Podcast
Questions and Answers
Which of the following is NOT a function of blood?
Which of the following is NOT a function of blood?
- Regulation of body temperature
- Defense against external threats
- Production of hormones (correct)
- Transport of oxygen and nutrients
Which of these cells are responsible for transporting oxygen throughout the body?
Which of these cells are responsible for transporting oxygen throughout the body?
- Plasma
- Red Blood Cells (correct)
- Platelets
- White Blood Cells
Which of these cells is NOT a formed element of blood?
Which of these cells is NOT a formed element of blood?
- Lymphocytes
- Platelets
- White Blood Cells
- Plasma (correct)
What is the main function of platelets?
What is the main function of platelets?
What is the primary site of hematopoiesis after birth?
What is the primary site of hematopoiesis after birth?
Which of the following is a component of plasma?
Which of the following is a component of plasma?
What is the approximate percentage of body weight accounted for by blood?
What is the approximate percentage of body weight accounted for by blood?
What happens to hemoglobin as it releases oxygen in the body tissues?
What happens to hemoglobin as it releases oxygen in the body tissues?
Which of the following is NOT a common cause of blood loss anemia?
Which of the following is NOT a common cause of blood loss anemia?
What percentage of carbon dioxide in the blood binds to the amino acids in hemoglobin?
What percentage of carbon dioxide in the blood binds to the amino acids in hemoglobin?
What does the term 'hypoxemia' refer to?
What does the term 'hypoxemia' refer to?
What is the normal range for pulse oximeter readings?
What is the normal range for pulse oximeter readings?
What is the clinical term for the percentage of hemoglobin sites occupied by oxygen in a patient's blood?
What is the clinical term for the percentage of hemoglobin sites occupied by oxygen in a patient's blood?
What is the typical unit of measurement for the partial pressure of oxygen (pO2)?
What is the typical unit of measurement for the partial pressure of oxygen (pO2)?
Which of the following is NOT a type of anemia caused by faulty or decreased RBC production?
Which of the following is NOT a type of anemia caused by faulty or decreased RBC production?
What are the two antigens involved in ABO blood typing?
What are the two antigens involved in ABO blood typing?
Which blood type has both A and B antigens on its erythrocytes?
Which blood type has both A and B antigens on its erythrocytes?
Which of the following individuals has preformed anti-B antibodies circulating in their blood plasma?
Which of the following individuals has preformed anti-B antibodies circulating in their blood plasma?
What is the clinically important antigen in the Rh blood group?
What is the clinically important antigen in the Rh blood group?
What percentage of Americans are Rh positive (Rh+)?
What percentage of Americans are Rh positive (Rh+)?
What happens when anti-A antibodies encounter erythrocytes with A antigens?
What happens when anti-A antibodies encounter erythrocytes with A antigens?
What is the primary function of erythrocytes?
What is the primary function of erythrocytes?
What cellular component is responsible for the red color of blood?
What cellular component is responsible for the red color of blood?
What is the name of the process by which the body produces new blood cells?
What is the name of the process by which the body produces new blood cells?
What is the lifespan of a typical erythrocyte?
What is the lifespan of a typical erythrocyte?
Where does extramedullary hemopoiesis primarily occur?
Where does extramedullary hemopoiesis primarily occur?
What is the buffy coat composed of?
What is the buffy coat composed of?
What percentage of a typical blood sample is composed of erythrocytes?
What percentage of a typical blood sample is composed of erythrocytes?
What is the primary component of plasma?
What is the primary component of plasma?
What is the function of heme in hemoglobin?
What is the function of heme in hemoglobin?
What is the role of hemopoietic growth factors in hematopoiesis?
What is the role of hemopoietic growth factors in hematopoiesis?
What is the average diameter of an erythrocyte?
What is the average diameter of an erythrocyte?
What is the name of the process by which worn-out erythrocytes are removed from circulation?
What is the name of the process by which worn-out erythrocytes are removed from circulation?
What is the primary location where macrophages remove worn-out erythrocytes?
What is the primary location where macrophages remove worn-out erythrocytes?
What is the term for the oxygen-carrying form of hemoglobin?
What is the term for the oxygen-carrying form of hemoglobin?
