Bleeding Disorders and Hemostasis
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Questions and Answers

What is the main function of platelets in haemostasis?

  • Produce coagulation factors
  • Initiate the coagulation process
  • Aggregate at sites of vessel injury to form the primary haemostatic plug (correct)
  • Limit coagulation throughout the body

    • Which component is responsible for limiting fibrin deposition at the site of injury?

  • Coagulation factors
  • Platelets
  • Blood vessels
  • Fibrinolysis (correct)

    • What is the role of intact vascular endothelium in the haemostasis process?

  • Inhibit coagulation (correct)
  • Stabilize the primary haemostatic plug
  • Limit coagulation throughout the body
  • Initiate coagulation

    • Which factor is mainly responsible for activating coagulation when tissue is injured?

    <p>Factor VII</p> Signup and view all the answers

    What is the main function of coagulation inhibitors in haemostasis?

    <p>Prevent activation of coagulation factors</p> Signup and view all the answers

    Which screening test measures the activity of factors II, V, VII, and X?

    <p>(PT)</p> Signup and view all the answers

    What does APTT measure?

    <p>Activity of factors II, V, VIII, IX, X, XI, and XII</p> Signup and view all the answers

    What does a mixing study involving a 1:1 ratio mix with normal plasma distinguish between?

    <p>Possible factor deficiency or presence of inhibitor</p> Signup and view all the answers

    Which factor deficiency can lead to easy bruising, hemarthrosis, mouth ulceration, and intramuscular hematoma?

    <p>Factor VIII deficiency</p> Signup and view all the answers

    What is the most common severe inherited bleeding disorder due to deficiencies of F8?

    <p>Hemophilia A</p> Signup and view all the answers

    At what factor level may mild deficiency of hemophilia be asymptomatic or require significant trauma to bleed?

    <p>&gt;5% of normal</p> Signup and view all the answers

    What is the function of Von Willebrand factor (VWF) in plasma?

    <p>Adheres to subendothelial matrix after vascular damage and acts as a carrier protein for F8</p> Signup and view all the answers

    What is the clinical manifestation of Von Willebrand disease (VWD)?

    <p>Excessive bruising, epistaxis, postoperative hemorrhage, and menorrhagia</p> Signup and view all the answers

    What may be required for prophylaxis in severe hemophilia to prevent spontaneous bleeding and early joint deformities?

    <p>Comprehensive Hemophilia Care Center involvement</p> Signup and view all the answers

    What complications may arise from Von Willebrand disease?

    <p><em>Chronic arthropathy</em> and <em>Transfusion-transmitted infectious diseases</em></p> Signup and view all the answers

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