Human Blood Functions and Components Quiz
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Questions and Answers

Which of the following is NOT a function of blood?

  • Regulation of body temperature
  • Defense against external threats
  • Production of hormones (correct)
  • Transport of oxygen and nutrients
  • Which of these cells are responsible for transporting oxygen throughout the body?

  • Plasma
  • Red Blood Cells (correct)
  • Platelets
  • White Blood Cells
  • Which of these cells is NOT a formed element of blood?

  • Lymphocytes
  • Platelets
  • White Blood Cells
  • Plasma (correct)
  • What is the main function of platelets?

    <p>Blood clotting (C)</p> Signup and view all the answers

    What is the primary site of hematopoiesis after birth?

    <p>Red Bone Marrow (D)</p> Signup and view all the answers

    Which of the following is a component of plasma?

    <p>Dissolved salts (C)</p> Signup and view all the answers

    What is the approximate percentage of body weight accounted for by blood?

    <p>8% (B)</p> Signup and view all the answers

    What happens to hemoglobin as it releases oxygen in the body tissues?

    <p>It becomes darker red and is referred to as deoxyhemoglobin. (A)</p> Signup and view all the answers

    Which of the following is NOT a common cause of blood loss anemia?

    <p>Iron deficiency (B)</p> Signup and view all the answers

    What percentage of carbon dioxide in the blood binds to the amino acids in hemoglobin?

    <p>23-24% (D)</p> Signup and view all the answers

    What does the term 'hypoxemia' refer to?

    <p>Low blood oxygen levels (A)</p> Signup and view all the answers

    What is the normal range for pulse oximeter readings?

    <p>95-100% (D)</p> Signup and view all the answers

    What is the clinical term for the percentage of hemoglobin sites occupied by oxygen in a patient's blood?

    <p>Oxygen saturation (B)</p> Signup and view all the answers

    What is the typical unit of measurement for the partial pressure of oxygen (pO2)?

    <p>Millimeters of mercury (mm Hg) (C)</p> Signup and view all the answers

    Which of the following is NOT a type of anemia caused by faulty or decreased RBC production?

    <p>Blood loss anemia (B)</p> Signup and view all the answers

    What are the two antigens involved in ABO blood typing?

    <p>A and B (C)</p> Signup and view all the answers

    Which blood type has both A and B antigens on its erythrocytes?

    <p>AB (A)</p> Signup and view all the answers

    Which of the following individuals has preformed anti-B antibodies circulating in their blood plasma?

    <p>Type A (A)</p> Signup and view all the answers

    What is the clinically important antigen in the Rh blood group?

    <p>D (D)</p> Signup and view all the answers

    What percentage of Americans are Rh positive (Rh+)?

    <p>85% (A)</p> Signup and view all the answers

    What happens when anti-A antibodies encounter erythrocytes with A antigens?

    <p>Agglutination and hemolysis (B)</p> Signup and view all the answers

    What is the primary function of erythrocytes?

    <p>To transport oxygen and carbon dioxide (B)</p> Signup and view all the answers

    What cellular component is responsible for the red color of blood?

    <p>Hemoglobin (D)</p> Signup and view all the answers

    What is the name of the process by which the body produces new blood cells?

    <p>Hematopoiesis (A)</p> Signup and view all the answers

    What is the lifespan of a typical erythrocyte?

    <p>Up to 120 days (B)</p> Signup and view all the answers

    Where does extramedullary hemopoiesis primarily occur?

    <p>Liver and spleen (D)</p> Signup and view all the answers

    What is the buffy coat composed of?

    <p>Leukocytes and platelets (C)</p> Signup and view all the answers

    What percentage of a typical blood sample is composed of erythrocytes?

    <p>45% (B)</p> Signup and view all the answers

    What is the primary component of plasma?

    <p>Water (D)</p> Signup and view all the answers

    What is the function of heme in hemoglobin?

    <p>To bind to oxygen (A)</p> Signup and view all the answers

    What is the role of hemopoietic growth factors in hematopoiesis?

    <p>To stimulate stem cell division and differentiation (A)</p> Signup and view all the answers

    What is the average diameter of an erythrocyte?

    <p>7-8 micrometers (A)</p> Signup and view all the answers

    What is the name of the process by which worn-out erythrocytes are removed from circulation?