What is the role of iron in hemoglobin?
What is the role of iron in hemoglobin?
Which type of leukocyte has the smallest nucleus-to-cytoplasm ratio?
Which type of leukocyte has the smallest nucleus-to-cytoplasm ratio?
Which of the following statements about eosinophils is NOT true?
Which of the following statements about eosinophils is NOT true?
What is the primary function of lysozyme, an enzyme found in neutrophil granules?
What is the primary function of lysozyme, an enzyme found in neutrophil granules?
Which type of leukocyte is primarily responsible for releasing histamines and heparin?
Which type of leukocyte is primarily responsible for releasing histamines and heparin?
Which type of lymphocyte is responsible for providing generalized, nonspecific immunity?
Which type of lymphocyte is responsible for providing generalized, nonspecific immunity?
Which of the following is NOT a characteristic of memory cells?
Which of the following is NOT a characteristic of memory cells?
Which type of leukocyte has granules that stain best with an acidic stain?
Which type of leukocyte has granules that stain best with an acidic stain?
Which of the following is a possible cause of an abnormally low neutrophil count?
Which of the following is a possible cause of an abnormally low neutrophil count?
Which of the following statements is TRUE about the development of lymphocytes?
Which of the following statements is TRUE about the development of lymphocytes?
Which of the following is NOT a function of lymphocytes?
Which of the following is NOT a function of lymphocytes?
Which of the following leukocytes is responsible for the production of immunoglobulins?
Which of the following leukocytes is responsible for the production of immunoglobulins?
Which type of leukocyte is most likely to be elevated in a patient with a parasitic worm infestation?
Which type of leukocyte is most likely to be elevated in a patient with a parasitic worm infestation?
Which of the following is a hallmark of the inflammatory response?
Which of the following is a hallmark of the inflammatory response?
Which type of leukocyte is most likely to be elevated in a patient with a bacterial infection?
Which type of leukocyte is most likely to be elevated in a patient with a bacterial infection?
Which type of leukocyte is responsible for the "halo" effect seen in some blood slides?
Which type of leukocyte is responsible for the "halo" effect seen in some blood slides?
Which of these components is NOT found in the granules of neutrophils?
Which of these components is NOT found in the granules of neutrophils?
Which of the following conditions is associated with abnormally high monocyte counts?
Which of the following conditions is associated with abnormally high monocyte counts?
What is the primary function of megakaryocytes?
What is the primary function of megakaryocytes?
Which of the following is NOT a characteristic of arteries?
Which of the following is NOT a characteristic of arteries?
Which of the following is TRUE about lymphocytes?
Which of the following is TRUE about lymphocytes?
What is the primary site of secondary production and maturation of lymphocytes?
What is the primary site of secondary production and maturation of lymphocytes?
Which of the following is a characteristic of thrombocytopenia?
Which of the following is a characteristic of thrombocytopenia?
Which of the following statements accurately describes the role of macrophages?
Which of the following statements accurately describes the role of macrophages?
Which of the following is a characteristic of a vein compared to an artery?
Which of the following is a characteristic of a vein compared to an artery?
Which of the following conditions is associated with abnormally low lymphocyte counts?
Which of the following conditions is associated with abnormally low lymphocyte counts?
Which of the following statements about blood vessels is TRUE?
Which of the following statements about blood vessels is TRUE?
What is the main function of the pulmonary circuit?
What is the main function of the pulmonary circuit?
Which of the following is a characteristic shared by both arteries and veins?
Which of the following is a characteristic shared by both arteries and veins?
Which of the following statements accurately describes the relationship between monocytes and macrophages?
Which of the following statements accurately describes the relationship between monocytes and macrophages?
What is the main function of the systemic circuit?
What is the main function of the systemic circuit?
Which of the following statements about leukocyte production is TRUE?
Which of the following statements about leukocyte production is TRUE?
Which of the following is NOT a characteristic of elastic arteries?
Which of the following is NOT a characteristic of elastic arteries?
What is the main function of the tunica media in a muscular artery?
What is the main function of the tunica media in a muscular artery?
Which type of blood vessel has the smallest lumen diameter?
Which type of blood vessel has the smallest lumen diameter?
