Blood Composition and Function

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Questions and Answers

What is the primary function of red blood cells?

  • Fighting infections
  • Clotting blood
  • Transporting oxygen (correct)
  • Producing antibodies

Which of the following formed elements is responsible for initiating the process of blood clot formation?

  • Thrombocytes (correct)
  • Erythrocytes
  • Basophils
  • Leukocytes

What is the role of erythropoietin in red blood cell production

  • It inhibits the production of red blood cells.
  • It stimulates red blood cell production. (correct)
  • It regulates the production of white blood cells.
  • It stimulates the production of platelets.

Which of the following blood types is considered the 'universal donor'?

<p>O- (C)</p> Signup and view all the answers

What is the primary function of the lymphatic system?

<p>Filtering lymph and housing immune cells (A)</p> Signup and view all the answers

Which of the following sequences correctly describes the flow of lymph through lymphatic vessels?

<p>Lymphatic capillaries → Lymphatic vessels → Lymph nodes → Lymphatic trunks → Lymphatic ducts (C)</p> Signup and view all the answers

What is the function of Peyer's patches, found in the small intestine?

<p>Monitoring intestinal bacteria populations and preventing the growth of pathogenic bacteria in the intestines (B)</p> Signup and view all the answers

Which of the following is a characteristic of lymphoid tissue?

<p>It provides a site for immune surveillance. (B)</p> Signup and view all the answers

Redness and heat associated with inflammation are primarily due to what physiological change?

<p>Vasodilation and increased blood flow to the area (C)</p> Signup and view all the answers

Which type of immune cell is responsible for directly attacking and destroying infected or cancerous cells?

<p>Natural killer (NK) cells (A)</p> Signup and view all the answers

If a patient's blood is unable to effectively transport oxygen due to a decreased number of red blood cells, which of the following functions of blood is most directly compromised?

<p>Transport of respiratory gases (B)</p> Signup and view all the answers

A researcher is studying the differentiation of blood cells in the bone marrow. Which of the following cells gives rise to all formed elements of blood?

<p>Hemocytoblast (D)</p> Signup and view all the answers

In a scenario where a patient with blood type A requires a blood transfusion, but only blood types B, AB, and O are available, which blood type would be the most suitable if compatibility is determined solely on ABO antigens?

<p>Type O (B)</p> Signup and view all the answers

Following a cut, several processes occur to achieve hemostasis. What is the correct order of these processes?

<p>Vascular spasm → platelet plug formation → coagulation (D)</p> Signup and view all the answers

A patient is diagnosed with pernicious anemia due to a deficiency in intrinsic factor. This deficiency directly impacts the absorption of which nutrient?

<p>Vitamin B12 (D)</p> Signup and view all the answers

In a high-altitude environment, the body compensates for lower oxygen levels by increasing red blood cell production. Which hormone primarily triggers this compensatory response?

<p>Erythropoietin (C)</p> Signup and view all the answers

During an autopsy, a pathologist examines bone marrow to determine where blood cells are formed. In which location would the pathologist most likely observe active hematopoiesis in an adult?

<p>Red bone marrow (B)</p> Signup and view all the answers

A hematology lab technician is analyzing a blood smear and observes a leukocyte with numerous granules and a multi-lobed nucleus. Which type of leukocyte is the technician most likely observing?

<p>Neutrophil (A)</p> Signup and view all the answers

A molecule of hemoglobin is fully saturated with oxygen. How many oxygen molecules are bound to this single hemoglobin molecule?

<p>Four (B)</p> Signup and view all the answers

A patient is diagnosed with aplastic anemia, where the bone marrow fails to produce sufficient blood cells. Which blood cell type is least affected?

<p>Aplastic (C)</p> Signup and view all the answers

A researcher is studying the flow of lymph in a lymphatic vessel. If they inject a dye into the tissues, what is the correct sequence of vessels the dye will follow to return to the bloodstream?

<p>Lymphatic capillaries → lymphatic vessels → lymphatic trunks → lymphatic ducts (B)</p> Signup and view all the answers

A surgeon removes a patient's left lymphatic duct during a procedure. From which region of the body will lymph drainage be most directly affected?

