Blood Clotting Cascade Quiz
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Questions and Answers

Which of the following is NOT a factor that limits clot formation in the coagulation process?

  • Protein C
  • Fibrinogen (correct)
  • Thrombomodulin
  • Antithrombin III
  • The extrinsic tenase complex is formed by the binding of:

  • Thrombin and fibrinogen
  • Tissue factor and factor VIIa (correct)
  • Factor IXa and factor VIIIa
  • Factor Xa and factor Va
  • The intrinsic tenase complex is formed by the binding of:

  • Thrombin and fibrinogen
  • Factor Xa and factor Va
  • Factor IXa and factor VIIIa (correct)
  • Tissue factor and factor VIIa
  • Which of the following is NOT a step in the coagulation cascade?

    <p>Activation of protein S</p> Signup and view all the answers

    Which of the following statements about the regulation of haemostasis is TRUE?

    <p>Thrombomodulin inhibits the activity of thrombin</p> Signup and view all the answers

    Which of the following is a key function of platelets in haemostasis?

    <p>Providing a surface for assembly of coagulation complexes</p> Signup and view all the answers

    Which genetic mutation eliminates the cleavage site 506 and leads to activated Protein C resistance?

    <p>Prothrombin G20210A mutation</p> Signup and view all the answers

    What is the predominant site of synthesis for Plasma Factor V?

    <p>Liver</p> Signup and view all the answers

    Which genetic mutation is associated with a 10-fold lower inactivation rate of Factor Va?

    <p>Factor V Leiden mutation</p> Signup and view all the answers

    What is the impact of Factor V Leiden mutation on coagulation?

    <p>APC resistance</p> Signup and view all the answers

    Which protein is predominantly synthesized in hepatocytes and stored in platelet alpha granules?

    <p>Factor V</p> Signup and view all the answers

    Which factor specifically inactivates both Factors Va and VIIIa in the coagulation cascade?

    <p>Protein C</p> Signup and view all the answers

    What is the function of Protein S in the clotting mechanism?

    <p>Inactivating Factors Va and VIIIa</p> Signup and view all the answers

    Which mutation leads to increased thrombotic risk in homozygotes?

    <p>Factor V Leiden mutation</p> Signup and view all the answers

    What is the normal plasma concentration of Factor V?

    <p>7-10ug/ml</p> Signup and view all the answers

    What does Thrombin specifically bind to on the surface of vascular endothelial cells?

    <p>Thrombomodulin</p> Signup and view all the answers

    What is the primary function of the extrinsic tenase complex?

    <p>To activate Factor X and initiate the common pathway</p> Signup and view all the answers

    Which of the following is a natural inhibitor of the coagulation cascade?

    <p>Tissue Factor Pathway Inhibitor (TFPI)</p> Signup and view all the answers

    What is the primary function of the intrinsic tenase complex?

    <p>To activate Factor X and initiate the common pathway</p> Signup and view all the answers

    Which of the following is a vitamin K-dependent protein involved in the regulation of the coagulation cascade?

    <p>Protein C</p> Signup and view all the answers

    What is the primary function of Protein S in the regulation of the coagulation cascade?

    <p>To act as a cofactor for the activation of Protein C</p> Signup and view all the answers

    Which of the following is a serine protease inhibitor (SERPIN) involved in the regulation of the coagulation cascade?

    <p>Antithrombin III</p> Signup and view all the answers

    What is the primary function of the fibrinolytic system in the regulation of haemostasis?

    <p>To break down and remove clots</p> Signup and view all the answers

    Which of the following is a cofactor for the activated Protein C (APC)-mediated inactivation of Factor Va and Factor VIIIa?

    <p>Protein S</p> Signup and view all the answers

    What is the primary function of the prothrombinase complex in the coagulation cascade?

    <p>To convert prothrombin to thrombin</p> Signup and view all the answers

    Which of the following is involved in the regulation of the fibrinolytic system?

    <p>Protein C</p> Signup and view all the answers

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