Blood Composition and Function

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Questions and Answers

What is the primary function of Colony forming unit-erythrocytes (CFU-E)?

  • To form lymphocytes
  • To develop into platelets
  • To develop into erythrocytes (correct)
  • To provide a source for granulocytes

At what stage of erythropoiesis does hemoglobin synthesis begin?

  • Intermediate normoblast
  • Reticulocyte
  • Early normoblast
  • Proerythroblast (correct)

Which of the following characteristics is true of the early normoblast stage?

  • Nucleoli are still present
  • It has a diameter of approximately 20 µ
  • Chromatin condensation occurs (correct)
  • The cytoplasm is only slightly basophilic

What is the size of a proerythroblast?

<p>20 µ (B)</p> Signup and view all the answers

In the intermediate normoblast stage, which of the following is observed?

<p>Hemoglobin starts appearing (C)</p> Signup and view all the answers

What is the primary function of erythrocytes in the blood?

<p>To carry oxygen (C)</p> Signup and view all the answers

What percentage of total blood volume do erythrocytes typically occupy?

<p>45% (D)</p> Signup and view all the answers

Which component of blood is primarily responsible for its red color?

<p>Hemoglobin in erythrocytes (C)</p> Signup and view all the answers

What is the average blood volume in a normal adult?

<p>5 L (C)</p> Signup and view all the answers

What is the normal pH of blood under healthy conditions?

<p>7.4 (C)</p> Signup and view all the answers

What is the main reason for blood's viscosity being five times more than water?

<p>Presence of red blood cells (C)</p> Signup and view all the answers

Which of the following statements about the hematocrit is true?

<p>It is determined by centrifuging a blood sample. (C)</p> Signup and view all the answers

What forms the thin layer known as the buffy coat in a hematocrit tube?

<p>Aggregate of leukocytes and platelets (C)</p> Signup and view all the answers

What substance is primarily responsible for the red color of red blood cells?

<p>Hemoglobin (A)</p> Signup and view all the answers

Which of the following is NOT a function of blood?

<p>Detoxification of glucose (A)</p> Signup and view all the answers

Which type of blood cell is primarily involved in immune defense?

<p>Leukocytes (A)</p> Signup and view all the answers

What component of blood is mainly responsible for blood clotting?

<p>Platelets (B)</p> Signup and view all the answers

Which of the following is a major function of the plasma proteins?

<p>Regulation of blood pressure (D)</p> Signup and view all the answers

What is the average lifespan of an erythrocyte?

<p>120 days (D)</p> Signup and view all the answers

How do erythrocytes contribute to gas exchange?

<p>By binding oxygen through hemoglobin (A)</p> Signup and view all the answers

What is the primary site of erythrocyte destruction in the body?

<p>Spleen (B)</p> Signup and view all the answers

The average lifespan of red blood cells is approximately how many days?

<p>120 days (A)</p> Signup and view all the answers

Which component of hemoglobin is primarily responsible for transport of oxygen?

<p>Iron (C)</p> Signup and view all the answers

What percentage of plasma is water?

<p>91% to 92% (D)</p> Signup and view all the answers

Which hormone stimulates erythropoiesis in response to hypoxia?

<p>Erythropoietin (C)</p> Signup and view all the answers

Which of the following ions is NOT typically found in plasma?

<p>Bromine (D)</p> Signup and view all the answers

What does bilirubin, the major breakdown product of hemoglobin, contribute to?

<p>Plasma color (A)</p> Signup and view all the answers

What is the primary role of albumin in blood plasma?

<p>Maintaining osmotic pressure (B)</p> Signup and view all the answers

What differentiates serum from plasma?

<p>Absence of fibrinogen (A)</p> Signup and view all the answers

What is the packed cell volume (PCV) in healthy adults?

<p>45% (C)</p> Signup and view all the answers

What is the main function of neutrophils?

<p>Engulf bacteria (B)</p> Signup and view all the answers

Which enzyme is necessary for the formation of bicarbonate from water and carbon dioxide in red blood cells?

<p>Carbonic anhydrase (D)</p> Signup and view all the answers

Which of the following best describes the shape of red blood cells?

<p>Biconcave disk (D)</p> Signup and view all the answers

What occurs to the erythrocyte membrane as it ages past 120 days?

<p>It becomes more fragile (B)</p> Signup and view all the answers

What is the role of hemoglobin in blood group determination?

<p>Carries blood group antigens (C)</p> Signup and view all the answers

What does hemoglobin bind most effectively with?

<p>Oxygen (B)</p> Signup and view all the answers

At what age does erythropoiesis primarily occur in the bone marrow?

<p>5 years (B)</p> Signup and view all the answers

What are the uncommitted pluripotent hemopoietic stem cells capable of?