    <p>Phagocytosis (A)</p> Signup and view all the answers

    What is the primary location where macrophages remove worn-out erythrocytes?

    <p>Liver and spleen (C)</p> Signup and view all the answers

    What is the term for the oxygen-carrying form of hemoglobin?

    <p>Oxyhemoglobin (D)</p> Signup and view all the answers

    What is the role of iron in hemoglobin?

    <p>To bind to oxygen (C)</p> Signup and view all the answers

    Which type of leukocyte has the smallest nucleus-to-cytoplasm ratio?

    <p>Neutrophil (A)</p> Signup and view all the answers

    Which of the following statements about eosinophils is NOT true?

    <p>Eosinophils are the least common type of leukocyte. (E)</p> Signup and view all the answers

    What is the primary function of lysozyme, an enzyme found in neutrophil granules?

    <p>To break down bacterial cell walls. (A)</p> Signup and view all the answers

    Which type of leukocyte is primarily responsible for releasing histamines and heparin?

    <p>Basophil (A)</p> Signup and view all the answers

    Which type of lymphocyte is responsible for providing generalized, nonspecific immunity?

    <p>Natural killer cells (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of memory cells?

    <p>They are only produced by B cells. (D)</p> Signup and view all the answers

    Which type of leukocyte has granules that stain best with an acidic stain?

    <p>Eosinophil (B)</p> Signup and view all the answers

    Which of the following is a possible cause of an abnormally low neutrophil count?

    <p>Drug toxicity (D)</p> Signup and view all the answers

    Which of the following statements is TRUE about the development of lymphocytes?

    <p>B cells mature in the bone marrow, and T cells mature in the thymus. (B)</p> Signup and view all the answers

    Which of the following is NOT a function of lymphocytes?

    <p>Providing generalized, nonspecific immunity (A)</p> Signup and view all the answers

    Which of the following leukocytes is responsible for the production of immunoglobulins?

    <p>B cells (C)</p> Signup and view all the answers

    Which type of leukocyte is most likely to be elevated in a patient with a parasitic worm infestation?

    <p>Eosinophil (B)</p> Signup and view all the answers

    Which of the following is a hallmark of the inflammatory response?

    <p>Release of histamines (C)</p> Signup and view all the answers

    Which type of leukocyte is most likely to be elevated in a patient with a bacterial infection?

    <p>Neutrophil (B)</p> Signup and view all the answers

    Which type of leukocyte is responsible for the "halo" effect seen in some blood slides?

    <p>Lymphocyte (D)</p> Signup and view all the answers

    Which of these components is NOT found in the granules of neutrophils?

    <p>Histamines (A)</p> Signup and view all the answers

    Which of the following conditions is associated with abnormally high monocyte counts?

    <p>Viral or fungal infections (A)</p> Signup and view all the answers

    What is the primary function of megakaryocytes?

    <p>Production of platelets (B)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of arteries?

    <p>Contain valves to prevent backflow (B)</p> Signup and view all the answers

    Which of the following is TRUE about lymphocytes?

    <p>They can differentiate into B or T cells (D)</p> Signup and view all the answers

    What is the primary site of secondary production and maturation of lymphocytes?

    <p>Lymph nodes (B)</p> Signup and view all the answers

    Which of the following is a characteristic of thrombocytopenia?

    <p>Decreased platelet count (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the role of macrophages?

    <p>They engulf and destroy foreign pathogens and cellular debris (A)</p> Signup and view all the answers

    Which of the following is a characteristic of a vein compared to an artery?

    <p>Thinner walls (B)</p> Signup and view all the answers

    Which of the following conditions is associated with abnormally low lymphocyte counts?

    <p>Chronic illness (A)</p> Signup and view all the answers

    Which of the following statements about blood vessels is TRUE?

    <p>Capillaries are the smallest blood vessels and are responsible for nutrient and waste exchange (D)</p> Signup and view all the answers

    What is the main function of the pulmonary circuit?

    <p>Transporting deoxygenated blood to the lungs (A)</p> Signup and view all the answers

    Which of the following is a characteristic shared by both arteries and veins?

    <p>They have thicker walls than capillaries (B)</p> Signup and view all the answers

    Which of the following statements accurately describes the relationship between monocytes and macrophages?