Which of the following statements is TRUE regarding the endothelial lining of capillaries?
Which of the following statements is TRUE regarding the endothelial lining of capillaries?
Which type of capillary is most prevalent in tissues with high nutrient absorption rates?
Which type of capillary is most prevalent in tissues with high nutrient absorption rates?
What is the primary mechanism for the distribution of blood flow in the body?
What is the primary mechanism for the distribution of blood flow in the body?
Which of the following helps maintain the pressure gradient that drives blood flow through the arterial system?
Which of the following helps maintain the pressure gradient that drives blood flow through the arterial system?
What is the function of the intercellular clefts found in continuous capillaries?
What is the function of the intercellular clefts found in continuous capillaries?
Which of the following structures is NOT found in arterioles?
Which of the following structures is NOT found in arterioles?
What is the main function of vasoconstriction in arterioles?
What is the main function of vasoconstriction in arterioles?
Which of the following types of capillaries is characterized by the presence of fenestrations?
Which of the following types of capillaries is characterized by the presence of fenestrations?
Which of the following statements is TRUE regarding muscular arteries?
Which of the following statements is TRUE regarding muscular arteries?
What is the main function of capillaries in the circulatory system?
What is the main function of capillaries in the circulatory system?
Which of the following factors can influence the diameter of an arteriole?
Which of the following factors can influence the diameter of an arteriole?
Which of the following statements is NOT true regarding elastic arteries?
Which of the following statements is NOT true regarding elastic arteries?
Which of the following describes the function of the tunica externa in blood vessels?
Which of the following describes the function of the tunica externa in blood vessels?
What is the primary role of venoconstriction in the circulatory system?
What is the primary role of venoconstriction in the circulatory system?
Which of the following best describes veins in comparison to arteries?
Which of the following best describes veins in comparison to arteries?
Approximately what percentage of venous blood is stored in venous networks within key organs?
Approximately what percentage of venous blood is stored in venous networks within key organs?
Where is the vasomotor center, responsible for controlling blood flow redistribution, located?
Where is the vasomotor center, responsible for controlling blood flow redistribution, located?
What term is used to refer to the volume of blood that can be mobilized from venous storage during increased demand?
What term is used to refer to the volume of blood that can be mobilized from venous storage during increased demand?
Which of the following statements accurately describes sinusoid capillaries?
Which of the following statements accurately describes sinusoid capillaries?
What role do precapillary sphincters play in the circulatory system?
What role do precapillary sphincters play in the circulatory system?
What is the main consequence of closed precapillary sphincters in a capillary bed?
What is the main consequence of closed precapillary sphincters in a capillary bed?
Which statement best describes a metarteriole?
Which statement best describes a metarteriole?
What anatomical feature is primarily responsible for the unidirectional flow of blood in veins?
What anatomical feature is primarily responsible for the unidirectional flow of blood in veins?
Which condition results from an accumulation of fluid around cells due to increased capillary pressure?
Which condition results from an accumulation of fluid around cells due to increased capillary pressure?
Varicose veins are often found in conjunction with which other condition?
Varicose veins are often found in conjunction with which other condition?
What primarily allows veins to act as blood reservoirs?
What primarily allows veins to act as blood reservoirs?
Which of the following is NOT a function of venules in the circulatory system?
Which of the following is NOT a function of venules in the circulatory system?
Which of the following is true regarding edema?
Which of the following is true regarding edema?
What is a characteristic of sinusoids compared to other types of capillaries?
What is a characteristic of sinusoids compared to other types of capillaries?
What anatomical feature ensures that blood can bypass capillary beds when necessary?
What anatomical feature ensures that blood can bypass capillary beds when necessary?
What might commonly contribute to the development of varicose veins?
What might commonly contribute to the development of varicose veins?
Which of the following would be considered a universal donor?
Which of the following would be considered a universal donor?
What is the term used for the process by which Rh- individuals produce antibodies to Rh antigens?
What is the term used for the process by which Rh- individuals produce antibodies to Rh antigens?
Which of the following best describes the function of RhoGAM?
Which of the following best describes the function of RhoGAM?
What is the primary reason for the decline in the incidence of hemolytic disease of the newborn (HDN)?