<p>Differentiating into all blood cell types (D)</p> Signup and view all the answers

What percentage of carbon dioxide is transported in blood as bicarbonate?

<p>63% (A)</p> Signup and view all the answers

What happens to globin after the destruction of red blood cells?

<p>It is stored for later use (A)</p> Signup and view all the answers

Why are older erythrocytes more likely to be destroyed in capillaries?

<p>They become more fragile (B)</p> Signup and view all the answers

Flashcards

Erythropoiesis

The process of red blood cell formation.

Proerythroblast

The first cell in erythropoiesis, derived from CFU-E, large with a prominent nucleus.

Proerythroblast

The stage of erythropoiesis where hemoglobin synthesis begins.

Intermediate normoblast (polychromophilic)

The stage of erythropoiesis where hemoglobin starts to appear.

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Reticulocyte

A cell that is released from the bone marrow into the bloodstream, still contains some RNA and ribosomes, matures into a red blood cell.

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What is blood?

Blood is a specialized connective tissue that circulates throughout the body, carrying essential substances and playing a vital role in maintaining homeostasis.

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What is the primary function of red blood cells?

Red blood cells (erythrocytes) are responsible for carrying oxygen from the lungs to the body's tissues and carbon dioxide back to the lungs for exhalation.

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What is the primary function of white blood cells?

White blood cells (leukocytes) play a crucial role in the immune system, defending the body against infections and diseases.

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What is the primary function of platelets?

Platelets are cell fragments that contribute to blood clotting, preventing excessive bleeding after an injury.

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What is plasma?

Plasma is the liquid component of blood, constituting about 55% of its volume. It contains various substances essential for blood's functions, such as water, proteins, electrolytes, and nutrients.

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What is the hematocrit?

The hematocrit is the percentage of blood volume occupied by red blood cells. It reflects the proportion of red blood cells in the blood.

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Why is arterial blood bright red?

Arterial blood is bright red because it is oxygenated and travels from the heart to the body tissues.

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Why is venous blood darker in color?

Venous blood is darker red or purple because it carries deoxygenated blood back to the heart from the body tissues.

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Nutritive Function of Blood

The process of transporting digested nutrients (glucose, amino acids, lipids, and vitamins) from the gut to the rest of the body via blood.

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Respiratory Function of Blood

Blood carries oxygen from the lungs (where it's picked up) to body tissues and carbon dioxide from tissues back to the lungs for exhalation.

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Excretory Function of Blood

Blood removes waste products created during metabolic activities in cells (like urea, creatinine) and transports them to organs like the kidneys, skin, and liver for expulsion from the body.

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Hormone Transport by Blood

Blood carries hormones produced by endocrine glands to their target organs or tissues where they exert their effects.

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Water Balance Regulation by Blood

Blood participates in maintaining the overall balance of fluids in your body through interactions with interstitial fluids (fluids surrounding cells).

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Acid-Base Balance Regulation by Blood

Blood plays a critical role in controlling the acid-base balance of the body by using plasma proteins and hemoglobin as buffers.

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Temperature Regulation by Blood

Blood's high specific heat capacity helps maintain a stable body temperature. It absorbs and distributes heat effectively to prevent extreme temperature fluctuations.

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Storage Function of Blood

Blood acts as a reserve for various substances like water, glucose, and electrolytes, which can be released to meet the body's needs during times of stress, starvation, fluid loss, etc.

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Defensive Function of Blood

Blood protects the body from infections and diseases through its white blood cells.

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Plasma

The liquid component of blood, containing dissolved substances like proteins, nutrients, waste products, and hormones.

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Plasma Proteins

Plasma proteins are mainly categorized into three groups: albumins, globulins, and fibrinogen.

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Serum

Serum is the clear fluid component of blood after clotting. It's essentially plasma without fibrinogen.

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Red Blood Cells (Erythrocytes)

Red blood cells are responsible for transporting oxygen and carbon dioxide.

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White Blood Cells (Leukocytes)

White blood cells play a crucial role in the body's immune defense.

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Platelets (Thrombocytes)

Platelets are small cell fragments that are involved in blood clotting.

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RBC Lifespan

The average lifespan of a red blood cell (RBC) is around 120 days, after which they are destroyed in the spleen and liver.

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RBC Structure

Red blood cells lack nuclei and organelles, meaning they cannot reproduce or maintain their structure for long.

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Hemoglobin

The protein contained within red blood cells that binds to and transports oxygen throughout the body.

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Bilirubin

The breakdown product of hemoglobin, primarily produced by the liver, and gives plasma its yellowish color.

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Hypoxia

A condition where there is insufficient oxygen in the blood, which triggers erythropoietin production.

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RBC Destruction

The small, fragile nature of older red blood cells makes them prone to destruction as they squeeze through narrow capillaries.