    <p>Macrophages differentiate from monocytes (A)</p> Signup and view all the answers

    What is the main function of the systemic circuit?

    <p>Transporting oxygenated blood to the body's tissues (A)</p> Signup and view all the answers

    Which of the following statements about leukocyte production is TRUE?

    <p>Leukocyte production is regulated by hormones called CSFs and interleukins (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of elastic arteries?

    <p>They are primarily responsible for vasoconstriction. (B)</p> Signup and view all the answers

    What is the main function of the tunica media in a muscular artery?

    <p>To regulate blood flow through vasoconstriction. (A)</p> Signup and view all the answers

    Which type of blood vessel has the smallest lumen diameter?

    <p>Capillary (A)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding the endothelial lining of capillaries?

    <p>It allows for the exchange of water and small molecules. (A)</p> Signup and view all the answers

    Which type of capillary is most prevalent in tissues with high nutrient absorption rates?

    <p>Fenestrated capillary (B)</p> Signup and view all the answers

    What is the primary mechanism for the distribution of blood flow in the body?

    <p>Vasoconstriction and vasodilation in arterioles (D)</p> Signup and view all the answers

    Which of the following helps maintain the pressure gradient that drives blood flow through the arterial system?

    <p>The elastic recoil of artery walls (B)</p> Signup and view all the answers

    What is the function of the intercellular clefts found in continuous capillaries?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following structures is NOT found in arterioles?

    <p>All of the above are present in arterioles. (D)</p> Signup and view all the answers

    What is the main function of vasoconstriction in arterioles?

    <p>To decrease blood flow to a specific area (D)</p> Signup and view all the answers

    Which of the following types of capillaries is characterized by the presence of fenestrations?

    <p>Fenestrated capillary (B)</p> Signup and view all the answers

    Which of the following statements is TRUE regarding muscular arteries?

    <p>They have a thinner tunica media than elastic arteries. (B)</p> Signup and view all the answers

    What is the main function of capillaries in the circulatory system?

    <p>To exchange substances between blood and tissues (C)</p> Signup and view all the answers

    Which of the following factors can influence the diameter of an arteriole?

    <p>All of the above (D)</p> Signup and view all the answers

    Which of the following statements is NOT true regarding elastic arteries?

    <p>They are less important in regulating blood pressure than arterioles. (A)</p> Signup and view all the answers

    Which of the following describes the function of the tunica externa in blood vessels?

    <p>It provides structural support and anchors the vessel to surrounding tissues. (A)</p> Signup and view all the answers

    What is the primary role of venoconstriction in the circulatory system?

    <p>To speed the return of blood to the heart (B)</p> Signup and view all the answers

    Which of the following best describes veins in comparison to arteries?

    <p>Veins serve as capacitance vessels (D)</p> Signup and view all the answers

    Approximately what percentage of venous blood is stored in venous networks within key organs?

    <p>21% (D)</p> Signup and view all the answers

    Where is the vasomotor center, responsible for controlling blood flow redistribution, located?

    <p>In the brainstem (B)</p> Signup and view all the answers

    What term is used to refer to the volume of blood that can be mobilized from venous storage during increased demand?

    <p>Venous reserve (D)</p> Signup and view all the answers

    Which of the following statements accurately describes sinusoid capillaries?

    <p>They allow for the passage of large molecules and cells. (B)</p> Signup and view all the answers

    What role do precapillary sphincters play in the circulatory system?

    <p>They regulate blood flow from metarterioles to capillary beds. (A)</p> Signup and view all the answers

    What is the main consequence of closed precapillary sphincters in a capillary bed?

    <p>Direct blood flow into the venous circulation via a thoroughfare channel. (D)</p> Signup and view all the answers

    Which statement best describes a metarteriole?

    <p>It serves as a connection between arterioles and capillary beds. (D)</p> Signup and view all the answers

    What anatomical feature is primarily responsible for the unidirectional flow of blood in veins?

    <p>Presence of valves within the veins. (C)</p> Signup and view all the answers

    Which condition results from an accumulation of fluid around cells due to increased capillary pressure?

    <p>Edema (D)</p> Signup and view all the answers

    Varicose veins are often found in conjunction with which other condition?