<p>Left arm and left side of the head (A)</p> Signup and view all the answers

A pathologist is examining a biopsy from a lymph node and observes an increase in plasma cells. This observation suggests an increase in what activity?

<p>Antibody production (D)</p> Signup and view all the answers

Researchers are investigating the function of lymphoid tissue in immunity. Which of the following is a key role of lymphoid tissue?

<p>Providing a site for immune surveillance (D)</p> Signup and view all the answers

A child is born without a thymus gland. Which of the following immune functions would be most severely affected?

<p>Maturation of T lymphocytes (D)</p> Signup and view all the answers

A doctor palpates a patient's abdomen during a routine check-up and notices an enlarged spleen. What condition might the enlarged spleen indicate?

<p>Increased filtering of pathogens from the blood (A)</p> Signup and view all the answers

During a tonsillectomy, a surgeon removes the patient's tonsils. What is the primary function of the tonsils that will be lost due to this procedure?

<p>Gathering and removing pathogens entering the pharynx (C)</p> Signup and view all the answers

A researcher is examining a lymph node biopsy and observes a region densely packed with B lymphocytes. Which specific area of the lymph node is the researcher likely observing?

<p>Germinal center (C)</p> Signup and view all the answers

A patient presents with buboes in the groin area. Which of the following conditions is most likely associated with this symptom?

<p>Bacterial infection (C)</p> Signup and view all the answers

A patient has several swollen lymph nodes but reports no pain. Which condition might this symptom indicate?

<p>Cancer (D)</p> Signup and view all the answers

A patient's immune system is compromised, leading to frequent opportunistic infections. Which division of the immune system is most likely impaired?

<p>Adaptive immunity (B)</p> Signup and view all the answers

Inflammation is characterized by several key signs. What physiological response is most directly responsible for the pain associated with inflammation?

<p>Release of inflammatory mediators (D)</p> Signup and view all the answers

A researcher is studying the actions of natural killer (NK) cells. What is the primary mechanism by which NK cells eliminate infected or cancerous cells.

<p>Releasing perforins and granzymes (A)</p> Signup and view all the answers

During phagocytosis what describes the correct sequence of events?

<p>Chemotaxis → adherence → ingestion → digestion → exocytosis (B)</p> Signup and view all the answers

A researcher is studying antigens and observes that some antigens trigger a strong immune response independently, while others require a carrier protein. What is the term for antigens that require a carrier protein to elicit an immune response?

<p>Hapten (D)</p> Signup and view all the answers

A medical student is studying MHC proteins and their role in antigen presentation. Which cells express MHC class II proteins?

<p>Antigen-presenting cells (C)</p> Signup and view all the answers

In the development of lymphocytes, where do T lymphocytes primarily mature

<p>Thymus (D)</p> Signup and view all the answers

What mechanisms contributes most significantly to the diversity of antigen receptors on lymphocytes?

<p>Somatic recombination of gene segments (B)</p> Signup and view all the answers

A researcher is investigating the function of plasma cells in the immune response. What is the primary role of plasma cells?

<p>Secretion of antibodies (B)</p> Signup and view all the answers

During a second exposure to the same antigen, which of the following characteristics distinguishes the secondary immune response from the primary immune response?

<p>Faster response with higher antibody levels (C)</p> Signup and view all the answers

Which is responsible for initiating the body's response to invading pathogens or tissue damage?

<p>The process of inflammation. (D)</p> Signup and view all the answers

What is the main reason for the redness during inflammation?

<p>Increased blood flow. (B)</p> Signup and view all the answers

How do natural killer cells differentiate between healthy and unhealthy cells?

<p>By recognizing the absence of certain proteins the cells surface. (B)</p> Signup and view all the answers

What initial event initiates the process of phagocytosis?

<p>The migration of the molecules, also known as chemotaxis. (B)</p> Signup and view all the answers

What is the primary factor that differentiates a complete antigen from an incomplete antigen?

<p>Their ability to stimulate an immune response on their own. (A)</p> Signup and view all the answers

What role self-antigens play in the immune system?