What is the primary reason for the decline in the incidence of hemolytic disease of the newborn (HDN)?
What is the main reason why blood type compatibility is crucial before a transfusion?
What is the main reason why blood type compatibility is crucial before a transfusion?
Which of the following blood types is considered the universal recipient?
Which of the following blood types is considered the universal recipient?
Which of the following statements accurately describes the Rh blood group?
Which of the following statements accurately describes the Rh blood group?
What is a potential complication of transfusing type O blood into a patient with type A, B, or AB blood?
What is a potential complication of transfusing type O blood into a patient with type A, B, or AB blood?
Why is the Rh factor a concern in subsequent pregnancies for an Rh- mother?
Why is the Rh factor a concern in subsequent pregnancies for an Rh- mother?
Which of the following accurately describes the relationship between leukocytes and erythrocytes?
Which of the following accurately describes the relationship between leukocytes and erythrocytes?
What is the main difference between leukocytes and erythrocytes in terms of location?
What is the main difference between leukocytes and erythrocytes in terms of location?
Which of the following is NOT a characteristic of leukocytes?
Which of the following is NOT a characteristic of leukocytes?
In an emergency situation, why may a patient receive blood from a universal donor?
In an emergency situation, why may a patient receive blood from a universal donor?
What is the role of platelets in the body?
What is the role of platelets in the body?
What is the most common reason for the sensitization of an Rh- mother?
What is the most common reason for the sensitization of an Rh- mother?
Although a patient with AB+ blood type is considered a universal recipient, what potential problem could arise from receiving blood from a donor?
Although a patient with AB+ blood type is considered a universal recipient, what potential problem could arise from receiving blood from a donor?
Which of the following is a primary cause of clot formation?
Which of the following is a primary cause of clot formation?
Vasa vasorum are found in which of the following?
Vasa vasorum are found in which of the following?
Which tunic is the thickest in arteries?
Which tunic is the thickest in arteries?
What is the function of the internal elastic membrane?
What is the function of the internal elastic membrane?
What is NOT true about the tunica externa?
What is NOT true about the tunica externa?
Which of the following is true about valves in veins?
Which of the following is true about valves in veins?
How does vasoconstriction affect blood flow?
How does vasoconstriction affect blood flow?
Which of the following is NOT a component of the tunica intima?
Which of the following is NOT a component of the tunica intima?
What is the main difference between the tunica media of arteries and veins?
What is the main difference between the tunica media of arteries and veins?
Where is the external elastic membrane found?
Where is the external elastic membrane found?
Which of the following statements about the vasa vasorum is correct?
Which of the following statements about the vasa vasorum is correct?
Why are arterial diseases more common than venous diseases?
Why are arterial diseases more common than venous diseases?
Which of the following is true about the basement membrane?
Which of the following is true about the basement membrane?
What is the function of the nervi vasorum?
What is the function of the nervi vasorum?
How does the appearance of an artery differ from that of a vein under a microscope?
How does the appearance of an artery differ from that of a vein under a microscope?
Which of the following statements is true about the tunics of arteries and veins?
Which of the following statements is true about the tunics of arteries and veins?
Flashcards
Blood
Blood
A fluid connective tissue that circulates throughout the body, carrying cells in a liquid matrix called plasma.
Hematopoietic stem cells
Hematopoietic stem cells
Stem cells located in the bone marrow that produce blood cells including RBCs, WBCs, and platelets.
Erythrocytes
Erythrocytes
Red blood cells responsible for transporting oxygen and some carbon dioxide in the blood.
