Bismuth Subsalicylate Flashcards

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Questions and Answers

What is the brand name for bismuth subsalicylate?

  • Pepto Bismol (correct)
  • Kaopectate (correct)
  • Tums
  • Imodium

What are the drug classes for bismuth subsalicylate?

  • Antidiarrheal (correct)
  • Antibiotic
  • Antacid (correct)
  • Analgesic

What are the indications for bismuth subsalicylate?

Diarrhea, heartburn, nausea

What are the dosage forms for bismuth subsalicylate?

<p>Oral suspension, chewable tablet</p>
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What is the dosing for bismuth subsalicylate?

<p>525 mg q 30-60 min prn, MAX: 8 doses/day</p>
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Is renal dosing adjustment necessary for bismuth subsalicylate?

<p>False (B)</p>
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What are the contraindications for bismuth subsalicylate?

<p>Presence of GI bleeding, active ulcer, blood/black stool</p>
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What are common adverse drug reactions (ADRs) for bismuth subsalicylate?

<p>Constipation, discoloration of the tongue, grayish black stools, anxiety, confusion, headache, mental depression, slurred speech, muscle spasms, weakness, hearing loss, tinnitus</p>
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What are serious adverse drug reactions (ADRs) for bismuth subsalicylate?

<p>Anaphylaxis, encephalopathy, neurotoxicity</p>
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What are the monitoring parameters for bismuth subsalicylate?

<p>Relief from diarrhea or heartburn; seek medical attention for severe constipation or abdominal pain.</p>
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What drug interactions are associated with bismuth subsalicylate?

<p>Tetracycline antibiotics</p>
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What are the counseling points for bismuth subsalicylate?

<p>Oral rehydration therapy for mild, uncomplicated diarrhea must accompany treatment; shake suspension before use; take tablets with water; may experience tongue or stool discoloration; inform HCP if tinnitus occurs.</p>
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Study Notes

Bismuth Subsalicylate Overview

  • Brand names include Pepto Bismol and Kaopectate.
  • Classified as both an antidiarrheal and an antacid.

Indications

  • Effective for treating diarrhea.
  • Alleviates heartburn symptoms.
  • Used to manage nausea.

Dosage Forms

  • Available as an oral suspension.
  • Also comes in chewable tablet form.

Dosing Guidelines

  • Typical dosing is 525 mg every 30 to 60 minutes as needed.
  • Maximum dosage is capped at 8 doses per day.

Renal Considerations

  • No renal dosing adjustments are necessary.

Contraindications

  • Should not be used if there is a presence of gastrointestinal (GI) bleeding.
  • Active ulcers are a contraindication.
  • Avoid use if blood or black stools are present.

Common Adverse Drug Reactions (ADRs)

  • Can cause constipation and discoloration of the tongue.
  • May lead to grayish-black stools.
  • Other potential side effects include anxiety, confusion, headache, mental depression, slurred speech, muscle spasms, weakness, and tinnitus.

Serious Adverse Drug Reactions

  • Risk of anaphylaxis, which is a severe allergic reaction.
  • Potential for encephalopathy, leading to brain dysfunction.
  • Neurotoxicity can occur with significant adverse effects on the nervous system.

Monitoring Parameters

  • Monitor for relief of diarrhea or heartburn symptoms.
  • Watch for signs of constipation or abdominal pain; severe symptoms warrant medical attention.

Drug Interactions

  • May interact with tetracycline antibiotics, which can affect their effectiveness.

Counseling Points

  • For mild, uncomplicated diarrhea, oral rehydration therapy should accompany bismuth subsalicylate treatment.
  • Shake the suspension before each use and utilize the measuring device included in the packaging.
  • Tablets should be consumed with 120-240 mL of water, either chewed or dissolved in the mouth.
  • Users may experience tongue or stool discoloration; this is typically benign but should be noted.
  • Inform a healthcare professional immediately if tinnitus develops.

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