    <p>Edema (D)</p> Signup and view all the answers

    What primarily allows veins to act as blood reservoirs?

    <p>Their low blood pressure and high capacitance. (A)</p> Signup and view all the answers

    Which of the following is NOT a function of venules in the circulatory system?

    <p>Providing a pathway for red blood cells to exit the bloodstream. (B)</p> Signup and view all the answers

    Which of the following is true regarding edema?

    <p>It may arise from various causes, including hypertension. (A)</p> Signup and view all the answers

    What is a characteristic of sinusoids compared to other types of capillaries?

    <p>They are able to transport the largest molecules and even cells. (A)</p> Signup and view all the answers

    What anatomical feature ensures that blood can bypass capillary beds when necessary?

    <p>Precapillary sphincters (C)</p> Signup and view all the answers

    What might commonly contribute to the development of varicose veins?

    <p>Hormonal changes associated with pregnancy. (C)</p> Signup and view all the answers

    Which of the following would be considered a universal donor?

    <p>O- (B)</p> Signup and view all the answers

    What is the term used for the process by which Rh- individuals produce antibodies to Rh antigens?

    <p>Sensitization (D)</p> Signup and view all the answers

    Which of the following best describes the function of RhoGAM?

    <p>Destroy fetal Rh+ erythrocytes that may cross the placental barrier (A)</p> Signup and view all the answers

    What is the primary reason for the decline in the incidence of hemolytic disease of the newborn (HDN)?

    <p>The introduction of RhoGAM (D)</p> Signup and view all the answers

    What is the main reason why blood type compatibility is crucial before a transfusion?

    <p>To prevent immune reactions to foreign antigens (B)</p> Signup and view all the answers

    Which of the following blood types is considered the universal recipient?

    <p>AB+ (D)</p> Signup and view all the answers

    Which of the following statements accurately describes the Rh blood group?

    <p>It is a separate system from the ABO blood group and individuals can be either Rh+ or Rh- regardless of their ABO blood type. (A)</p> Signup and view all the answers

    What is a potential complication of transfusing type O blood into a patient with type A, B, or AB blood?

    <p>The recipient's blood may start to agglutinate (D)</p> Signup and view all the answers

    Why is the Rh factor a concern in subsequent pregnancies for an Rh- mother?

    <p>The mother's Rh antibodies can cross the placenta and destroy the fetus's red blood cells. (B)</p> Signup and view all the answers

    Which of the following accurately describes the relationship between leukocytes and erythrocytes?

    <p>Leukocytes are less numerous than erythrocytes and have a shorter lifespan. (C)</p> Signup and view all the answers

    What is the main difference between leukocytes and erythrocytes in terms of location?

    <p>Erythrocytes primarily circulate in the bloodstream, while leukocytes can leave the bloodstream to perform their functions. (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of leukocytes?

    <p>They are involved in the transport of oxygen to the tissues. (D)</p> Signup and view all the answers

    In an emergency situation, why may a patient receive blood from a universal donor?

    <p>There may not be time to cross-match blood types in a life-threatening emergency. (C)</p> Signup and view all the answers

    What is the role of platelets in the body?

    <p>To repair damaged blood vessels and provide growth factors for healing. (A)</p> Signup and view all the answers

    What is the most common reason for the sensitization of an Rh- mother?

    <p>Having a child with Rh+ blood. (D)</p> Signup and view all the answers

    Although a patient with AB+ blood type is considered a universal recipient, what potential problem could arise from receiving blood from a donor?

    <p>The donor's blood might contain antibodies that could cause a reaction. (C)</p> Signup and view all the answers

    Which of the following is a primary cause of clot formation?

    <p>Damage to the endothelial lining and exposure of blood to collagenous fibers beneath (A)</p> Signup and view all the answers

    Vasa vasorum are found in which of the following?

    <p>Large arteries and veins (B)</p> Signup and view all the answers

    Which tunic is the thickest in arteries?

    <p>Tunica media (B)</p> Signup and view all the answers

    What is the function of the internal elastic membrane?

    <p>To provide additional flexibility to the vessel (D)</p> Signup and view all the answers

    What is NOT true about the tunica externa?