Leukocytes
Leukocytes
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Platelets
Platelets
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Plasma
Plasma
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Hematopoiesis
Hematopoiesis
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Functions of Blood
Functions of Blood
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Extramedullary Hemopoiesis
Extramedullary Hemopoiesis
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Lifespan of Blood Cells
Lifespan of Blood Cells
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Hematocrit
Hematocrit
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Buffy Coat
Buffy Coat
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Plasma Composition
Plasma Composition
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Biconcave Shape of Erythrocytes
Biconcave Shape of Erythrocytes
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Hemoglobin Function
Hemoglobin Function
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Erythrocyte Lifespan
Erythrocyte Lifespan
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White Blood Cells (Leukocytes)
White Blood Cells (Leukocytes)
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Platelets (Thrombocytes)
Platelets (Thrombocytes)
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Hematopoietic Growth Factors
Hematopoietic Growth Factors
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Oxyhemoglobin
Oxyhemoglobin
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Oxygenated hemoglobin
Oxygenated hemoglobin
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Carbaminohemoglobin
Carbaminohemoglobin
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Percent saturation
Percent saturation
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Pulse oximeter
Pulse oximeter
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Hypoxemia
Hypoxemia
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Hypoxia
Hypoxia
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Partial pressure of oxygen (pO2)
Partial pressure of oxygen (pO2)
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Anemia
Anemia
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Blood loss anemia
Blood loss anemia
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RBC production anemia
RBC production anemia
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A blood type
A blood type
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B blood type
B blood type
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AB blood type
AB blood type
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O blood type
O blood type
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Lymphocytes
Lymphocytes
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Rh group
Rh group
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High lymphocyte counts
High lymphocyte counts
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Sensitization
Sensitization
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HDN (Hemolytic Disease of the Newborn)
HDN (Hemolytic Disease of the Newborn)
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Low lymphocyte counts
Low lymphocyte counts
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Monocytes
Monocytes
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RhoGAM
RhoGAM
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Macrophages
Macrophages
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Universal donor
Universal donor
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Leukocyte lifespan
Leukocyte lifespan
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Universal recipient
Universal recipient
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Germinal centers
Germinal centers
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Erythrocyte antigens
Erythrocyte antigens
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Megakaryocytes
Megakaryocytes
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Transfusion reaction
Transfusion reaction
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Leukocyte movement
Leukocyte movement
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Hemostasis
Hemostasis
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Macrophage
Macrophage
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Thrombocytosis
Thrombocytosis
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Platelet functions
Platelet functions
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Thrombocytopenia
Thrombocytopenia
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Anti-Rh antibodies
Anti-Rh antibodies
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Arterioles
Arterioles
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Systemic circulation
Systemic circulation
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Pulmonary circulation
Pulmonary circulation
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Acute hemorrhage
Acute hemorrhage
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Blood plasma
Blood plasma
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Vein structure
Vein structure
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Capacitance Vessels
Capacitance Vessels
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Venoconstriction
Venoconstriction
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Granular leukocytes
Granular leukocytes
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Blood Redistributing
Blood Redistributing
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Neutrophils
Neutrophils
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Eosinophils
Eosinophils
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Venous Reserve
Venous Reserve
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Basophils
Basophils
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Vasomotor Center
Vasomotor Center
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Agranular leukocytes
Agranular leukocytes
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Natural Killer (NK) cells
Natural Killer (NK) cells
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B cells
B cells
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T cells
T cells
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Memory cells
Memory cells
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Phagocytosis
Phagocytosis
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Antigen-antibody complex
Antigen-antibody complex
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Histamines
Histamines
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Sinusoid Capillary
Sinusoid Capillary
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Function of Sinusoids
Function of Sinusoids
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Location of Sinusoids
Location of Sinusoids
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Metarteriole
Metarteriole
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Precapillary Sphincters
Precapillary Sphincters
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Vascular Shunt
Vascular Shunt
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Venule
Venule
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Walls of Venules
Walls of Venules
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Diapedesis
Diapedesis
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Vein Function
Vein Function
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Varicose Veins
Varicose Veins
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Edema
Edema
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Causes of Edema
Causes of Edema
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Blood Reservoirs
Blood Reservoirs
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Thrombus Risk in Varicose Veins
Thrombus Risk in Varicose Veins
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Tunica Externa
Tunica Externa
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Elastic Artery
Elastic Artery
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Muscular Artery
Muscular Artery
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Capillary
Capillary
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Vascular Tone
Vascular Tone
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Elastic Recoil
Elastic Recoil
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Fenestrated Capillary
Fenestrated Capillary
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Continuous Capillary
Continuous Capillary
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Tunica Intima
Tunica Intima
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Tunica Media
Tunica Media
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Vasodilation
Vasodilation
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Pressure Gradient
Pressure Gradient
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Vasa Vasorum
Vasa Vasorum
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Nervi Vasorum
Nervi Vasorum
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Tunics
Tunics
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Endothelium
Endothelium
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Basement Membrane
Basement Membrane
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Internal Elastic Membrane
Internal Elastic Membrane
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Valves in Veins
Valves in Veins
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External Elastic Membrane
External Elastic Membrane
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Collagenous Fibers
Collagenous Fibers
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Smooth Muscle
Smooth Muscle
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Study Notes
Blood Composition and Function
- Blood is a fluid connective tissue, unique because its extracellular matrix (plasma) is liquid.