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Spleen as 'RBC Graveyard

The red pulp of the spleen, where older red blood cells are destroyed and fragmented.

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Macrophage Role

Macrophages, specialized immune cells, engulf and break down hemoglobin from destroyed red blood cells.

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Iron Recycling

Iron released from hemoglobin during RBC degradation is stored as ferritin for later use in the body.

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Oxygen Transport

The main function of red blood cells is to transport oxygen from the lungs to the tissues.

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Carbon Dioxide Transport

Hemoglobin binds to carbon dioxide in the tissues and carries it back to the lungs for exhalation.

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Buffering Action

Hemoglobin acts as a buffer in the blood, helping to maintain the proper acid-base balance.

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Blood Type

Red blood cells carry antigens on their surface, determining a person's blood type.

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Study Notes

Blood Composition and Function

  • Blood is a fluid connective tissue, vital for oxygen and carbon dioxide transport.
  • Composed of cells (erythrocytes, leukocytes, platelets) suspended in plasma.
  • Erythrocytes (red blood cells) carry oxygen; leukocytes (white blood cells) fight infection and cancer; platelets are cell fragments involved in clotting.
  • Blood volume in a normal adult male is approximately 5 liters.
  • Blood volume in a normal adult female is approximately 4.5 liters.

Hematocrit

  • Hematocrit is the percentage of blood volume occupied by erythrocytes.
  • Measured by centrifuging a blood sample.
  • Normal hematocrit: ~45% in males, ~42% in females.
  • Plasma comprises ~55% of blood volume, erythrocytes ~45%, and a thin buffy coat (leukocytes and platelets) in between.

Blood Color, Volume, and Properties

  • Blood is red, arterial blood is scarlet (high oxygen), venous blood more purple-red (high carbon dioxide).
  • Average blood volume in a newborn is 450 ml.
  • Blood is slightly alkaline with a pH of 7.4.
  • Blood is 5 times more viscous than water.
  • The specific gravity of blood is 1.052 to 1.061

Functions of Blood

  • Nutritive: Transports absorbed nutrients (glucose, amino acids, lipids, vitamins) from the digestive system to the body.
  • Respiratory: Transports oxygen from lungs to tissues, and carbon dioxide from tissues to lungs.
  • Excretory: Removes waste products from tissues and transports them to excretory organs (kidneys, skin, liver).
  • Hormone/Enzyme Transport: Carries hormones from endocrine glands to their target organs/tissues; transports enzymes.
  • Water Balance: Blood water is interchangeable with interstitial fluid, helping regulate body water content.
  • Acid-Base Balance: Plasma proteins and hemoglobin act as buffers.
  • Temperature Regulation: Blood's high specific heat helps maintain body temperature.
  • Storage: Blood acts as a reservoir for some substances (water, electrolytes).
  • Defensive: White blood cells (WBCs) defend against pathogens.

Plasma Composition

  • Plasma is the liquid portion of blood, mostly water (~91-92%).
  • Contains dissolved organic and inorganic substances (proteins, nutrients, waste products, hormones, electrolytes, gases).
  • Plasma proteins (albumins, globulins, fibrinogen) are major solutes.
  • Albumins are the most abundant; synthesized by the liver.
    • Other proteins are synthesized by reticuloendothelial cells in the liver, spleen, bone marrow, and other tissue cells.

Serum

  • Serum is plasma without fibrinogen (removed during clotting).
  • Serum contains all other plasma components except fibrinogen.

Cellular Components of Blood

  • Red blood cells (erythrocytes)
  • White blood cells (leukocytes)
  • Platelets (thrombocytes)

Red Blood Cells (Erythrocytes)

  • Structure: Biconcave disk shape, high surface-to-volume ratio, lacks nucleus and organelles.
  • Number Variability: ~4.5-6 million per cubic millimeter in blood. (~5.2 million in males, ~4.7 million in females)
  • Hemoglobin: Contains hemoglobin, a red pigment for oxygen and carbon dioxide transport.
  • Oxygen Transport: 97% of oxygen bound to hemoglobin
  • Carbon Dioxide Transport: 30% of carbon dioxide bound to hemoglobin; remains that are in the form of bicarbonate ions.
  • Life Span: ~120 days. Destroyed in the spleen.
  • Hemoglobin breakdown: Hemoglobin is broken down into iron, globin, and porphyrin. Iron is reused; globin is recycled; bilirubin is excreted, which give the plasma its color.

Erythropoiesis

  • Production of red blood cells.
  • Location changes throughout development (yolk sac, liver, bone marrow).
  • Stimulated by hypoxia (low oxygen), triggering erythropoietin (EPO) release from the kidneys.
  • Stages of development: proerythroblast, early/intermediate/late normoblast, reticulocyte, mature erythrocyte.

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