<p>Indenting cells as 'self'. (B)</p> Signup and view all the answers

Which body organ is primarily responsible for the maturation of our T lympocytes?

<p>The thymus. (C)</p> Signup and view all the answers

What biological mechanism generates the diversity of antigen receptors on lymphocytes?

<p>Genetic recombination (A)</p> Signup and view all the answers

What role do plasma cells have in immune responses?

<p>Secreting antibodies. (D)</p> Signup and view all the answers

How does the efficiency and speed of an immune response change upon subsequent exposures to the same antigen?

<p>It becomes faster with increasing antibody production. (C)</p> Signup and view all the answers

Flashcards

Functions of Blood?

Transport oxygen, nutrients, hormones, and waste products; regulate pH, body temperature, and water content of cells; protect against blood loss and infection.

Formed Elements in Blood?

Red blood cells (erythrocytes), white blood cells (leukocytes), and platelets (thrombocytes).

Erythropoiesis?

Production of red blood cells, stimulated by erythropoietin.

Hemocytoblast?

A type of stem cell in bone marrow that can differentiate into all types of blood cells.

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Universal Donor?

O−; red blood cells with no A or B antigens and Rh negative.

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Universal Acceptor?

AB+; red blood cells with both A and B antigens and Rh positive.

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Stages of Hemostasis?

Vascular spasm, platelet plug formation, and coagulation (blood clotting).

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Agglutinins/Agglutinogens?

Agglutinins are antibodies that cause agglutination; agglutinogens are antigens on red blood cells that react with agglutinins.

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Pernicious Anemia?

Autoimmune disease leads to a deficiency in red blood cells caused by impaired absorption of vitamin B12.

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Triggers of Erythropoiesis?

Erythropoietin, hypoxia (low oxygen levels).

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Where are blood cells formed?

Red blood cells are generated in bone marrow.

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Granular vs. Agranular Leukocytes?

Granular leukocytes contain visible granules; agranular leukocytes do not.

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Hormone for RBC production?

Erythropoietin, produced by kidneys, stimulates red blood cell production.

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Oxygen molecules per hemoglobin?

Each hemoglobin molecule can bind to four oxygen molecules.

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Types of Anemia?

Includes iron-deficiency, aplastic, hemolytic, and sickle-cell anemia.

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Functions of lymphatic system?

Returns fluids leaked from blood vessels back to the blood, transports fats and acts as a site for immunity.

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Components of the lymphatic system?

Lymph, lymphatic vessels, structures and organs containing lymphoid tissue and red bone marrow.

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Lymphatic Vessels (Smallest to Largest)?

Lymphatic capillaries, collecting vessels, trunks, and ducts.

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Drainage of lymphatic duct?

Drainage of the lymphatic duct depends on if it is the right lymphatic duct, or the thoracic lymphatic duct depending on the side of the body.

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Lymph node function?

Filters and cleanses lymph, activates the immune system.

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Peyer's Patches?

Aggregated lymphoid nodules in the small intestine; important for immune surveillance.

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Afferent vs. Efferent Lymphatic Vessels?

Afferent vessels bring lymph to a node; efferent vessels carry lymph away from a node.

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Functions of lymphoid tissue?

Site of lymphocyte proliferation, immune surveillance, and response.

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Characteristics of Lymphoid tissue?

Reticular connective tissue dominates; provides a scaffolding for immune cells.

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Functions of thymus gland?

T cell maturation and production of hormones like thymosin.

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Functions of Spleen?

Filters blood, stores platelets and iron, and is involved in immune functions.

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Tonsils function?

Masses of lymphoid tissue that protect against ingested or inhaled pathogens.

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Germinal center?

Contain dividing B cells.

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Buboes?

Swollen, inflamed lymph nodes due to infection.

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Non Painful Swollen Node?

May indicate chronic infection like TB or lymphoma

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Divisions of Immune System?

Innate and adaptive immune systems.

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Functions of Inflammation?

Attract immune cells to site, promote healing

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Redness, heat in inflammation is due to?

Increased blood flow to the inflamed area.

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Natural Killer Cells?

