Blood Coagulation Factors
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Questions and Answers

What is the primary cause of Hemophilia A?

  • Acquired deficiency of Factor IX
  • Vitamin C deficiency
  • Inherited deficiency of Factor VIII (correct)
  • Liver disease

    • Which of the following is an acquired factor deficiency?

  • Hemophilia B
  • Anticoagulant therapy (correct)
  • Myeloproliferative disorders
  • Von Willebrand's disease

    • What is the primary cause of Hemophilia B?

  • Liver disease
  • Acquired deficiency of Factor VIII
  • Inherited deficiency of Factor IX (correct)
  • Vitamin C deficiency

    • Which of the following is an inherited factor deficiency?

    <p>Von Willebrand's disease</p> Signup and view all the answers

    What is the primary cause of Von Willebrand's disease?

    <p>Inherited deficiency of Factor VIII-related antigen</p> Signup and view all the answers

    Which factor is most commonly affected in Von Willebrand's disease?

    <p>Factor VIII-related antigen</p> Signup and view all the answers

    What percentage of hemophiliacs have a deficiency of Factor VIII?

    <p>80-85%</p> Signup and view all the answers

    Which of the following laboratory tests is used to diagnose Von Willebrand's disease?

    <p>Prolonged BT and PTT</p> Signup and view all the answers

    What is the immediate effect of Coumadin anticoagulants?

    <p>It takes at least 48 to 72 hours for the anticoagulant effect to develop</p> Signup and view all the answers

    Which of the following is an acquired factor deficiency?

    <p>Anticoagulant therapy</p> Signup and view all the answers

    What is the role of Von Willebrand factor in circulation?

    <p>It binds to Factor VIII while it is inactive</p> Signup and view all the answers

    What is the primary mechanism of action of heparin in preventing blood clotting?

    <p>Activating antithrombin III to block thrombin</p> Signup and view all the answers

    What is the purpose of administering heparin concomitantly with Coumadin?

    <p>To provide an immediate anticoagulant effect</p> Signup and view all the answers

    In liver disease, which coagulation factors are reduced in production?

    <p>I, II, V, VII, IX, X</p> Signup and view all the answers

    What is the consequence of disseminated intravascular coagulation (DIC) on blood flow to organs?

    <p>Disrupted blood flow to organs, leading to organ malfunction</p> Signup and view all the answers

    What is the characteristic laboratory finding in disseminated intravascular coagulation (DIC)?

    <p>Prolonged PT and APTT, and reduced fibrinogen level</p> Signup and view all the answers

    What is the significance of high levels of fibrin degradation products, including D-dimer, in DIC?

    <p>It indicates the presence of intense fibrinolytic activity</p> Signup and view all the answers

    What is the advantage of using low molecular weight heparin over unfractionated heparin?

    <p>It has fewer side effects and more predictable plasma levels</p> Signup and view all the answers

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