- Formed elements (RBCs, WBCs, platelets) are suspended in the plasma.
- These elements originate from hematopoietic stem cells in bone marrow.
- Hematopoiesis (blood cell production) occurs in yolk sac, fetal liver, spleen and red bone marrow. Postnatally, primarily in red marrow of spongy bone.
Formed Elements
-
Erythrocytes (RBCs): Transport oxygen and some carbon dioxide.
- Biconcave shape maximizes surface area for gas exchange.
- Lack most organelles, maximizing space for hemoglobin.
- Lifespan: ~120 days. Removed by macrophages in bone marrow, liver, and spleen.
-
Leukocytes (WBCs): Defend against harmful microorganisms or molecules.
- Several types (neutrophils, eosinophils, basophils, lymphocytes, monocytes)
- Can leave blood vessels to enter tissues
- Vary in lifespan (from hours to years)
- Important in different immune responses
-
Platelets (thrombocytes): Involved in blood clotting and tissue repair.
- Fragments of megakaryocytes.
- Lifespan: ~10 days. Removed by macrophages.
Blood Composition and Plasma
- Plasma: Mostly water (92%), with dissolved/suspended proteins and other substances.
- Approximately 8% of adult body weight
- Male average: 5-6 liters, Female average: 4-5 liters
- Blood function involves oxygen/nutrient delivery and waste removal, defense and regulation.
Hematopoiesis (Blood Cell Production)
- Hemopoiesis occurs continuously to replenish blood cells.
- Hematopoietic growth factors stimulate stem cell division and differentiation.
- Stem cells are organized hierarchically, with progressively reduced diversification ability at each step.
- Blood loss requires a number of weeks to replace cells.
Blood Typing and Transfusions
- ABO blood groups are based on the presence or absence of A and B antigens on RBCs membranes.
- Type O is the universal donor; AB is the universal recipient.
- Rh factor (presence/absence of Rh D antigen) is also crucial in blood transfusions and can cause complications in pregnancies.
- RhoGAM prevents Rh incompatibility in Rh-negative mothers.
Blood Vessels
-
Blood flow in closed circulatory system with arteries, arterioles, capillaries, venules and veins.
-
Arteries are high-pressure vessels that carry blood away from the heart, with thick walls containing elastic and muscular fibers.
- Elastic arteries (conducting) expand and recoil.
- Muscular arteries (distributing) control blood flow via vasoconstriction and vasodilation.
-
Arterioles control blood flow into capillaries further regulating pressure.
-
Capillaries are where exchange of nutrients and wastes occurs with the tissues via a leaky endothelium.
-
Continuous, fenestrated and sinusoids are different types of capillaries based on how leaky they are.
-
Venules carry blood from capillaries to veins, smaller versions of veins.
-
Veins are low-pressure vessels that carry blood toward the heart with thin walls and valves to prevent backflow.
-
Venoconstriction increases blood return to heart
Disorders
- Anemia: Insufficient RBCs or hemoglobin. Various types (blood loss, decreased production, excessive destruction).
- Thrombocytosis: Excessive platelets, potentially leading to clots.
- Thrombocytopenia: Insufficient platelets leading to excessive bleeding.
- Edema: Excess tissue fluid due to various causes.
- Varicose veins: Impaired venous valves leading to distended veins.
- Hypoxia: low oxygen levels (more general)
- Hypoxemia, low oxygen content in the blood itself; measured by pO2, oxygen partial pressure.
Hematology tests and analysis
- Hematocrit: Measures the percentage of red blood cells in a blood sample (45%)
- Pulse oximetry measures hemoglobin saturation using light absorption in the blood.
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