Recognize and kill cells infected with viruses or cancerous cells.

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Sequence of events in phagocytosis?

Chemotaxis, adherence, ingestion, digestion, killing.

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Complete vs. Incomplete Antigens?

Complete antigens induce a full immune response; incomplete antigens (haptens) do not unless attached to a carrier.

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Self-Antigens - MHC Proteins?

Major Histocompatibility Complex identifies cells as 'self'.

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Origin, maturation for B and T lymphocytes?

B cells mature in bone marrow; T cells mature in the thymus.

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Antigen Receptor Diversity in Lymphocytes?

Genetic recombination and mutation during lymphocyte development.

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Plasma cells?

Antibody-secreting B cells.

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Primary vs. Secondary Immune Response?

Primary: initial response, slower; Secondary: faster, stronger response due to memory cells.

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Study Notes

Chapter 17

  • Blood aids in the transport of oxygen, nutrients, hormones and waste
  • Blood regulates pH, body temperature and water content of cells
  • Blood protects against blood loss, prevents clotting and defends against infection
  • Formed elements of blood include erythrocytes, leukocytes, and thrombocytes
  • Erythropoiesis refers to the production of red blood cells
  • Hemocytoblasts are stem cells from which blood cells develop
  • Type O blood is considered the universal donor
  • Type AB blood is considered the universal acceptor
  • Hemostasis stages include vascular spasm, platelet plug formation, and coagulation
  • Agglutinins are antibodies that cause agglutination
  • Agglutinogens are antigens on the surface of red blood cells
  • Pernicious anemia is caused by a vitamin B12 deficiency
  • Hypoxia triggers erythropoiesis by stimulating the release of erythropoietin
  • Blood cells are formed in the red bone marrow
  • Granular leukocytes consist of neutrophils, eosinophils, and basophils
  • Agranular leukocytes consist of lymphocytes and monocytes
  • Erythropoietin induces red blood cell production
  • One hemoglobin molecule can bind to four oxygen molecules
  • Types of anemia include iron-deficiency anemia, sickle cell anemia, and hemolytic anemia

Chapter 20

  • The Lymphatic system functions include fluid recovery, immunity and lipid absorption
  • Lymph components include water, proteins, fats and lymphocytes
  • Lymphatic vessels are lymphatic capillaries, collecting vessels, and lymphatic trunks (smallest to largest)
  • Lymph is drained from the upper right side of the body by the lymphatic duct
  • Lymph nodes filter lymph and activate the immune system
  • Peyer's patches are aggregated lymphoid nodules found in the small intestine
  • Afferent lymphatic vessels transport lymph to lymph nodes, while efferent vessels carry lymph away
  • Lymphoid tissue functions in immune surveillance and response
  • Lymphoid tissue features a high concentration of lymphocytes
  • The thymus gland functions T lymphocyte maturation
  • The spleen filters blood, stores platelets, and destroys old red blood cells
  • Tonsils protect against ingested or inhaled pathogens
  • Germinal centers within lymphoid nodules contain B lymphocytes
  • Buboes are swollen and inflamed lymph nodes in the groin or axilla
  • Certain infections or cancers may be indicated by swollen, non-painful lymph nodes

Chapter 21

  • The divisions of the immune system are the innate and adaptive immune systems
  • Inflammation functions to contain infection, remove debris, and promote healing
  • Redness and heat in inflammation are due to increased blood flow to the affected area
  • Natural killer cells are lymphocytes that kill infected or cancerous cells
  • Phagocytosis involves chemotaxis, adherence, ingestion, digestion, and exocytosis
  • Complete antigens are immunogenic and reactive, incomplete antigens (haptens) are reactive but not immunogenic unless attached to a carrier molecule
  • Self-antigens are MHC proteins on the surface of cells distinct for each individual
  • B lymphocytes mature in the bone marrow, while T lymphocytes mature in the thymus
  • Genetic recombination leads to antigen receptor diversity in lymphocytes
  • Plasma cells are antibody-secreting cells
  • The primary immune response occurs on first exposure to an antigen, while the secondary response is faster and stronger because of immunological memory

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