can produce an A antigen?
- AB
- AA or AO (correct)
- BB or BO
- OO
What is the phenotype associated with the OO genotype?
What is the phenotype associated with the OO genotype?
- A
- B
- AB
Which blood group has no antibodies in its plasma?
Which blood group has no antibodies in its plasma?
- AB (correct)
- B
- A
What type of antibody is found in the plasma of an individual with blood group B?
What type of antibody is found in the plasma of an individual with blood group B?
What is the dominant gene responsible for producing the B antigen?
What is the dominant gene responsible for producing the B antigen?
What can cause fetal RBCs to leak into the maternal circulation?
What can cause fetal RBCs to leak into the maternal circulation?
When is the leakage of fetal RBCs most likely to occur?
When is the leakage of fetal RBCs most likely to occur?
How long does it typically take for a mother to produce appreciable amounts of anti-D antibodies after leakage?
How long does it typically take for a mother to produce appreciable amounts of anti-D antibodies after leakage?
What is typically the outcome for the fetus during the mother's first pregnancy regarding anti-D antibodies?
What is typically the outcome for the fetus during the mother's first pregnancy regarding anti-D antibodies?
What stimulates the production of anti-D antibodies in the mother?
What stimulates the production of anti-D antibodies in the mother?
What is the genotype for an individual who inherits the D allele from both parents?
What is the genotype for an individual who inherits the D allele from both parents?
Which genotypes result in a Rhesus positive blood type?
Which genotypes result in a Rhesus positive blood type?
What condition might occur when an Rh-negative woman has a child with an Rh-positive father?
What condition might occur when an Rh-negative woman has a child with an Rh-positive father?
If a child has a dd genotype, what does that indicate about the parents' alleles?
If a child has a dd genotype, what does that indicate about the parents' alleles?
Which of the following statements about the D-gene and d allele is true?
Which of the following statements about the D-gene and d allele is true?
What causes hemolysis in the fetus during Rhesus Disease?
What causes hemolysis in the fetus during Rhesus Disease?
What is one common syndrome associated with Hemolytic Disease of the Newborn?
What is one common syndrome associated with Hemolytic Disease of the Newborn?
What is a consequence of increased hemolysis in Rhesus Disease?
What is a consequence of increased hemolysis in Rhesus Disease?
Why is Rhesus Disease usually more severe in subsequent pregnancies?
Why is Rhesus Disease usually more severe in subsequent pregnancies?
What is the primary indicator of jaundice caused by Rhesus Disease in newborns?
What is the primary indicator of jaundice caused by Rhesus Disease in newborns?
What is a characteristic of Hydrops Foetalis?
What is a characteristic of Hydrops Foetalis?
Which statement describes Icterus Gravis Neonatorum?
Which statement describes Icterus Gravis Neonatorum?
What can occur to the fetus in cases of Hydrops Foetalis?
What can occur to the fetus in cases of Hydrops Foetalis?
What is a key preventive measure for Hemolytic Disease of the Newborn?
What is a key preventive measure for Hemolytic Disease of the Newborn?
Which of the following describes a typical outcome in cases of Hydrops Foetalis?
Which of the following describes a typical outcome in cases of Hydrops Foetalis?
What is the purpose of administering anti-D immunoglobulin to a rhesus-negative mother after delivery?
What is the purpose of administering anti-D immunoglobulin to a rhesus-negative mother after delivery?
Which procedure is considered the best treatment for severe hemolytic diseases like hydrops fetalis?
Which procedure is considered the best treatment for severe hemolytic diseases like hydrops fetalis?
In the exchange blood transfusion (EBT) procedure, what is replaced with compatible rhesus-negative blood?
In the exchange blood transfusion (EBT) procedure, what is replaced with compatible rhesus-negative blood?
What is the first step in managing potential Rhesus incompatibility in expecting couples?
What is the first step in managing potential Rhesus incompatibility in expecting couples?
How is blood withdrawn from the neonate during the EBT procedure?
How is blood withdrawn from the neonate during the EBT procedure?
Flashcards
D-gene
D-gene
The gene responsible for determining an individual's Rhesus blood group.
d allele
d allele
The allele that determines a Rhesus negative blood type. It's present when the D-gene is absent.
Homozygous Rhesus Genotype
Homozygous Rhesus Genotype
A genetic combination where both alleles for the D-gene are the same, resulting in either DD (positive) or dd (negative) phenotypes.
Heterozygous Rhesus Genotype
Heterozygous Rhesus Genotype
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Hemolytic Disease of the Newborn (Rh Incompatibility)
Hemolytic Disease of the Newborn (Rh Incompatibility)
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Anti-D Antibodies
Anti-D Antibodies
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Placental Membranes
Placental Membranes
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Fetal RBC Leakage
Fetal RBC Leakage
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Hemolytic Disease of the Newborn (HDN)
Hemolytic Disease of the Newborn (HDN)
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First Pregnancy and Anti-D
First Pregnancy and Anti-D
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Hydrops Fetalis
Hydrops Fetalis
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Icterus Gravis Neonatorum
Icterus Gravis Neonatorum
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Rh Sensitization
Rh Sensitization
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Rh-positive Blood Transfusion to Rh-negative Females
Rh-positive Blood Transfusion to Rh-negative Females
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What is the cause of Rhesus disease?
What is the cause of Rhesus disease?
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Why is Rhesus disease worse in later pregnancies?
Why is Rhesus disease worse in later pregnancies?
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How does Rhesus disease cause jaundice?
How does Rhesus disease cause jaundice?
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What is Hydrops Foetalis?
What is Hydrops Foetalis?
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What is Icterus Gravis Neonatorum (IGN)?
What is Icterus Gravis Neonatorum (IGN)?
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Premarital Genetic Testing & Counseling
Premarital Genetic Testing & Counseling
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Anti-D Immunoglobulin
Anti-D Immunoglobulin
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Exchange Blood Transfusion (EBT)
Exchange Blood Transfusion (EBT)
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Study Notes
Rhesus Blood Group Inheritance
- Rhesus blood group inheritance is similar to ABO blood groups.
- The gene responsible is the D gene.
- When the D gene is absent from the chromosome, it's space is occupied by an alleleomorph called 'd'.
- If both parents give D, the resulting genotype is DD (homozygous).
- If parents contribute D and d, the resulting genotype is Dd (heterozygous).
- If parents contribute two 'd', the resulting genotype is dd (homozygous), which is Rhesus negative.
- DD and Dd are Rhesus positive.
Hemolytic Disease of the Newborn (Rh Incompatibility)
- This is an abnormal condition.
- It results when a Rhesus negative woman conceives for a Rhesus positive man.
- During pregnancy with a Rhesus positive foetus, some fetal RBCs may enter the maternal circulation.
- This stimulates the production of anti-D antibodies in the mother.
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Description
Test your knowledge on blood group genotypes, phenotypes, and the Rh factor. This quiz covers topics such as antigen production, antibody presence, and maternal-fetal blood circulation issues. Perfect for students of biology or anyone interested in hematology!
