15 Questions
What is the main function of platelets in haemostasis?
Aggregate at sites of vessel injury to form the primary haemostatic plug
Which component is responsible for limiting fibrin deposition at the site of injury?
Fibrinolysis
What is the role of intact vascular endothelium in the haemostasis process?
Inhibit coagulation
Which factor is mainly responsible for activating coagulation when tissue is injured?
Factor VII
What is the main function of coagulation inhibitors in haemostasis?
Prevent activation of coagulation factors
Which screening test measures the activity of factors II, V, VII, and X?
(PT)
What does APTT measure?
Activity of factors II, V, VIII, IX, X, XI, and XII
What does a mixing study involving a 1:1 ratio mix with normal plasma distinguish between?
Possible factor deficiency or presence of inhibitor
Which factor deficiency can lead to easy bruising, hemarthrosis, mouth ulceration, and intramuscular hematoma?
Factor VIII deficiency
What is the most common severe inherited bleeding disorder due to deficiencies of F8?
Hemophilia A
At what factor level may mild deficiency of hemophilia be asymptomatic or require significant trauma to bleed?
>5% of normal
What is the function of Von Willebrand factor (VWF) in plasma?
Adheres to subendothelial matrix after vascular damage and acts as a carrier protein for F8
What is the clinical manifestation of Von Willebrand disease (VWD)?
Excessive bruising, epistaxis, postoperative hemorrhage, and menorrhagia
What may be required for prophylaxis in severe hemophilia to prevent spontaneous bleeding and early joint deformities?
Comprehensive Hemophilia Care Center involvement
What complications may arise from Von Willebrand disease?
Chronic arthropathy and Transfusion-transmitted infectious diseases
Test your knowledge on bleeding disorders, hemostasis, and the process of blood clotting. Learn about the components involved in the regulation of clot formation and restoration of normal blood flow.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