    <p>It is the thickest tunic in both arteries and veins. (D)</p> Signup and view all the answers

    Which of the following is true about valves in veins?

    <p>They prevent backflow of blood (D)</p> Signup and view all the answers

    How does vasoconstriction affect blood flow?

    <p>It decreases blood flow by narrowing the lumen of the vessel. (A)</p> Signup and view all the answers

    Which of the following is NOT a component of the tunica intima?

    <p>Smooth muscle fibers (C)</p> Signup and view all the answers

    What is the main difference between the tunica media of arteries and veins?

    <p>Arteries have a thicker tunica media than veins. (B)</p> Signup and view all the answers

    Where is the external elastic membrane found?

    <p>In the tunica media of larger arteries (D)</p> Signup and view all the answers

    Which of the following statements about the vasa vasorum is correct?

    <p>They provide nourishment to the cells of the vessel walls. (A)</p> Signup and view all the answers

    Why are arterial diseases more common than venous diseases?

    <p>The vasa vasorum is located closer to the lumen of arteries, making it more difficult for nutrients to reach the outer layers of the artery wall. (B)</p> Signup and view all the answers

    Which of the following is true about the basement membrane?

    <p>It binds the endothelium to the connective tissue. (B)</p> Signup and view all the answers

    What is the function of the nervi vasorum?

    <p>To control the flow of blood through the vessel. (B)</p> Signup and view all the answers

    How does the appearance of an artery differ from that of a vein under a microscope?

    <p>Arteries appear wavy due to the partial constriction of smooth muscle in the tunica media. (B)</p> Signup and view all the answers

    Which of the following statements is true about the tunics of arteries and veins?

    <p>Both arteries and veins have three tunics, but the thickness of each tunic can vary depending on the size of the vessel. (A)</p> Signup and view all the answers

    Flashcards

    Blood

    A fluid connective tissue that circulates throughout the body, carrying cells in a liquid matrix called plasma.

    Hematopoietic stem cells

    Stem cells located in the bone marrow that produce blood cells including RBCs, WBCs, and platelets.

    Erythrocytes

    Red blood cells responsible for transporting oxygen and some carbon dioxide in the blood.

    Leukocytes

    White blood cells that defend the body against harmful microorganisms and diseases.

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    Platelets

    Cell fragments in the blood that are critical for blood clotting to prevent excessive bleeding.

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    Plasma

    The liquid extracellular matrix of blood, which suspends formed elements and transports nutrients, salts, and wastes.

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    Hematopoiesis

    The process of blood cell formation, occurring mainly in the red bone marrow after birth.

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    Functions of Blood

    Mainly to deliver oxygen and nutrients, remove wastes, and provide defense and regulation within the body.

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    Extramedullary Hemopoiesis

    Blood cell production occurring outside the bone marrow, especially in liver and spleen.

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    Lifespan of Blood Cells

    Most blood cells survive only a few hours to weeks; memory cells can last years.

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    Hematocrit

    A test measuring the percentage of red blood cells in blood.

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    Buffy Coat

    The thin layer of white blood cells and platelets in a hematocrit tube.

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    Plasma Composition

    The liquid component of blood, about 92% water with dissolved substances.

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    Biconcave Shape of Erythrocytes

    The unique shape of red blood cells that increases surface area for gas exchange.

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    Hemoglobin Function

    A protein in red blood cells that binds oxygen and transports it through the bloodstream.

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    Erythrocyte Lifespan

    Red blood cells live up to 120 days before being removed by macrophages.

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    White Blood Cells (Leukocytes)

    Cells that are part of the immune system, defending the body against infections.

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    Platelets (Thrombocytes)

    Cell fragments involved in blood clotting.

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    Hematopoietic Growth Factors

    Chemical stimuli that prompt hemopoietic stem cells to divide and differentiate.

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    Oxyhemoglobin

    Formed when hemoglobin binds with oxygen in the lungs.

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    Oxygenated hemoglobin

    Hemoglobin bound to oxygen, appears bright red.

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    Carbaminohemoglobin

    Hemoglobin that binds with carbon dioxide.

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    Percent saturation

    Percentage of hemoglobin sites occupied by oxygen.

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    Pulse oximeter

    Device used to measure blood oxygen saturation.

