26 Questions
Which of the following is NOT a factor that limits clot formation in the coagulation process?
Fibrinogen
The extrinsic tenase complex is formed by the binding of:
Tissue factor and factor VIIa
The intrinsic tenase complex is formed by the binding of:
Factor IXa and factor VIIIa
Which of the following is NOT a step in the coagulation cascade?
Activation of protein S
Which of the following statements about the regulation of haemostasis is TRUE?
Thrombomodulin inhibits the activity of thrombin
Which of the following is a key function of platelets in haemostasis?
Providing a surface for assembly of coagulation complexes
Which genetic mutation eliminates the cleavage site 506 and leads to activated Protein C resistance?
Prothrombin G20210A mutation
What is the predominant site of synthesis for Plasma Factor V?
Liver
Which genetic mutation is associated with a 10-fold lower inactivation rate of Factor Va?
Factor V Leiden mutation
What is the impact of Factor V Leiden mutation on coagulation?
APC resistance
Which protein is predominantly synthesized in hepatocytes and stored in platelet alpha granules?
Factor V
Which factor specifically inactivates both Factors Va and VIIIa in the coagulation cascade?
Protein C
What is the function of Protein S in the clotting mechanism?
Inactivating Factors Va and VIIIa
Which mutation leads to increased thrombotic risk in homozygotes?
Factor V Leiden mutation
What is the normal plasma concentration of Factor V?
7-10ug/ml
What does Thrombin specifically bind to on the surface of vascular endothelial cells?
Thrombomodulin
What is the primary function of the extrinsic tenase complex?
To activate Factor X and initiate the common pathway
Which of the following is a natural inhibitor of the coagulation cascade?
Tissue Factor Pathway Inhibitor (TFPI)
What is the primary function of the intrinsic tenase complex?
To activate Factor X and initiate the common pathway
Which of the following is a vitamin K-dependent protein involved in the regulation of the coagulation cascade?
Protein C
What is the primary function of Protein S in the regulation of the coagulation cascade?
To act as a cofactor for the activation of Protein C
Which of the following is a serine protease inhibitor (SERPIN) involved in the regulation of the coagulation cascade?
Antithrombin III
What is the primary function of the fibrinolytic system in the regulation of haemostasis?
To break down and remove clots
Which of the following is a cofactor for the activated Protein C (APC)-mediated inactivation of Factor Va and Factor VIIIa?
Protein S
What is the primary function of the prothrombinase complex in the coagulation cascade?
To convert prothrombin to thrombin
Which of the following is involved in the regulation of the fibrinolytic system?
Protein C
Test your knowledge of the blood clotting cascade from contact initiation to fibrin clot formation. Learn about the roles of phospholipids, collagen, subendothelial surfaces, and factors like IXa, VIIIa, Xa, IIa, and thrombin.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
