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Blood Coagulation: Platelet Activation

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Questions and Answers

What is the primary function of endothelial cells in the context of haemostasis?

To stimulate the immune response

To release platelet-activating factors

To form a blood clot

To secrete nitric oxide and prostaglandins (correct)

What is the effect of endothelial cell injury on smooth muscle cells?

Apoptosis

Contraction (correct)

Relaxation

Proliferation

What is the purpose of the vascular spasm that occurs in response to endothelial injury?

To activate the immune response

To reduce blood flow to the damaged area (correct)

To stimulate platelet activation

To increase blood flow to the damaged area

What protein is released by damaged endothelial cells that binds to collagen and promotes platelet adhesion?

Von Willebrand factor Signup and view all the answers

What is the surface protein on platelets that allows them to bind to Von Willebrand factor?

GP1B Signup and view all the answers

What is the primary function of platelets in haemostasis?

To adhere to damaged endothelial cells Signup and view all the answers

What is the consequence of endothelial cell injury on nitric oxide and prostaglandin secretion?

Decreased secretion Signup and view all the answers

What is the primary function of collagen in the context of haemostasis?

To provide a surface for platelet adhesion Signup and view all the answers

What is the consequence of platelet adhesion to Von Willebrand factor?

Platelet activation and degranulation Signup and view all the answers

What is the term for the sequence of events that leads to the formation of a blood clot?

Primary haemostasis Signup and view all the answers