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    Hypoxemia

    Low blood oxygen saturation levels.

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    Hypoxia

    General term for low oxygen levels in tissue.

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    Partial pressure of oxygen (pO2)

    Measure of oxygen concentration in arterial blood.

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    Anemia

    Condition characterized by insufficient red blood cells or hemoglobin.

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    Blood loss anemia

    Anemia caused by the loss of blood due to various factors.

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    RBC production anemia

    Anemia due to faulty or decreased red blood cell production.

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    A blood type

    Blood type with A antigens, has anti-B antibodies.

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    B blood type

    Blood type with B antigens, has anti-A antibodies.

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    AB blood type

    Blood type with both A and B antigens, no anti-A or B antibodies.

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    O blood type

    Blood type with neither A nor B antigens, has anti-A and anti-B antibodies.

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    Lymphocytes

    A type of white blood cell involved in immune responses and can be B or T cells.

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    Rh group

    A blood group determined by the presence or absence of the Rh antigen.

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    High lymphocyte counts

    Elevated levels indicate viral infections or certain cancers.

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    Sensitization

    The process where Rh− individuals produce antibodies after exposure to Rh+ blood.

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    HDN (Hemolytic Disease of the Newborn)

    A condition in which Rh antibodies from the mother destroy fetal red blood cells.

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    Low lymphocyte counts

    Reduced levels typically indicate prolonged illness or suppression of the immune system.

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    Monocytes

    A type of white blood cell that becomes macrophages and helps in phagocytosis.

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    RhoGAM

    A medication that prevents Rh antibody formation in Rh− mothers after exposure to Rh+ cells.

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    Macrophages

    Monocytes that have left circulation to consume debris and pathogens.

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    Universal donor

    An individual with type O− blood that can donate to any blood type.

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    Leukocyte lifespan

    Most white blood cells live for hours to days.

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    Universal recipient

    A person with type AB+ blood who can receive any blood type.

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    Germinal centers

    Specific regions in lymphatic tissue where lymphocytes mature.

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    Erythrocyte antigens

    Surface proteins on red blood cells that determine blood type.

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    Megakaryocytes

    Large cells in the bone marrow that fragment to form platelets.

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    Transfusion reaction

    An immune response that occurs when mismatched blood is transfused.

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    Leukocyte movement

    Leukocytes leave the bloodstream to perform their immune functions in tissues.

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    Hemostasis

    The process of stopping blood flow following vessel damage.

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    Macrophage

    A type of white blood cell that engulfs and digests pathogens.

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    Thrombocytosis

    Condition of having too many platelets, risking blood clots.

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    Platelet functions

    Platelets help in blood clotting and tissue repair after injury.

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    Thrombocytopenia

    Condition of having insufficient platelets, leading to excessive bleeding.

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    Anti-Rh antibodies

    Antibodies produced by Rh− individuals after exposure to Rh+ blood.

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    Arterioles

    Small arteries that branch into capillaries for nutrient exchange.

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    Systemic circulation

    Pathway that carries oxygen-rich blood from the heart to the body.

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    Pulmonary circulation

    Pathway that carries oxygen-poor blood to the lungs for gas exchange.

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    Acute hemorrhage

    A sudden and severe loss of blood that requires emergency action.

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    Blood plasma

    The liquid portion of blood that transports cells and nutrients.

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    Vein structure

    Veins have thinner walls and larger lumens compared to arteries, allowing lower pressure blood flow.

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    Capacitance Vessels

    Veins that are highly distensible and can hold large volumes of blood.

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    Venoconstriction

    Constriction of the veins to increase blood pressure and speed up return to the heart.

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    Granular leukocytes

    Leukocytes with visible granules in their cytoplasm, including neutrophils, eosinophils, and basophils.

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    Blood Redistributing

    The process of redirecting blood flow to different body parts as needed.

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    Neutrophils

    The most common leukocytes, making up 50-70% of the total count; they rapidly respond to infections.

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    Eosinophils

    Leukocytes that account for 2-4% of leukocytes, effective in fighting allergies and parasitic worms.

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    Venous Reserve

    The volume of blood stored in venous networks, available for rapid distribution.

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    Basophils

    The least common leukocytes, less than 1% of total count, involved in inflammation and allergic reactions.

