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Questions and Answers
What stimulates the increased production of red blood cells in response to low oxygen levels?
What stimulates the increased production of red blood cells in response to low oxygen levels?
Which type of white blood cell is classified as a granulocyte?
Which type of white blood cell is classified as a granulocyte?
How are leukocytes classified based on their function?
How are leukocytes classified based on their function?
Which of the following statements about neutrophils is correct?
Which of the following statements about neutrophils is correct?
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What is the primary function of erythropoietin in the body?
What is the primary function of erythropoietin in the body?
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What is the main structural feature of red blood cells that facilitates their function in the bloodstream?
What is the main structural feature of red blood cells that facilitates their function in the bloodstream?
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What distinguishes agranular leukocytes from other types of white blood cells?
What distinguishes agranular leukocytes from other types of white blood cells?
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Which blood component represents the liquid portion after clotting has taken place?
Which blood component represents the liquid portion after clotting has taken place?
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What percentage of blood volume generally consists of red blood cells in an average adult?
What percentage of blood volume generally consists of red blood cells in an average adult?
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What is the expected lifespan of a red blood cell in the human body?
What is the expected lifespan of a red blood cell in the human body?
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Study Notes
Blood Components
- Average human has ~5 L of blood, roughly 70 mL/kg body weight.
- Blood consists of ~50-60% plasma (liquid) and ~40-50% formed elements (cells).
- Plasma is approximately 90% water; remaining 10% includes ions, glucose, amino acids, hormones, and proteins (notably coagulation proteins).
- Serum is plasma without clotting factors and fibrinogen.
- Erythrocytes (RBCs) account for ~99% of formed elements in blood.
Functions of Blood
- Transports nutrients, gases, hormones, and waste products.
- Regulates body temperature, pH levels, and fluid balance.
- Protects against infections and excessive bleeding.
Red Blood Cells (Erythrocytes)
- RBCs lack a nucleus, organelles, and undergo no cell division.
- Characterized by a biconcave shape for enhanced surface area and flexibility.
- Average life span of RBCs is ~120 days.
White Blood Cells (Leukocytes)
- Complete cells comprising two main types: agranular and granular.
- Agranular leukocytes lack cytoplasmic granules (e.g., monocytes, lymphocytes).
- Granular leukocytes include neutrophils, eosinophils, and basophils.
- Normal WBC count is 4,000 – 10,000 cells/mm³; normal RBC:WBC ratio is ~700:1.
- Conditions:
- Leukocytosis: WBC count over 10,000 cells/mm³ (high).
- Leukocytopenia: WBC count below 3,000 cells/mm³ (low).
Granulocytes
- Neutrophils make up 40-80% of total WBCs and have pink-blue granules.
- Lifespan of WBCs varies; found predominantly in lymphatic fluid and organs.
Platelets (Thrombocytes)
- Cytoplasmic fragments of megakaryocytes; contain no nucleus but possess mitochondria.
- Two types of granules: alpha granules (contain clotting factors) and dense granules (contain calcium, serotonin, ADP, ATP).
- Shape changes based on activation: discoid in stimulated states, spiny-spheric when unstimulated.
- Assist in hemostasis (stopping bleeding).
Hematopoiesis
- Refers to blood cell formation; approximately 5 x 10¹¹ cells produced daily in adults.
- Regulated and balanced process, includes:
- Erythropoiesis: formation of RBCs.
- Leukopoiesis: formation of WBCs (includes myelopoiesis for granulocytes/monocytes and lymphopoiesis for lymphocytes).
- Thrombopoiesis: formation of platelets.
Embryonic Hematopoiesis
- Begins in the yolk sac during early embryogenesis; later shifts to the liver and spleen as primary sites of blood cell production.
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Description
Explore the essential components of blood and the process of hematopoiesis. This quiz covers key aspects of blood volume, plasma contents, and the cellular makeup of blood. Test your understanding of how our body's blood composition supports various functions.
