Blood Composition and Function
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Questions and Answers

Which of the following is NOT a primary function of blood?

  • Transporting oxygen and carbon dioxide
  • Regulating body temperature
  • Maintaining pH and fluid balance
  • Producing digestive enzymes (correct)

What percentage of plasma volume is typically made up of water?

  • 50%
  • 4%
  • 45%
  • 92% (correct)

Which of the following plasma proteins plays a significant role in blood coagulation?

  • Albumin
  • Immunoglobulin
  • Fibrinogen (correct)
  • Globulin

Albumins are a major component of osmotic pressure in plasma, what percentage does it occupy of the plasma proteins?

<p>60% (A)</p> Signup and view all the answers

What is the primary function of erythrocytes?

<p>Transporting oxygen (B)</p> Signup and view all the answers

What structural feature of erythrocytes allows them to efficiently pass through narrow capillaries?

<p>Biconcave shape (B)</p> Signup and view all the answers

In hemoglobin, what type of ion is central to the porphyrin ring and binds oxygen?

<p>Ferrous ($Fe^{2+}$) (D)</p> Signup and view all the answers

What happens to beta subunits of hemoglobin in fetal hemoglobin?

<p>They are replaced by gamma subunits (D)</p> Signup and view all the answers

What is the approximate lifespan of erythrocytes?

<p>120 days (D)</p> Signup and view all the answers

Where does the breakdown of expired erythrocytes primarily occur?

<p>Liver and Spleen (D)</p> Signup and view all the answers

What is the significance of hematopoietic stem cells?

<p>Generating all blood cell types (D)</p> Signup and view all the answers

In adults, hematopoiesis primarily occurs in which location?

<p>Red bone marrow (D)</p> Signup and view all the answers

Which of the following directly stimulates erythropoiesis?

<p>Erythropoietin (EPO) (A)</p> Signup and view all the answers

What is the definition of Hematocrit (HCT or Ht)?

<p>The volume % of red blood cells in whole blood (C)</p> Signup and view all the answers

What is the term given to unipotent stem cells committed to forming granulocytes?

<p>Granulopoiesis (C)</p> Signup and view all the answers

Which type of cell is part of the innate immune system and acts non-specifically to kill virus-infected and cancerous cells?

<p>Natural killer (NK) cells (D)</p> Signup and view all the answers

Which of the following leukocytes is primarily responsible for attacking parasites?

<p>Eosinophils (A)</p> Signup and view all the answers

What is a key feature that distinguishes agranulocytes from granulocytes?

<p>Lack of visible granules in the cytoplasm (C)</p> Signup and view all the answers

From what cells are platelets derived?

<p>Megakaryocytes (A)</p> Signup and view all the answers

What is the main function of platelet α-granules?

<p>Functions like coagulation &amp; platelet adhesion (B)</p> Signup and view all the answers

Flashcards

Hemostasis

The process of stopping bleeding.

Immune Defense

The body's defense against infection.

Blood Transport

Delivering oxygen, nutrients, and hormones while removing metabolic wastes.

Plasma

Liquid extracellular matrix of blood.

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Erythrocytes

Red blood cells; transport oxygen.

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Albumins

A type of blood protein that contributes to osmotic pressure.

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Fibrinogen

A blood protein involved in blood clotting.

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Globulins

Also known as immunoglobulins, produced by the immune system.

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Erythrocytes Features

Disk-shaped cells that transport oxygen and carbon dioxide.

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Hemoglobin

Metal-containing protein in red blood cells that binds oxygen.

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Porphyrin Ring

Iron-containing ring that binds oxygen in hemoglobin.

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Liver and Spleen

Site where old red blood cells are broken down.

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Hematopoietic Stem Cells

Stem cells in bone marrow that can differentiate into all blood cell types.

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Hemopoiesis

The formation and maturation of new cellular components of blood.

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Erythropoiesis

Process of forming red blood cells.

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Hematocrit

Volume percentage of red blood cells in whole blood.

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Leukopoiesis

Process of forming white blood cells.

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Colony-Stimulating Factors

Glycoproteins that regulate the production of myeloid lineage cells.

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Histamine

Important in inflammatory reactions and cause swelling and itching

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Study Notes

  • Blood I includes blood composition and hematopoiesis.

  • Beatriz Castro, Ph.D., created this information of Blood I in 2025.

  • Blood functions to maintain hemostasis.

  • Hemostasis is the process responsible for stopping bleeding.

  • Blood helps to regulate pH and fluid balance.

  • The immune defense of the body relies on cells and antibodies found in the blood.

  • Blood also plays a role in thermoregulation.

  • It transports oxygen, nutrients and hormones to body tissues whilst removing metabolic wastes like urea and carbon dioxide.

  • Blood is a connective tissue with an extracellular matrix (ECM) making it a fluid.

  • Plasma makes up 55% of blood and is a straw-colored, viscous fluid.

  • Formed elements, which include cells, arise from hematopoietic stem cells in red bone marrow.

  • Blood consists of plasma and formed elements (3 types of cells).

  • Plasma consists of 4% proteins, 50% water, and 1% other solutes

  • Proteins found in plasma are Albumin (60%), Globulins (36%), and Fibrinogen (4%)

  • Water makes up 50% of plasma.

  • Neutrophils (55-70%), Lymphocytes (20-40%), Monocytes (2-8%), Eosinophils (1-4%), and Basophils (0.5-1%) are electrolytes, nutrients, and hormones that make up 1% of plasma.

  • Water makes up 50% of blood and arises from hematopoietic stem cells in red bone marrow.

  • A normal adult has a blood volume of approx 5L.

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Description

Blood is a connective tissue that maintains homeostasis. It regulates pH and fluid balance, provides immune defense, and aids in thermoregulation. Blood transports oxygen, nutrients, and hormones while removing metabolic wastes.

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