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    Vasomotor Center

    Part of the medulla oblongata that regulates blood vessel constriction and dilation.

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    Agranular leukocytes

    Leukocytes with smaller, less visible granules; includes lymphocytes and monocytes.

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    Natural Killer (NK) cells

    Lymphocytes that recognize and destroy abnormal cells, providing nonspecific immunity.

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    B cells

    Lymphocytes that produce antibodies to fight specific pathogens; involved in humoral immunity.

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    T cells

    Lymphocytes responsible for cellular immunity by attacking infected or cancerous cells directly.

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    Memory cells

    Long-lived B and T cells that provide rapid responses upon re-exposure to a pathogen.

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    Phagocytosis

    The process by which cells engulf and digest pathogens or debris.

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    Antigen-antibody complex

    A formed structure when antibodies bind to specific foreign components, aiding in their destruction.

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    Histamines

    Chemical substances released by basophils that promote inflammation.

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    Sinusoid Capillary

    The least common type of capillary with large openings for molecule passage.

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    Function of Sinusoids

    Allow slow blood flow for nutrient and gas exchange.

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    Location of Sinusoids

    Found in the liver, spleen, and endocrine glands.

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    Metarteriole

    Vessel with characteristics of arterioles and capillaries, supplying capillary beds.

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    Precapillary Sphincters

    Regulate blood flow into capillaries from metarterioles.

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    Vascular Shunt

    Blood flow bypassing capillaries, moving directly into venous circulation.

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    Venule

    Small vein that collects blood from capillary beds.

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    Walls of Venules

    Thin, with endothelium and few muscle cells.

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    Diapedesis

    Process of white blood cells exiting the bloodstream into tissues.

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    Vein Function

    Conduct blood toward the heart; low-pressure vessels with valves.

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    Varicose Veins

    Enlarged veins caused by valve defects allowing blood pooling.

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    Edema

    Swelling due to excess fluid in interstitial spaces.

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    Causes of Edema

    Includes hypertension, heart failure, and protein deficiency.

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    Blood Reservoirs

    Veins can hold 64% of blood volume, adapting to low pressure.

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    Thrombus Risk in Varicose Veins

    Patients have a greater risk of clot formation in varicose veins.

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    Tunica Externa

    The outermost layer of blood vessel walls that provides structural support.

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    Elastic Artery

    A type of artery with thick walls and abundant elastic fibers that conduct blood away from the heart.

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    Muscular Artery

    Arteries with thick tunica media and less elastic fibers, allowing for vasoconstriction.

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    Capillary

    Microscopic blood vessels where gas and nutrient exchange occurs with tissues.

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    Vascular Tone

    The degree of constriction of blood vessels caused by smooth muscle contraction.

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    Elastic Recoil

    The ability of arteries to return to shape after stretching, aiding in blood circulation.

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    Fenestrated Capillary

    Capillaries with pores that allow passage of larger molecules, found in specific organs.

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    Continuous Capillary

    The most common type of capillary with tight junctions, found in most tissues.

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    Tunica Intima

    The innermost layer of blood vessels, composed of endothelial cells.

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    Tunica Media

    The middle layer of blood vessel walls, containing smooth muscle and elastic fibers.

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    Vasodilation

    The widening of blood vessels, decreasing blood pressure.

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    Pressure Gradient

    The difference in pressure that drives blood flow through the circulatory system.

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    Vasa Vasorum

    Small blood vessels that supply nutrients to the walls of larger arteries and veins.

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    Nervi Vasorum

    Minute nerves in blood vessel walls that control smooth muscle contraction and dilation.

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    Tunics

    Three distinct tissue layers of arteries and veins: tunica intima, media, and externa.

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    Endothelium

    Specialized simple squamous epithelium lining the tunica intima throughout the vascular system.

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    Basement Membrane

    A layer that binds the endothelium to connective tissue, providing strength and flexibility.

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    Internal Elastic Membrane

    Layer of elastic fibers in larger arteries at the boundary with the tunica media.

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    Valves in Veins

    Structures formed by the endothelium that prevent backflow of blood in veins.

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    External Elastic Membrane

    Layer of elastic fibers separating the tunica media from the tunica externa in larger arteries.

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    Collagenous Fibers

    Strong fibers in the blood vessel wall providing structural support.

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    Smooth Muscle

    Muscle type in the tunica media controlling vessel diameter through contraction and relaxation.

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    Study Notes

    Blood Composition and Function

    • Blood is a fluid connective tissue, unique because its extracellular matrix (plasma) is liquid.
    • Formed elements (RBCs, WBCs, platelets) are suspended in the plasma.
    • These elements originate from hematopoietic stem cells in bone marrow.
    • Hematopoiesis (blood cell production) occurs in yolk sac, fetal liver, spleen and red bone marrow. Postnatally, primarily in red marrow of spongy bone.

    Formed Elements

    • Erythrocytes (RBCs): Transport oxygen and some carbon dioxide.

      • Biconcave shape maximizes surface area for gas exchange.
      • Lack most organelles, maximizing space for hemoglobin.
      • Lifespan: ~120 days. Removed by macrophages in bone marrow, liver, and spleen.
    • Leukocytes (WBCs): Defend against harmful microorganisms or molecules.

      • Several types (neutrophils, eosinophils, basophils, lymphocytes, monocytes)
      • Can leave blood vessels to enter tissues
      • Vary in lifespan (from hours to years)
      • Important in different immune responses
    • Platelets (thrombocytes): Involved in blood clotting and tissue repair.

      • Fragments of megakaryocytes.
      • Lifespan: ~10 days. Removed by macrophages.

    Blood Composition and Plasma

    • Plasma: Mostly water (92%), with dissolved/suspended proteins and other substances.
    • Approximately 8% of adult body weight
    • Male average: 5-6 liters, Female average: 4-5 liters
    • Blood function involves oxygen/nutrient delivery and waste removal, defense and regulation.

    Hematopoiesis (Blood Cell Production)

    • Hemopoiesis occurs continuously to replenish blood cells.
    • Hematopoietic growth factors stimulate stem cell division and differentiation.
    • Stem cells are organized hierarchically, with progressively reduced diversification ability at each step.
    • Blood loss requires a number of weeks to replace cells.

    Blood Typing and Transfusions

    • ABO blood groups are based on the presence or absence of A and B antigens on RBCs membranes.
    • Type O is the universal donor; AB is the universal recipient.
    • Rh factor (presence/absence of Rh D antigen) is also crucial in blood transfusions and can cause complications in pregnancies.
    • RhoGAM prevents Rh incompatibility in Rh-negative mothers.

    Blood Vessels

    • Blood flow in closed circulatory system with arteries, arterioles, capillaries, venules and veins.

    • Arteries are high-pressure vessels that carry blood away from the heart, with thick walls containing elastic and muscular fibers.

      • Elastic arteries (conducting) expand and recoil.
      • Muscular arteries (distributing) control blood flow via vasoconstriction and vasodilation.
    • Arterioles control blood flow into capillaries further regulating pressure.

    • Capillaries are where exchange of nutrients and wastes occurs with the tissues via a leaky endothelium.

    • Continuous, fenestrated and sinusoids are different types of capillaries based on how leaky they are.

    • Venules carry blood from capillaries to veins, smaller versions of veins.

    • Veins are low-pressure vessels that carry blood toward the heart with thin walls and valves to prevent backflow.

    • Venoconstriction increases blood return to heart

    Disorders

    • Anemia: Insufficient RBCs or hemoglobin. Various types (blood loss, decreased production, excessive destruction).
    • Thrombocytosis: Excessive platelets, potentially leading to clots.
    • Thrombocytopenia: Insufficient platelets leading to excessive bleeding.
    • Edema: Excess tissue fluid due to various causes.
    • Varicose veins: Impaired venous valves leading to distended veins.
    • Hypoxia: low oxygen levels (more general)
    • Hypoxemia, low oxygen content in the blood itself; measured by pO2, oxygen partial pressure.

    Hematology tests and analysis

    • Hematocrit: Measures the percentage of red blood cells in a blood sample (45%)
    • Pulse oximetry measures hemoglobin saturation using light absorption in the blood.

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    Test your knowledge on the functions and components of human blood with this quiz. Discover key concepts such as the role of different blood cells, hematopoiesis, and oxygen transport. Perfect for biology students looking to reinforce their understanding of human physiology.

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